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Protein

PWWP domain-containing protein 2B

Gene

PWWP2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
PWWP domain-containing protein 2B
Gene namesi
Name:PWWP2B
Synonyms:PWWP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000171813.13
HGNCiHGNC:25150 PWWP2B
neXtProtiNX_Q6NUJ5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi170394
OpenTargetsiENSG00000171813
PharmGKBiPA162400513

Polymorphism and mutation databases

BioMutaiPWWP2B
DMDMi160140805

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002408781 – 590PWWP domain-containing protein 2BAdd BLAST590

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei84PhosphoserineCombined sources1
Modified residuei186PhosphoserineCombined sources1
Modified residuei206PhosphoserineCombined sources1
Modified residuei250PhosphoserineCombined sources1
Modified residuei447PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6NUJ5
MaxQBiQ6NUJ5
PaxDbiQ6NUJ5
PeptideAtlasiQ6NUJ5
PRIDEiQ6NUJ5
ProteomicsDBi66684

PTM databases

iPTMnetiQ6NUJ5
PhosphoSitePlusiQ6NUJ5

Expressioni

Gene expression databases

BgeeiENSG00000171813
CleanExiHS_PWWP2B
GenevisibleiQ6NUJ5 HS

Organism-specific databases

HPAiHPA038056
HPA038502

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PSMA3P257883EBI-10251192,EBI-348380

Protein-protein interaction databases

BioGridi128004, 6 interactors
IntActiQ6NUJ5, 4 interactors

Structurei

Secondary structure

1590
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi475 – 481Combined sources7
Beta strandi487 – 489Combined sources3
Beta strandi493 – 496Combined sources4
Beta strandi504 – 513Combined sources10
Beta strandi518 – 520Combined sources3
Beta strandi524 – 530Combined sources7
Beta strandi536 – 540Combined sources5
Helixi541 – 543Combined sources3
Beta strandi544 – 546Combined sources3
Turni547 – 550Combined sources4
Helixi551 – 554Combined sources4
Helixi562 – 573Combined sources12
Turni574 – 577Combined sources4
Helixi579 – 588Combined sources10

3D structure databases

ProteinModelPortaliQ6NUJ5
SMRiQ6NUJ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini490 – 550PWWPPROSITE-ProRule annotationAdd BLAST61

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi85 – 145Pro-richAdd BLAST61

Phylogenomic databases

eggNOGiENOG410IIF8 Eukaryota
ENOG410XSSY LUCA
GeneTreeiENSGT00530000063940
HOGENOMiHOG000054216
HOVERGENiHBG062115
InParanoidiQ6NUJ5
OMAiDCTKKSG
OrthoDBiEOG091G08LI
PhylomeDBiQ6NUJ5
TreeFamiTF331271

Family and domain databases

InterProiView protein in InterPro
IPR000313 PWWP_dom
PfamiView protein in Pfam
PF00855 PWWP, 1 hit
SMARTiView protein in SMART
SM00293 PWWP, 1 hit
PROSITEiView protein in PROSITE
PS50812 PWWP, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6NUJ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPRAGCRLP VRVEQVVNGA LVVTVSCGER SFAGILLDCT KKSGLFGLPP
60 70 80 90 100
LAPLPQVDES PVNDSHGRAP EEGDAEVMQL GSSSPPPARG VQPPETTRPE
110 120 130 140 150
PPPPLVPPLP AGSLPPYPPY FEGAPFPHPL WLRDTYKLWV PQPPPRTIKR
160 170 180 190 200
TRRRLSRNRD PGRLILSTIR LRPRQVLCEK CKSTLSPPEA SPGPPAAPRA
210 220 230 240 250
RRRLGSGPDR ELRKPEEPEN GEPTAAATAR RSKRERREED RAPAEQVPRS
260 270 280 290 300
PVIKISYSTP QGKGEVVKIP SRVHGSLEPF RPQQAPQDDG SQDPEVLDRE
310 320 330 340 350
SRDRPSCAPS ASIPKLKLTR PVPAGADLPP PKIRLKPHRL GDSEHEPVYR
360 370 380 390 400
AELVGELNGY LRDSSPAPCA DGPAGGLADL SSGSSGEDDD FKSCPQGPQG
410 420 430 440 450
REGLAFLVSC PEGRADCASE SACSSDSLDE ARSSGSEGTP ADTGDLSPGH
460 470 480 490 500
GASAPSVSRE ARQTVPPLTV RLHTQSVSEC ITEDGRTVAV GDIVWGKIHG
510 520 530 540 550
FPWWPARVLD ISLGQKEDGE PSWREAKVSW FGSPTTSFLS ISKLSPFSEF
560 570 580 590
FKLRFNRKKK GMYRKAITEA ANAARHVAPE IRELLTQFET
Length:590
Mass (Da):63,967
Last modified:November 13, 2007 - v3
Checksum:i67C9124B40258EC4
GO
Isoform 2 (identifier: Q6NUJ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     497-499: KIH → HRR
     500-590: Missing.

Show »
Length:499
Mass (Da):53,550
Checksum:i9AD9EB51C343A3E7
GO

Sequence cautioni

The sequence AAH68574 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AK128663 differs from that shown. Reason: Frameshift at position 342.Curated
The sequence AK128663 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03723389R → C2 PublicationsCorresponds to variant dbSNP:rs11146363Ensembl.1
Natural variantiVAR_03723498R → G1 PublicationCorresponds to variant dbSNP:rs10747057Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054223497 – 499KIH → HRR in isoform 2. Curated3
Alternative sequenceiVSP_054224500 – 590Missing in isoform 2. CuratedAdd BLAST91

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590105 Genomic DNA No translation available.
BC011630 mRNA Translation: AAH11630.2
BC068574 mRNA Translation: AAH68574.1 Different initiation.
AK128663 mRNA No translation available.
CCDSiCCDS44497.1 [Q6NUJ5-2]
CCDS7667.2 [Q6NUJ5-1]
RefSeqiNP_001092107.1, NM_001098637.1 [Q6NUJ5-2]
NP_612508.3, NM_138499.3 [Q6NUJ5-1]
XP_006717722.1, XM_006717659.3 [Q6NUJ5-1]
UniGeneiHs.527751

Genome annotation databases

EnsembliENST00000305233; ENSP00000306324; ENSG00000171813 [Q6NUJ5-1]
ENST00000631148; ENSP00000486501; ENSG00000171813 [Q6NUJ5-2]
GeneIDi170394
KEGGihsa:170394
UCSCiuc001lll.5 human [Q6NUJ5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPWP2B_HUMAN
AccessioniPrimary (citable) accession number: Q6NUJ5
Secondary accession number(s): A6NM90
, B5MDQ1, H9KV61, Q5SZI0, Q6ZQX5, Q96F43
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 13, 2007
Last modified: July 18, 2018
This is version 121 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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