UniProtKB - Q6NUQ4 (TM214_HUMAN)
Protein
Transmembrane protein 214
Gene
TMEM214
Organism
Homo sapiens (Human)
Status
Functioni
Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.1 Publication
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
Keywordsi
Biological process | Apoptosis |
Enzyme and pathway databases
PathwayCommonsi | Q6NUQ4 |
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 214 |
Gene namesi | Name:TMEM214 ORF Names:PP446 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25983, TMEM214 |
MIMi | 615301, gene |
neXtProti | NX_Q6NUQ4 |
VEuPathDBi | HostDB:ENSG00000119777.18 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication
Cytoskeleton
- cytoplasmic microtubule Source: UniProtKB
Cytosol
- cytosol Source: HPA
Endoplasmic reticulum
- endoplasmic reticulum Source: HPA
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Golgi apparatus
- Golgi apparatus Source: HPA
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 480 – 500 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 616 – 636 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 54867 |
OpenTargetsi | ENSG00000119777 |
PharmGKBi | PA162406505 |
Miscellaneous databases
Pharosi | Q6NUQ4, Tdark |
Genetic variation databases
BioMutai | TMEM214 |
DMDMi | 189042272 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000321897 | 2 – 689 | Transmembrane protein 214Add BLAST | 688 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Glycosylationi | 269 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 307 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Acetylation, GlycoproteinProteomic databases
EPDi | Q6NUQ4 |
jPOSTi | Q6NUQ4 |
MassIVEi | Q6NUQ4 |
MaxQBi | Q6NUQ4 |
PaxDbi | Q6NUQ4 |
PeptideAtlasi | Q6NUQ4 |
PRIDEi | Q6NUQ4 |
ProteomicsDBi | 66702 [Q6NUQ4-1] 66703 [Q6NUQ4-2] |
PTM databases
GlyGeni | Q6NUQ4, 2 sites |
iPTMneti | Q6NUQ4 |
PhosphoSitePlusi | Q6NUQ4 |
SwissPalmi | Q6NUQ4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000119777, Expressed in adenohypophysis and 238 other tissues |
ExpressionAtlasi | Q6NUQ4, baseline and differential |
Genevisiblei | Q6NUQ4, HS |
Organism-specific databases
HPAi | ENSG00000119777, Low tissue specificity |
Interactioni
Subunit structurei
Constitutively interacts with CASP4; required for the localization of procaspase 4 to the ER.
Protein-protein interaction databases
BioGRIDi | 120216, 86 interactors |
IntActi | Q6NUQ4, 49 interactors |
MINTi | Q6NUQ4 |
STRINGi | 9606.ENSP00000238788 |
Miscellaneous databases
RNActi | Q6NUQ4, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the TMEM214 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4467, Eukaryota |
GeneTreei | ENSGT00390000002693 |
HOGENOMi | CLU_025330_1_0_1 |
InParanoidi | Q6NUQ4 |
OMAi | VKHANIF |
OrthoDBi | 1409017at2759 |
PhylomeDBi | Q6NUQ4 |
TreeFami | TF329489 |
Family and domain databases
InterProi | View protein in InterPro IPR019308, TMEM214 |
PANTHERi | PTHR13448, PTHR13448, 1 hit |
Pfami | View protein in Pfam PF10151, TMEM214, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6NUQ4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MATKTAGVGR WEVVKKGRRP GVGAGAGGRG GGRNRRALGE ANGVWKYDLT
60 70 80 90 100
