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Entry version 142 (16 Oct 2019)
Sequence version 2 (07 Mar 2006)
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Protein

All-trans-retinol 13,14-reductase

Gene

RETSAT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the saturation of all-trans-retinol to all-trans-13,14-dihydroretinol. Does not exhibit any activity toward all-trans-retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers. May play a role in the metabolism of vitamin A. Independently of retinol conversion, may regulate liver metabolism upstream of MLXIPL/ChREBP. May play a role in adipocyte differentiation.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

NAD+By similarity, NADP+By similarity, FADBy similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi70 – 98FAD or NAD or NADPSequence analysisAdd BLAST29

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, NAD, NADP

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-975634 Retinoid metabolism and transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
All-trans-retinol 13,14-reductase (EC:1.3.99.23By similarity)
Alternative name(s):
All-trans-13,14-dihydroretinol saturase
Short name:
RetSat
PPAR-alpha-regulated and starvation-induced gene protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RETSAT
Synonyms:PPSIG
ORF Names:UNQ439/PRO872
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25991 RETSAT

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617597 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6NUM9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
54884

Open Targets

More...
OpenTargetsi
ENSG00000042445

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA145007867

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6NUM9

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00162 Vitamin A

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RETSAT

Domain mapping of disease mutations (DMDM)

More...
DMDMi
90108452

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000022566519 – 610All-trans-retinol 13,14-reductaseAdd BLAST592

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6NUM9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6NUM9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6NUM9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6NUM9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6NUM9

PeptideAtlas

More...
PeptideAtlasi
Q6NUM9

PRoteomics IDEntifications database

More...
PRIDEi
Q6NUM9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
66690 [Q6NUM9-1]
66691 [Q6NUM9-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6NUM9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6NUM9

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q6NUM9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in liver; expression positively correlates with obesity and liver steatosis (PubMed:28855500). Expressed in adipose tissue; expression tends to be decreased in obese versus lean individuals (PubMed:19139408).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000042445 Expressed in 222 organ(s), highest expression level in adipose tissue

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6NUM9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6NUM9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA007961
HPA046513

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120232, 32 interactors

Protein interaction database and analysis system

More...
IntActi
Q6NUM9, 19 interactors

Molecular INTeraction database

More...
MINTi
Q6NUM9

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000295802

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6NUM9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4254 Eukaryota
COG1233 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017613

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6NUM9

KEGG Orthology (KO)

More...
KOi
K09516

Identification of Orthologs from Complete Genome Data

More...
OMAi
TPGNEPY

Database of Orthologous Groups

More...
OrthoDBi
873686at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6NUM9

TreeFam database of animal gene trees

More...
TreeFami
TF328375

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.50.50.60, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036188 FAD/NAD-bd_sf

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51905 SSF51905, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6NUM9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWLPLVLLLA VLLLAVLCKV YLGLFSGSSP NPFSEDVKRP PAPLVTDKEA
60 70 80 90 100
RKKVLKQAFS ANQVPEKLDV VVIGSGFGGL AAAAILAKAG KRVLVLEQHT
110 120 130 140 150
KAGGCCHTFG KNGLEFDTGI HYIGRMEEGS IGRFILDQIT EGQLDWAPLS
160 170 180 190 200
SPFDIMVLEG PNGRKEYPMY SGEKAYIQGL KEKFPQEEAI IDKYIKLVKV
210 220 230 240 250
VSSGAPHAIL LKFLPLPVVQ LLDRCGLLTR FSPFLQASTQ SLAEVLQQLG
260 270 280 290 300
ASSELQAVLS YIFPTYGVTP NHSAFSMHAL LVNHYMKGGF YPRGGSSEIA
310 320 330 340 350
FHTIPVIQRA GGAVLTKATV QSVLLDSAGK ACGVSVKKGH ELVNIYCPIV
360 370 380 390 400
VSNAGLFNTY EHLLPGNARC LPGVKQQLGT VRPGLGMTSV FICLRGTKED
410 420 430 440 450
LHLPSTNYYV YYDTDMDQAM ERYVSMPREE AAEHIPLLFF AFPSAKDPTW
460 470 480 490 500
EDRFPGRSTM IMLIPTAYEW FEEWQAELKG KRGSDYETFK NSFVEASMSV
510 520 530 540 550
VLKLFPQLEG KVESVTAGSP LTNQFYLAAP RGACYGADHD LGRLHPCVMA
560 570 580 590 600
SLRAQSPIPN LYLTGQDIFT CGLVGALQGA LLCSSAILKR NLYSDLKNLD
610
SRIRAQKKKN
Length:610
Mass (Da):66,820
Last modified:March 7, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i06AE8EBC16BBA2EC
GO
Isoform 2 (identifier: Q6NUM9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     457-481: RSTMIMLIPTAYEWFEEWQAELKGK → GECDCRIPTHQPVLSGCSPRCLLRG
     482-610: Missing.

