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Protein

Proactivator polypeptide-like 1

Gene

PSAPL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May activate the lysosomal degradation of sphingolipids.By similarity

GO - Biological processi

Keywordsi

Biological processLipid metabolism, Sphingolipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Proactivator polypeptide-like 1
Cleaved into the following 5 chains:
Gene namesi
Name:PSAPL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000178597.5
HGNCiHGNC:33131 PSAPL1
neXtProtiNX_Q6NUJ1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000178597
PharmGKBiPA162400215

Polymorphism and mutation databases

BioMutaiPSAPL1
DMDMi134035030

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
PropeptideiPRO_000028030518 – 59By similarityAdd BLAST42
ChainiPRO_000028030661 – 144Saposin A-likeBy similarityAdd BLAST84
PropeptideiPRO_0000280307146 – 180By similarityAdd BLAST35
ChainiPRO_0000280308181 – 257Saposin B-Val-likeBy similarityAdd BLAST77
ChainiPRO_0000280309181 – 256Saposin B-likeBy similarityAdd BLAST76
PropeptideiPRO_0000280310259 – 288By similarityAdd BLAST30
ChainiPRO_0000280311290 – 369Saposin C-likeBy similarityAdd BLAST80
PropeptideiPRO_0000280312370 – 391By similarityAdd BLAST22
ChainiPRO_0000280313392 – 473Saposin D-likeBy similarityAdd BLAST82
PropeptideiPRO_0000280314474 – 521By similarityAdd BLAST48

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi64 ↔ 140PROSITE-ProRule annotation
Disulfide bondi67 ↔ 134PROSITE-ProRule annotation
Disulfide bondi95 ↔ 107PROSITE-ProRule annotation
Disulfide bondi184 ↔ 254PROSITE-ProRule annotation
Disulfide bondi187 ↔ 248PROSITE-ProRule annotation
Glycosylationi201N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi213 ↔ 224PROSITE-ProRule annotation
Disulfide bondi294 ↔ 366PROSITE-ProRule annotation
Disulfide bondi297 ↔ 360PROSITE-ProRule annotation
Glycosylationi311N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi325 ↔ 336PROSITE-ProRule annotation
Disulfide bondi396 ↔ 469PROSITE-ProRule annotation
Disulfide bondi399 ↔ 463PROSITE-ProRule annotation
Disulfide bondi427 ↔ 438PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ6NUJ1
PaxDbiQ6NUJ1
PeptideAtlasiQ6NUJ1
PRIDEiQ6NUJ1
ProteomicsDBi66682

PTM databases

iPTMnetiQ6NUJ1
PhosphoSitePlusiQ6NUJ1

Expressioni

Gene expression databases

BgeeiENSG00000178597 Expressed in 71 organ(s), highest expression level in mammalian vulva
CleanExiHS_PSAPL1
GenevisibleiQ6NUJ1 HS

Organism-specific databases

HPAiHPA038013
HPA038482

Interactioni

Protein-protein interaction databases

BioGridi612854, 1 interactor
STRINGi9606.ENSP00000317445

Structurei

3D structure databases

ProteinModelPortaliQ6NUJ1
SMRiQ6NUJ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 59Saposin A-type 1PROSITE-ProRule annotationAdd BLAST41
Domaini60 – 144Saposin B-type 1PROSITE-ProRule annotationAdd BLAST85
Domaini180 – 258Saposin B-type 2PROSITE-ProRule annotationAdd BLAST79
Domaini290 – 370Saposin B-type 3PROSITE-ProRule annotationAdd BLAST81
Domaini392 – 473Saposin B-type 4PROSITE-ProRule annotationAdd BLAST82
Domaini475 – 515Saposin A-type 2PROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1340 Eukaryota
ENOG410XSI5 LUCA
GeneTreeiENSGT00530000063434
HOGENOMiHOG000049216
HOVERGENiHBG002617
InParanoidiQ6NUJ1
KOiK12382
OMAiKTCEWLP
OrthoDBiEOG091G0K86
PhylomeDBiQ6NUJ1
TreeFamiTF316942

Family and domain databases

InterProiView protein in InterPro
IPR003119 SAP_A
IPR007856 SapB_1
IPR008138 SapB_2
IPR008373 Saposin
IPR011001 Saposin-like
IPR021165 Saposin_chordata
IPR008139 SaposinB_dom
PfamiView protein in Pfam
PF02199 SapA, 2 hits
PF05184 SapB_1, 2 hits
PF03489 SapB_2, 2 hits
PIRSFiPIRSF002431 Saposin, 1 hit
PRINTSiPR01797 SAPOSIN
SMARTiView protein in SMART
SM00162 SAPA, 2 hits
SM00741 SapB, 4 hits
SUPFAMiSSF47862 SSF47862, 4 hits
PROSITEiView protein in PROSITE
PS51110 SAP_A, 2 hits
PS50015 SAP_B, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6NUJ1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLCALLLLPS LLGATRASPT SGPQECAKGS TVWCQDLQTA ARCGAVGYCQ
60 70 80 90 100
GAVWNKPTAK SLPCDVCQDI AAAAGNGLNP DATESDILAL VMKTCEWLPS
110 120 130 140 150
QESSAGCKWM VDAHSSAILS MLRGAPDSAP AQVCTALSLC EPLQRHLATL
160 170 180 190 200
RPLSKEDTFE AVAPFMANGP LTFHPRQAPE GALCQDCVRQ VSRLQEAVRS
210 220 230 240 250
NLTLADLNIQ EQCESLGPGL AVLCKNYLFQ FFVPADQALR LLPPQELCRK
260 270 280 290 300
GGFCEELGAP ARLTQVVAMD GVPSLELGLP RKQSEMQMKA GVTCEVCMNV
310 320 330 340 350
VQKLDHWLMS NSSELMITHA LERVCSVMPA SITKECIILV DTYSPSLVQL
360 370 380 390 400
VAKITPEKVC KFIRLCGNRR RARAVHDAYA IVPSPEWDAE NQGSFCNGCK
410 420 430 440 450
RLLTVSSHNL ESKSTKRDIL VAFKGGCSIL PLPYMIQCKH FVTQYEPVLI
460 470 480 490 500
ESLKDMMDPV AVCKKVGACH GPRTPLLGTD QCALGPSFWC RSQEAAKLCN
510 520
AVQHCQKHVW KEMHLHAGEH A
Length:521
Mass (Da):56,627
Last modified:March 20, 2007 - v2
Checksum:i0E1ED7B942D1ECB2
GO

