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Entry version 129 (31 Jul 2019)
Sequence version 3 (13 Nov 2007)
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Protein

PWWP domain-containing protein 2B

Gene

PWWP2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PWWP domain-containing protein 2B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PWWP2B
Synonyms:PWWP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25150 PWWP2B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6NUJ5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
170394

Open Targets

More...
OpenTargetsi
ENSG00000171813

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162400513

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PWWP2B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
160140805

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002408781 – 590PWWP domain-containing protein 2BAdd BLAST590

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei84PhosphoserineCombined sources1
Modified residuei186PhosphoserineCombined sources1
Modified residuei206PhosphoserineCombined sources1
Modified residuei250PhosphoserineCombined sources1
Modified residuei447PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q6NUJ5

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q6NUJ5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6NUJ5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6NUJ5

PeptideAtlas

More...
PeptideAtlasi
Q6NUJ5

PRoteomics IDEntifications database

More...
PRIDEi
Q6NUJ5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
46217
66684 [Q6NUJ5-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6NUJ5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6NUJ5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000171813 Expressed in 192 organ(s), highest expression level in islet of Langerhans

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6NUJ5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038056
HPA038502

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
PSMA3P257883EBI-10251192,EBI-348380

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
128004, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q6NUJ5, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000306324

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1590
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6NUJ5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini490 – 550PWWPPROSITE-ProRule annotationAdd BLAST61

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi85 – 145Pro-richAdd BLAST61

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IIF8 Eukaryota
ENOG410XSSY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160735

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000054216

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6NUJ5

Identification of Orthologs from Complete Genome Data

More...
OMAi
CPEGRAD

Database of Orthologous Groups

More...
OrthoDBi
326248at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6NUJ5

TreeFam database of animal gene trees

More...
TreeFami
TF331271

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000313 PWWP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00855 PWWP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00293 PWWP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50812 PWWP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6NUJ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPRAGCRLP VRVEQVVNGA LVVTVSCGER SFAGILLDCT KKSGLFGLPP
60 70 80 90 100
LAPLPQVDES PVNDSHGRAP EEGDAEVMQL GSSSPPPARG VQPPETTRPE
110 120 130 140 150
PPPPLVPPLP AGSLPPYPPY FEGAPFPHPL WLRDTYKLWV PQPPPRTIKR
160 170 180 190 200
TRRRLSRNRD PGRLILSTIR LRPRQVLCEK CKSTLSPPEA SPGPPAAPRA
210 220 230 240 250
RRRLGSGPDR ELRKPEEPEN GEPTAAATAR RSKRERREED RAPAEQVPRS
260 270 280 290 300
PVIKISYSTP QGKGEVVKIP SRVHGSLEPF RPQQAPQDDG SQDPEVLDRE
310 320 330 340 350
SRDRPSCAPS ASIPKLKLTR PVPAGADLPP PKIRLKPHRL GDSEHEPVYR
360 370 380 390 400
AELVGELNGY LRDSSPAPCA DGPAGGLADL SSGSSGEDDD FKSCPQGPQG
410 420 430 440 450
REGLAFLVSC PEGRADCASE SACSSDSLDE ARSSGSEGTP ADTGDLSPGH
460 470 480 490 500
GASAPSVSRE ARQTVPPLTV RLHTQSVSEC ITEDGRTVAV GDIVWGKIHG
510 520 530 540 550
FPWWPARVLD ISLGQKEDGE PSWREAKVSW FGSPTTSFLS ISKLSPFSEF
560 570 580 590
FKLRFNRKKK GMYRKAITEA ANAARHVAPE IRELLTQFET
Length:590
Mass (Da):63,967
Last modified:November 13, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i67C9124B40258EC4
GO
Isoform 2 (identifier: Q6NUJ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     497-499: KIH → HRR
     500-590: Missing.

