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Entry version 141 (16 Oct 2019)
Sequence version 2 (05 Feb 2008)
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Protein

Calcium-binding mitochondrial carrier protein SCaMC-1

Gene

SLC25A24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, catalyzing the net uptake or efflux of adenine nucleotides across the mitochondrial inner membrane. Nucleotide transport is inactive when cytosolic calcium levels are low, and is activated by an increase in cytosolic calcium levels. May play a role in protecting cells against oxidative stress-induced cell death, probably by promoting the formation of calcium-phosphate precipitates in the mitochondrial matrix, and thereby buffering calcium levels in the mitochondrial matrix.3 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.97 mM for AMP1 Publication
  2. KM=0.3 mM for ADP1 Publication
  3. KM=0.33 mM for ATP1 Publication
  4. KM=0.2 mM for ATP-Mg1 Publication
  5. KM=1.64 mM for Pi1 Publication
  1. Vmax=337 µmol/min/g enzyme with AMP as substrate1 Publication
  2. Vmax=345 µmol/min/g enzyme with ADP as substrate1 Publication
  3. Vmax=320 µmol/min/g enzyme with ATP as substrate1 Publication
  4. Vmax=365 µmol/min/g enzyme with ATP-Mg as substrate1 Publication
  5. Vmax=380 µmol/min/g enzyme with Pi as substrate1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi32 – 431Add BLAST12
Calcium bindingi68 – 792Add BLAST12
Calcium bindingi99 – 1103Add BLAST12
Calcium bindingi135 – 1464Add BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP transmembrane transporter activity Source: UniProtKB
  • calcium ion binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandCalcium, Metal-binding

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.29.23.8 the mitochondrial carrier (mc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calcium-binding mitochondrial carrier protein SCaMC-1
Alternative name(s):
Mitochondrial ATP-Mg/Pi carrier protein 1
Mitochondrial Ca(2+)-dependent solute carrier protein 1
Small calcium-binding mitochondrial carrier protein 1
Solute carrier family 25 member 24
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC25A24
Synonyms:APC1, MCSC1, SCAMC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20662 SLC25A24

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608744 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6NUK1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 197Mitochondrial intermembraneSequence analysisAdd BLAST197
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei198 – 215Helical; Name=1Sequence analysisAdd BLAST18
Topological domaini216 – 252Mitochondrial matrixSequence analysisAdd BLAST37
Transmembranei253 – 272Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini273 – 295Mitochondrial intermembraneSequence analysisAdd BLAST23
Transmembranei296 – 309Helical; Name=3Sequence analysisAdd BLAST14
Topological domaini310 – 345Mitochondrial matrixSequence analysisAdd BLAST36
Transmembranei346 – 365Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini366 – 388Mitochondrial intermembraneSequence analysisAdd BLAST23
Transmembranei389 – 406Helical; Name=5Sequence analysisAdd BLAST18
Topological domaini407 – 445Mitochondrial matrixSequence analysisAdd BLAST39
Transmembranei446 – 465Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini466 – 477Mitochondrial intermembraneSequence analysisAdd BLAST12

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Fontaine progeroid syndrome (FPS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant progeroid disorder characterized by prenatal and postnatal growth retardation, decreased subcutaneous fat tissue, wrinkled skin, an aged appearance since birth, an abnormal scalp hair pattern, sparse hair, hypoplastic distal phalanges with hypoplastic nails, a widely open anterior fontanel, facial dysmorphisms, and craniosynostosis. Early death is observed in some patients.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_080617217R → C in FPS. 1 PublicationCorresponds to variant dbSNP:rs1553253990EnsemblClinVar.1
Natural variantiVAR_080618217R → H in FPS; no effect on protein abundance; no effect on localization to the mitochondrion; altered mitochondrial ATP transport; increased sensitivity to oxidative stress that leads to mitochondrial swelling. 1 PublicationCorresponds to variant dbSNP:rs1553253989EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
29957

