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Entry version 80 (07 Apr 2021)
Sequence version 1 (05 Jul 2004)
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Protein

Zinc finger protein 521

Gene

znf521

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri48 – 68C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri119 – 141C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri147 – 169C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri175 – 197C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri203 – 225C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri247 – 270C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri282 – 305C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri311 – 333C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri404 – 428C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri436 – 459C2H2-type 10PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri476 – 499C2H2-type 11PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri512 – 535C2H2-type 12PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri559 – 584C2H2-type 13; atypicalPROSITE-ProRule annotationAdd BLAST26
Zinc fingeri633 – 655C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri663 – 685C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri693 – 716C2H2-type 16PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri721 – 744C2H2-type 17PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri751 – 774C2H2-type 18PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri782 – 804C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri808 – 831C2H2-type 20PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri885 – 907C2H2-type 21; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri929 – 951C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri958 – 980C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1019 – 1041C2H2-type 24PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1064 – 1082C2H2-type 25; degeneratePROSITE-ProRule annotationAdd BLAST19
Zinc fingeri1138 – 1161C2H2-type 26PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1194 – 1216C2H2-type 27PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1224 – 1246C2H2-type 28PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1255 – 1278C2H2-type 29PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1285 – 1308C2H2-type 30PROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding, Repressor
Biological processDifferentiation, Transcription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 521
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:znf521
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-6252560, znf521.S

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003068731 – 1310Zinc finger protein 521Add BLAST1310

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6NUD7

PRoteomics IDEntifications database

More...
PRIDEi
Q6NUD7

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6NUD7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri48 – 68C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri119 – 141C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri147 – 169C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri175 – 197C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri203 – 225C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri247 – 270C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri282 – 305C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri311 – 333C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri404 – 428C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri436 – 459C2H2-type 10PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri476 – 499C2H2-type 11PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri512 – 535C2H2-type 12PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri559 – 584C2H2-type 13; atypicalPROSITE-ProRule annotationAdd BLAST26
Zinc fingeri633 – 655C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri663 – 685C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri693 – 716C2H2-type 16PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri721 – 744C2H2-type 17PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri751 – 774C2H2-type 18PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri782 – 804C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri808 – 831C2H2-type 20PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri885 – 907C2H2-type 21; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri929 – 951C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri958 – 980C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1019 – 1041C2H2-type 24PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1064 – 1082C2H2-type 25; degeneratePROSITE-ProRule annotationAdd BLAST19
Zinc fingeri1138 – 1161C2H2-type 26PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1194 – 1216C2H2-type 27PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1224 – 1246C2H2-type 28PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1255 – 1278C2H2-type 29PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1285 – 1308C2H2-type 30PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
LACMYCT

