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UniProtKB - Q6NTV6 (INF2_XENLA)

Entry version 73 (25 May 2022)
Sequence version 1 (05 Jul 2004)
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Protein

Inverted formin-2

Gene

inf2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inverted formin-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:inf2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000186698 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8S

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...Xenbasei		XB-GENE-5862221, inf2.S

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002598911 – 1099Inverted formin-2Add BLAST1099

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q6NTV6, 1 interactor

Molecular INTeraction database

More...MINTi		Q6NTV6

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q6NTV6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6NTV6

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 330GBD/FH3PROSITE-ProRule annotationAdd BLAST330
Domaini426 – 569FH1Add BLAST144
Domaini621 – 1009FH2PROSITE-ProRule annotationAdd BLAST389
Domaini1037 – 1052WH2PROSITE-ProRule annotationAdd BLAST16

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni348 – 391DisorderedSequence analysisAdd BLAST44
Regioni432 – 509DisorderedSequence analysisAdd BLAST78
Regioni1000 – 1019DisorderedSequence analysisAdd BLAST20
Regioni1064 – 1085DisorderedSequence analysisAdd BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili907 – 1019Sequence analysisAdd BLAST113

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi366 – 381Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi450 – 509Pro residuesSequence analysisAdd BLAST60

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the formin homology family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

Database of Orthologous Groups

More...OrthoDBi		1204639at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.58.2220, 1 hit
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR015425, FH2_Formin
IPR042201, FH2_Formin_sf
IPR010472, FH3_dom
IPR014768, GBD/FH3_dom
IPR010473, GTPase-bd
IPR027649, Inf2
IPR003124, WH2_dom

The PANTHER Classification System

More...PANTHERi		PTHR46345, PTHR46345, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF06367, Drf_FH3, 1 hit
PF06371, Drf_GBD, 1 hit
PF02181, FH2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01139, Drf_FH3, 1 hit
SM01140, Drf_GBD, 1 hit
SM00498, FH2, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51444, FH2, 1 hit
PS51232, GBD_FH3, 1 hit
PS51082, WH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6NTV6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLTEGAHTK WGVLKQKLGP QDPDQIEGNL ENADPELCIR LLQIPSVVNY 
        60         70         80         90        100
SGLKKRLESS DDEWMCQFLE LSGLDLLLEA LDRLSGRGVA RIADALLQLT 
       110        120        130        140        150
CINCVRTLMN SHKGIEYIVN NEGYVRKLSQ ALDTSNVMVK KQVFELLAAL 
       160        170        180        190        200
CIYSPEGHAL CLDALEHYKV VKNQQYRFSV ITNELSSSDN VPYMVTLLSV 
       210        220        230        240        250
INAIIFGTEE LRNRVQLRNE FIGLQLLDLL TKLRDLEDED LLIQALVFEE 
       260        270        280        290        300
AKSEDEEELL KIYGGINMNN HQEVFSTLFN KVSCSPLSVQ LLSILQGLLQ 
       310        320        330        340        350
LDQSHPTSPL LWEALEVLVN RAVLLADDCQ NNNVEEVMDR LVTSKKLSSK 
       360        370        380        390        400
EKRKTDKCTN KVNKSIQTDK PKEESCEGKT VKKDPVSSGI PADSLQLLDA 
       410        420        430        440        450
LLAPPTKEDS PACITPLHTH LSGELTCSSV LPSPPSPLVP NADERISSSS 
       460        470        480        490        500
SPLPPPPPPL PGTELSPPPP GMVALSLPPP PPPLPGMGGM LPPPPPPLPG 
       510        520        530        540        550
MGGMLPTPPP PPLPGMGGML PPPPPPLPGM GGMLPPPPPP LPGMGGMLPP 
       560        570        580        590        600
PPPPLPGMGG MLPPPPPLPG MGGMLPPPPP PLPGMGGMPP PPPPMPGMGT 
       610        620        630        640        650
FTDEVVVARV DYSLGYLPKA FLKVNKPTLK MKKLNWQKIP PNVIKDSHSM 
       660        670        680        690        700
WASASSIEDT VEPNYSSIEQ LFCLPQAAVK ESAVPVKKPP KEITFLDSKK 
       710        720        730        740        750
NLNLNIFLKQ FKCPNKEVIE LIEKGDRSRF DIEILKQFLK LLPEKHEVEN 
       760        770        780        790        800
LKSYQEDKAK LSNADQFYLL LLGVPCYQLR IECMLICEEI NLMIDMIRPR 
       810        820        830        840        850
AKVVSSACDD IISSHRLPLF CQLILKVGNF LNYGSHTGNA NGFKISTLLK 
       860        870        880        890        900
LTETRANQTR ITLLHHILEE IEHNHTDLLQ LPTDLENVST VAGINIENMY 
       910        920        930        940        950
TETSGNLKKL RDLQNKISTA ATDVKEQYEK SIQDCMDTLK ELEEQLTDIS 
       960        970        980        990       1000
QKKVKLADYL CEDPTKLSLE ETFSTMKAFR ELFLKAKKDN KDRKEQAVKA 
      1010       1020       1030       1040       1050
EKRKQQIADE ETKRQKGENG KIIRKGAAKL EEGCIIDDLL ADIKKGFQLR 
      1060       1070       1080       1090 
KTAKTKTKAD ACPKTLSSET NRTDIQHVGK RPEVPPVHPQ RKIIILKRQ
Length:1,099
Mass (Da):121,481
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7CF57CE48928CE85
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BC068848 mRNA Translation: AAH68848.1

NCBI Reference Sequences

More...RefSeqi		NP_001084562.1, NM_001091093.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		414513

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		xla:414513

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC068848 mRNA Translation: AAH68848.1
RefSeqiNP_001084562.1, NM_001091093.1

3D structure databases

AlphaFoldDBiQ6NTV6
SMRiQ6NTV6
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ6NTV6, 1 interactor
MINTiQ6NTV6

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		414513

Genome annotation databases

GeneIDi414513
KEGGixla:414513

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		414513
XenbaseiXB-GENE-5862221, inf2.S

Phylogenomic databases

OrthoDBi1204639at2759

Family and domain databases

Gene3Di1.20.58.2220, 1 hit
1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR015425, FH2_Formin
IPR042201, FH2_Formin_sf
IPR010472, FH3_dom
IPR014768, GBD/FH3_dom
IPR010473, GTPase-bd
IPR027649, Inf2
IPR003124, WH2_dom
PANTHERiPTHR46345, PTHR46345, 2 hits
PfamiView protein in Pfam
PF06367, Drf_FH3, 1 hit
PF06371, Drf_GBD, 1 hit
PF02181, FH2, 1 hit
SMARTiView protein in SMART
SM01139, Drf_FH3, 1 hit
SM01140, Drf_GBD, 1 hit
SM00498, FH2, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51444, FH2, 1 hit
PS51232, GBD_FH3, 1 hit
PS51082, WH2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiINF2_XENLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NTV6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: July 5, 2004
Last modified: May 25, 2022
This is version 73 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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