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Protein
Submitted name:

Tumor necrosis factor receptor superfamily, member 1a

Gene

tnfrsf1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Biological processi

  • defense response to bacterium Source: ZFIN
  • fin regeneration Source: ZFIN
  • innate immune response Source: ZFIN
  • neutrophil chemotaxis Source: ZFIN
  • regulation of granuloma formation Source: ZFIN
  • response to bacterium Source: ZFIN
  • response to virus Source: ZFIN
  • signal transduction Source: InterPro

Keywordsi

Molecular functionReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Tumor necrosis factor receptor superfamily, member 1aImported
Gene namesi
Name:tnfrsf1aImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-040426-2252 tnfrsf1a

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei206 – 225HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500427785924 – 389Sequence analysisAdd BLAST366

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi72 ↔ 87PROSITE-ProRule annotation
Disulfide bondi133 ↔ 146PROSITE-ProRule annotation
Disulfide bondi136 ↔ 154PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ6NUU6
SMRiQ6NUU6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini71 – 112TNFR-CysInterPro annotationAdd BLAST42
Repeati71 – 112TNFR-CysPROSITE-ProRule annotationAdd BLAST42
Domaini113 – 154TNFR-CysInterPro annotationAdd BLAST42
Repeati113 – 154TNFR-CysPROSITE-ProRule annotationAdd BLAST42
Domaini305 – 381DeathInterPro annotationAdd BLAST77

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IXBX Eukaryota
ENOG4111YG2 LUCA
HOGENOMiHOG000205796
KOiK03158
PhylomeDBiQ6NUU6

Family and domain databases

CDDicd08313 Death_TNFR1, 1 hit
cd15834 TNFRSF1A_teleost, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR033994 TNFRSF1A_death
IPR033995 TNFRSF1A_N_teleost
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF00020 TNFR_c6, 2 hits
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM00208 TNFR, 3 hits
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS00652 TNFR_NGFR_1, 1 hit
PS50050 TNFR_NGFR_2, 2 hits

Sequencei

Sequence statusi: Complete.

Q6NUU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRICQLTTCL FLVLTSQLYT ISGLGGNKTM KGNCLENEYW NKEGFCCDKC
60 70 80 90 100
HQGYKLKQEC SAENMRSKCE KCDEGTYLEQ ANYSPNCFRC QQCTKPHSRE
110 120 130 140 150
SSPCTPYSNR VCECDTDYYK KKLGDLGWEC SRCKKCGDGQ IEIQNCTKEE
160 170 180 190 200
NRQCKCQENH YPFNKNSCKL CDKCQPGCDH LCKTSIPPVF FTSTKSNSPE
210 220 230 240 250
DTVPKIVVPV CASIMVLSLA IFMAYEGIRH WRKRAQASSS QSSSPATEEE
260 270 280 290 300
AFIITVVQDS KNKSVSFTNQ PCESKPLGNL PDCIPREIKI HEFFYFVLDE
310 320 330 340 350
VPIGRFKELV RRLGVSEQNI DRAEHDHRNC KDAQYQMLKV WSDGGSGGGN
360 370 380
NVVPYDQIQM LMSTLKDMCL VSCADNIENK FLSQNTSVS
Length:389
Mass (Da):44,099
Last modified:July 5, 2004 - v1
Checksum:i9EB46F454519FB3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC068424 mRNA Translation: AAH68424.1
RefSeqiNP_998355.1, NM_213190.1
UniGeneiDr.27758

Genome annotation databases

GeneIDi406471
KEGGidre:406471

Similar proteinsi

Entry informationi

Entry nameiQ6NUU6_DANRE
AccessioniPrimary (citable) accession number: Q6NUU6
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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