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Entry version 133 (16 Oct 2019)
Sequence version 2 (26 Feb 2008)
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Protein

Transmembrane protein 214

Gene

TMEM214

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 214
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM214
ORF Names:PP446
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25983 TMEM214

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615301 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6NUQ4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei480 – 500HelicalSequence analysisAdd BLAST21
Transmembranei616 – 636HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000119777

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162406505

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6NUQ4

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMEM214

Domain mapping of disease mutations (DMDM)

More...
DMDMi
189042272

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003218972 – 689Transmembrane protein 214Add BLAST688

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi269N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi307N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6NUQ4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6NUQ4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6NUQ4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6NUQ4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6NUQ4

PeptideAtlas

More...
PeptideAtlasi
Q6NUQ4

PRoteomics IDEntifications database

More...
PRIDEi
Q6NUQ4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
66702 [Q6NUQ4-1]
66703 [Q6NUQ4-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6NUQ4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6NUQ4

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q6NUQ4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000119777 Expressed in 226 organ(s), highest expression level in adenohypophysis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6NUQ4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6NUQ4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA034551

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Constitutively interacts with CASP4; required for the localization of procaspase 4 to the ER.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120216, 64 interactors

Protein interaction database and analysis system

More...
IntActi
Q6NUQ4, 45 interactors

Molecular INTeraction database

More...
MINTi
Q6NUQ4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000238788

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6NUQ4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM214 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4467 Eukaryota
ENOG410ZR2A LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000002693

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6NUQ4

Identification of Orthologs from Complete Genome Data

More...
OMAi
VKHANIF

Database of Orthologous Groups

More...
OrthoDBi
1409017at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6NUQ4

TreeFam database of animal gene trees

More...
TreeFami
TF329489

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019308 TMEM214

The PANTHER Classification System

More...
PANTHERi
PTHR13448 PTHR13448, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10151 TMEM214, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6NUQ4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATKTAGVGR WEVVKKGRRP GVGAGAGGRG GGRNRRALGE ANGVWKYDLT
60 70 80 90 100
PAIQTTSTLY ERGFENIMKR QNKEQVPPPA VEPKKPGNKK QPKKVATPPN
110 120 130 140 150
QNQKQGRFRS LEEALKALDV ADLQKELDKS QSVFSGNPSI WLKDLASYLN
160 170 180 190 200
YKLQAPLSEP TLSQHTHDYP YSLVSRELRG IIRGLLAKAA GSLELFFDHC
210 220 230 240 250
LFTMLQELDK TPGESLHGYR ICIQAILQDK PKIATANLGK FLELLRSHQS
260 270 280 290 300
RPAKCLTIMW ALGQAGFANL TEGLKVWLGI MLPVLGIKSL SPFAITYLDR
310 320 330 340 350
LLLMHPNLTK GFGMIGPKDF FPLLDFAYMP NNSLTPSLQE QLCQLYPRLK
360 370 380 390 400
VLAFGAKPDS TLHTYFPSFL SRATPSCPPE MKKELLSSLT ECLTVDPLSA
410 420 430 440 450
SVWRQLYPKH LSQSSLLLEH LLSSWEQIPK KVQKSLQETI QSLKLTNQEL
460 470 480 490 500
LRKGSSNNQD VVTCDMACKG LLQQVQGPRL PWTRLLLLLL VFAVGFLCHD
510 520 530 540 550
LRSHSSFQAS LTGRLLRSSG FLPASQQACA KLYSYSLQGY SWLGETLPLW
560 570 580 590 600
GSHLLTVVRP SLQLAWAHTN ATVSFLSAHC ASHLAWFGDS LTSLSQRLQI
610 620 630 640 650
QLPDSVNQLL RYLRELPLLF HQNVLLPLWH LLLEALAWAQ EHCHEACRGE
660 670 680
VTWDCMKTQL SEAVHWTWLC LQDITVAFLD WALALISQQ
Length:689
Mass (Da):77,151
Last modified:February 26, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA12259676BA5B8E4
GO
Isoform 2 (identifier: Q6NUQ4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     168-212: Missing.

Show »
Length:644
Mass (Da):72,040
Checksum:i3239DD7F41C1623C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C008H7C008_HUMAN
Transmembrane protein 214
TMEM214
306Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C085H7C085_HUMAN
Transmembrane protein 214
TMEM214
247Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0H8H7C0H8_HUMAN
Transmembrane protein 214
TMEM214
387Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZI0H7BZI0_HUMAN
Transmembrane protein 214
TMEM214
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL55739 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA91038 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC11331 differs from that shown. Reason: Frameshift.Curated
The sequence CAH10591 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti99P → H in AAH68479 (PubMed:15489334).Curated1
Sequence conflicti138P → Q in AAH68479 (PubMed:15489334).Curated1
Sequence conflicti326F → Y in BAA91038 (PubMed:14702039).Curated1
Sequence conflicti502R → W in AAL55739 (PubMed:15498874).Curated1
Sequence conflicti651V → A in BAG53451 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_039370351V → M. Corresponds to variant dbSNP:rs1124649Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_041155168 – 212Missing in isoform 2. 1 PublicationAdd BLAST45

