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Entry version 122 (10 Apr 2019)
Sequence version 2 (04 Apr 2006)
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Protein

Tectonic-3

Gene

TCTN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). May be involved in apoptosis regulation. Necessary for signal transduction through the sonic hedgehog (Shh) signaling pathway.By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis, Cilium biogenesis/degradation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5620912 Anchoring of the basal body to the plasma membrane

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...
MoonDBi
Q6NUS6 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tectonic-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TCTN3
Synonyms:C10orf61, TECT3
ORF Names:PSEC0041, UNQ1881/PRO4324
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000119977.20

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24519 TCTN3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613847 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6NUS6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini23 – 581ExtracellularSequence analysisAdd BLAST559
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei582 – 602HelicalSequence analysisAdd BLAST21
Topological domaini603 – 607CytoplasmicSequence analysis5

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Orofaciodigital syndrome 4 (OFD4)
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of orofaciodigital syndrome, a group of heterogeneous disorders characterized by malformations of the oral cavity, face and digits, and associated phenotypic abnormalities that lead to the delineation of various subtypes. OFD4 patients have tongue nodules, multiple frenulae, broad flat nose, hypertelorism, and short rib polydactyly with tibial dysplasia (Majewski syndrome). The presence of severe tibial aplasia differentiates OFD4 from OFD1. Additional features of cystic dysplastic kidneys and brain malformation, including occipital encephalocele, are observed in severely affected patients.
See also OMIM:258860
Joubert syndrome 18 (JBTS18)1 Publication
The disease is caused by mutations affecting the gene represented in this entry. TCTN3-mutated fibroblasts from JBTS18 patients fail to respond to Shh agonists suggesting that at least some of the defects in affected individuals may be secondary to reduced Shh signaling (PubMed:22883145).1 Publication
Disease descriptionA form of Joubert syndrome, a disorder presenting with cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay. Neuroradiologically, it is characterized by cerebellar vermian hypoplasia/aplasia, thickened and reoriented superior cerebellar peduncles, and an abnormally large interpeduncular fossa, giving the appearance of a molar tooth on transaxial slices (molar tooth sign). Additional variable features include retinal dystrophy and renal disease. JBTS18 patients have vermis agenesis and the molar tooth sign as well as severe kyphoscoliosis. Other features include intrauterine growth retardation, oral anomalies, micrognathism, polydactyly and camptodactyly, joint laxity, horseshoe kidney, and ventricular septal defect.
See also OMIM:614815
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_068823314G → R in JBTS18. 1 PublicationCorresponds to variant dbSNP:rs793888508EnsemblClinVar.1

Keywords - Diseasei

Ciliopathy, Disease mutation, Joubert syndrome

Organism-specific databases

DisGeNET

More...
DisGeNETi
26123

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
TCTN3

MalaCards human disease database

More...
MalaCardsi
TCTN3
MIMi258860 phenotype
614815 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000119977

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
2753 Orofaciodigital syndrome type 4
2754 Orofaciodigital syndrome type 6

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162405513

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TCTN3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
91208025

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000022992123 – 607Tectonic-3Add BLAST585

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi78N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi179N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi347N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q6NUS6

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q6NUS6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6NUS6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6NUS6

PeptideAtlas

More...
PeptideAtlasi
Q6NUS6

PRoteomics IDEntifications database

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PRIDEi
Q6NUS6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
66705
66706 [Q6NUS6-2]
66707 [Q6NUS6-3]
66708 [Q6NUS6-4]
66709 [Q6NUS6-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6NUS6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q6NUS6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000119977 Expressed in 210 organ(s), highest expression level in corpus epididymis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q6NUS6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q6NUS6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA026987

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the tectonic-like complex (also named B9 complex).By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
117565, 319 interactors

Protein interaction database and analysis system

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IntActi
Q6NUS6, 307 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000483364

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q6NUS6

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi90 – 109Cys-richAdd BLAST20

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tectonic family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFR0 Eukaryota
ENOG4111GX2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00570000079101

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000070061

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG094032

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q6NUS6

KEGG Orthology (KO)

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KOi
K19382

Database of Orthologous Groups

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OrthoDBi
446525at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q6NUS6

TreeFam database of animal gene trees

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TreeFami
TF329169

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011677 DUF1619
IPR040354 Tectonic

