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Protein

TMF-regulated nuclear protein 1

Gene

TRNP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

DNA-binding factor that regulates the expression of a subset of genes and plays a key role in tangential, radial, and lateral expansion of the brain neocortex. Regulates neural stem cells proliferation and the production of intermediate neural progenitors and basal radial glial cells affecting the process of cerebral cortex gyrification. May control the proliferation rate of cells by regulating their progression through key cell-cycle transition points (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processCell cycle, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
TMF-regulated nuclear protein 1
Gene namesi
Name:TRNP1
Synonyms:C1orf225, TRNP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000253368.3
HGNCiHGNC:34348 TRNP1
neXtProtiNX_Q6NT89

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000253368
PharmGKBiPA164727311

Polymorphism and mutation databases

BioMutaiTRNP1
DMDMi224471860

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003360881 – 227TMF-regulated nuclear protein 1Add BLAST227

Post-translational modificationi

Ubiquitinated, leading to its degradation by the proteasome.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ6NT89
PeptideAtlasiQ6NT89
PRIDEiQ6NT89
ProteomicsDBi66667

PTM databases

iPTMnetiQ6NT89
PhosphoSitePlusiQ6NT89

Expressioni

Developmental stagei

Expression is detected in the ventricular zone and neuronal layers of the developing cerebral cortex at 12, 18 and 21 gestation weeks. Differences in regional expression seem to correlate with the process of gyrification of the cortex. Highly expressed in germinal layers of the precentral and parahippocampal gyri, that exhibit little radial expansion and folding, and weakly expressed in germinal layers of the occipital and temporal lobes, that undergo greater expansion and folding.1 Publication

Gene expression databases

BgeeiENSG00000253368
CleanExiHS_C1orf225
ExpressionAtlasiQ6NT89 baseline and differential
GenevisibleiQ6NT89 HS

Interactioni

Subunit structurei

Interacts with TMF1; may regulate TRNP1 proteasomal degradation.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000429216

Structurei

3D structure databases

ProteinModelPortaliQ6NT89
SMRiQ6NT89
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi23 – 55Pro-richAdd BLAST33

Phylogenomic databases

eggNOGiENOG410IYYM Eukaryota
ENOG410Z8IN LUCA
GeneTreeiENSGT00390000017418
HOGENOMiHOG000154686
InParanoidiQ6NT89
OMAiCVPWGAG
OrthoDBiEOG091G148T
PhylomeDBiQ6NT89
TreeFamiTF338814

Sequencei

Sequence statusi: Complete.

Q6NT89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGCRISACG PGAQEGTAEQ RSPPPPWDPM PSSQPPPPTP TLTPTPTPGQ
60 70 80 90 100
SPPLPDAAGA SAGAAEDQEL QRWRQGASGI AGLAGPGGGS GAAAGAGGRA
110 120 130 140 150
LELAEARRRL LEVEGRRRLV SELESRVLQL HRVFLAAELR LAHRAESLSR
160 170 180 190 200
LSGGVAQAEL YLAAHGSRLK KGPRRGRRGR PPALLASALG LGGCVPWGAG
210 220
RLRRGHGPEP DSPFRRSPPR GPASPQR
Length:227
Mass (Da):23,482
Last modified:March 3, 2009 - v2
Checksum:i01FBA6DC86CCD7CA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04354527W → R1 PublicationCorresponds to variant dbSNP:rs6689941Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356390 Genomic DNA No translation available.
BC069216 mRNA Translation: AAH69216.1
CCDSiCCDS41289.1
RefSeqiNP_001013664.1, NM_001013642.2
XP_005245924.1, XM_005245867.3
UniGeneiHs.355747

Genome annotation databases

EnsembliENST00000522111; ENSP00000429216; ENSG00000253368
GeneIDi388610
KEGGihsa:388610
UCSCiuc001bnj.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTRNP1_HUMAN
AccessioniPrimary (citable) accession number: Q6NT89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 3, 2009
Last modified: June 20, 2018
This is version 91 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

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