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Entry version 132 (17 Jun 2020)
Sequence version 1 (05 Jul 2004)
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Protein

Serine/threonine-protein phosphatase 4 regulatory subunit 4

Gene

PPP4R4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Putative regulatory subunit of serine/threonine-protein phosphatase 4.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 4 regulatory subunit 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPP4R4
Synonyms:KIAA1622, PP4R4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000119698.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23788 PPP4R4

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6NUP7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi501R → W: Abolishes interaction with PPP4C. 1 Publication1
Mutagenesisi618V → A: Diminishes interaction with PPP4C. 1 Publication1
Mutagenesisi618V → D: Abolishes interaction with PPP4C. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
57718

Open Targets

More...
OpenTargetsi
ENSG00000119698

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164724938

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6NUP7 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PPP4R4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74736832

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003118501 – 873Serine/threonine-protein phosphatase 4 regulatory subunit 4Add BLAST873

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei775PhosphoserineBy similarity1
Modified residuei797PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6NUP7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6NUP7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6NUP7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6NUP7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6NUP7

PeptideAtlas

More...
PeptideAtlasi
Q6NUP7

PRoteomics IDEntifications database

More...
PRIDEi
Q6NUP7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
66699 [Q6NUP7-1]
66700 [Q6NUP7-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6NUP7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6NUP7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000119698 Expressed in caudate nucleus and 127 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6NUP7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6NUP7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000119698 Tissue enhanced (brain, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits.

Component of the PP4 complex PPP4C-PPP4R4.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
121741, 5 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1845 PPP4C-PPP4R4 protein phosphatase 4 complex

Protein interaction database and analysis system

More...
IntActi
Q6NUP7, 3 interactors

Molecular INTeraction database

More...
MINTi
Q6NUP7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000305924

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6NUP7 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati213 – 251HEAT 1Add BLAST39
Repeati252 – 290HEAT 2Add BLAST39
Repeati392 – 427HEAT 3Add BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili686 – 720Sequence analysisAdd BLAST35

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IUDH Eukaryota
ENOG410XPMD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000047895

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010601_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6NUP7

KEGG Orthology (KO)

More...
KOi
K15426

Identification of Orthologs from Complete Genome Data

More...
OMAi
NEREAEC

Database of Orthologous Groups

More...
OrthoDBi
447572at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6NUP7

TreeFam database of animal gene trees

More...
TreeFami
TF313717

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR021133 HEAT_type_2
IPR039918 PPP4R4

The PANTHER Classification System

More...
PANTHERi
PTHR21467 PTHR21467, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50077 HEAT_REPEAT, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6NUP7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHPPPPAAAM DFSQNSLFGY MEDLQELTII ERPVRRSLKT PEEIERLTVD
60 70 80 90 100
EDLSDIERAV YLLSAGQDVQ GTSVIANLPF LMRQNPTETL RRVLPKVREA
110 120 130 140 150
LHVAGVEMQL TAAMSFLTIL QDESVSIHAY THSFLQVILL HLEHRDTGVS
160 170 180 190 200
NAWLETLLSV IEVLPKETLR HEILNPLVSK AQLSQTVQSR LVSCKILGKL
210 220 230 240 250
TNKFDAHTIK REILPLVKSL CQDVEYEVRS CMCRQLENIA QGIGTELTKS
260 270 280 290 300
VVLPELIELS RDEGSSVRLA AFETLVNLLD IFDTDDRSQT ILPLVKSFCE
310 320 330 340 350
KSFKADESIL ISLSFHLGKL CHGLYGIFTP DQHLRFLEFY KKLCTLGLQQ
360 370 380 390 400
ENGHNENQIP PQILEQEKKY ISVRKNCAYN FPAMIVFVDP KNFHMELYST
410 420 430 440 450
FFCLCHDPEV PVRYTIAICF YEVSKLLNSG VYLIHKELIT LLQDESLEVL
460 470 480 490 500
DALIDHLPEI LELMSTGGES SVQENKLSSL PDLIPALTAA EQRAAASLKW
510 520 530 540 550
RTHEKLLQKY ACLPHVISSD QIYYRFLQRM FTIMMTNNVL PVQKAASRTL
560 570 580 590 600
CIFLRYNRKQ EQRHEVIQKL IEQLGQGKSY WNRLRFLDTC EFIIEIFSKS
610 620 630 640 650
FFCKYFFLPA IELTHDPVAN VRMKLCYLLP KVKSTLKIPA DKHLLQQLEM
660 670 680 690 700
CVRKLLCQEK DKDVLAIVKR TVLELDRMEM SMDAFQKKFY EKDLLDQEKE
710 720 730 740 750
REELLLLEME QLEKEKQQND GRPMSDKMFE KKRRDTKTPT QSLPKNIPIS
760 770 780 790 800
VPGPSSVTPS TSKEIKKSKL IRSQSFNNQA FHAKYGNLEK CASKSSTTGY
810 820 830 840 850
TTSVSGLGKT SVLSLADDSF RTRNASSVPS SFSPNTPLPS TSRGTGNSVD
860 870
PKSSGSKDTQ PRKATLKSRK SNP
Length:873
Mass (Da):99,452
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9C1A9CD4584447C1
GO
Isoform 2 (identifier: Q6NUP7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     99-120: EALHVAGVEMQLTAAMSFLTIL → VHEDAHLFIQRVWISHMFVQRV
     121-873: Missing.