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK000261 mRNA Translation: BAA91038.1 Different initiation.
AK074981 mRNA Translation: BAC11331.1 Frameshift.
AK097308 mRNA Translation: BAG53451.1
AC013472 Genomic DNA Translation: AAY14654.1
CH471053 Genomic DNA Translation: EAX00655.1
CH471053 Genomic DNA Translation: EAX00657.1
CH471053 Genomic DNA Translation: EAX00659.1
AL833725 mRNA Translation: CAH10591.1 Different initiation.
BC068479 mRNA Translation: AAH68479.1
AF289555 mRNA Translation: AAL55739.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42664.1 [Q6NUQ4-1]
CCDS46242.1 [Q6NUQ4-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001077059.1, NM_001083590.1 [Q6NUQ4-2]
NP_060197.4, NM_017727.4 [Q6NUQ4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000238788; ENSP00000238788; ENSG00000119777 [Q6NUQ4-1]
ENST00000321326; ENSP00000319469; ENSG00000119777 [Q6NUQ4-1]
ENST00000404032; ENSP00000384417; ENSG00000119777 [Q6NUQ4-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54867

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54867

UCSC genome browser

More...
UCSCi
uc002ria.5 human [Q6NUQ4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000261 mRNA Translation: BAA91038.1 Different initiation.
AK074981 mRNA Translation: BAC11331.1 Frameshift.
AK097308 mRNA Translation: BAG53451.1
AC013472 Genomic DNA Translation: AAY14654.1
CH471053 Genomic DNA Translation: EAX00655.1
CH471053 Genomic DNA Translation: EAX00657.1
CH471053 Genomic DNA Translation: EAX00659.1
AL833725 mRNA Translation: CAH10591.1 Different initiation.
BC068479 mRNA Translation: AAH68479.1
AF289555 mRNA Translation: AAL55739.1 Different initiation.
CCDSiCCDS42664.1 [Q6NUQ4-1]
CCDS46242.1 [Q6NUQ4-2]
RefSeqiNP_001077059.1, NM_001083590.1 [Q6NUQ4-2]
NP_060197.4, NM_017727.4 [Q6NUQ4-1]

3D structure databases

SMRiQ6NUQ4
ModBaseiSearch...

Protein-protein interaction databases

BioGridi120216, 64 interactors
IntActiQ6NUQ4, 45 interactors
MINTiQ6NUQ4
STRINGi9606.ENSP00000238788

PTM databases

iPTMnetiQ6NUQ4
PhosphoSitePlusiQ6NUQ4
SwissPalmiQ6NUQ4

Polymorphism and mutation databases

BioMutaiTMEM214
DMDMi189042272

Proteomic databases

EPDiQ6NUQ4
jPOSTiQ6NUQ4
MassIVEiQ6NUQ4
MaxQBiQ6NUQ4
PaxDbiQ6NUQ4
PeptideAtlasiQ6NUQ4
PRIDEiQ6NUQ4
ProteomicsDBi66702 [Q6NUQ4-1]
66703 [Q6NUQ4-2]

Genome annotation databases

EnsembliENST00000238788; ENSP00000238788; ENSG00000119777 [Q6NUQ4-1]
ENST00000321326; ENSP00000319469; ENSG00000119777 [Q6NUQ4-1]
ENST00000404032; ENSP00000384417; ENSG00000119777 [Q6NUQ4-2]
GeneIDi54867
KEGGihsa:54867
UCSCiuc002ria.5 human [Q6NUQ4-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
54867

GeneCards: human genes, protein and diseases

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GeneCardsi
TMEM214
HGNCiHGNC:25983 TMEM214
HPAiHPA034551
MIMi615301 gene
neXtProtiNX_Q6NUQ4
OpenTargetsiENSG00000119777
PharmGKBiPA162406505

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4467 Eukaryota
ENOG410ZR2A LUCA
GeneTreeiENSGT00390000002693
InParanoidiQ6NUQ4
OMAiVKHANIF
OrthoDBi1409017at2759
PhylomeDBiQ6NUQ4
TreeFamiTF329489

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TMEM214 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54867
PharosiQ6NUQ4

Protein Ontology

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PROi
PR:Q6NUQ4

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000119777 Expressed in 226 organ(s), highest expression level in adenohypophysis
ExpressionAtlasiQ6NUQ4 baseline and differential
GenevisibleiQ6NUQ4 HS

Family and domain databases

InterProiView protein in InterPro
IPR019308 TMEM214
PANTHERiPTHR13448 PTHR13448, 1 hit
PfamiView protein in Pfam
PF10151 TMEM214, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM214_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NUQ4
Secondary accession number(s): A6NNF2
, B3KUI9, B5MCD8, D6W547, Q53SW1, Q69YH4, Q8NC45, Q8WZ37, Q9NXH2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: October 16, 2019
This is version 133 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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