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Entry version 122 (16 Oct 2019)
Sequence version 2 (11 Sep 2007)
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Protein

Chondroadherin-like protein

Gene

CHADL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Potential negative modulator of chondrocyte differentiation. Inhibits collagen fibrillogenesis in vitro. May influence chondrocyte's differentiation by acting on its cellular collagenous microenvironment.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chondroadherin-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHADL
Synonyms:SLRR4B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25165 CHADL

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616236 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6NUI6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
150356

Open Targets

More...
OpenTargetsi
ENSG00000100399

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162382224

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6NUI6

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CHADL

Domain mapping of disease mutations (DMDM)

More...
DMDMi
158563972

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 30Sequence analysisAdd BLAST30
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000029954831 – 762Chondroadherin-like proteinAdd BLAST732

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi52N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi396 ↔ 411By similarity
Glycosylationi626N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi679 ↔ 722By similarity
Disulfide bondi681 ↔ 701By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6NUI6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6NUI6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6NUI6

PeptideAtlas

More...
PeptideAtlasi
Q6NUI6

PRoteomics IDEntifications database

More...
PRIDEi
Q6NUI6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
66680 [Q6NUI6-1]
66681 [Q6NUI6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6NUI6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6NUI6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000100399 Expressed in 117 organ(s), highest expression level in C1 segment of cervical spinal cord

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6NUI6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6NUI6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA005696
HPA024654

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with collagen and binds to collagen fibrils.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127285, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000216241

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 62LRRNT 1Add BLAST32
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati87 – 108LRR 1Add BLAST22
Repeati111 – 132LRR 2Add BLAST22
Repeati135 – 156LRR 3Add BLAST22
Repeati159 – 180LRR 4Add BLAST22
Repeati183 – 204LRR 5Add BLAST22
Repeati207 – 228LRR 6Add BLAST22
Repeati231 – 252LRR 7Add BLAST22
Repeati255 – 276LRR 8Add BLAST22
Repeati279 – 300LRR 9Add BLAST22
Domaini310 – 359LRRCT 1Add BLAST50
Domaini387 – 425LRRNT 2Add BLAST39
Repeati426 – 447LRR 10Add BLAST22
Repeati450 – 471LRR 11Add BLAST22
Repeati474 – 495LRR 12Add BLAST22
Repeati498 – 519LRR 13Add BLAST22
Repeati522 – 543LRR 14Add BLAST22
Repeati546 – 566LRR 15Add BLAST21
Repeati570 – 591LRR 16Add BLAST22
Repeati594 – 615LRR 17Add BLAST22
Repeati619 – 640LRR 18Add BLAST22
Repeati644 – 665LRR 19Add BLAST22
Domaini675 – 724LRRCT 2Add BLAST50

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi109 – 325Leu-richAdd BLAST217
Compositional biasi364 – 370Poly-Glu7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0619 Eukaryota
COG4886 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154464

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000111626

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6NUI6

Identification of Orthologs from Complete Genome Data

More...
OMAi
VYLPDMV

Database of Orthologous Groups

More...
OrthoDBi
826997at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6NUI6

TreeFam database of animal gene trees

More...
TreeFami
TF337463

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13855 LRR_8, 6 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369 LRR_TYP, 19 hits
SM00082 LRRCT, 2 hits
SM00013 LRRNT, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450 LRR, 18 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6NUI6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGPRSSTHV PLVLPLLVLL LLAPARQAAA QRCPQACICD NSRRHVACRY
60 70 80 90 100
QNLTEVPDAI PELTQRLDLQ GNLLKVIPAA AFQGVPHLTH LDLRHCEVEL
110 120 130 140 150
VAEGAFRGLG RLLLLNLASN HLRELPQEAL DGLGSLRRLE LEGNALEELR
160 170 180 190 200
PGTFGALGAL ATLNLAHNAL VYLPAMAFQG LLRVRWLRLS HNALSVLAPE
210 220 230 240 250
ALAGLPALRR LSLHHNELQA LPGPVLSQAR GLARLELGHN PLTYAGEEDG
260 270 280 290 300
LALPGLRELL LDGGALQALG PRAFAHCPRL HTLDLRGNQL DTLPPLQGPG
310 320 330 340 350
QLRRLRLQGN PLWCGCQARP LLEWLARARV RSDGACQGPR RLRGEALDAL
360 370 380 390 400
RPWDLRCPGD AAQEEEELEE RAVAGPRAPP RGPPRGPGEE RAVAPCPRAC
410 420 430 440 450
VCVPESRHSS CEGCGLQAVP RGFPSDTQLL DLRRNHFPSV PRAAFPGLGH
460 470 480 490 500
LVSLHLQHCG IAELEAGALA GLGRLIYLYL SDNQLAGLSA AALEGAPRLG
510 520 530 540 550
YLYLERNRFL QVPGAALRAL PSLFSLHLQD NAVDRLAPGD LGRTRALRWV
560 570 580 590 600
YLSGNRITEV SLGALGPARE LEKLHLDRNQ LREVPTGALE GLPALLELQL
610 620 630 640 650
SGNPLRALRD GAFQPVGRSL QHLFLNSSGL EQICPGAFSG LGPGLQSLHL
660 670 680 690 700
QKNQLRALPA LPSLSQLELI DLSSNPFHCD CQLLPLHRWL TGLNLRVGAT
710 720 730 740 750
CATPPNARGQ RVKAAAAVFE DCPGWAARKA KRTPASRPSA RRTPIKGRQC
760
GADKVGKEKG RL
Length:762
Mass (Da):82,388
Last modified:September 11, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBE01DF94D3408A70
GO
Isoform 2 (identifier: Q6NUI6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     662-737: Missing.