Show »
Length:120
Mass (Da):13,894
Checksum:i0B935EB2909EBB6A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V431G3V431_HUMAN
Serine/threonine-protein phosphatas...
PPP4R4
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V422G3V422_HUMAN
Serine/threonine-protein phosphatas...
PPP4R4
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V516G3V516_HUMAN
Serine/threonine-protein phosphatas...
PPP4R4
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB13448 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02961699 – 120EALHV…FLTIL → VHEDAHLFIQRVWISHMFVQ RV in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_029617121 – 873Missing in isoform 2. 1 PublicationAdd BLAST753

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB046842 mRNA Translation: BAB13448.1 Different initiation.
CH471061 Genomic DNA Translation: EAW81561.1
CH471061 Genomic DNA Translation: EAW81562.1
BC002650 mRNA Translation: AAH02650.2
BC068491 mRNA Translation: AAH68491.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9921.1 [Q6NUP7-1]
CCDS9922.1 [Q6NUP7-2]

NCBI Reference Sequences

More...
RefSeqi
NP_066009.2, NM_020958.2 [Q6NUP7-2]
NP_478144.1, NM_058237.1 [Q6NUP7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000304338; ENSP00000305924; ENSG00000119698 [Q6NUP7-1]
ENST00000328839; ENSP00000330831; ENSG00000119698 [Q6NUP7-2]
ENST00000614957; ENSP00000482849; ENSG00000278326 [Q6NUP7-2]
ENST00000619905; ENSP00000480902; ENSG00000278326 [Q6NUP7-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57718

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57718

UCSC genome browser

More...
UCSCi
uc001ycr.4 human [Q6NUP7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046842 mRNA Translation: BAB13448.1 Different initiation.
CH471061 Genomic DNA Translation: EAW81561.1
CH471061 Genomic DNA Translation: EAW81562.1
BC002650 mRNA Translation: AAH02650.2
BC068491 mRNA Translation: AAH68491.1
CCDSiCCDS9921.1 [Q6NUP7-1]
CCDS9922.1 [Q6NUP7-2]
RefSeqiNP_066009.2, NM_020958.2 [Q6NUP7-2]
NP_478144.1, NM_058237.1 [Q6NUP7-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi121741, 5 interactors
ComplexPortaliCPX-1845 PPP4C-PPP4R4 protein phosphatase 4 complex
IntActiQ6NUP7, 3 interactors
MINTiQ6NUP7
STRINGi9606.ENSP00000305924

PTM databases

iPTMnetiQ6NUP7
PhosphoSitePlusiQ6NUP7

Polymorphism and mutation databases

BioMutaiPPP4R4
DMDMi74736832

Proteomic databases

EPDiQ6NUP7
jPOSTiQ6NUP7
MassIVEiQ6NUP7
MaxQBiQ6NUP7
PaxDbiQ6NUP7
PeptideAtlasiQ6NUP7
PRIDEiQ6NUP7
ProteomicsDBi66699 [Q6NUP7-1]
66700 [Q6NUP7-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
49053 44 antibodies

Genome annotation databases

EnsembliENST00000304338; ENSP00000305924; ENSG00000119698 [Q6NUP7-1]
ENST00000328839; ENSP00000330831; ENSG00000119698 [Q6NUP7-2]
ENST00000614957; ENSP00000482849; ENSG00000278326 [Q6NUP7-2]
ENST00000619905; ENSP00000480902; ENSG00000278326 [Q6NUP7-1]
GeneIDi57718
KEGGihsa:57718
UCSCiuc001ycr.4 human [Q6NUP7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
57718
DisGeNETi57718
EuPathDBiHostDB:ENSG00000119698.11

GeneCards: human genes, protein and diseases

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GeneCardsi
PPP4R4
HGNCiHGNC:23788 PPP4R4
HPAiENSG00000119698 Tissue enhanced (brain, testis)
neXtProtiNX_Q6NUP7
OpenTargetsiENSG00000119698
PharmGKBiPA164724938

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IUDH Eukaryota
ENOG410XPMD LUCA
GeneTreeiENSGT00510000047895
HOGENOMiCLU_010601_0_0_1
InParanoidiQ6NUP7
KOiK15426
OMAiNEREAEC
OrthoDBi447572at2759
PhylomeDBiQ6NUP7
TreeFamiTF313717

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
57718 3 hits in 786 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PPP4R4 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
57718
PharosiQ6NUP7 Tdark

Protein Ontology

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PROi
PR:Q6NUP7
RNActiQ6NUP7 protein

Gene expression databases

BgeeiENSG00000119698 Expressed in caudate nucleus and 127 other tissues
ExpressionAtlasiQ6NUP7 baseline and differential
GenevisibleiQ6NUP7 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR021133 HEAT_type_2
IPR039918 PPP4R4
PANTHERiPTHR21467 PTHR21467, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50077 HEAT_REPEAT, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPP4R4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NUP7
Secondary accession number(s): Q9BUF8, Q9HCF0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 5, 2004
Last modified: June 17, 2020
This is version 132 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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