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Entry version 92 (07 Apr 2021)
Sequence version 1 (05 Jul 2004)
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Protein

Myotubularin-related protein 13

Gene

sbf2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide exchange factor (GEF) which may activate Rab small GTPases (By similarity). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity). Acts as an adapter for the phosphatase mtmr2 (By similarity).By similarity

Caution

Although it belongs to the non-receptor class myotubularin subfamily, lacks the conserved active site cysteine residue at position 1439 in the dsPTPase catalytic loop, suggesting that it has no phosphatase activity.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processAutophagy

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myotubularin-related protein 13
Alternative name(s):
Inactive phosphatidylinositol 3-phosphatase 13Curated
SET-binding factor 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sbf2
Synonyms:mtmr13
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-1004473, sbf2.L

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000949461 – 1873Myotubularin-related protein 13Add BLAST1873

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6NTN5

PRoteomics IDEntifications database

More...
PRIDEi
Q6NTN5

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q6NTN5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 171uDENNPROSITE-ProRule annotationAdd BLAST165
Domaini190 – 323cDENNPROSITE-ProRule annotationAdd BLAST134
Domaini325 – 426dDENNPROSITE-ProRule annotationAdd BLAST102
Domaini869 – 955GRAMSequence analysisAdd BLAST87
Domaini1105 – 1613Myotubularin phosphatasePROSITE-ProRule annotationAdd BLAST509
Domaini1767 – 1871PHPROSITE-ProRule annotationAdd BLAST105

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
PNAYVCL

Database of Orthologous Groups

More...
OrthoDBi
45015at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13339, PH-GRAM_MTMR13, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit
3.40.50.11500, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001194, cDENN_dom
IPR005112, dDENN_dom
IPR043153, DENN_C
IPR004182, GRAM
IPR030567, MTMR13
IPR037823, MTMR13_PH-GRAM
IPR010569, Myotubularin-like_Pase_dom
IPR030564, Myotubularin_fam
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR029021, Prot-tyrosine_phosphatase-like
IPR022096, SBF1/SBF2
IPR037516, Tripartite_DENN
IPR005113, uDENN_dom

The PANTHER Classification System

More...
PANTHERi
PTHR10807, PTHR10807, 1 hit
PTHR10807:SF4, PTHR10807:SF4, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02141, DENN, 1 hit
PF02893, GRAM, 1 hit
PF06602, Myotub-related, 1 hit
PF00169, PH, 1 hit
PF12335, SBF2, 1 hit
PF03456, uDENN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00801, dDENN, 1 hit
SM00799, DENN, 1 hit
SM00568, GRAM, 1 hit
SM00233, PH, 1 hit
SM00800, uDENN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52799, SSF52799, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50211, DENN, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS51339, PPASE_MYOTUBULARIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6NTN5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARLADYFIV VGYDHEKTGS EGFGKIIQRF PMTDWSDTPF PQGIELFCQP
60 70 80 90 100
GGWQLSRERK QPTFFIVVLT DIDSDRHYCA CLTFYEAEIN LQGTKREHSE
110 120 130 140 150
TEEEDSGLIQ PAQVFAPKSL VLVSRLDYPE IFRACLGLIY TVYIDSLNVS
160 170 180 190 200
LENLVSNLVT CIVPCAGGSQ KLFSLGAGDR QLIQTPLHDS LPVTGTSVAL
210 220 230 240 250
LFQQLGIQNV LSLFCAVLTE NKVLFHSSSF QRLGDACRAL EALIYPLKYS
260 270 280 290 300
YPYIPILPAQ LLEVLSSPTP FIIGVHSVFC SEIHDLLDVI IADLDGGTIK
310 320 330 340 350
IPECIHLSPI PEPLLHQTQA ALSLVLHPDL EVADNAFAPL RTPVPHIKLL
360 370 380 390 400
DKEVRAVFLR LFAQIFQGYR SCLQLIRIHA EPIIHFHKAA FLGQRGLIEN
410 420 430 440 450
DFLTKVLSGM SFAGFVSERG PPYRPCDLFD ELVSFEVERI KDDDQNDTHK
460 470 480 490 500
ILKHIRELAE QLFKNENPNP HMAFQKVPKP TEGSHLRVHI LPFSKMNDLK
510 520 530 540 550
VQELIQEGLN KNQNSILSPR AEKKCVVPAG SPVVSIVDKA SSVFNSARRL
560 570 580 590 600
EVVRNCIMYI FENKTLETEK TLPAALRALK GKAARQCLTE ELALHVQQNR
610 620 630 640 650
SMLNHQQFDY IVRMMNCALQ DCSGSEEYTI ASQLLPLATA FCRKLSAAVS
660 670 680 690 700
QFAYTCVQDH GVWANQQFWE TTFYNDVQNQ VRSLYLTTKN GNQGASEPKE
710 720 730 740 750
NGVDSGNPER TVMDLAAEQL RLWPTLSKET QQELIQSEES TVFSQAIHFA
760 770 780 790 800
NLMVYLLVPL DTSKNKLLRT SATGDWESGS NSIVTNSIAG SVAESYDTES
810 820 830 840 850
GFEDSENDIA NSVVRFITRF IDKVCTESGV TQDHIKSLHC MIPGIVAMHI
860 870 880 890 900
ETLEAVHRES RRLPPIKKPK IMRPALLPGE EFVCEALRVL LDPDGREEAT
910 920 930 940 950
GGMLGGPHIL PAEGALFLTT YRIIFKGTPH DALVGEQTVI RSVPIASITR
960 970 980 990 1000
EKKINVQNQL HQNMQEGLQI RSATFQLIKV AFDEEVSAEM VDLFKKQLMK
1010 1020 1030 1040 1050
FRYPLSIFSA FAFAAGQTAP PIILPKQKEK NTSFRTISKT IVKGAKRAGK
1060 1070 1080 1090 1100
MTIGRQYAAK KKTGTILEER GSRSGGNEDD DISVSDDNEL PSGTLKPSEK
1110 1120 1130 1140 1150
STMEQLVERA CFRDYQRLAL GTISNSSTRF KSEHFRVTAL NRMHSLCRSY
1160 1170 1180 1190 1200
PGLLVVPQSV QDSSLQKVAR CYRHNRLPVV SWKNAKTNAV LLRGGGFHGK
1210 1220 1230 1240 1250
TVVGLFKSQN THTAAPASSL ESSSSIEQEK YLQALLNAIS VHYKMNGNST
1260 1270 1280 1290 1300
LTVRPTLALS PGSDRKSSRM SSVVKHVVPS HVDGSLSHSF ARGGVWASLR
1310 1320 1330 1340 1350
SSNRLITTQT PLIDVGARLV GKDLQTTYTD HSALQSQLLK RQAALYIFGE
1360 1370 1380 1390 1400
KSQLRGFKFD FALNCEFVPV EFGDIRQVKT SFKKLMRACV PSSNPTDSES
1410 1420 1430 1440 1450
TFLKAMGESE WFLQIHRIIQ LSVIISELME SGSSVMICLE DGWDITTQVV
1460 1470 1480 1490 1500
SLVQILGDPF YRTLEGFRML IEKEWLSFGH KFSQRSNLSP SSQGTGFVPI
1510 1520 1530 1540 1550
FLQFLDCVHQ IHNQYPTEFE FNRYYLKFLA YHHVSNRFKT FLLDSDYERL
1560 1570 1580 1590 1600
EHGTLFEDKG DKHSRRGICI WEYIERIHKK KTVFFNYLFA PTELEALKPS
1610 1620 1630 1640 1650
ANISTLRKWE YYMEETLASG PSYDWIITPS RFNASDETDS GEEAQQQGKR
1660 1670 1680 1690 1700
KIVWPCYDDV QKVQPDAITH LMNEIERLEI KLNQTSERWQ LLWERAKVKL
1710 1720 1730 1740 1750
KENAKKENNN PASLVSANLQ SYQKRSMVHL PDSGLGDEQN LNASPSNGVD
1760 1770 1780 1790 1800
RRTATLYNHF TSKNEENRSY EGILYKRGAL LKGWKPRWFV LDITKHQLRY
1810 1820 1830 1840 1850
YDSGEDTSCK GYIDLADVET VVPAAPTIGA PKHANEKAFF DVKTSKRVYN
1860 1870
FCAQDAQSAQ LWMDKIQNCI SDA
Length:1,873
Mass (Da):210,866
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i46D9D716D1716FDA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC068924 mRNA Translation: AAH68924.1