MalaCards human disease database

More...
MalaCardsi
SLC25A24
MIMi612289 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000085491

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
2095 Gorlin-Chaudhry-Moss syndrome
2963 Progeroid syndrome, Petty type

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134978257

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6NUK1

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC25A24

Domain mapping of disease mutations (DMDM)

More...
DMDMi
167016554

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003175941 – 477Calcium-binding mitochondrial carrier protein SCaMC-1Add BLAST477

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei320N6-acetyllysine; alternateBy similarity1
Modified residuei320N6-succinyllysine; alternateBy similarity1
Modified residuei336N6-acetyllysineCombined sources1
Modified residuei437N6-acetyllysine; alternateCombined sources1
Modified residuei437N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6NUK1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6NUK1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6NUK1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6NUK1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6NUK1

PeptideAtlas

More...
PeptideAtlasi
Q6NUK1

PRoteomics IDEntifications database

More...
PRIDEi
Q6NUK1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
66685 [Q6NUK1-1]
66686 [Q6NUK1-2]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q6NUK1-1 [Q6NUK1-1]
Q6NUK1-2 [Q6NUK1-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6NUK1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6NUK1

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q6NUK1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Present in various cell lines (at protein level). Expressed in all tissues tested. Highly expressed in testis, expressed at intermediate level in small intestine and pancreas, and weakly expressed in kidney, spleen, liver, skeletal muscle and heart.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000085491 Expressed in 208 organ(s), highest expression level in colon

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6NUK1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6NUK1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA028519
HPA063636

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
118993, 43 interactors

Protein interaction database and analysis system

More...
IntActi
Q6NUK1, 26 interactors

Molecular INTeraction database

More...
MINTi
Q6NUK1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000457733

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1477
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6NUK1

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini19 – 54EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini55 – 88EF-hand 2PROSITE-ProRule annotationAdd BLAST34
Domaini86 – 121EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini122 – 157EF-hand 4PROSITE-ProRule annotationAdd BLAST36
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati192 – 278Solcar 1Add BLAST87
Repeati286 – 371Solcar 2Add BLAST86
Repeati383 – 471Solcar 3Add BLAST89

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal domain can bind calcium and regulates the ATP carrier activity of the transmembrane domain. The apo form of the N-terminal domain is intrinsically disordered and binds to the transmembrane domain, leading to inhibition of the ATP carrier activity. Calcium binding leads to a major conformation change and abolishes the interaction with the transmembrane domain and the inhibition of the ATP carrier activity (PubMed:24332718).1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0036 Eukaryota
ENOG410XQ4P LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158786

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6NUK1

KEGG Orthology (KO)

More...
KOi
K14684

Identification of Orthologs from Complete Genome Data

More...
OMAi
KKTGQWW

Database of Orthologous Groups

More...
OrthoDBi
442523at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6NUK1

TreeFam database of animal gene trees

More...
TreeFami
TF313492

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.50.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR002167 Graves_DC
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13499 EF-hand_7, 2 hits
PF00153 Mito_carr, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00928 GRAVESDC
PR00926 MITOCARRIER

