UniProtKB - Q6NUQ4 (TM214_HUMAN)

BLAST

>sp|Q6NUQ4|TM214_HUMAN Transmembrane protein 214 OS=Homo sapiens OX=9606 GN=TMEM214 PE=1 SV=2
MATKTAGVGRWEVVKKGRRPGVGAGAGGRGGGRNRRALGEANGVWKYDLTPAIQTTSTLY
ERGFENIMKRQNKEQVPPPAVEPKKPGNKKQPKKVATPPNQNQKQGRFRSLEEALKALDV
ADLQKELDKSQSVFSGNPSIWLKDLASYLNYKLQAPLSEPTLSQHTHDYPYSLVSRELRG
IIRGLLAKAAGSLELFFDHCLFTMLQELDKTPGESLHGYRICIQAILQDKPKIATANLGK
FLELLRSHQSRPAKCLTIMWALGQAGFANLTEGLKVWLGIMLPVLGIKSLSPFAITYLDR
LLLMHPNLTKGFGMIGPKDFFPLLDFAYMPNNSLTPSLQEQLCQLYPRLKVLAFGAKPDS
TLHTYFPSFLSRATPSCPPEMKKELLSSLTECLTVDPLSASVWRQLYPKHLSQSSLLLEH
LLSSWEQIPKKVQKSLQETIQSLKLTNQELLRKGSSNNQDVVTCDMACKGLLQQVQGPRL
PWTRLLLLLLVFAVGFLCHDLRSHSSFQASLTGRLLRSSGFLPASQQACAKLYSYSLQGY
SWLGETLPLWGSHLLTVVRPSLQLAWAHTNATVSFLSAHCASHLAWFGDSLTSLSQRLQI
QLPDSVNQLLRYLRELPLLFHQNVLLPLWHLLLEALAWAQEHCHEACRGEVTWDCMKTQL
SEAVHWTWLCLQDITVAFLDWALALISQQ

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History
Entry version 125 (10 Oct 2018)
Sequence version 2 (26 Feb 2008)
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Protein

Transmembrane protein 214

Gene

TMEM214

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.1 Publication

GO - Biological processⁱ

apoptotic process Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Apoptosis

Biological process

Apoptosis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transmembrane protein 214
Gene namesⁱ	Name:TMEM214 ORF Names:PP446
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000119777.18
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25983 TMEM214
MIMⁱ	615301 gene
neXtProtⁱ	NX_Q6NUQ4

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	480 – 500	HelicalSequence analysisAdd BLAST		21
Transmembraneⁱ	616 – 636	HelicalSequence analysisAdd BLAST		21

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000119777
PharmGKBⁱ	PA162406505

Polymorphism and mutation databases

BioMutaⁱ	TMEM214
DMDMⁱ	189042272

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000321897	2 – 689	Transmembrane protein 214Add BLAST		688

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources	1
Glycosylationⁱ	269	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	307	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Acetylation, Glycoprotein

Proteomic databases

EPDⁱ	Q6NUQ4
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6NUQ4
PaxDbⁱ	Q6NUQ4
PeptideAtlas More...PeptideAtlasⁱ	Q6NUQ4
PRIDEⁱ	Q6NUQ4
ProteomicsDBⁱ	66702 66703 [Q6NUQ4-2]

PTM databases

iPTMnetⁱ	Q6NUQ4
PhosphoSitePlusⁱ	Q6NUQ4
SwissPalmⁱ	Q6NUQ4

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000119777 Expressed in 226 organ(s), highest expression level in adenohypophysis
CleanExⁱ	HS_TMEM214
ExpressionAtlasⁱ	Q6NUQ4 baseline and differential
Genevisibleⁱ	Q6NUQ4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA034551

HPAⁱ

HPA034551

Interactionⁱ

Subunit structureⁱ

Constitutively interacts with CASP4; required for the localization of procaspase 4 to the ER.

