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Protein

RAD50-interacting protein 1

Gene

RINT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER. May play a role in cell cycle checkpoint control (PubMed:11096100). Essential for telomere length control (PubMed:16600870).Curated2 Publications

Miscellaneous

According to PubMed:11096100, a longer form, which may be due to the differential initiation of translation using a non-AUG codon, may exist. However, the existence of such form has not been clearly demonstrated.

GO - Biological processi

Keywordsi

Biological processCell cycle, ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
RAD50-interacting protein 1
Alternative name(s):
RAD50 interactor 1
Short name:
HsRINT-1
Short name:
RINT-1
Gene namesi
Name:RINT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000135249.7
HGNCiHGNC:21876 RINT1
MIMi610089 gene
neXtProtiNX_Q6NUQ1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi60561
OpenTargetsiENSG00000135249
PharmGKBiPA143485595

Polymorphism and mutation databases

BioMutaiRINT1
DMDMi71152944

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000973491 – 792RAD50-interacting protein 1Add BLAST792

Proteomic databases

EPDiQ6NUQ1
MaxQBiQ6NUQ1
PaxDbiQ6NUQ1
PeptideAtlasiQ6NUQ1
PRIDEiQ6NUQ1
ProteomicsDBi66701

PTM databases

iPTMnetiQ6NUQ1
PhosphoSitePlusiQ6NUQ1

Expressioni

Developmental stagei

Expressed throughout the cell cycle.1 Publication

Gene expression databases

BgeeiENSG00000135249 Expressed in 204 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_RINT1
ExpressionAtlasiQ6NUQ1 baseline and differential
GenevisibleiQ6NUQ1 HS

Organism-specific databases

HPAiHPA019875
HPA031646

Interactioni

Subunit structurei

Component of the NRZ complex composed of NBAS, ZW10 and RINT1/TIP20L; NRZ associates with SNAREs STX18, USE1L, BNIP1/SEC20L and SEC22B (the assembly has been described as syntaxin 18 complex) (PubMed:15029241, PubMed:20462495, PubMed:19369418). Interacts directly with BNIP1/SEC20L and ZW10 (PubMed:15029241, PubMed:15272311). Interacts with UVRAG (PubMed:24056303). Interacts with RAD50 during late S and G2/M phases (PubMed:11096100). Interacts with RBL2, preferentially with the active, hypophosphorylated form (PubMed:16600870).7 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi121942, 88 interactors
CORUMiQ6NUQ1
DIPiDIP-36477N
IntActiQ6NUQ1, 114 interactors
MINTiQ6NUQ1
STRINGi9606.ENSP00000257700

Structurei

3D structure databases

ProteinModelPortaliQ6NUQ1
SMRiQ6NUQ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini220 – 792RINT1/TIP20PROSITE-ProRule annotationAdd BLAST573

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili103 – 124Sequence analysisAdd BLAST22

Sequence similaritiesi

Belongs to the RINT1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2218 Eukaryota
ENOG410XZD1 LUCA
GeneTreeiENSGT00390000017006
HOGENOMiHOG000118368
HOVERGENiHBG057727
InParanoidiQ6NUQ1
KOiK20474
OMAiWGENVHY
OrthoDBiEOG091G036T
PhylomeDBiQ6NUQ1
TreeFamiTF324274

Family and domain databases

InterProiView protein in InterPro
IPR007528 RINT1_Tip20
PANTHERiPTHR13520 PTHR13520, 1 hit
PfamiView protein in Pfam
PF04437 RINT1_TIP1, 1 hit
PROSITEiView protein in PROSITE
PS51386 RINT1_TIP20, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q6NUQ1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPAGEIGAS PAAPCCSESG DERKNLEEKS DINVTVLIGS KQVSEGTDNG
60 70 80 90 100
DLPSYVSAFI EKEVGNDLKS LKKLDKLIEQ RTVSKMQLEE QVLTISSEIP
110 120 130 140 150
KRIRSALKNA EESKQFLNQF LEQETHLFSA INSHLLTAQP WMDDLGTMIS
160 170 180 190 200
QIEEIERHLA YLKWISQIEE LSDNIQQYLM TNNVPEAAST LVSMAELDIK
210 220 230 240 250
LQESSCTHLL GFMRATVKFW HKILKDKLTS DFEEILAQLH WPFIAPPQSQ
260 270 280 290 300
TVGLSRPASA PEIYSYLETL FCQLLKLQTS DELLTEPKQL PEKYSLPASP
310 320 330 340 350
SVILPIQVML TPLQKRFRYH FRGNRQTNVL SKPEWYLAQV LMWIGNHTEF
360 370 380 390 400
LDEKIQPILD KVGSLVNARL EFSRGLMMLV LEKLATDIPC LLYDDNLFCH
410 420 430 440 450
LVDEVLLFER ELHSVHGYPG TFASCMHILS EETCFQRWLT VERKFALQKM
460 470 480 490 500
DSMLSSEAAW VSQYKDITDV DEMKVPDCAE TFMTLLLVIT DRYKNLPTAS
510 520 530 540 550
RKLQFLELQK DLVDDFRIRL TQVMKEETRA SLGFRYCAIL NAVNYISTVL
560 570 580 590 600
ADWADNVFFL QLQQAALEVF AENNTLSKLQ LGQLASMESS VFDDMINLLE
610 620 630 640 650
RLKHDMLTRQ VDHVFREVKD AAKLYKKERW LSLPSQSEQA VMSLSSSACP
660 670 680 690 700
LLLTLRDHLL QLEQQLCFSL FKIFWQMLVE KLDVYIYQEI ILANHFNEGG
710 720 730 740 750
AAQLQFDMTR NLFPLFSHYC KRPENYFKHI KEACIVLNLN VGSALLLKDV
760 770 780 790
LQSASGQLPA TAALNEVGIY KLAQQDVEIL LNLRTNWPNT GK
Length:792
Mass (Da):90,632
Last modified:July 5, 2004 - v1
Checksum:i6671066FCC5E74D6
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J5S3C9J5S3_HUMAN
RAD50-interacting protein 1
RINT1
143Annotation score:
F8WC46F8WC46_HUMAN
RAD50-interacting protein 1
RINT1
54Annotation score:
F8WAZ2F8WAZ2_HUMAN
RAD50-interacting protein 1
RINT1
41Annotation score:
F8WDC5F8WDC5_HUMAN
RAD50-interacting protein 1
RINT1
57Annotation score:

Sequence cautioni

The sequence AAG42101 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAQ96849 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAQ96850 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAB13910 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti758L → P (PubMed:14702039).Curated1
Sequence conflicti759 – 760PA → ST in AAG42101 (PubMed:11096100).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05132240S → C. Corresponds to variant dbSNP:rs11556986EnsemblClinVar.1
Natural variantiVAR_034418668F → S. Corresponds to variant dbSNP:rs35971380EnsemblClinVar.1
Natural variantiVAR_034419759P → L. Corresponds to variant dbSNP:rs34310648EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF317622 mRNA Translation: AAG42101.1 Different initiation.
AC073073 Genomic DNA Translation: AAQ96849.1 Sequence problems.
AC073073 Genomic DNA Translation: AAQ96850.1 Sequence problems.
BC007120 mRNA Translation: AAH07120.2
BC068483 mRNA Translation: AAH68483.1
AK021847 mRNA Translation: BAB13910.1 Different initiation.
CCDSiCCDS34726.1
RefSeqiNP_068749.3, NM_021930.5
UniGeneiHs.531388

Genome annotation databases

EnsembliENST00000257700; ENSP00000257700; ENSG00000135249
GeneIDi60561
KEGGihsa:60561
UCSCiuc003vda.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF317622 mRNA Translation: AAG42101.1 Different initiation.
AC073073 Genomic DNA Translation: AAQ96849.1 Sequence problems.
AC073073 Genomic DNA Translation: AAQ96850.1 Sequence problems.
BC007120 mRNA Translation: AAH07120.2
BC068483 mRNA Translation: AAH68483.1
AK021847 mRNA Translation: BAB13910.1 Different initiation.
CCDSiCCDS34726.1
RefSeqiNP_068749.3, NM_021930.5
UniGeneiHs.531388

3D structure databases

ProteinModelPortaliQ6NUQ1
SMRiQ6NUQ1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121942, 88 interactors
CORUMiQ6NUQ1
DIPiDIP-36477N
IntActiQ6NUQ1, 114 interactors
MINTiQ6NUQ1
STRINGi9606.ENSP00000257700

PTM databases

iPTMnetiQ6NUQ1
PhosphoSitePlusiQ6NUQ1

Polymorphism and mutation databases

BioMutaiRINT1
DMDMi71152944

Proteomic databases

EPDiQ6NUQ1
MaxQBiQ6NUQ1
PaxDbiQ6NUQ1
PeptideAtlasiQ6NUQ1
PRIDEiQ6NUQ1
ProteomicsDBi66701

Protocols and materials databases

DNASUi60561
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000257700; ENSP00000257700; ENSG00000135249
GeneIDi60561
KEGGihsa:60561
UCSCiuc003vda.1 human

Organism-specific databases

CTDi60561
DisGeNETi60561
EuPathDBiHostDB:ENSG00000135249.7
GeneCardsiRINT1
H-InvDBiHIX0033650
HGNCiHGNC:21876 RINT1
HPAiHPA019875
HPA031646
MIMi610089 gene
neXtProtiNX_Q6NUQ1
OpenTargetsiENSG00000135249
PharmGKBiPA143485595
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2218 Eukaryota
ENOG410XZD1 LUCA
GeneTreeiENSGT00390000017006
HOGENOMiHOG000118368
HOVERGENiHBG057727
InParanoidiQ6NUQ1
KOiK20474
OMAiWGENVHY
OrthoDBiEOG091G036T
PhylomeDBiQ6NUQ1
TreeFamiTF324274

Enzyme and pathway databases

ReactomeiR-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Miscellaneous databases

ChiTaRSiRINT1 human
GeneWikiiRINT1
GenomeRNAii60561
PROiPR:Q6NUQ1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135249 Expressed in 204 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_RINT1
ExpressionAtlasiQ6NUQ1 baseline and differential
GenevisibleiQ6NUQ1 HS

Family and domain databases

InterProiView protein in InterPro
IPR007528 RINT1_Tip20
PANTHERiPTHR13520 PTHR13520, 1 hit
PfamiView protein in Pfam
PF04437 RINT1_TIP1, 1 hit
PROSITEiView protein in PROSITE
PS51386 RINT1_TIP20, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRINT1_HUMAN
AccessioniPrimary (citable) accession number: Q6NUQ1
Secondary accession number(s): Q75MG9
, Q75MH0, Q96IW8, Q9H229, Q9HAD9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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