PAIQTTSTLY ERGFENIMKR QNKEQVPPPA VEPKKPGNKK QPKKVATPPN
110 120 130 140 150
QNQKQGRFRS LEEALKALDV ADLQKELDKS QSVFSGNPSI WLKDLASYLN
160 170 180 190 200
YKLQAPLSEP TLSQHTHDYP YSLVSRELRG IIRGLLAKAA GSLELFFDHC
210 220 230 240 250
LFTMLQELDK TPGESLHGYR ICIQAILQDK PKIATANLGK FLELLRSHQS
260 270 280 290 300
RPAKCLTIMW ALGQAGFANL TEGLKVWLGI MLPVLGIKSL SPFAITYLDR
310 320 330 340 350
LLLMHPNLTK GFGMIGPKDF FPLLDFAYMP NNSLTPSLQE QLCQLYPRLK
360 370 380 390 400
VLAFGAKPDS TLHTYFPSFL SRATPSCPPE MKKELLSSLT ECLTVDPLSA
410 420 430 440 450
SVWRQLYPKH LSQSSLLLEH LLSSWEQIPK KVQKSLQETI QSLKLTNQEL
460 470 480 490 500
LRKGSSNNQD VVTCDMACKG LLQQVQGPRL PWTRLLLLLL VFAVGFLCHD
510 520 530 540 550
LRSHSSFQAS LTGRLLRSSG FLPASQQACA KLYSYSLQGY SWLGETLPLW
560 570 580 590 600
GSHLLTVVRP SLQLAWAHTN ATVSFLSAHC ASHLAWFGDS LTSLSQRLQI
610 620 630 640 650
QLPDSVNQLL RYLRELPLLF HQNVLLPLWH LLLEALAWAQ EHCHEACRGE
660 670 680
VTWDCMKTQL SEAVHWTWLC LQDITVAFLD WALALISQQ
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7C008 | H7C008_HUMAN | Transmembrane protein 214 | TMEM214 | 306 | Annotation score: | ||
H7C085 | H7C085_HUMAN | Transmembrane protein 214 | TMEM214 | 247 | Annotation score: | ||
H7C0H8 | H7C0H8_HUMAN | Transmembrane protein 214 | TMEM214 | 387 | Annotation score: | ||
H7BZI0 | H7BZI0_HUMAN | Transmembrane protein 214 | TMEM214 | 140 | Annotation score: |
Sequence cautioni
The sequence AAL55739 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA91038 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC11331 differs from that shown. Reason: Frameshift.Curated
The sequence CAH10591 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 99 | P → H in AAH68479 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 138 | P → Q in AAH68479 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 326 | F → Y in BAA91038 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 502 | R → W in AAL55739 (PubMed:15498874).Curated | 1 | |
Sequence conflicti | 651 | V → A in BAG53451 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_039370 | 351 | V → M. Corresponds to variant dbSNP:rs1124649Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_041155 | 168 – 212 | Missing in isoform 2. 1 PublicationAdd BLAST | 45 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK000261 mRNA Translation: BAA91038.1 Different initiation. AK074981 mRNA Translation: BAC11331.1 Frameshift. AK097308 mRNA Translation: BAG53451.1 AC013472 Genomic DNA Translation: AAY14654.1 CH471053 Genomic DNA Translation: EAX00655.1 CH471053 Genomic DNA Translation: EAX00657.1 CH471053 Genomic DNA Translation: EAX00659.1 AL833725 mRNA Translation: CAH10591.1 Different initiation. BC068479 mRNA Translation: AAH68479.1 AF289555 mRNA Translation: AAL55739.1 Different initiation. |
CCDSi | CCDS42664.1 [Q6NUQ4-1] CCDS46242.1 [Q6NUQ4-2] |
RefSeqi | NP_001077059.1, NM_001083590.1 [Q6NUQ4-2] NP_060197.4, NM_017727.4 [Q6NUQ4-1] |
Genome annotation databases
Ensembli | ENST00000238788; ENSP00000238788; ENSG00000119777 [Q6NUQ4-1] ENST00000321326; ENSP00000319469; ENSG00000119777 [Q6NUQ4-1] ENST00000404032; ENSP00000384417; ENSG00000119777 [Q6NUQ4-2] |
GeneIDi | 54867 |
KEGGi | hsa:54867 |