Protein-protein interaction databases

BioGridⁱ	120216, 61 interactors
IntActⁱ	Q6NUQ4, 15 interactors
Molecular INTeraction database More...MINTⁱ	Q6NUQ4
STRINGⁱ	9606.ENSP00000238788

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6NUQ4
SMRⁱ	Q6NUQ4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the TMEM214 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4467 Eukaryota ENOG410ZR2A LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000002693
HOVERGENⁱ	HBG054145
InParanoidⁱ	Q6NUQ4
OMAⁱ	VKHANIF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0WVG
PhylomeDBⁱ	Q6NUQ4
TreeFamⁱ	TF329489

Family and domain databases

InterProⁱ	View protein in InterPro IPR019308 TMEM214
PANTHERⁱ	PTHR13448 PTHR13448, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10151 TMEM214, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q6NUQ4-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATKTAGVGR WEVVKKGRRP GVGAGAGGRG GGRNRRALGE ANGVWKYDLT 
        60         70         80         90        100
PAIQTTSTLY ERGFENIMKR QNKEQVPPPA VEPKKPGNKK QPKKVATPPN 
       110        120        130        140        150
QNQKQGRFRS LEEALKALDV ADLQKELDKS QSVFSGNPSI WLKDLASYLN 
       160        170        180        190        200
YKLQAPLSEP TLSQHTHDYP YSLVSRELRG IIRGLLAKAA GSLELFFDHC 
       210        220        230        240        250
LFTMLQELDK TPGESLHGYR ICIQAILQDK PKIATANLGK FLELLRSHQS 
       260        270        280        290        300
RPAKCLTIMW ALGQAGFANL TEGLKVWLGI MLPVLGIKSL SPFAITYLDR 
       310        320        330        340        350
LLLMHPNLTK GFGMIGPKDF FPLLDFAYMP NNSLTPSLQE QLCQLYPRLK 
       360        370        380        390        400
VLAFGAKPDS TLHTYFPSFL SRATPSCPPE MKKELLSSLT ECLTVDPLSA 
       410        420        430        440        450
SVWRQLYPKH LSQSSLLLEH LLSSWEQIPK KVQKSLQETI QSLKLTNQEL 
       460        470        480        490        500
LRKGSSNNQD VVTCDMACKG LLQQVQGPRL PWTRLLLLLL VFAVGFLCHD 
       510        520        530        540        550
LRSHSSFQAS LTGRLLRSSG FLPASQQACA KLYSYSLQGY SWLGETLPLW 
       560        570        580        590        600
GSHLLTVVRP SLQLAWAHTN ATVSFLSAHC ASHLAWFGDS LTSLSQRLQI 
       610        620        630        640        650
QLPDSVNQLL RYLRELPLLF HQNVLLPLWH LLLEALAWAQ EHCHEACRGE 
       660        670        680 
VTWDCMKTQL SEAVHWTWLC LQDITVAFLD WALALISQQ

Length:689

Mass (Da):77,151

Last modified:February 26, 2008 - v2

Checksum:ⁱA12259676BA5B8E4

Isoform 2 (identifier: Q6NUQ4-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
168-212: Missing.

« Hide

        10         20         30         40         50
MATKTAGVGR WEVVKKGRRP GVGAGAGGRG GGRNRRALGE ANGVWKYDLT 
        60         70         80         90        100
PAIQTTSTLY ERGFENIMKR QNKEQVPPPA VEPKKPGNKK QPKKVATPPN 
       110        120        130        140        150
QNQKQGRFRS LEEALKALDV ADLQKELDKS QSVFSGNPSI WLKDLASYLN 
       160        170        180        190        200
YKLQAPLSEP TLSQHTHGES LHGYRICIQA ILQDKPKIAT ANLGKFLELL 
       210        220        230        240        250
RSHQSRPAKC LTIMWALGQA GFANLTEGLK VWLGIMLPVL GIKSLSPFAI 
       260        270        280        290        300
TYLDRLLLMH PNLTKGFGMI GPKDFFPLLD FAYMPNNSLT PSLQEQLCQL 
       310        320        330        340        350
YPRLKVLAFG AKPDSTLHTY FPSFLSRATP SCPPEMKKEL LSSLTECLTV 
       360        370        380        390        400
DPLSASVWRQ LYPKHLSQSS LLLEHLLSSW EQIPKKVQKS LQETIQSLKL 
       410        420        430        440        450
TNQELLRKGS SNNQDVVTCD MACKGLLQQV QGPRLPWTRL LLLLLVFAVG 
       460        470        480        490        500
FLCHDLRSHS SFQASLTGRL LRSSGFLPAS QQACAKLYSY SLQGYSWLGE 
       510        520        530        540        550
TLPLWGSHLL TVVRPSLQLA WAHTNATVSF LSAHCASHLA WFGDSLTSLS 
       560        570        580        590        600
QRLQIQLPDS VNQLLRYLRE LPLLFHQNVL LPLWHLLLEA LAWAQEHCHE 
       610        620        630        640 
ACRGEVTWDC MKTQLSEAVH WTWLCLQDIT VAFLDWALAL ISQQ

