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UniProtKB - Q6NTN5 (MTMRD_XENLA)

Entry version 92 (07 Apr 2021)
Sequence version 1 (05 Jul 2004)
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Protein

Myotubularin-related protein 13

Gene

sbf2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide exchange factor (GEF) which may activate Rab small GTPases (By similarity). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity). Acts as an adapter for the phosphatase mtmr2 (By similarity).By similarity

Caution

Although it belongs to the non-receptor class myotubularin subfamily, lacks the conserved active site cysteine residue at position 1439 in the dsPTPase catalytic loop, suggesting that it has no phosphatase activity.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processAutophagy

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myotubularin-related protein 13
Alternative name(s):
Inactive phosphatidylinositol 3-phosphatase 13Curated
SET-binding factor 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sbf2
Synonyms:mtmr13
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...Xenbasei		XB-GENE-1004473, sbf2.L

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000949461 – 1873Myotubularin-related protein 13Add BLAST1873

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6NTN5

PRoteomics IDEntifications database

More...PRIDEi		Q6NTN5

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6NTN5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 171uDENNPROSITE-ProRule annotationAdd BLAST165
Domaini190 – 323cDENNPROSITE-ProRule annotationAdd BLAST134
Domaini325 – 426dDENNPROSITE-ProRule annotationAdd BLAST102
Domaini869 – 955GRAMSequence analysisAdd BLAST87
Domaini1105 – 1613Myotubularin phosphatasePROSITE-ProRule annotationAdd BLAST509
Domaini1767 – 1871PHPROSITE-ProRule annotationAdd BLAST105

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.Curated

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...OMAi		PNAYVCL

Database of Orthologous Groups

More...OrthoDBi		45015at2759

Family and domain databases

Conserved Domains Database

More...CDDi		cd13339, PH-GRAM_MTMR13, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.29.30, 1 hit
3.40.50.11500, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001194, cDENN_dom
IPR005112, dDENN_dom
IPR043153, DENN_C
IPR004182, GRAM
IPR030567, MTMR13
IPR037823, MTMR13_PH-GRAM
IPR010569, Myotubularin-like_Pase_dom
IPR030564, Myotubularin_fam
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR029021, Prot-tyrosine_phosphatase-like
IPR022096, SBF1/SBF2
IPR037516, Tripartite_DENN
IPR005113, uDENN_dom