Note: No experimental confirmation available.
Show »
Length:481
Mass (Da):52,439
Checksum:i6266754EA5A201E4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C3J0H7C3J0_HUMAN
All-trans-retinol 13,14-reductase
RETSAT
399Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZ16H7BZ16_HUMAN
All-trans-retinol 13,14-reductase
RETSAT
255Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YGU3H0YGU3_HUMAN
All-trans-retinol 13,14-reductase
RETSAT
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZ81H7BZ81_HUMAN
All-trans-retinol 13,14-reductase
RETSAT
320Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH11418 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAA91069 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti140T → S in AAH68517 (PubMed:15489334).Curated1
Sequence conflicti298E → Q in AAH11418 (PubMed:15489334).Curated1
Sequence conflicti353N → S in BAC11505 (PubMed:16303743).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_025473533A → V. Corresponds to variant dbSNP:rs4832169Ensembl.1
Natural variantiVAR_059243536G → R. Corresponds to variant dbSNP:rs4832168Ensembl.1
Natural variantiVAR_059244559P → T. Corresponds to variant dbSNP:rs13384912Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_017410457 – 481RSTMI…ELKGK → GECDCRIPTHQPVLSGCSPR CLLRG in isoform 2. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_017411482 – 610Missing in isoform 2. 1 PublicationAdd BLAST129

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY358568 mRNA Translation: AAQ88931.1
AK075261 mRNA Translation: BAC11505.1
AC062037 Genomic DNA Translation: AAY24126.1
AC093162 Genomic DNA Translation: AAY24096.1
BC068517 mRNA Translation: AAH68517.1
BC011418 mRNA Translation: AAH11418.1 Different initiation.
AK000303 mRNA Translation: BAA91069.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1972.1 [Q6NUM9-1]

NCBI Reference Sequences

More...
RefSeqi
NP_060220.3, NM_017750.3 [Q6NUM9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000295802; ENSP00000295802; ENSG00000042445 [Q6NUM9-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54884

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54884

UCSC genome browser

More...
UCSCi
uc002spd.4 human [Q6NUM9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358568 mRNA Translation: AAQ88931.1
AK075261 mRNA Translation: BAC11505.1
AC062037 Genomic DNA Translation: AAY24126.1
AC093162 Genomic DNA Translation: AAY24096.1
BC068517 mRNA Translation: AAH68517.1
BC011418 mRNA Translation: AAH11418.1 Different initiation.
AK000303 mRNA Translation: BAA91069.1 Different initiation.
CCDSiCCDS1972.1 [Q6NUM9-1]
RefSeqiNP_060220.3, NM_017750.3 [Q6NUM9-1]

3D structure databases

SMRiQ6NUM9
ModBaseiSearch...

Protein-protein interaction databases

BioGridi120232, 32 interactors
IntActiQ6NUM9, 19 interactors
MINTiQ6NUM9
STRINGi9606.ENSP00000295802

Chemistry databases

DrugBankiDB00162 Vitamin A

PTM databases

iPTMnetiQ6NUM9
PhosphoSitePlusiQ6NUM9
SwissPalmiQ6NUM9

Polymorphism and mutation databases

BioMutaiRETSAT
DMDMi90108452

Proteomic databases

EPDiQ6NUM9
jPOSTiQ6NUM9
MassIVEiQ6NUM9
MaxQBiQ6NUM9
PaxDbiQ6NUM9
PeptideAtlasiQ6NUM9
PRIDEiQ6NUM9
ProteomicsDBi66690 [Q6NUM9-1]
66691 [Q6NUM9-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
54884

Genome annotation databases

EnsembliENST00000295802; ENSP00000295802; ENSG00000042445 [Q6NUM9-1]
GeneIDi54884
KEGGihsa:54884
UCSCiuc002spd.4 human [Q6NUM9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
54884
DisGeNETi54884

GeneCards: human genes, protein and diseases

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GeneCardsi
RETSAT
HGNCiHGNC:25991 RETSAT
HPAiHPA007961
HPA046513
MIMi617597 gene
neXtProtiNX_Q6NUM9
OpenTargetsiENSG00000042445
PharmGKBiPA145007867

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4254 Eukaryota
COG1233 LUCA
GeneTreeiENSGT00390000017613
InParanoidiQ6NUM9
KOiK09516
OMAiTPGNEPY
OrthoDBi873686at2759
PhylomeDBiQ6NUM9
TreeFamiTF328375

Enzyme and pathway databases

ReactomeiR-HSA-975634 Retinoid metabolism and transport

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RETSAT human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RETSAT

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54884
PharosiQ6NUM9

Protein Ontology

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PROi
PR:Q6NUM9

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000042445 Expressed in 222 organ(s), highest expression level in adipose tissue
ExpressionAtlasiQ6NUM9 baseline and differential
GenevisibleiQ6NUM9 HS

Family and domain databases

Gene3Di3.50.50.60, 2 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
SUPFAMiSSF51905 SSF51905, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRETST_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NUM9
Secondary accession number(s): A6NIK3
, Q53R95, Q53SA9, Q6UX05, Q8N2H5, Q96FA4, Q9NXE5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 7, 2006
Last modified: October 16, 2019
This is version 142 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
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