Show »

Length:644

Mass (Da):72,040

Checksum:ⁱ3239DD7F41C1623C

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H7C008	H7C008_HUMAN	Transmembrane protein 214 Transmembrane protein 214	TMEM214	306	Annotation score:
H7C085	H7C085_HUMAN	Transmembrane protein 214 Transmembrane protein 214	TMEM214	247	Annotation score:
H7C0H8	H7C0H8_HUMAN	Transmembrane protein 214 Transmembrane protein 214	TMEM214	225	Annotation score:
H7BZI0	H7BZI0_HUMAN	Transmembrane protein 214 Transmembrane protein 214	TMEM214	140	Annotation score:

Sequence cautionⁱ

The sequence AAL55739 differs from that shown. Reason: Erroneous initiation.Curated

The sequence BAA91038 differs from that shown. Reason: Erroneous initiation.Curated

The sequence BAC11331 differs from that shown. Reason: Frameshift at position 94.Curated

The sequence CAH10591 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	99	P → H in AAH68479 (PubMed:15489334).Curated	1
Sequence conflictⁱ	138	P → Q in AAH68479 (PubMed:15489334).Curated	1
Sequence conflictⁱ	326	F → Y in BAA91038 (PubMed:14702039).Curated	1
Sequence conflictⁱ	502	R → W in AAL55739 (PubMed:15498874).Curated	1
Sequence conflictⁱ	651	V → A in BAG53451 (PubMed:14702039).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_039370	351	V → M. Corresponds to variant dbSNP:rs1124649Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_041155	168 – 212	Missing in isoform 2. 1 PublicationAdd BLAST		45

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK000261 mRNA Translation: BAA91038.1 Different initiation. AK074981 mRNA Translation: BAC11331.1 Frameshift. AK097308 mRNA Translation: BAG53451.1 AC013472 Genomic DNA Translation: AAY14654.1 CH471053 Genomic DNA Translation: EAX00655.1 CH471053 Genomic DNA Translation: EAX00657.1 CH471053 Genomic DNA Translation: EAX00659.1 AL833725 mRNA Translation: CAH10591.1 Different initiation. BC068479 mRNA Translation: AAH68479.1 AF289555 mRNA Translation: AAL55739.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS42664.1 [Q6NUQ4-1] CCDS46242.1 [Q6NUQ4-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001077059.1, NM_001083590.1 [Q6NUQ4-2] NP_060197.4, NM_017727.4 [Q6NUQ4-1]
UniGeneⁱ	Hs.533934

Genome annotation databases

Ensemblⁱ	ENST00000238788; ENSP00000238788; ENSG00000119777 [Q6NUQ4-1] ENST00000321326; ENSP00000319469; ENSG00000119777 [Q6NUQ4-1] ENST00000404032; ENSP00000384417; ENSG00000119777 [Q6NUQ4-2]
GeneIDⁱ	54867
KEGGⁱ	hsa:54867
UCSC genome browser More...UCSCⁱ	uc002ria.5 human [Q6NUQ4-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6NUQ4	cDNA, FLJ96404		HUMAN		431	UniRef100_Q6NUQ4

Protein	Similar proteins		Species	Score	Length	Source
Q6NUQ4	cDNA, FLJ96404		HUMAN		431	UniRef90_Q6NUQ4
Uncharacterized protein		RHIRO		692
Uncharacterized protein		RHIBE		692
Transmembrane protein 214		GORGO		689
TMEM214 isoform 1		PANTR		689
+24
Q6NUQ4-2	TMEM214 isoform 3		PANTR		644	UniRef90_Q6NUQ4-2
Transmembrane protein 214		GORGO		644
Transmembrane protein 214		SAIBB		642
Uncharacterized protein		CALJA		642
Uncharacterized protein		MACMU		642
+12

Protein	Similar proteins		Species	Score	Length	Source
Q6NUQ4	Transmembrane protein 214		MOUSE		687	UniRef50_Q6NUQ4
Transmembrane protein 214		RAT		685
Transmembrane protein 214		BOVIN		687
cDNA, FLJ96404		HUMAN		431
Uncharacterized protein		RHIBE		692
+183
Q6NUQ4-2	TMEM214 isoform 3		PANTR		644	UniRef50_Q6NUQ4-2
Transmembrane protein 214		GORGO		644
Uncharacterized protein		CALJA		642
Uncharacterized protein		AOTNA		642
Uncharacterized protein		RHIRO		642
+29