NCBI Reference Sequences

More...
RefSeqi
NP_001084507.1, NM_001091038.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
414452

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xla:414452

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC068924 mRNA Translation: AAH68924.1
RefSeqiNP_001084507.1, NM_001091038.1

3D structure databases

SMRiQ6NTN5
ModBaseiSearch...

Proteomic databases

MaxQBiQ6NTN5
PRIDEiQ6NTN5

Genome annotation databases

GeneIDi414452
KEGGixla:414452

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
414452
XenbaseiXB-GENE-1004473, sbf2.L

Phylogenomic databases

OMAiPNAYVCL
OrthoDBi45015at2759

Family and domain databases

CDDicd13339, PH-GRAM_MTMR13, 1 hit
Gene3Di2.30.29.30, 1 hit
3.40.50.11500, 1 hit
InterProiView protein in InterPro
IPR001194, cDENN_dom
IPR005112, dDENN_dom
IPR043153, DENN_C
IPR004182, GRAM
IPR030567, MTMR13
IPR037823, MTMR13_PH-GRAM
IPR010569, Myotubularin-like_Pase_dom
IPR030564, Myotubularin_fam
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR029021, Prot-tyrosine_phosphatase-like
IPR022096, SBF1/SBF2
IPR037516, Tripartite_DENN
IPR005113, uDENN_dom
PANTHERiPTHR10807, PTHR10807, 1 hit
PTHR10807:SF4, PTHR10807:SF4, 1 hit
PfamiView protein in Pfam
PF02141, DENN, 1 hit
PF02893, GRAM, 1 hit
PF06602, Myotub-related, 1 hit
PF00169, PH, 1 hit
PF12335, SBF2, 1 hit
PF03456, uDENN, 1 hit
SMARTiView protein in SMART
SM00801, dDENN, 1 hit
SM00799, DENN, 1 hit
SM00568, GRAM, 1 hit
SM00233, PH, 1 hit
SM00800, uDENN, 1 hit
SUPFAMiSSF52799, SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS50211, DENN, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS51339, PPASE_MYOTUBULARIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMTMRD_XENLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NTN5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: July 5, 2004
Last modified: April 7, 2021
This is version 92 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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