Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 111 (13 Feb 2019)
Sequence version 2 (25 Nov 2008)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

MRN complex-interacting protein

Gene

MRNIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex (PubMed:27568553). Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair (PubMed:27568553).

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chromatin binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA damage, DNA repair

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
MRN complex-interacting proteinImported
Alternative name(s):
MRN-interacting protein1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MRNIPImported
Synonyms:C5orf45
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000161010.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30817 MRNIP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617154 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6NTE8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi100S → A: Does not affect nuclear localization. Decreases weakly the association with the MRN complex. Reduces phosphorylation; when associated with A-115 and A-143. 1 Publication1
Mutagenesisi115S → A: Reduces nuclear localization and increases DNA damage accumulation. Decreases weakly the association with the MRN complex. Reduces phosphorylation; when associated with A-100 and A-143. 1 Publication1
Mutagenesisi115S → D: Does not affect nuclear localization. 1 Publication1
Mutagenesisi141R → A: Reduces nuclear localization and increases DNA damage accumulation and does not affect the association with the MRN complex; when associated with 148-A--A-151 and A-154. 1 Publication1
Mutagenesisi143S → A: Reduces phosphorylation; when associated with A-100 and A-115. 1 Publication1
Mutagenesisi148 – 151RKRK → AAAA: Decreases nuclear localization. Reduces nuclear localization and increases DNA damage accumulation and does not affect the association with the MRN complex; when associated with A-141 and A-154. 1 Publication4
Mutagenesisi154R → A: Reduces nuclear localization and increases DNA damage accumulation and does not affect the association with the MRN complex; when associated with A-141 and 148-A--A-151. 1 Publication1
Mutagenesisi213 – 237Missing : Reduces the association with the MRN complex. 1 PublicationAdd BLAST25

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000161010

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162380286

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MRNIP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215273989

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003261191 – 343MRN complex-interacting proteinAdd BLAST343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei100Phosphoserine1 Publication1
Modified residuei115Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated; phosphorylation is constitutive and occurs in the absence of any DNA-damaging stimulus. Phosphorylation on Ser-115 is necessary for its nuclear retention.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6NTE8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6NTE8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6NTE8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6NTE8

PeptideAtlas

More...
PeptideAtlasi
Q6NTE8

PRoteomics IDEntifications database

More...
PRIDEi
Q6NTE8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
66668
66669 [Q6NTE8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6NTE8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6NTE8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000161010 Expressed in 179 organ(s), highest expression level in right hemisphere of cerebellum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6NTE8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6NTE8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043975

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with the MRE11-RAD50-NBN (MRN) damage-sensing complex; this association is constitutive (PubMed:27568553). Interacts with MRE11 (PubMed:27568553). Interacts with NBN (PubMed:27568553). Interacts with RAD50 (PubMed:27568553).1 Publication

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q6NTE8, 11 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000292586

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q6NTE8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni213 – 237Necessary for the association with the MRN complex1 PublicationAdd BLAST25

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi148 – 151Nuclear localization signal (NLS)1 Publication4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MRNIP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J2EG Eukaryota
ENOG411227Z LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006124

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000293216

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG106110

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6NTE8

Identification of Orthologs from Complete Genome Data

More...
OMAi
CDLFKTG

Database of Orthologous Groups

More...
OrthoDBi
1146272at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6NTE8

TreeFam database of animal gene trees

More...
TreeFami
TF333430

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032739 MRNIP

The PANTHER Classification System

More...
PANTHERi
PTHR15863 PTHR15863, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15749 MRNIP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6NTE8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASLQRSRVL RCCSCRLFQA HQVKKSVKWT CKACGEKQSF LQAYGEGSGA
60 70 80 90 100
DCRRHVQKLN LLQGQVSELP LRSLEETVSA SEEENVGHQQ AGNVKQQEKS
110 120 130 140 150
QPSESRWLKY LEKDSQELEL EGTGVCFSKQ PSSKMEEPGP RFSQDLPRKR
160 170 180 190 200
KWSRSTVQPP CSRGVQDSGG SEVAWGPQKG QAGLTWKVKQ GSSPCLQENS
210 220 230 240 250
ADCSAGELRG PGKELWSPIQ QVTATSSKWA QFVLPPRKSS HVDSEQPRSL
260 270 280 290 300
QRDPRPAGPA QAKQGTPRAQ ASREGLSRPT AAVQLPRATH PVTSGSERPC
310 320 330 340
GKTSWDARTP WAEGGPLVLE AQNPRPTRLC DLFITGEDFD DDV
Length:343
Mass (Da):37,743
Last modified:November 25, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i08C3CE3C1BC827EC
GO
Isoform 2 (identifier: Q6NTE8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: MASLQRSRVL...ACGEKQSFLQ → MQSARAWLPG...SEMDGAESGK
     222-229: VTATSSKW → DGYKEILF
     230-343: Missing.

