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Protein

Putative hydroxypyruvate isomerase

Gene

hyi

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).By similarity

Catalytic activityi

Hydroxypyruvate = 2-hydroxy-3-oxopropanoate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei147Proton donor/acceptorBy similarity1
Active sitei246Proton donor/acceptorBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionIsomerase

Names & Taxonomyi

Protein namesi
Recommended name:
Putative hydroxypyruvate isomerase (EC:5.3.1.22)
Gene namesi
Name:hyi
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-5847302 hyi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002892441 – 275Putative hydroxypyruvate isomeraseAdd BLAST275

Structurei

3D structure databases

ProteinModelPortaliQ6NUD4
SMRiQ6NUD4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the hyi family.Curated

Phylogenomic databases

HOVERGENiHBG056845
KOiK01816

Family and domain databases

InterProiView protein in InterPro
IPR026040 HyI-like
IPR036237 Xyl_isomerase-like_sf
IPR013022 Xyl_isomerase-like_TIM-brl
PfamiView protein in Pfam
PF01261 AP_endonuc_2, 1 hit
PIRSFiPIRSF006241 HyI, 1 hit
SUPFAMiSSF51658 SSF51658, 1 hit

Sequencei

Sequence statusi: Complete.

Q6NUD4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRFSANISWL FPEVPDFPGR IKAASQSGFR AVEVAWPYAT DRTLFKAALN
60 70 80 90 100
THRMSLVLLN TPPGNIEAGE LGLAAVPGRQ DEFRTGLNEA VSWASDLGCD
110 120 130 140 150
RIHIMAGRVP LGLERQFIEK EMEETFIENL QYAADILGQA GMVGLLEPIN
160 170 180 190 200
SLITEPRYFL NTPQHAASIL HKVKRPNLKL QMDLYHWQIM GGNLTQNIKT
210 220 230 240 250
YFPLIGHVQI AQIPHRNEPD SPGELNFMYL FDLLQDLGYQ GYVGCEYKPQ
260 270
GDTVKGLGWM EKYLKNCDGD EDKTK
Length:275
Mass (Da):30,983
Last modified:May 29, 2007 - v2
Checksum:i0DE84F0C3D930551
GO

Sequence cautioni

The sequence AAH68661 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC068661 mRNA Translation: AAH68661.1 Different initiation.
RefSeqiNP_001084705.1, NM_001091236.1
UniGeneiXl.46725

Genome annotation databases

GeneIDi414666
KEGGixla:414666

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC068661 mRNA Translation: AAH68661.1 Different initiation.
RefSeqiNP_001084705.1, NM_001091236.1
UniGeneiXl.46725

3D structure databases

ProteinModelPortaliQ6NUD4
SMRiQ6NUD4
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi414666
KEGGixla:414666

Organism-specific databases

CTDi414666
XenbaseiXB-GENE-5847302 hyi

Phylogenomic databases

HOVERGENiHBG056845
KOiK01816

Family and domain databases

InterProiView protein in InterPro
IPR026040 HyI-like
IPR036237 Xyl_isomerase-like_sf
IPR013022 Xyl_isomerase-like_TIM-brl
PfamiView protein in Pfam
PF01261 AP_endonuc_2, 1 hit
PIRSFiPIRSF006241 HyI, 1 hit
SUPFAMiSSF51658 SSF51658, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHYI_XENLA
AccessioniPrimary (citable) accession number: Q6NUD4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: October 25, 2017
This is version 53 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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