Show »
Length:499
Mass (Da):53,550
Checksum:i9AD9EB51C343A3E7
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH68574 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AK128663 differs from that shown. Reason: Frameshift at position 342.Curated
The sequence AK128663 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03723389R → C2 PublicationsCorresponds to variant dbSNP:rs11146363Ensembl.1
Natural variantiVAR_03723498R → G1 PublicationCorresponds to variant dbSNP:rs10747057Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054223497 – 499KIH → HRR in isoform 2. Curated3
Alternative sequenceiVSP_054224500 – 590Missing in isoform 2. CuratedAdd BLAST91

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL590105 Genomic DNA No translation available.
BC011630 mRNA Translation: AAH11630.2
BC068574 mRNA Translation: AAH68574.1 Different initiation.
AK128663 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44497.1 [Q6NUJ5-2]
CCDS7667.2 [Q6NUJ5-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001092107.1, NM_001098637.1 [Q6NUJ5-2]
NP_612508.3, NM_138499.3 [Q6NUJ5-1]
XP_006717722.1, XM_006717659.3 [Q6NUJ5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000305233; ENSP00000306324; ENSG00000171813 [Q6NUJ5-1]
ENST00000631148; ENSP00000486501; ENSG00000171813 [Q6NUJ5-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
170394

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:170394

UCSC genome browser

More...
UCSCi
uc001lll.5 human [Q6NUJ5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590105 Genomic DNA No translation available.
BC011630 mRNA Translation: AAH11630.2
BC068574 mRNA Translation: AAH68574.1 Different initiation.
AK128663 mRNA No translation available.
CCDSiCCDS44497.1 [Q6NUJ5-2]
CCDS7667.2 [Q6NUJ5-1]
RefSeqiNP_001092107.1, NM_001098637.1 [Q6NUJ5-2]
NP_612508.3, NM_138499.3 [Q6NUJ5-1]
XP_006717722.1, XM_006717659.3 [Q6NUJ5-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4LD6X-ray1.70A475-590[»]
SMRiQ6NUJ5
ModBaseiSearch...

Protein-protein interaction databases

BioGridi128004, 6 interactors
IntActiQ6NUJ5, 5 interactors
STRINGi9606.ENSP00000306324

PTM databases

iPTMnetiQ6NUJ5
PhosphoSitePlusiQ6NUJ5

Polymorphism and mutation databases

BioMutaiPWWP2B
DMDMi160140805

Proteomic databases

EPDiQ6NUJ5
jPOSTiQ6NUJ5
MaxQBiQ6NUJ5
PaxDbiQ6NUJ5
PeptideAtlasiQ6NUJ5
PRIDEiQ6NUJ5
ProteomicsDBi46217
66684 [Q6NUJ5-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305233; ENSP00000306324; ENSG00000171813 [Q6NUJ5-1]
ENST00000631148; ENSP00000486501; ENSG00000171813 [Q6NUJ5-2]
GeneIDi170394
KEGGihsa:170394
UCSCiuc001lll.5 human [Q6NUJ5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
170394
DisGeNETi170394

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PWWP2B
HGNCiHGNC:25150 PWWP2B
HPAiHPA038056
HPA038502
neXtProtiNX_Q6NUJ5
OpenTargetsiENSG00000171813
PharmGKBiPA162400513

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IIF8 Eukaryota
ENOG410XSSY LUCA
GeneTreeiENSGT00940000160735
HOGENOMiHOG000054216
InParanoidiQ6NUJ5
OMAiCPEGRAD
OrthoDBi326248at2759
PhylomeDBiQ6NUJ5
TreeFamiTF331271

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PWWP2B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
170394

Protein Ontology

More...
PROi
PR:Q6NUJ5

Gene expression databases

BgeeiENSG00000171813 Expressed in 192 organ(s), highest expression level in islet of Langerhans
GenevisibleiQ6NUJ5 HS

Family and domain databases

InterProiView protein in InterPro
IPR000313 PWWP_dom
PfamiView protein in Pfam
PF00855 PWWP, 1 hit
SMARTiView protein in SMART
SM00293 PWWP, 1 hit
PROSITEiView protein in PROSITE
PS50812 PWWP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPWP2B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NUJ5
Secondary accession number(s): A6NM90
, B5MDQ1, H9KV61, Q5SZI0, Q6ZQX5, Q96F43
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 13, 2007
Last modified: July 31, 2019
This is version 129 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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