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK000261 mRNA Translation: BAA91038.1 Different initiation. AK074981 mRNA Translation: BAC11331.1 Frameshift. AK097308 mRNA Translation: BAG53451.1 AC013472 Genomic DNA Translation: AAY14654.1 CH471053 Genomic DNA Translation: EAX00655.1 CH471053 Genomic DNA Translation: EAX00657.1 CH471053 Genomic DNA Translation: EAX00659.1 AL833725 mRNA Translation: CAH10591.1 Different initiation. BC068479 mRNA Translation: AAH68479.1 AF289555 mRNA Translation: AAL55739.1 Different initiation.
CCDSⁱ	CCDS42664.1 [Q6NUQ4-1] CCDS46242.1 [Q6NUQ4-2]
RefSeqⁱ	NP_001077059.1, NM_001083590.1 [Q6NUQ4-2] NP_060197.4, NM_017727.4 [Q6NUQ4-1]
UniGeneⁱ	Hs.533934

3D structure databases

ProteinModelPortalⁱ	Q6NUQ4
SMRⁱ	Q6NUQ4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120216, 61 interactors
IntActⁱ	Q6NUQ4, 15 interactors
MINTⁱ	Q6NUQ4
STRINGⁱ	9606.ENSP00000238788

PTM databases

iPTMnetⁱ	Q6NUQ4
PhosphoSitePlusⁱ	Q6NUQ4
SwissPalmⁱ	Q6NUQ4

Polymorphism and mutation databases

BioMutaⁱ	TMEM214
DMDMⁱ	189042272

Proteomic databases

EPDⁱ	Q6NUQ4
MaxQBⁱ	Q6NUQ4
PaxDbⁱ	Q6NUQ4
PeptideAtlasⁱ	Q6NUQ4
PRIDEⁱ	Q6NUQ4
ProteomicsDBⁱ	66702 66703 [Q6NUQ4-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000238788; ENSP00000238788; ENSG00000119777 [Q6NUQ4-1] ENST00000321326; ENSP00000319469; ENSG00000119777 [Q6NUQ4-1] ENST00000404032; ENSP00000384417; ENSG00000119777 [Q6NUQ4-2]
GeneIDⁱ	54867
KEGGⁱ	hsa:54867
UCSCⁱ	uc002ria.5 human [Q6NUQ4-1]

Organism-specific databases

CTDⁱ	54867
EuPathDBⁱ	HostDB:ENSG00000119777.18
GeneCardsⁱ	TMEM214
HGNCⁱ	HGNC:25983 TMEM214
HPAⁱ	HPA034551
MIMⁱ	615301 gene
neXtProtⁱ	NX_Q6NUQ4
OpenTargetsⁱ	ENSG00000119777
PharmGKBⁱ	PA162406505
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4467 Eukaryota ENOG410ZR2A LUCA
GeneTreeⁱ	ENSGT00390000002693
HOVERGENⁱ	HBG054145
InParanoidⁱ	Q6NUQ4
OMAⁱ	VKHANIF
OrthoDBⁱ	EOG091G0WVG
PhylomeDBⁱ	Q6NUQ4
TreeFamⁱ	TF329489

Miscellaneous databases

ChiTaRSⁱ	TMEM214 human
GenomeRNAiⁱ	54867
Protein Ontology More...PROⁱ	PR:Q6NUQ4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000119777 Expressed in 226 organ(s), highest expression level in adenohypophysis
CleanExⁱ	HS_TMEM214
ExpressionAtlasⁱ	Q6NUQ4 baseline and differential
Genevisibleⁱ	Q6NUQ4 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR019308 TMEM214
PANTHERⁱ	PTHR13448 PTHR13448, 1 hit
Pfamⁱ	View protein in Pfam PF10151 TMEM214, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TM214_HUMAN
Accessionⁱ	Q6NUQ4Primary (citable) accession number: Q6NUQ4 Secondary accession number(s): A6NNF2 Q9NXH2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
	Last sequence update:	February 26, 2008
	Last modified:	October 10, 2018
	This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
SIMILARITY comments
Index of protein domains and families
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations

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UniProtKB - Q6NUQ4 (TM214_HUMAN)

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Transmembrane protein 214

TMEM214

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Cytoskeleton

Cytosol

Endoplasmic reticulum

Golgi apparatus

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