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Entry version 140 (17 Jun 2020)
Sequence version 1 (05 Jul 2004)
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Protein

RAD50-interacting protein 1

Gene

RINT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER. May play a role in cell cycle checkpoint control (PubMed:11096100). Essential for telomere length control (PubMed:16600870).Curated2 Publications

Miscellaneous

According to PubMed:11096100, a longer form, which may be due to the differential initiation of translation using a non-AUG codon, may exist. However, the existence of such form has not been clearly demonstrated.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RAD50-interacting protein 1
Alternative name(s):
RAD50 interactor 1
Short name:
HsRINT-1
Short name:
RINT-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RINT1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000135249.7

Human Gene Nomenclature Database

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HGNCi
HGNC:21876 RINT1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610089 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q6NUQ1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Infantile liver failure syndrome 3 (ILFS3)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of infantile liver failure syndrome, a life-threatening disorder of hepatic function that manifests with acute liver failure in the first months or years of life. ILFS3 is an autosomal recessive form characterized by recurrent episodes of acute liver failure often triggered by infection or fever. Affected individuals also have skeletal anomalies of the vertebral bodies and femoral heads.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_083238368A → T in ILFS3. 1 Publication1
Natural variantiVAR_083239370L → P in ILFS3. 1 Publication1
Natural variantiVAR_083240618 – 619Missing in ILFS3. 1 Publication2

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
60561

MalaCards human disease database

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MalaCardsi
RINT1
MIMi618641 phenotype

Open Targets

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OpenTargetsi
ENSG00000135249

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA143485595

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6NUQ1 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
RINT1

Domain mapping of disease mutations (DMDM)

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DMDMi
71152944

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000973491 – 792RAD50-interacting protein 1Add BLAST792

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q6NUQ1

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q6NUQ1

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q6NUQ1

MaxQB - The MaxQuant DataBase

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MaxQBi
Q6NUQ1

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q6NUQ1

PeptideAtlas

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PeptideAtlasi
Q6NUQ1

PRoteomics IDEntifications database

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PRIDEi
Q6NUQ1

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
66701

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6NUQ1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q6NUQ1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed throughout the cell cycle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000135249 Expressed in small intestine Peyer's patch and 203 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q6NUQ1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q6NUQ1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000135249 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the NRZ complex composed of NBAS, ZW10 and RINT1/TIP20L; NRZ associates with SNAREs STX18, USE1L, BNIP1/SEC20L and SEC22B (the assembly has been described as syntaxin 18 complex) (PubMed:15029241, PubMed:20462495, PubMed:19369418).

Interacts directly with BNIP1/SEC20L and ZW10 (PubMed:15029241, PubMed:15272311).

Interacts with UVRAG (PubMed:24056303).

Interacts with RAD50 during late S and G2/M phases (PubMed:11096100).

Interacts with RBL2, preferentially with the active, hypophosphorylated form (PubMed:16600870).