The PANTHER Classification System

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PANTHERi
PTHR14611 PTHR14611, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07773 DUF1619, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6NUS6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRTPQLALLQ VFFLVFPDGV RPQPSSSPSG AVPTSLELQR GTDGGTLQSP
60 70 80 90 100
SEATATRPAV PGLPTVVPTL VTPSAPGNRT VDLFPVLPIC VCDLTPGACD
110 120 130 140 150
INCCCDRDCY LLHPRTVFSF CLPGSVRSSS WVCVDNSVIF RSNSPFPSRV
160 170 180 190 200
FMDSNGIRQF CVHVNNSNLN YFQKLQKVNA TNFQALAAEF GGESFTSTFQ
210 220 230 240 250
TQSPPSFYRA GDPILTYFPK WSVISLLRQP AGVGAGGLCA ESNPAGFLES
260 270 280 290 300
KSTTCTRFFK NLASSCTLDS ALNAASYYNF TVLKVPRSMT DPQNMEFQVP
310 320 330 340 350
VILTSQANAP LLAGNTCQNV VSQVTYEIET NGTFGIQKVS VSLGQTNLTV
360 370 380 390 400
EPGASLQQHF ILRFRAFQQS TAASLTSPRS GNPGYIVGKP LLALTDDISY
410 420 430 440 450
SMTLLQSQGN GSCSVKRHEV QFGVNAISGC KLRLKKADCS HLQQEIYQTL
460 470 480 490 500
HGRPRPEYVA IFGNADPAQK GGWTRILNRH CSISAINCTS CCLIPVSLEI
510 520 530 540 550
QVLWAYVGLL SNPQAHVSGV RFLYQCQSIQ DSQQVTEVSL TTLVNFVDIT
560 570 580 590 600
QKPQPPRGQP KMDWKWPFDF FPFKVAFSRG VFSQKCSVSP ILILCLLLLG

VLNLETM
Length:607
Mass (Da):66,157
Last modified:April 4, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i41CE275DEDF358E6
GO
Isoform 2 (identifier: Q6NUS6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     402-443: MTLLQSQGNG...LKKADCSHLQ → VSFLELGGLL...FVHYNEVLIY
     444-607: Missing.

Note: No experimental confirmation available.
Show »
Length:443
Mass (Da):47,985
Checksum:i12499DB14EB8C0D2
GO
Isoform 3 (identifier: Q6NUS6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-151: Missing.
     297-323: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:429
Mass (Da):47,284
Checksum:iBA9CF7DC7490F6C3
GO
Isoform 4 (identifier: Q6NUS6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     210-211: AG → VS
     212-607: Missing.

Note: No experimental confirmation available.
Show »
Length:211
Mass (Da):22,846
Checksum:iBFFB9036766D2867
GO
Isoform 5 (identifier: Q6NUS6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     167-246: SNLNYFQKLQ...GLCAESNPAG → C
     297-365: Missing.

Note: No experimental confirmation available.
Show »
Length:459
Mass (Da):50,258
Checksum:i3BCD657AE2F53BDB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DFN5A0A0C4DFN5_HUMAN
Chromosome 10 open reading frame 61
TCTN3 C10orf61, hCG_39491
625Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH68449 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence ABB90564 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC11567 differs from that shown. Reason: Frameshift at position 238.Curated
The sequence BAC87634 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti30G → E in BAC11567 (PubMed:14702039).Curated1
Sequence conflicti492C → R in BAC11567 (PubMed:14702039).Curated1
Sequence conflicti516H → Q in CAB43242 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07752195T → P Found in a patient with Joubert syndrome also carrying 2 mutations in MKS1 gene, a deletion in intron 15 and a missense mutation 'C-80'; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs749447795EnsemblClinVar.1
Natural variantiVAR_068823314G → R in JBTS18. 1 PublicationCorresponds to variant dbSNP:rs793888508EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0177911 – 151Missing in isoform 3. 1 PublicationAdd BLAST151
Alternative sequenceiVSP_043266167 – 246SNLNY…SNPAG → C in isoform 5. 1 PublicationAdd BLAST80
Alternative sequenceiVSP_017792210 – 211AG → VS in isoform 4. 1 Publication2
Alternative sequenceiVSP_017793212 – 607Missing in isoform 4. 1 PublicationAdd BLAST396
Alternative sequenceiVSP_043267297 – 365Missing in isoform 5. 1 PublicationAdd BLAST69
Alternative sequenceiVSP_017794297 – 323Missing in isoform 3. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_017795402 – 443MTLLQ…CSHLQ → VSFLELGGLLQPNEKSCKGF QTYVRLAKGEEFFVHYNEVL IY in isoform 2. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_017796444 – 607Missing in isoform 2. 1 PublicationAdd BLAST164

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
DQ278872 mRNA Translation: ABB90564.1 Different initiation.
AK075357 mRNA Translation: BAC11567.1 Frameshift.
AY359022 mRNA Translation: AAQ89381.1
AK098295 mRNA Translation: BAC05278.1
AK128834 mRNA Translation: BAC87634.1 Different initiation.
AK299141 mRNA Translation: BAG61193.1
AL050022 mRNA Translation: CAB43242.2
AL356632 Genomic DNA No translation available.
BC009494 mRNA Translation: AAH09494.2
BC061582 mRNA Translation: AAH61582.1
BC068449 mRNA Translation: AAH68449.2 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS31258.2 [Q6NUS6-1]
CCDS44461.1 [Q6NUS6-5]

