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Entry version 89 (08 May 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Rho GTPase-activating protein 35

Gene

arhgap35

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Rho GTPase-activating protein (GAP). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity. This binding is inhibited by phosphorylation by PRKCA (By similarity). Involved in cell differentiation as well as cell adhesion and migration (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei28GTPBy similarity1
Binding sitei52GTP; via carbonyl oxygenBy similarity1
Binding sitei56GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi33 – 37GTPBy similarity5
Nucleotide bindingi95 – 97GTPBy similarity3
Nucleotide bindingi201 – 203GTPBy similarity3
Nucleotide bindingi229 – 231GTPBy similarity3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation
LigandGTP-binding, Lipid-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho GTPase-activating protein 35By similarity
Alternative name(s):
Rho GAP p190A1 Publication
Short name:
p190-A1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:arhgap35Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-999480 arhgap35

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004432891 – 1477Rho GTPase-activating protein 35Add BLAST1477

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini270 – 327FF 1PROSITE-ProRule annotationAdd BLAST58
Domaini428 – 482FF 2PROSITE-ProRule annotationAdd BLAST55
Domaini484 – 549FF 3PROSITE-ProRule annotationAdd BLAST66
Domaini587 – 762pG1 pseudoGTPasePROSITE-ProRule annotationAdd BLAST176
Domaini778 – 940pG2 pseudoGTPasePROSITE-ProRule annotationAdd BLAST163
Domaini1243 – 1430Rho-GAPPROSITE-ProRule annotationAdd BLAST188

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 266Has GTPase activity, required for proper localizationBy similarityAdd BLAST266
Regioni1207 – 1230Required for phospholipid binding and regulation of the substrate preferenceBy similarityAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1435 – 1465Pro-richPROSITE-ProRule annotationAdd BLAST31

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

N-terminal part (1-266) has GTPase activity. Required for proper cellular localization.By similarity
The pG1 pseudoGTPase domain does not bind GTP.1 Publication

Keywords - Domaini

Repeat

Phylogenomic databases

KEGG Orthology (KO)