The PANTHER Classification System

More...PANTHERi		PTHR10807, PTHR10807, 1 hit
PTHR10807:SF4, PTHR10807:SF4, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02141, DENN, 1 hit
PF02893, GRAM, 1 hit
PF06602, Myotub-related, 1 hit
PF00169, PH, 1 hit
PF12335, SBF2, 1 hit
PF03456, uDENN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00801, dDENN, 1 hit
SM00799, DENN, 1 hit
SM00568, GRAM, 1 hit
SM00233, PH, 1 hit
SM00800, uDENN, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52799, SSF52799, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50211, DENN, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS51339, PPASE_MYOTUBULARIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6NTN5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARLADYFIV VGYDHEKTGS EGFGKIIQRF PMTDWSDTPF PQGIELFCQP 
        60         70         80         90        100
GGWQLSRERK QPTFFIVVLT DIDSDRHYCA CLTFYEAEIN LQGTKREHSE 
       110        120        130        140        150
TEEEDSGLIQ PAQVFAPKSL VLVSRLDYPE IFRACLGLIY TVYIDSLNVS 
       160        170        180        190        200
LENLVSNLVT CIVPCAGGSQ KLFSLGAGDR QLIQTPLHDS LPVTGTSVAL 
       210        220        230        240        250
LFQQLGIQNV LSLFCAVLTE NKVLFHSSSF QRLGDACRAL EALIYPLKYS 
       260        270        280        290        300
YPYIPILPAQ LLEVLSSPTP FIIGVHSVFC SEIHDLLDVI IADLDGGTIK 
       310        320        330        340        350
IPECIHLSPI PEPLLHQTQA ALSLVLHPDL EVADNAFAPL RTPVPHIKLL 
       360        370        380        390        400
DKEVRAVFLR LFAQIFQGYR SCLQLIRIHA EPIIHFHKAA FLGQRGLIEN 
       410        420        430        440        450
DFLTKVLSGM SFAGFVSERG PPYRPCDLFD ELVSFEVERI KDDDQNDTHK 
       460        470        480        490        500
ILKHIRELAE QLFKNENPNP HMAFQKVPKP TEGSHLRVHI LPFSKMNDLK 
       510        520        530        540        550
VQELIQEGLN KNQNSILSPR AEKKCVVPAG SPVVSIVDKA SSVFNSARRL 
       560        570        580        590        600
EVVRNCIMYI FENKTLETEK TLPAALRALK GKAARQCLTE ELALHVQQNR 
       610        620        630        640        650
SMLNHQQFDY IVRMMNCALQ DCSGSEEYTI ASQLLPLATA FCRKLSAAVS 
       660        670        680        690        700
QFAYTCVQDH GVWANQQFWE TTFYNDVQNQ VRSLYLTTKN GNQGASEPKE 
       710        720        730        740        750
NGVDSGNPER TVMDLAAEQL RLWPTLSKET QQELIQSEES TVFSQAIHFA 
       760        770        780        790        800
NLMVYLLVPL DTSKNKLLRT SATGDWESGS NSIVTNSIAG SVAESYDTES 
       810        820        830        840        850
GFEDSENDIA NSVVRFITRF IDKVCTESGV TQDHIKSLHC MIPGIVAMHI 
       860        870        880        890        900
ETLEAVHRES RRLPPIKKPK IMRPALLPGE EFVCEALRVL LDPDGREEAT 
       910        920        930        940        950
GGMLGGPHIL PAEGALFLTT YRIIFKGTPH DALVGEQTVI RSVPIASITR 
       960        970        980        990       1000
EKKINVQNQL HQNMQEGLQI RSATFQLIKV AFDEEVSAEM VDLFKKQLMK 
      1010       1020       1030       1040       1050
FRYPLSIFSA FAFAAGQTAP PIILPKQKEK NTSFRTISKT IVKGAKRAGK 
      1060       1070       1080       1090       1100
MTIGRQYAAK KKTGTILEER GSRSGGNEDD DISVSDDNEL PSGTLKPSEK 
      1110       1120       1130       1140       1150
STMEQLVERA CFRDYQRLAL GTISNSSTRF KSEHFRVTAL NRMHSLCRSY 
      1160       1170       1180       1190       1200
PGLLVVPQSV QDSSLQKVAR CYRHNRLPVV SWKNAKTNAV LLRGGGFHGK 
      1210       1220       1230       1240       1250
TVVGLFKSQN THTAAPASSL ESSSSIEQEK YLQALLNAIS VHYKMNGNST 
      1260       1270       1280       1290       1300
LTVRPTLALS PGSDRKSSRM SSVVKHVVPS HVDGSLSHSF ARGGVWASLR 
      1310       1320       1330       1340       1350
SSNRLITTQT PLIDVGARLV GKDLQTTYTD HSALQSQLLK RQAALYIFGE 
      1360       1370       1380       1390       1400
KSQLRGFKFD FALNCEFVPV EFGDIRQVKT SFKKLMRACV PSSNPTDSES 
      1410       1420       1430       1440       1450
TFLKAMGESE WFLQIHRIIQ LSVIISELME SGSSVMICLE DGWDITTQVV 
      1460       1470       1480       1490       1500
SLVQILGDPF YRTLEGFRML IEKEWLSFGH KFSQRSNLSP SSQGTGFVPI 
      1510       1520       1530       1540       1550
FLQFLDCVHQ IHNQYPTEFE FNRYYLKFLA YHHVSNRFKT FLLDSDYERL 
      1560       1570       1580       1590       1600
EHGTLFEDKG DKHSRRGICI WEYIERIHKK KTVFFNYLFA PTELEALKPS 
      1610       1620       1630       1640       1650
ANISTLRKWE YYMEETLASG PSYDWIITPS RFNASDETDS GEEAQQQGKR 
      1660       1670       1680       1690       1700
KIVWPCYDDV QKVQPDAITH LMNEIERLEI KLNQTSERWQ LLWERAKVKL 
      1710       1720       1730       1740       1750
KENAKKENNN PASLVSANLQ SYQKRSMVHL PDSGLGDEQN LNASPSNGVD 
      1760       1770       1780       1790       1800
RRTATLYNHF TSKNEENRSY EGILYKRGAL LKGWKPRWFV LDITKHQLRY 
      1810       1820       1830       1840       1850
YDSGEDTSCK GYIDLADVET VVPAAPTIGA PKHANEKAFF DVKTSKRVYN 
      1860       1870 
FCAQDAQSAQ LWMDKIQNCI SDA
Length:1,873
Mass (Da):210,866
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i46D9D716D1716FDA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BC068924 mRNA Translation: AAH68924.1

NCBI Reference Sequences

More...RefSeqi		NP_001084507.1, NM_001091038.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		414452

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		xla:414452

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC068924 mRNA Translation: AAH68924.1
RefSeqiNP_001084507.1, NM_001091038.1

3D structure databases

SMRiQ6NTN5
ModBaseiSearch...

Proteomic databases

MaxQBiQ6NTN5
PRIDEiQ6NTN5

Genome annotation databases

GeneIDi414452
KEGGixla:414452

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		414452
XenbaseiXB-GENE-1004473, sbf2.L

Phylogenomic databases

OMAiPNAYVCL
OrthoDBi45015at2759

Family and domain databases

CDDicd13339, PH-GRAM_MTMR13, 1 hit
Gene3Di2.30.29.30, 1 hit
3.40.50.11500, 1 hit
InterProiView protein in InterPro
IPR001194, cDENN_dom
IPR005112, dDENN_dom
IPR043153, DENN_C
IPR004182, GRAM
IPR030567, MTMR13
IPR037823, MTMR13_PH-GRAM
IPR010569, Myotubularin-like_Pase_dom
IPR030564, Myotubularin_fam
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR029021, Prot-tyrosine_phosphatase-like
IPR022096, SBF1/SBF2
IPR037516, Tripartite_DENN
IPR005113, uDENN_dom
PANTHERiPTHR10807, PTHR10807, 1 hit
PTHR10807:SF4, PTHR10807:SF4, 1 hit
PfamiView protein in Pfam
PF02141, DENN, 1 hit
PF02893, GRAM, 1 hit
PF06602, Myotub-related, 1 hit
PF00169, PH, 1 hit
PF12335, SBF2, 1 hit
PF03456, uDENN, 1 hit
SMARTiView protein in SMART
SM00801, dDENN, 1 hit
SM00799, DENN, 1 hit
SM00568, GRAM, 1 hit
SM00233, PH, 1 hit
SM00800, uDENN, 1 hit
SUPFAMiSSF52799, SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS50211, DENN, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS51339, PPASE_MYOTUBULARIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMTMRD_XENLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NTN5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: July 5, 2004
Last modified: April 7, 2021
This is version 92 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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