Sequence cautioni

The sequence AAH68579 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC05143 differs from that shown. Reason: Erroneous termination at position 510. Translated as Trp.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06178041A → S. Corresponds to variant dbSNP:rs11548325Ensembl.1
Natural variantiVAR_06178144G → R. Corresponds to variant dbSNP:rs58482081Ensembl.1
Natural variantiVAR_06178259A → T. Corresponds to variant dbSNP:rs56737582Ensembl.1
Natural variantiVAR_051895268A → S. Corresponds to variant dbSNP:rs3796905Ensembl.1
Natural variantiVAR_051896296V → M. Corresponds to variant dbSNP:rs6850206Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ991252 mRNA Translation: ABJ55983.1
BC068579 mRNA Translation: AAH68579.1 Different initiation.
AK097698 mRNA Translation: BAC05143.1 Sequence problems.
CCDSiCCDS47009.1
RefSeqiNP_001078851.1, NM_001085382.1
UniGeneiHs.662523

Genome annotation databases

EnsembliENST00000319098; ENSP00000317445; ENSG00000178597
GeneIDi768239
KEGGihsa:768239
UCSCiuc011bwj.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ991252 mRNA Translation: ABJ55983.1
BC068579 mRNA Translation: AAH68579.1 Different initiation.
AK097698 mRNA Translation: BAC05143.1 Sequence problems.
CCDSiCCDS47009.1
RefSeqiNP_001078851.1, NM_001085382.1
UniGeneiHs.662523

3D structure databases

ProteinModelPortaliQ6NUJ1
SMRiQ6NUJ1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi612854, 1 interactor
STRINGi9606.ENSP00000317445

PTM databases

iPTMnetiQ6NUJ1
PhosphoSitePlusiQ6NUJ1

Polymorphism and mutation databases

BioMutaiPSAPL1
DMDMi134035030

Proteomic databases

MaxQBiQ6NUJ1
PaxDbiQ6NUJ1
PeptideAtlasiQ6NUJ1
PRIDEiQ6NUJ1
ProteomicsDBi66682

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319098; ENSP00000317445; ENSG00000178597
GeneIDi768239
KEGGihsa:768239
UCSCiuc011bwj.3 human

Organism-specific databases

CTDi768239
EuPathDBiHostDB:ENSG00000178597.5
GeneCardsiPSAPL1
HGNCiHGNC:33131 PSAPL1
HPAiHPA038013
HPA038482
neXtProtiNX_Q6NUJ1
OpenTargetsiENSG00000178597
PharmGKBiPA162400215
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1340 Eukaryota
ENOG410XSI5 LUCA
GeneTreeiENSGT00530000063434
HOGENOMiHOG000049216
HOVERGENiHBG002617
InParanoidiQ6NUJ1
KOiK12382
OMAiKTCEWLP
OrthoDBiEOG091G0K86
PhylomeDBiQ6NUJ1
TreeFamiTF316942

Miscellaneous databases

GenomeRNAii768239
PROiPR:Q6NUJ1

Gene expression databases

BgeeiENSG00000178597 Expressed in 71 organ(s), highest expression level in mammalian vulva
CleanExiHS_PSAPL1
GenevisibleiQ6NUJ1 HS

Family and domain databases

InterProiView protein in InterPro
IPR003119 SAP_A
IPR007856 SapB_1
IPR008138 SapB_2
IPR008373 Saposin
IPR011001 Saposin-like
IPR021165 Saposin_chordata
IPR008139 SaposinB_dom
PfamiView protein in Pfam
PF02199 SapA, 2 hits
PF05184 SapB_1, 2 hits
PF03489 SapB_2, 2 hits
PIRSFiPIRSF002431 Saposin, 1 hit
PRINTSiPR01797 SAPOSIN
SMARTiView protein in SMART
SM00162 SAPA, 2 hits
SM00741 SapB, 4 hits
SUPFAMiSSF47862 SSF47862, 4 hits
PROSITEiView protein in PROSITE
PS51110 SAP_A, 2 hits
PS50015 SAP_B, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSAPL1_HUMAN
AccessioniPrimary (citable) accession number: Q6NUJ1
Secondary accession number(s): A0A184, Q8N7T4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: November 7, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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