Note: No experimental confirmation available.
Show »
Length:686
Mass (Da):74,155
Checksum:iC7BD512ECAC83CC9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y4I5H0Y4I5_HUMAN
Chondroadherin-like protein
CHADL
684Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B0QYT2B0QYT2_HUMAN
Chondroadherin-like protein
CHADL
252Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH19839 differs from that shown. Reason: Frameshift.Curated
The sequence AAH68590 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti11P → T in AAH40188 (PubMed:15489334).Curated1
Sequence conflicti30A → T in AAH40188 (PubMed:15489334).Curated1
Sequence conflicti148E → G in AAH40188 (PubMed:15489334).Curated1
Sequence conflicti424P → R in AAH68590 (PubMed:15489334).Curated1
Sequence conflicti478L → V in AAH40188 (PubMed:15489334).Curated1
Sequence conflicti508R → S in AAH48421 (PubMed:15489334).Curated1
Sequence conflicti529Q → H in AAH68590 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059805710Q → R. Corresponds to variant dbSNP:rs9619955Ensembl.1
Natural variantiVAR_061805721D → N. Corresponds to variant dbSNP:rs9619954Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_027735662 – 737Missing in isoform 2. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL035681 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60419.1
BC012882 mRNA Translation: AAH12882.1
BC019839 mRNA Translation: AAH19839.1 Frameshift.
BC040188 mRNA Translation: AAH40188.1
BC048421 mRNA Translation: AAH48421.1
BC068590 mRNA Translation: AAH68590.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS46715.1 [Q6NUI6-1]

NCBI Reference Sequences

More...
RefSeqi
NP_612490.1, NM_138481.1 [Q6NUI6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000216241; ENSP00000216241; ENSG00000100399 [Q6NUI6-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
150356

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:150356

UCSC genome browser

More...
UCSCi
uc003azq.5 human [Q6NUI6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035681 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60419.1
BC012882 mRNA Translation: AAH12882.1
BC019839 mRNA Translation: AAH19839.1 Frameshift.
BC040188 mRNA Translation: AAH40188.1
BC048421 mRNA Translation: AAH48421.1
BC068590 mRNA Translation: AAH68590.1 Different initiation.
CCDSiCCDS46715.1 [Q6NUI6-1]
RefSeqiNP_612490.1, NM_138481.1 [Q6NUI6-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi127285, 1 interactor
STRINGi9606.ENSP00000216241

PTM databases

iPTMnetiQ6NUI6
PhosphoSitePlusiQ6NUI6

Polymorphism and mutation databases

BioMutaiCHADL
DMDMi158563972

Proteomic databases

jPOSTiQ6NUI6
MassIVEiQ6NUI6
PaxDbiQ6NUI6
PeptideAtlasiQ6NUI6
PRIDEiQ6NUI6
ProteomicsDBi66680 [Q6NUI6-1]
66681 [Q6NUI6-2]

Genome annotation databases

EnsembliENST00000216241; ENSP00000216241; ENSG00000100399 [Q6NUI6-1]
GeneIDi150356
KEGGihsa:150356
UCSCiuc003azq.5 human [Q6NUI6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
150356
DisGeNETi150356

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CHADL
HGNCiHGNC:25165 CHADL
HPAiHPA005696
HPA024654
MIMi616236 gene
neXtProtiNX_Q6NUI6
OpenTargetsiENSG00000100399
PharmGKBiPA162382224

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00940000154464
HOGENOMiHOG000111626
InParanoidiQ6NUI6
OMAiVYLPDMV
OrthoDBi826997at2759
PhylomeDBiQ6NUI6
TreeFamiTF337463

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CHADL human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
150356
PharosiQ6NUI6

Protein Ontology

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PROi
PR:Q6NUI6

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000100399 Expressed in 117 organ(s), highest expression level in C1 segment of cervical spinal cord
ExpressionAtlasiQ6NUI6 baseline and differential
GenevisibleiQ6NUI6 HS

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF13855 LRR_8, 6 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 19 hits
SM00082 LRRCT, 2 hits
SM00013 LRRNT, 2 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 18 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHADL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NUI6
Secondary accession number(s): Q05CY2
, Q4G0S0, Q5JY13, Q86XY1, Q96E60
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: October 16, 2019
This is version 122 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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