UCSCi | uc002ria.5, human [Q6NUQ4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK000261 mRNA Translation: BAA91038.1 Different initiation. AK074981 mRNA Translation: BAC11331.1 Frameshift. AK097308 mRNA Translation: BAG53451.1 AC013472 Genomic DNA Translation: AAY14654.1 CH471053 Genomic DNA Translation: EAX00655.1 CH471053 Genomic DNA Translation: EAX00657.1 CH471053 Genomic DNA Translation: EAX00659.1 AL833725 mRNA Translation: CAH10591.1 Different initiation. BC068479 mRNA Translation: AAH68479.1 AF289555 mRNA Translation: AAL55739.1 Different initiation. |
CCDSi | CCDS42664.1 [Q6NUQ4-1] CCDS46242.1 [Q6NUQ4-2] |
RefSeqi | NP_001077059.1, NM_001083590.1 [Q6NUQ4-2] NP_060197.4, NM_017727.4 [Q6NUQ4-1] |
3D structure databases
SMRi | Q6NUQ4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120216, 86 interactors |
IntActi | Q6NUQ4, 49 interactors |
MINTi | Q6NUQ4 |
STRINGi | 9606.ENSP00000238788 |
PTM databases
GlyGeni | Q6NUQ4, 2 sites |
iPTMneti | Q6NUQ4 |
PhosphoSitePlusi | Q6NUQ4 |
SwissPalmi | Q6NUQ4 |
Genetic variation databases
BioMutai | TMEM214 |
DMDMi | 189042272 |
Proteomic databases
EPDi | Q6NUQ4 |
jPOSTi | Q6NUQ4 |
MassIVEi | Q6NUQ4 |
MaxQBi | Q6NUQ4 |
PaxDbi | Q6NUQ4 |
PeptideAtlasi | Q6NUQ4 |
PRIDEi | Q6NUQ4 |
ProteomicsDBi | 66702 [Q6NUQ4-1] 66703 [Q6NUQ4-2] |
Protocols and materials databases
Antibodypediai | 28071, 113 antibodies |
Genome annotation databases
Ensembli | ENST00000238788; ENSP00000238788; ENSG00000119777 [Q6NUQ4-1] ENST00000321326; ENSP00000319469; ENSG00000119777 [Q6NUQ4-1] ENST00000404032; ENSP00000384417; ENSG00000119777 [Q6NUQ4-2] |
GeneIDi | 54867 |
KEGGi | hsa:54867 |
UCSCi | uc002ria.5, human [Q6NUQ4-1] |
Organism-specific databases
CTDi | 54867 |
DisGeNETi | 54867 |
GeneCardsi | TMEM214 |
HGNCi | HGNC:25983, TMEM214 |
HPAi | ENSG00000119777, Low tissue specificity |
MIMi | 615301, gene |
neXtProti | NX_Q6NUQ4 |
OpenTargetsi | ENSG00000119777 |
PharmGKBi | PA162406505 |
VEuPathDBi | HostDB:ENSG00000119777.18 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4467, Eukaryota |
GeneTreei | ENSGT00390000002693 |
HOGENOMi | CLU_025330_1_0_1 |
InParanoidi | Q6NUQ4 |
OMAi | VKHANIF |
OrthoDBi | 1409017at2759 |
PhylomeDBi | Q6NUQ4 |
TreeFami | TF329489 |
Enzyme and pathway databases
PathwayCommonsi | Q6NUQ4 |
Miscellaneous databases
BioGRID-ORCSi | 54867, 5 hits in 881 CRISPR screens |
ChiTaRSi | TMEM214, human |
GenomeRNAii | 54867 |
Pharosi | Q6NUQ4, Tdark |
PROi | PR:Q6NUQ4 |
RNActi | Q6NUQ4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000119777, Expressed in adenohypophysis and 238 other tissues |
ExpressionAtlasi | Q6NUQ4, baseline and differential |
Genevisiblei | Q6NUQ4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR019308, TMEM214 |
PANTHERi | PTHR13448, PTHR13448, 1 hit |
Pfami | View protein in Pfam PF10151, TMEM214, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TM214_HUMAN | |
Accessioni | Q6NUQ4Primary (citable) accession number: Q6NUQ4 Secondary accession number(s): A6NNF2 Q9NXH2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | February 26, 2008 | |
Last modified: | February 10, 2021 | |
This is version 141 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families