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KOi
K05732

Database of Orthologous Groups

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OrthoDBi
110157at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.440, 2 hits
1.10.555.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002713 FF_domain
IPR036517 FF_domain_sf
IPR027417 P-loop_NTPase
IPR039007 pG1
IPR008936 Rho_GTPase_activation_prot
IPR032835 RhoGAP-FF1
IPR000198 RhoGAP_dom
IPR039006 RhoGAP_pG2
IPR001806 Small_GTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01846 FF, 1 hit
PF00071 Ras, 1 hit
PF00620 RhoGAP, 1 hit
PF16512 RhoGAP-FF1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00441 FF, 4 hits
SM00324 RhoGAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350 SSF48350, 1 hit
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51676 FF, 3 hits
PS51852 PG1, 1 hit
PS51853 PG2, 1 hit
PS50238 RHOGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6NU25-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMMARKQDVR VPTYSISVVG LSGTEKEKGQ CGVGKSCLCN RFVRPSADDF
60 70 80 90 100
HLDHTSVLST SDFGGRVVNN DHFLYWGESG QMPEDCVDFK VHVVEQTEFI
110 120 130 140 150
DDQTFQPHRS TALQPYIKRA ASCKLASAEK LMYFCTDQLG LEQDFEQKQM
160 170 180 190 200
PEGKLLIDGF LLCIDVSRGM NRNFDDQLKF VSNLYTQMAK TKKPMVMVLT
210 220 230 240 250
KCDEGVERYI RDAHSFALNK KNLQVVETSA RSNVNVDLAF TTLVQLIDKS
260 270 280 290 300
RGKSKIIPYF EALKQQSQLI AAAKDKYEWL VSRVVKSHNE TWINVNRRMQ
310 320 330 340 350
SSIEYQDYVH LEGTDKAKKL FHQHVQRLKQ EHIERRRKNY LSALPRALES
360 370 380 390 400
LVPELDEIDR LSWVKVSNLL ESKAEFLKVF IVLEETPWEF TNHIDSIDER
410 420 430 440 450
IPYDLLETVS AAEVYASYLE KLRNARKKEE MKRSFKDNLI TSPFITPGKP
460 470 480 490 500
WEEARSFIMS EEFYQWLEEP VYMEIYSRHQ KEIIDKAKEE FQELLLEYSE
510 520 530 540 550
LFYELELDAK PSKEKMGVIQ DVLGEEQRFK ALQKLQAERD ALILKHIHFV
560 570 580 590 600
YHPTKDTCPS NPSCVDTKIE HILCSRCTYP YDRLQKDPNV DRINLVILGR
610 620 630 640 650
DGLARELANE IRALCTNDDK YVIDGKMYEL SLRPIEGNVR LPVNSFQTST
660 670 680 690 700
FQPHGCLCLY NSKESLSYVV ESIEKSRESS LGRKENHLIN LPLTLILVNR
710 720 730 740 750
RGDTSSETAH SLIQHGQQVA SKLQCVFLDA ASTGLGYGRN INEKQISLIL
760 770 780 790 800
RGLLESKRNL NLVGSTPSIK DLTDCELRIV MCLMCADLFN IEDVLNALKP
810 820 830 840 850
HTYRPSQCGL GGSVLLDLPI GSQKRRLELM MLSYHSSFNV RKTRLVHGYM
860 870 880 890 900
IFYAAKRRAS LAMLRAFLCE VQDIVPVQIV ALTEGPLTFL ENVAREQLQE
910 920 930 940 950
GEEIAQDIEG KFLILPQGQT QPKFDVFYPF FKDVLEKKVI IEASHMYDNT
960 970 980 990 1000
AEACSTTEEV FSSPRAGSPL CNSHLPDSEE DPEPSPQHLL FREEPNISVP
1010 1020 1030 1040 1050
TKFTRELEET ENLHFIPMIN PLESKFNNKV PPPLKPKPPI PYEISKPELS
1060 1070 1080 1090 1100
YLDTGSRDGH RKSLTSINWP PLEAFDPSDY AEPMDSVVKP RNQEENIYSV
1110 1120 1130 1140 1150
PHDSTQGKII TIRNTNKPQS NGSGNGSDSD MDTNSLERAR KASIVTKPVL
1160 1170 1180 1190 1200
YRTKCAKLGK FSSYRSSLSV GSDDELGPIQ RKEVETGTQG TKGDNTTNSY
1210 1220 1230 1240 1250
EADVEDPRKR NILRSLRRTT KKVKPKPRPS LTKATWESNY FGYPLSSVVT
1260 1270 1280 1290 1300
SERPIPVFIE KCVEYIEATG MTTEGIYRVS GNKSEMDSLQ RQFDQDHNLD
1310 1320 1330 1340 1350
LVEKDFTVNT VAGALKSFFS ELPDPLVPYN MQTELVEAYK INDLEQKLQA
1360 1370 1380 1390 1400
MKELLKKFPK ENHEIFKYVI SHLNRVSQHH HVNLMTSENL SICFWPTLMR
1410 1420 1430 1440 1450
PDFTTMDALT ATRTYQTIIE LFIHQCPFFF YQRLPVDLPT PSSPSTPPLT
1460 1470
QPSPPQSPPL TPVSPSLSLL PAEHNIL
Length:1,477
Mass (Da):168,766
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i90C150E1A7BB9F4A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC068777 mRNA Translation: AAH68777.1

NCBI Reference Sequences

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RefSeqi
NP_001084674.1, NM_001091205.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
414634

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xla:414634

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC068777 mRNA Translation: AAH68777.1
RefSeqiNP_001084674.1, NM_001091205.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5U4UX-ray1.90A587-762[»]
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi414634
KEGGixla:414634

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
414634
XenbaseiXB-GENE-999480 arhgap35

Phylogenomic databases

KOiK05732
OrthoDBi110157at2759

Family and domain databases

Gene3Di1.10.10.440, 2 hits
1.10.555.10, 1 hit
InterProiView protein in InterPro
IPR002713 FF_domain
IPR036517 FF_domain_sf
IPR027417 P-loop_NTPase
IPR039007 pG1
IPR008936 Rho_GTPase_activation_prot
IPR032835 RhoGAP-FF1
IPR000198 RhoGAP_dom
IPR039006 RhoGAP_pG2
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF01846 FF, 1 hit
PF00071 Ras, 1 hit
PF00620 RhoGAP, 1 hit
PF16512 RhoGAP-FF1, 1 hit
SMARTiView protein in SMART
SM00441 FF, 4 hits
SM00324 RhoGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51676 FF, 3 hits
PS51852 PG1, 1 hit
PS51853 PG2, 1 hit
PS50238 RHOGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRHG35_XENLA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NU25
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2018
Last sequence update: July 5, 2004
Last modified: May 8, 2019
This is version 89 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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