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00054 EFh, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103506 SSF103506, 1 hit
SSF47473 SSF47473, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018 EF_HAND_1, 3 hits
PS50222 EF_HAND_2, 4 hits
PS50920 SOLCAR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6NUK1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLRWLRDFVL PTAACQDAEQ PTRYETLFQA LDRNGDGVVD IGELQEGLRN
60 70 80 90 100
LGIPLGQDAE EKIFTTGDVN KDGKLDFEEF MKYLKDHEKK MKLAFKSLDK
110 120 130 140 150
NNDGKIEASE IVQSLQTLGL TISEQQAELI LQSIDVDGTM TVDWNEWRDY
160 170 180 190 200
FLFNPVTDIE EIIRFWKHST GIDIGDSLTI PDEFTEDEKK SGQWWRQLLA
210 220 230 240 250
GGIAGAVSRT STAPLDRLKI MMQVHGSKSD KMNIFGGFRQ MVKEGGIRSL
260 270 280 290 300
WRGNGTNVIK IAPETAVKFW AYEQYKKLLT EEGQKIGTFE RFISGSMAGA
310 320 330 340 350
TAQTFIYPME VMKTRLAVGK TGQYSGIYDC AKKILKHEGL GAFYKGYVPN
360 370 380 390 400
LLGIIPYAGI DLAVYELLKS YWLDNFAKDS VNPGVMVLLG CGALSSTCGQ
410 420 430 440 450
LASYPLALVR TRMQAQAMLE GSPQLNMVGL FRRIISKEGI PGLYRGITPN
460 470
FMKVLPAVGI SYVVYENMKQ TLGVTQK
Length:477
Mass (Da):53,354
Last modified:February 5, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF533D47B2457123F
GO
Isoform 2 (identifier: Q6NUK1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: MLRWLRDFVL...GIPLGQDAEE → MDSLYGDLFW...GAIQSLEEAK

Show »
Length:458
Mass (Da):51,354
Checksum:i8C70A5782DE8BF3D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B3IU96A0A3B3IU96_HUMAN
Calcium-binding mitochondrial carri...
SLC25A24
270Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BMI3H3BMI3_HUMAN
Calcium-binding mitochondrial carri...
SLC25A24
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KN42J3KN42_HUMAN
Calcium-binding mitochondrial carri...
SLC25A24
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF28888 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti75L → P in AAH68561 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_080617217R → C in FPS. 1 PublicationCorresponds to variant dbSNP:rs1553253990EnsemblClinVar.1
Natural variantiVAR_080618217R → H in FPS; no effect on protein abundance; no effect on localization to the mitochondrion; altered mitochondrial ATP transport; increased sensitivity to oxidative stress that leads to mitochondrial swelling. 1 PublicationCorresponds to variant dbSNP:rs1553253989EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0310661 – 61MLRWL…QDAEE → MDSLYGDLFWYLDYNKDGTL DIFELQEGLEDVGAIQSLEE AK in isoform 2. 2 PublicationsAdd BLAST61

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ619987 mRNA Translation: CAF04493.1
AJ619961 mRNA Translation: CAF04058.1
AK292567 mRNA Translation: BAF85256.1
AK316304 mRNA Translation: BAH14675.1
AL359258 Genomic DNA No translation available.
AL390036 Genomic DNA No translation available.
CH471156 Genomic DNA Translation: EAW51254.1
CH471156 Genomic DNA Translation: EAW51255.1
BC014519 mRNA Translation: AAH14519.1
BC068561 mRNA Translation: AAH68561.1
AF123303 mRNA Translation: AAF28888.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41361.1 [Q6NUK1-1]
CCDS786.1 [Q6NUK1-2]

NCBI Reference Sequences

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RefSeqi
NP_037518.3, NM_013386.4 [Q6NUK1-1]
NP_998816.1, NM_213651.2 [Q6NUK1-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000370041; ENSP00000359058; ENSG00000085491 [Q6NUK1-2]
ENST00000565488; ENSP00000457733; ENSG00000085491 [Q6NUK1-1]
ENST00000639032; ENSP00000492810; ENSG00000284468 [Q6NUK1-2]
ENST00000640416; ENSP00000491572; ENSG00000284468 [Q6NUK1-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
29957