7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q6NUQ1
With#Exp.IntAct
ANKRD11 [X5D778]3EBI-726876,EBI-17183751
ARHGAP45 [Q92619]5EBI-726876,EBI-2825900
BFSP2 [Q13515]3EBI-726876,EBI-10229433
BLOC1S6 [Q9UL45]3EBI-726876,EBI-465781
C19orf25 [Q9UFG5]4EBI-726876,EBI-741214
C19orf44 - isoform 2 [Q9H6X5-2]3EBI-726876,EBI-12061599
C1orf109 [Q9NX04]6EBI-726876,EBI-8643161
CCDC120 [Q96HB5]3EBI-726876,EBI-744556
CCDC121 [Q6ZUS5]4EBI-726876,EBI-2836982
CCDC146 - isoform 2 [Q8IYE0-2]3EBI-726876,EBI-10247802
CCDC57 - isoform 2 [Q2TAC2-2]3EBI-726876,EBI-10961624
CCDC88B [A6NC98]3EBI-726876,EBI-347573
CCHCR1 - isoform 3 [Q8TD31-3]5EBI-726876,EBI-10175300
CDR2L [Q86X02]3EBI-726876,EBI-11063830
CEP57L1 - isoform 2 [Q8IYX8-2]3EBI-726876,EBI-10181988
CSPP1 - isoform 1 [Q1MSJ5-1]3EBI-726876,EBI-10239122
CWF19L2 [Q2TBE0]6EBI-726876,EBI-5453285
DCTN2 [Q13561]3EBI-726876,EBI-715074
DCX [O43602]4EBI-726876,EBI-8646694
DPF2 [Q92785]3EBI-726876,EBI-359932
EPC1 [Q9H2F5]5EBI-726876,EBI-769270
ESRRG - isoform 3 [P62508-3]3EBI-726876,EBI-12001340
EXOC8 [Q8IYI6]5EBI-726876,EBI-742102
FAM107A - isoform 3 [O95990-3]3EBI-726876,EBI-10192902
FAM110A [Q9BQ89]6EBI-726876,EBI-1752811
FAM124B [Q9H5Z6]3EBI-726876,EBI-741626
FAM161A [Q3B820]3EBI-726876,EBI-719941
FAM161B [Q96MY7]3EBI-726876,EBI-7225287
FAM81B [Q96LP2]5EBI-726876,EBI-10290827
FAM90A1 [Q86YD7]3EBI-726876,EBI-6658203
FCHSD2 - isoform 3 [O94868-3]3EBI-726876,EBI-11958845
GAS8 [O95995]3EBI-726876,EBI-1052570
HDAC4 [P56524]3EBI-726876,EBI-308629
HGS [A0A0S2Z4Q4]3EBI-726876,EBI-16429135
INPP5J [Q15735]3EBI-726876,EBI-10236940
JMY - isoform 2 [Q8N9B5-2]3EBI-726876,EBI-10268138
KIAA1217 - isoform 6 [Q5T5P2-6]3EBI-726876,EBI-10188326
KRT1 [P04264]3EBI-726876,EBI-298429
LMO2 [P25791]4EBI-726876,EBI-739696
LOC729862 [Q0VAF8]3EBI-726876,EBI-10226726
LOC729862 [Q0VAF9]3EBI-726876,EBI-10226748
LYSMD1 [Q96S90]3EBI-726876,EBI-10293291
MBD3 - isoform 2 [O95983-2]3EBI-726876,EBI-11978579
MGC50722 [Q8IVT4]3EBI-726876,EBI-14086479
MISP [Q8IVT2]3EBI-726876,EBI-2555085
MMTAG2 [Q9BU76]3EBI-726876,EBI-742459
MYOZ3 [Q8TDC0]3EBI-726876,EBI-5662487
NAB2 [Q15742]3EBI-726876,EBI-8641936
NFIL3 [Q16649]3EBI-726876,EBI-3951858
PIK3R2 [O00459]3EBI-726876,EBI-346930
PIMREG [Q9BSJ6]3EBI-726876,EBI-2568609
PRPF18 [Q99633]3EBI-726876,EBI-2798416
PSTPIP1 [A0A0S2Z528]3EBI-726876,EBI-16430249
RAMAC [Q9BTL3]3EBI-726876,EBI-744023
RBM41 [Q96IZ5]6EBI-726876,EBI-740773
RIBC1 [Q8N443]7EBI-726876,EBI-10265323
RNF39 [Q9H2S5]3EBI-726876,EBI-12235180
RNF6 [A0A0S2Z4G9]3EBI-726876,EBI-16428950
RSRC2 - isoform 2 [Q7L4I2-2]3EBI-726876,EBI-10256202
RTP5 [Q14D33]3EBI-726876,EBI-10217913
SCNM1 [Q9BWG6]5EBI-726876,EBI-748391
SFR1 [Q86XK3]4EBI-726876,EBI-1104535
SGF29 [Q96ES7]7EBI-726876,EBI-743117
SH2D4A [Q9H788]6EBI-726876,EBI-747035
SH2D4A - isoform 2 [Q9H788-2]3EBI-726876,EBI-10308083
SMARCE1 [Q969G3]3EBI-726876,EBI-455078
SNW1 [Q13573]7EBI-726876,EBI-632715
STRN [O43815]3EBI-726876,EBI-1046642
SUOX [P51687]3EBI-726876,EBI-3921347
TACO1 [Q9BSH4]3EBI-726876,EBI-747797
TEX9 [A0A0S2Z5Z9]3EBI-726876,EBI-16431655
TRIM69 - isoform 2 [Q86WT6-2]3EBI-726876,EBI-11525489
TSEN54 [Q7Z6J9]3EBI-726876,EBI-2559824
TSHZ2 [Q9NRE2]3EBI-726876,EBI-10687282
TSHZ3 [Q63HK5]5EBI-726876,EBI-9053916
TXLNA [P40222]6EBI-726876,EBI-359793
USHBP1 [Q8N6Y0]3EBI-726876,EBI-739895
UTP14C [Q5TAP6]3EBI-726876,EBI-11737646
UVRAG [Q9P2Y5]18EBI-726876,EBI-2952704
VAV3 [Q9UKW4]3EBI-726876,EBI-297568
VPS37C [A5D8V6]3EBI-726876,EBI-2559305
ZBTB16 [Q05516]3EBI-726876,EBI-711925
ZC2HC1C - isoform 2 [Q53FD0-2]3EBI-726876,EBI-14104088
ZNF648 [Q5T619]3EBI-726876,EBI-11985915
ZNF655 [Q8N720]5EBI-726876,EBI-625509
ZNF688 [A0A0S2Z5X4]3EBI-726876,EBI-16429014
ZNF688 [A0A0S2Z6P0]3EBI-726876,EBI-16429989
ZNF697 [Q8N508]3EBI-726876,EBI-10265733
ZNF835 [Q9Y2P0]3EBI-726876,EBI-5667516
ZSCAN5B [A6NJL1]3EBI-726876,EBI-17968892
ZW10 [O43264]16EBI-726876,EBI-1001217