Protein sequence database of the Protein Information Resource

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PIRi
T08708

NCBI Reference Sequences

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RefSeqi
NP_001137445.1, NM_001143973.1 [Q6NUS6-5]
NP_056446.4, NM_015631.5 [Q6NUS6-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.438991

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000371209; ENSP00000360253; ENSG00000119977 [Q6NUS6-2]
ENST00000371217; ENSP00000360261; ENSG00000119977 [Q6NUS6-1]
ENST00000430368; ENSP00000387567; ENSG00000119977 [Q6NUS6-5]
ENST00000614499; ENSP00000483364; ENSG00000119977 [Q6NUS6-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
26123

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:26123

UCSC genome browser

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UCSCi
uc001klb.4 human [Q6NUS6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ278872 mRNA Translation: ABB90564.1 Different initiation.
AK075357 mRNA Translation: BAC11567.1 Frameshift.
AY359022 mRNA Translation: AAQ89381.1
AK098295 mRNA Translation: BAC05278.1
AK128834 mRNA Translation: BAC87634.1 Different initiation.
AK299141 mRNA Translation: BAG61193.1
AL050022 mRNA Translation: CAB43242.2
AL356632 Genomic DNA No translation available.
BC009494 mRNA Translation: AAH09494.2
BC061582 mRNA Translation: AAH61582.1
BC068449 mRNA Translation: AAH68449.2 Different initiation.
CCDSiCCDS31258.2 [Q6NUS6-1]
CCDS44461.1 [Q6NUS6-5]
PIRiT08708
RefSeqiNP_001137445.1, NM_001143973.1 [Q6NUS6-5]
NP_056446.4, NM_015631.5 [Q6NUS6-1]
UniGeneiHs.438991

3D structure databases

ProteinModelPortaliQ6NUS6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117565, 319 interactors
IntActiQ6NUS6, 307 interactors
STRINGi9606.ENSP00000483364

Protein family/group databases

MoonDBiQ6NUS6 Predicted

PTM databases

iPTMnetiQ6NUS6
PhosphoSitePlusiQ6NUS6

Polymorphism and mutation databases

BioMutaiTCTN3
DMDMi91208025

Proteomic databases

EPDiQ6NUS6
jPOSTiQ6NUS6
MaxQBiQ6NUS6
PaxDbiQ6NUS6
PeptideAtlasiQ6NUS6
PRIDEiQ6NUS6
ProteomicsDBi66705
66706 [Q6NUS6-2]
66707 [Q6NUS6-3]
66708 [Q6NUS6-4]
66709 [Q6NUS6-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371209; ENSP00000360253; ENSG00000119977 [Q6NUS6-2]
ENST00000371217; ENSP00000360261; ENSG00000119977 [Q6NUS6-1]
ENST00000430368; ENSP00000387567; ENSG00000119977 [Q6NUS6-5]
ENST00000614499; ENSP00000483364; ENSG00000119977 [Q6NUS6-1]
GeneIDi26123
KEGGihsa:26123
UCSCiuc001klb.4 human [Q6NUS6-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
26123
DisGeNETi26123
EuPathDBiHostDB:ENSG00000119977.20

GeneCards: human genes, protein and diseases

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GeneCardsi
TCTN3
GeneReviewsiTCTN3
HGNCiHGNC:24519 TCTN3
HPAiHPA026987
MalaCardsiTCTN3
MIMi258860 phenotype
613847 gene
614815 phenotype
neXtProtiNX_Q6NUS6
OpenTargetsiENSG00000119977
Orphaneti2753 Orofaciodigital syndrome type 4
2754 Orofaciodigital syndrome type 6
PharmGKBiPA162405513

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFR0 Eukaryota
ENOG4111GX2 LUCA
GeneTreeiENSGT00570000079101
HOGENOMiHOG000070061
HOVERGENiHBG094032
InParanoidiQ6NUS6
KOiK19382
OrthoDBi446525at2759
PhylomeDBiQ6NUS6
TreeFamiTF329169

Enzyme and pathway databases

ReactomeiR-HSA-5620912 Anchoring of the basal body to the plasma membrane

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TCTN3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
26123

Protein Ontology

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PROi
PR:Q6NUS6

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000119977 Expressed in 210 organ(s), highest expression level in corpus epididymis
ExpressionAtlasiQ6NUS6 baseline and differential
GenevisibleiQ6NUS6 HS

Family and domain databases

InterProiView protein in InterPro
IPR011677 DUF1619
IPR040354 Tectonic
PANTHERiPTHR14611 PTHR14611, 1 hit
PfamiView protein in Pfam
PF07773 DUF1619, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTECT3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NUS6
Secondary accession number(s): A6NIC8
, B0QZ90, B4DR81, Q6P7P3, Q6UW27, Q6ZQQ0, Q8N7K1, Q8NBQ0, Q96GF7, Q9Y3U1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: April 10, 2019
This is version 122 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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