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:29957

UCSC genome browser

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UCSCi
uc001dvm.5 human [Q6NUK1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ619987 mRNA Translation: CAF04493.1
AJ619961 mRNA Translation: CAF04058.1
AK292567 mRNA Translation: BAF85256.1
AK316304 mRNA Translation: BAH14675.1
AL359258 Genomic DNA No translation available.
AL390036 Genomic DNA No translation available.
CH471156 Genomic DNA Translation: EAW51254.1
CH471156 Genomic DNA Translation: EAW51255.1
BC014519 mRNA Translation: AAH14519.1
BC068561 mRNA Translation: AAH68561.1
AF123303 mRNA Translation: AAF28888.1 Frameshift.
CCDSiCCDS41361.1 [Q6NUK1-1]
CCDS786.1 [Q6NUK1-2]
RefSeqiNP_037518.3, NM_013386.4 [Q6NUK1-1]
NP_998816.1, NM_213651.2 [Q6NUK1-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4N5XX-ray2.10A1-193[»]
4ZCUX-ray2.10A/B/C14-174[»]
4ZCVX-ray2.80A/B/C/D14-174[»]
SMRiQ6NUK1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi118993, 43 interactors
IntActiQ6NUK1, 26 interactors
MINTiQ6NUK1
STRINGi9606.ENSP00000457733

Protein family/group databases

TCDBi2.A.29.23.8 the mitochondrial carrier (mc) family

PTM databases

iPTMnetiQ6NUK1
PhosphoSitePlusiQ6NUK1
SwissPalmiQ6NUK1

Polymorphism and mutation databases

BioMutaiSLC25A24
DMDMi167016554

Proteomic databases

EPDiQ6NUK1
jPOSTiQ6NUK1
MassIVEiQ6NUK1
MaxQBiQ6NUK1
PaxDbiQ6NUK1
PeptideAtlasiQ6NUK1
PRIDEiQ6NUK1
ProteomicsDBi66685 [Q6NUK1-1]
66686 [Q6NUK1-2]
TopDownProteomicsiQ6NUK1-1 [Q6NUK1-1]
Q6NUK1-2 [Q6NUK1-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
29957

Genome annotation databases

EnsembliENST00000370041; ENSP00000359058; ENSG00000085491 [Q6NUK1-2]
ENST00000565488; ENSP00000457733; ENSG00000085491 [Q6NUK1-1]
ENST00000639032; ENSP00000492810; ENSG00000284468 [Q6NUK1-2]
ENST00000640416; ENSP00000491572; ENSG00000284468 [Q6NUK1-1]
GeneIDi29957
KEGGihsa:29957
UCSCiuc001dvm.5 human [Q6NUK1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
29957
DisGeNETi29957

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLC25A24
HGNCiHGNC:20662 SLC25A24
HPAiHPA028519
HPA063636
MalaCardsiSLC25A24
MIMi608744 gene
612289 phenotype
neXtProtiNX_Q6NUK1
OpenTargetsiENSG00000085491
Orphaneti2095 Gorlin-Chaudhry-Moss syndrome
2963 Progeroid syndrome, Petty type
PharmGKBiPA134978257

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0036 Eukaryota
ENOG410XQ4P LUCA
GeneTreeiENSGT00940000158786
InParanoidiQ6NUK1
KOiK14684
OMAiKKTGQWW
OrthoDBi442523at2759
PhylomeDBiQ6NUK1
TreeFamiTF313492

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SLC25A24 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
29957
PharosiQ6NUK1

Protein Ontology

More...
PROi
PR:Q6NUK1

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000085491 Expressed in 208 organ(s), highest expression level in colon
ExpressionAtlasiQ6NUK1 baseline and differential
GenevisibleiQ6NUK1 HS

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR002167 Graves_DC
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF13499 EF-hand_7, 2 hits
PF00153 Mito_carr, 3 hits
PRINTSiPR00928 GRAVESDC
PR00926 MITOCARRIER
SMARTiView protein in SMART
SM00054 EFh, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
SSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 3 hits
PS50222 EF_HAND_2, 4 hits
PS50920 SOLCAR, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSCMC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NUK1
Secondary accession number(s): B7ZAI9
, Q5T331, Q5T485, Q6PJJ9, Q705K4, Q9P129
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: October 16, 2019
This is version 141 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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