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096, zf-C2H2, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355, ZnF_C2H2, 30 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667, SSF57667, 11 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 27 hits
PS50157, ZINC_FINGER_C2H2_2, 24 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6NUD7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRRKQAKPR SLKDPNCKLE DTSEDGESPD CKKRQEEGDE LEEEEAVHSC
60 70 80 90 100
DSCLQVFESL SDITEHKISQ CQLTDGADIE DDPTCSWPAS SPSSKDQASP
110 120 130 140 150
IHGEGFDFGE EEGIPGLPYP CQFCDKSFSR LSYLKHHEQS HSDKLPFKCT
160 170 180 190 200
YCSRLFKHKR SRDRHIKLHT GDKKYHCSEC DASFSRSDHL KIHLKTHTSN
210 220 230 240 250
KPYKCAICRR GFLSSSSLHG HMQVHERNKD CSQSGSRMEE WKMKDTQKCS
260 270 280 290 300
QCEEGFDFPE DLQKHIAECH PECSPNDDRG ALQCMYCHEL FMEETSLLNH
310 320 330 340 350
MEQIHNSEKK NSCNICSENF HSVEELYSHM DSHQHPESCN PSNSPSLVTV
360 370 380 390 400
GYTSVSSTTP DSNLSVDSST MVEVAPPLAK GRGRKRAVQQ TGDAPTSKQA
410 420 430 440 450
RVSYSCIYCS KQLFSSLAVL QIHLKTMHLD KPEQAHICQY CLEVLPSLFN
460 470 480 490 500
LNEHLKQVHE TQDPALIVST MSAMVYQCNF CSEIFNDLNM LQDHIRSSHG
510 520 530 540 550
FPNPVTKDSN AFFCPHCYMG FLTDTSLEEH IRQVHCELGN SRFGSPVLGT
560 570 580 590 600
PKEPVVEVYS CSYCTNSPIF NSVLKLNKHI KENHKNIPLA LNYIHNGKKS
610 620 630 640 650
RALSPLSPIT LEQSSLKMMQ SLGGTPSRLA GEYICNQCGA KYTSLDGFQT
660 670 680 690 700
HLKTHLDTVL PKLTCPQCNK EFPNQESLLK HVTIHFMITS TYYICESCDK
710 720 730 740 750
QFTSVDDLQK HLLDMHTFGF FRCTLCQEVF DSKVSIQLHL AVKHSNEKKV
760 770 780 790 800
YRCTSCNWDF RTETDLQLHV KHNHLENQGK MHKCIFCGES FGTEVELQCH
810 820 830 840 850
ITTHSKKYNC KFCSKAFHAI ILLEKHLREK HCVFEDKTQN CGTNGASEQI
860 870 880 890 900
QKEEVELQTL LTNNQESHNS HDGSEEDIDT SEPMYGCDIC GAAYTMESLL
910 920 930 940 950
QNHQLRDHNI RPGESAIVKK KAELIKGNYK CNVCSRTFFS EGGLREHMQT
960 970 980 990 1000
HLGPVKHYMC PICGERFPSL LTLTEHKVTH SKSLDTGNCR ICKLPLQCEE
1010 1020 1030 1040 1050
DFLEHCQMHP DLRNSLTGFR CVVCMQTVTS TLELKIHGTF HMQKTGTASV
1060 1070 1080 1090 1100
VQSAGRVQNL QKLYKCASCL KEFRSKQDLV KLDINGLPYG LCASCVNLSK
1110 1120 1130 1140 1150
SASPNANVTL STNRQVISQT DSLTCVEAKN YKTSVLKTRC SSCNVKFESE
1160 1170 1180 1190 1200
TELQNHIQTI HRELTSENSA TQLKTPQVSP MARISPQSDE KKTYQCIKCQ
1210 1220 1230 1240 1250
MVFYNEWDIQ VHVANHMIDE GLNHECKLCS QTFDSPAKLQ CHLIEHSFEG
1260 1270 1280 1290 1300
MGGTFKCPVC FTVFVQANKL QQHIFSAHGQ EDKIYDCAQC PQKFFFQTEL
1310
QNHTMSQHSS
Length:1,310
Mass (Da):148,640
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i75D9B7680EB7B270
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC068658 mRNA Translation: AAH68658.1

NCBI Reference Sequences

More...
RefSeqi
NP_001084597.1, NM_001091128.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
414550

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xla:414550

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC068658 mRNA Translation: AAH68658.1
RefSeqiNP_001084597.1, NM_001091128.1

3D structure databases

SMRiQ6NUD7
ModBaseiSearch...

Proteomic databases

MaxQBiQ6NUD7
PRIDEiQ6NUD7

Genome annotation databases

GeneIDi414550
KEGGixla:414550

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
414550
XenbaseiXB-GENE-6252560, znf521.S

Phylogenomic databases

OMAiLACMYCT
OrthoDBi1318335at2759

Family and domain databases

InterProiView protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 30 hits
SUPFAMiSSF57667, SSF57667, 11 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 27 hits
PS50157, ZINC_FINGER_C2H2_2, 24 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN521_XENLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NUD7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: July 5, 2004
Last modified: April 7, 2021
This is version 80 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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