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
121942, 105 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q6NUQ1

Database of interacting proteins

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DIPi
DIP-36477N

Protein interaction database and analysis system

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IntActi
Q6NUQ1, 137 interactors

Molecular INTeraction database

More...
MINTi
Q6NUQ1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000257700

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6NUQ1 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q6NUQ1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini220 – 792RINT1/TIP20PROSITE-ProRule annotationAdd BLAST573

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili103 – 124Sequence analysisAdd BLAST22

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RINT1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2218 Eukaryota
ENOG410XZD1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017006

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_020201_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6NUQ1

KEGG Orthology (KO)

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KOi
K20474

Identification of Orthologs from Complete Genome Data

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OMAi
WGENVHY

Database of Orthologous Groups

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OrthoDBi
1393136at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6NUQ1

TreeFam database of animal gene trees

More...
TreeFami
TF324274

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR007528 RINT1_Tip20

The PANTHER Classification System

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PANTHERi
PTHR13520 PTHR13520, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF04437 RINT1_TIP1, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51386 RINT1_TIP20, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q6NUQ1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPAGEIGAS PAAPCCSESG DERKNLEEKS DINVTVLIGS KQVSEGTDNG
60 70 80 90 100
DLPSYVSAFI EKEVGNDLKS LKKLDKLIEQ RTVSKMQLEE QVLTISSEIP
110 120 130 140 150
KRIRSALKNA EESKQFLNQF LEQETHLFSA INSHLLTAQP WMDDLGTMIS
160 170 180 190 200
QIEEIERHLA YLKWISQIEE LSDNIQQYLM TNNVPEAAST LVSMAELDIK
210 220 230 240 250
LQESSCTHLL GFMRATVKFW HKILKDKLTS DFEEILAQLH WPFIAPPQSQ
260 270 280 290 300
TVGLSRPASA PEIYSYLETL FCQLLKLQTS DELLTEPKQL PEKYSLPASP
310 320 330 340 350
SVILPIQVML TPLQKRFRYH FRGNRQTNVL SKPEWYLAQV LMWIGNHTEF
360 370 380 390 400
LDEKIQPILD KVGSLVNARL EFSRGLMMLV LEKLATDIPC LLYDDNLFCH
410 420 430 440 450
LVDEVLLFER ELHSVHGYPG TFASCMHILS EETCFQRWLT VERKFALQKM
460 470 480 490 500
DSMLSSEAAW VSQYKDITDV DEMKVPDCAE TFMTLLLVIT DRYKNLPTAS
510 520 530 540 550
RKLQFLELQK DLVDDFRIRL TQVMKEETRA SLGFRYCAIL NAVNYISTVL
560 570 580 590 600
ADWADNVFFL QLQQAALEVF AENNTLSKLQ LGQLASMESS VFDDMINLLE
610 620 630 640 650
RLKHDMLTRQ VDHVFREVKD AAKLYKKERW LSLPSQSEQA VMSLSSSACP
660 670 680 690 700
LLLTLRDHLL QLEQQLCFSL FKIFWQMLVE KLDVYIYQEI ILANHFNEGG
710 720 730 740 750
AAQLQFDMTR NLFPLFSHYC KRPENYFKHI KEACIVLNLN VGSALLLKDV
760 770 780 790
LQSASGQLPA TAALNEVGIY KLAQQDVEIL LNLRTNWPNT GK
Length:792
Mass (Da):90,632
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6671066FCC5E74D6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J5S3C9J5S3_HUMAN
RAD50-interacting protein 1
RINT1
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WAZ2F8WAZ2_HUMAN
RAD50-interacting protein 1
RINT1
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WC46F8WC46_HUMAN
RAD50-interacting protein 1
RINT1
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDC5F8WDC5_HUMAN
RAD50-interacting protein 1
RINT1
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG42101 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAQ96849 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAQ96850 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAB13910 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti758L → P (PubMed:14702039).Curated1
Sequence conflicti759 – 760PA → ST in AAG42101 (PubMed:11096100).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05132240S → C. Corresponds to variant dbSNP:rs11556986EnsemblClinVar.1
Natural variantiVAR_083238368A → T in ILFS3. 1 Publication1
Natural variantiVAR_083239370L → P in ILFS3. 1 Publication1
Natural variantiVAR_083240618 – 619Missing in ILFS3. 1 Publication2
Natural variantiVAR_034418668F → S. Corresponds to variant dbSNP:rs35971380EnsemblClinVar.1
Natural variantiVAR_034419759P → L. Corresponds to variant dbSNP:rs34310648EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF317622 mRNA Translation: AAG42101.1 Different initiation.
AC073073 Genomic DNA Translation: AAQ96849.1 Sequence problems.
AC073073 Genomic DNA Translation: AAQ96850.1 Sequence problems.
BC007120 mRNA Translation: AAH07120.2
BC068483 mRNA Translation: AAH68483.1
AK021847 mRNA Translation: BAB13910.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34726.1