Show »
Length:271
Mass (Da):29,397
Checksum:i19B8802E2B23B8A6
GO
Isoform 3 (identifier: Q6NTE8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-97: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:288
Mass (Da):31,785
Checksum:iDC94589DA003A79F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7Z1T6B7Z1T6_HUMAN
MRN complex-interacting protein
MRNIP
229Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RI52E5RI52_HUMAN
MRN complex-interacting protein
MRNIP
192Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIC8E5RIC8_HUMAN
MRN complex-interacting protein
MRNIP
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6XPR0F6XPR0_HUMAN
MRN complex-interacting protein
MRNIP
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHV0E5RHV0_HUMAN
MRN complex-interacting protein
MRNIP
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGF8E5RGF8_HUMAN
MRN complex-interacting protein
MRNIP
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RK98E5RK98_HUMAN
MRN complex-interacting protein
MRNIP
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJC6E5RJC6_HUMAN
MRN complex-interacting protein
MRNIP
209Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WZ47A0A087WZ47_HUMAN
MRN complex-interacting protein
MRNIP
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIJ7E5RIJ7_HUMAN
MRN complex-interacting protein
MRNIP
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD51611 differs from that shown. Reason: Frameshift at position 191.Curated
The sequence CAD97932 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 3 (identifier: Q6NTE8-3)
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti42Q → R in BC050714 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05403042Q → R. Corresponds to variant dbSNP:rs1650893Ensembl.1
Natural variantiVAR_03999097Q → R. Corresponds to variant dbSNP:rs1650893Ensembl.1
Natural variantiVAR_039991154R → G1 PublicationCorresponds to variant dbSNP:rs248248Ensembl.1
Natural variantiVAR_039992231Q → R2 PublicationsCorresponds to variant dbSNP:rs10277Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0325601 – 42MASLQ…QSFLQ → MQSARAWLPGDCTSRDGVAS AFSGATLLQLPPLPGAPGKK ECQVDMQSLWREAVLFAEFP RHGAPASELPVPSGSEMDGA ESGK in isoform 2. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_04722743 – 97Missing in isoform 3. 1 PublicationAdd BLAST55
Alternative sequenceiVSP_032561222 – 229VTATSSKW → DGYKEILF in isoform 2. 1 Publication8
Alternative sequenceiVSP_032562230 – 343Missing in isoform 2. 1 PublicationAdd BLAST114

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX537968 mRNA Translation: CAD97932.1 Different initiation.
AC008393 Genomic DNA No translation available.
BC002739 mRNA Translation: AAH02739.2
BC050714 mRNA No translation available.
BC069051 mRNA Translation: AAH69051.1
AF153685 mRNA Translation: AAD51611.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34318.1 [Q6NTE8-3]
CCDS34319.1 [Q6NTE8-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001017987.1, NM_001017987.2 [Q6NTE8-3]
NP_057259.2, NM_016175.3 [Q6NTE8-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.741169

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000292586; ENSP00000292586; ENSG00000161010 [Q6NTE8-1]
ENST00000376931; ENSP00000366130; ENSG00000161010 [Q6NTE8-3]
ENST00000639632; ENSP00000491991; ENSG00000283918 [Q6NTE8-1]
ENST00000640658; ENSP00000491128; ENSG00000283918 [Q6NTE8-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
51149

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51149

UCSC genome browser

More...
UCSCi
uc003mla.4 human [Q6NTE8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX537968 mRNA Translation: CAD97932.1 Different initiation.
AC008393 Genomic DNA No translation available.
BC002739 mRNA Translation: AAH02739.2
BC050714 mRNA No translation available.
BC069051 mRNA Translation: AAH69051.1
AF153685 mRNA Translation: AAD51611.1 Frameshift.
CCDSiCCDS34318.1 [Q6NTE8-3]
CCDS34319.1 [Q6NTE8-1]
RefSeqiNP_001017987.1, NM_001017987.2 [Q6NTE8-3]
NP_057259.2, NM_016175.3 [Q6NTE8-1]
UniGeneiHs.741169

3D structure databases

ProteinModelPortaliQ6NTE8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6NTE8, 11 interactors
STRINGi9606.ENSP00000292586

PTM databases

iPTMnetiQ6NTE8
PhosphoSitePlusiQ6NTE8

Polymorphism and mutation databases

BioMutaiMRNIP
DMDMi215273989

Proteomic databases

EPDiQ6NTE8
jPOSTiQ6NTE8
MaxQBiQ6NTE8
PaxDbiQ6NTE8
PeptideAtlasiQ6NTE8
PRIDEiQ6NTE8
ProteomicsDBi66668
66669 [Q6NTE8-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
51149
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292586; ENSP00000292586; ENSG00000161010 [Q6NTE8-1]
ENST00000376931; ENSP00000366130; ENSG00000161010 [Q6NTE8-3]
ENST00000639632; ENSP00000491991; ENSG00000283918 [Q6NTE8-1]
ENST00000640658; ENSP00000491128; ENSG00000283918 [Q6NTE8-3]
GeneIDi51149
KEGGihsa:51149
UCSCiuc003mla.4 human [Q6NTE8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51149
EuPathDBiHostDB:ENSG00000161010.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MRNIP
HGNCiHGNC:30817 MRNIP
HPAiHPA043975
MIMi617154 gene
neXtProtiNX_Q6NTE8
OpenTargetsiENSG00000161010
PharmGKBiPA162380286

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J2EG Eukaryota
ENOG411227Z LUCA
GeneTreeiENSGT00390000006124
HOGENOMiHOG000293216
HOVERGENiHBG106110
InParanoidiQ6NTE8
OMAiCDLFKTG
OrthoDBi1146272at2759
PhylomeDBiQ6NTE8
TreeFamiTF333430

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
C5orf45 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
51149

Protein Ontology

More...
PROi
PR:Q6NTE8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000161010 Expressed in 179 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiQ6NTE8 baseline and differential
GenevisibleiQ6NTE8 HS

Family and domain databases

InterProiView protein in InterPro
IPR032739 MRNIP
PANTHERiPTHR15863 PTHR15863, 1 hit
PfamiView protein in Pfam
PF15749 MRNIP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMRNIP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NTE8
Secondary accession number(s): B5MD09
, E9PAK6, Q7Z3D8, Q9BUC1, Q9UN54
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: November 25, 2008
Last modified: February 13, 2019
This is version 111 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again