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UniProtKB - Q6NTV6 (INF2_XENLA)
Protein
Inverted formin-2
Gene
inf2
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
- small GTPase binding Source: InterPro
GO - Biological processi
- actin cytoskeleton organization Source: InterPro
Keywordsi
Molecular function | Actin-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Inverted formin-2 |
Gene namesi | Name:inf2 |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Proteomesi |
|
Organism-specific databases
Xenbasei | XB-GENE-5862221, inf2.S |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000259891 | 1 – 1099 | Inverted formin-2Add BLAST | 1099 |
Interactioni
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
- small GTPase binding Source: InterPro
Protein-protein interaction databases
IntActi | Q6NTV6, 1 interactor |
MINTi | Q6NTV6 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 330 | GBD/FH3PROSITE-ProRule annotationAdd BLAST | 330 | |
Domaini | 426 – 569 | FH1Add BLAST | 144 | |
Domaini | 621 – 1009 | FH2PROSITE-ProRule annotationAdd BLAST | 389 | |
Domaini | 1037 – 1052 | WH2PROSITE-ProRule annotationAdd BLAST | 16 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 348 – 391 | DisorderedSequence analysisAdd BLAST | 44 | |
Regioni | 432 – 509 | DisorderedSequence analysisAdd BLAST | 78 | |
Regioni | 1000 – 1019 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 1064 – 1085 | DisorderedSequence analysisAdd BLAST | 22 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 907 – 1019 | Sequence analysisAdd BLAST | 113 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 366 – 381 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 450 – 509 | Pro residuesSequence analysisAdd BLAST | 60 |
Sequence similaritiesi
Belongs to the formin homology family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
OrthoDBi | 1204639at2759 |
Family and domain databases
Gene3Di | 1.20.58.2220, 1 hit 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR015425, FH2_Formin IPR042201, FH2_Formin_sf IPR010472, FH3_dom IPR014768, GBD/FH3_dom IPR010473, GTPase-bd IPR027649, Inf2 IPR003124, WH2_dom |
PANTHERi | PTHR46345, PTHR46345, 2 hits |
Pfami | View protein in Pfam PF06367, Drf_FH3, 1 hit PF06371, Drf_GBD, 1 hit PF02181, FH2, 1 hit |
SMARTi | View protein in SMART SM01139, Drf_FH3, 1 hit SM01140, Drf_GBD, 1 hit SM00498, FH2, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS51444, FH2, 1 hit PS51232, GBD_FH3, 1 hit PS51082, WH2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6NTV6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLTEGAHTK WGVLKQKLGP QDPDQIEGNL ENADPELCIR LLQIPSVVNY
60 70 80 90 100
SGLKKRLESS DDEWMCQFLE LSGLDLLLEA LDRLSGRGVA RIADALLQLT
110 120 130 140 150
CINCVRTLMN SHKGIEYIVN NEGYVRKLSQ ALDTSNVMVK KQVFELLAAL
160 170 180 190 200
CIYSPEGHAL CLDALEHYKV VKNQQYRFSV ITNELSSSDN VPYMVTLLSV
210 220 230 240 250
INAIIFGTEE LRNRVQLRNE FIGLQLLDLL TKLRDLEDED LLIQALVFEE
260 270 280 290 300
AKSEDEEELL KIYGGINMNN HQEVFSTLFN KVSCSPLSVQ LLSILQGLLQ
310 320 330 340 350
LDQSHPTSPL LWEALEVLVN RAVLLADDCQ NNNVEEVMDR LVTSKKLSSK
360 370 380 390 400
EKRKTDKCTN KVNKSIQTDK PKEESCEGKT VKKDPVSSGI PADSLQLLDA
410 420 430 440 450
LLAPPTKEDS PACITPLHTH LSGELTCSSV LPSPPSPLVP NADERISSSS
460 470 480 490 500
SPLPPPPPPL PGTELSPPPP GMVALSLPPP PPPLPGMGGM LPPPPPPLPG
510 520 530 540 550
MGGMLPTPPP PPLPGMGGML PPPPPPLPGM GGMLPPPPPP LPGMGGMLPP
560 570 580 590 600
PPPPLPGMGG MLPPPPPLPG MGGMLPPPPP PLPGMGGMPP PPPPMPGMGT
610 620 630 640 650
FTDEVVVARV DYSLGYLPKA FLKVNKPTLK MKKLNWQKIP PNVIKDSHSM
660 670 680 690 700
WASASSIEDT VEPNYSSIEQ LFCLPQAAVK ESAVPVKKPP KEITFLDSKK
710 720 730 740 750
NLNLNIFLKQ FKCPNKEVIE LIEKGDRSRF DIEILKQFLK LLPEKHEVEN
760 770 780 790 800
LKSYQEDKAK LSNADQFYLL LLGVPCYQLR IECMLICEEI NLMIDMIRPR
810 820 830 840 850
AKVVSSACDD IISSHRLPLF CQLILKVGNF LNYGSHTGNA NGFKISTLLK
860 870 880 890 900
LTETRANQTR ITLLHHILEE IEHNHTDLLQ LPTDLENVST VAGINIENMY
910 920 930 940 950
TETSGNLKKL RDLQNKISTA ATDVKEQYEK SIQDCMDTLK ELEEQLTDIS
960 970 980 990 1000
QKKVKLADYL CEDPTKLSLE ETFSTMKAFR ELFLKAKKDN KDRKEQAVKA
1010 1020 1030 1040 1050
EKRKQQIADE ETKRQKGENG KIIRKGAAKL EEGCIIDDLL ADIKKGFQLR
1060 1070 1080 1090
KTAKTKTKAD ACPKTLSSET NRTDIQHVGK RPEVPPVHPQ RKIIILKRQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC068848 mRNA Translation: AAH68848.1 |
RefSeqi | NP_001084562.1, NM_001091093.1 |
Genome annotation databases
GeneIDi | 414513 |
KEGGi | xla:414513 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC068848 mRNA Translation: AAH68848.1 |
RefSeqi | NP_001084562.1, NM_001091093.1 |
3D structure databases
AlphaFoldDBi | Q6NTV6 |
SMRi | Q6NTV6 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q6NTV6, 1 interactor |
MINTi | Q6NTV6 |
Protocols and materials databases
DNASUi | 414513 |
Genome annotation databases
GeneIDi | 414513 |
KEGGi | xla:414513 |
Organism-specific databases
CTDi | 414513 |
Xenbasei | XB-GENE-5862221, inf2.S |
Phylogenomic databases
OrthoDBi | 1204639at2759 |
Family and domain databases
Gene3Di | 1.20.58.2220, 1 hit 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR015425, FH2_Formin IPR042201, FH2_Formin_sf IPR010472, FH3_dom IPR014768, GBD/FH3_dom IPR010473, GTPase-bd IPR027649, Inf2 IPR003124, WH2_dom |
PANTHERi | PTHR46345, PTHR46345, 2 hits |
Pfami | View protein in Pfam PF06367, Drf_FH3, 1 hit PF06371, Drf_GBD, 1 hit PF02181, FH2, 1 hit |
SMARTi | View protein in SMART SM01139, Drf_FH3, 1 hit SM01140, Drf_GBD, 1 hit SM00498, FH2, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS51444, FH2, 1 hit PS51232, GBD_FH3, 1 hit PS51082, WH2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | INF2_XENLA | |
Accessioni | Q6NTV6Primary (citable) accession number: Q6NTV6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2006 |
Last sequence update: | July 5, 2004 | |
Last modified: | May 25, 2022 | |
This is version 73 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families