NCBI Reference Sequences

More...
RefSeqi
NP_068749.3, NM_021930.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000257700; ENSP00000257700; ENSG00000135249

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
60561

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:60561

UCSC genome browser

More...
UCSCi
uc003vda.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF317622 mRNA Translation: AAG42101.1 Different initiation.
AC073073 Genomic DNA Translation: AAQ96849.1 Sequence problems.
AC073073 Genomic DNA Translation: AAQ96850.1 Sequence problems.
BC007120 mRNA Translation: AAH07120.2
BC068483 mRNA Translation: AAH68483.1
AK021847 mRNA Translation: BAB13910.1 Different initiation.
CCDSiCCDS34726.1
RefSeqiNP_068749.3, NM_021930.5

3D structure databases

SMRiQ6NUQ1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121942, 105 interactors
CORUMiQ6NUQ1
DIPiDIP-36477N
IntActiQ6NUQ1, 137 interactors
MINTiQ6NUQ1
STRINGi9606.ENSP00000257700

PTM databases

iPTMnetiQ6NUQ1
PhosphoSitePlusiQ6NUQ1

Polymorphism and mutation databases

BioMutaiRINT1
DMDMi71152944

Proteomic databases

EPDiQ6NUQ1
jPOSTiQ6NUQ1
MassIVEiQ6NUQ1
MaxQBiQ6NUQ1
PaxDbiQ6NUQ1
PeptideAtlasiQ6NUQ1
PRIDEiQ6NUQ1
ProteomicsDBi66701

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
17090 95 antibodies

The DNASU plasmid repository

More...
DNASUi
60561

Genome annotation databases

EnsembliENST00000257700; ENSP00000257700; ENSG00000135249
GeneIDi60561
KEGGihsa:60561
UCSCiuc003vda.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
60561
DisGeNETi60561
EuPathDBiHostDB:ENSG00000135249.7

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RINT1
HGNCiHGNC:21876 RINT1
HPAiENSG00000135249 Low tissue specificity
MalaCardsiRINT1
MIMi610089 gene
618641 phenotype
neXtProtiNX_Q6NUQ1
OpenTargetsiENSG00000135249
PharmGKBiPA143485595

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2218 Eukaryota
ENOG410XZD1 LUCA
GeneTreeiENSGT00390000017006
HOGENOMiCLU_020201_0_0_1
InParanoidiQ6NUQ1
KOiK20474
OMAiWGENVHY
OrthoDBi1393136at2759
PhylomeDBiQ6NUQ1
TreeFamiTF324274

Enzyme and pathway databases

ReactomeiR-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
60561 505 hits in 790 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RINT1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
RINT1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
60561
PharosiQ6NUQ1 Tbio

Protein Ontology

More...
PROi
PR:Q6NUQ1
RNActiQ6NUQ1 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000135249 Expressed in small intestine Peyer's patch and 203 other tissues
ExpressionAtlasiQ6NUQ1 baseline and differential
GenevisibleiQ6NUQ1 HS

Family and domain databases

InterProiView protein in InterPro
IPR007528 RINT1_Tip20
PANTHERiPTHR13520 PTHR13520, 1 hit
PfamiView protein in Pfam
PF04437 RINT1_TIP1, 1 hit
PROSITEiView protein in PROSITE
PS51386 RINT1_TIP20, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRINT1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NUQ1
Secondary accession number(s): Q75MG9
, Q75MH0, Q96IW8, Q9H229, Q9HAD9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: June 17, 2020
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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