Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

G antigen 2A

Gene

GAGE2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

Caution

The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
G antigen 2A
Short name:
GAGE-2A
Gene namesi
Name:GAGE2A
Synonyms:GAGE2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000189064.8
HGNCiHGNC:4099 GAGE2A
MIMi300720 gene
neXtProtiNX_Q6NT46

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000189064
PharmGKBiPA162389230

Polymorphism and mutation databases

BioMutaiGAGE2A
DMDMi74736753

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003954451 – 116G antigen 2AAdd BLAST116

Proteomic databases

MaxQBiQ6NT46
PaxDbiQ6NT46
PeptideAtlasiQ6NT46
PRIDEiQ6NT46
ProteomicsDBi66657
TopDownProteomicsiQ6NT46

PTM databases

iPTMnetiQ6NT46
PhosphoSitePlusiQ6NT46

Expressioni

Gene expression databases

BgeeiENSG00000189064
GenevisibleiQ6NT46 HS

Organism-specific databases

HPAiHPA043232

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000355421

Structurei

3D structure databases

ProteinModelPortaliQ6NT46
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

eggNOGiENOG410KIHC Eukaryota
ENOG4110Q8D LUCA
GeneTreeiENSGT00900000141202
HOGENOMiHOG000237345
HOVERGENiHBG056227
InParanoidiQ6NT46
OMAiNSREILW
OrthoDBiEOG091G0UGV
PhylomeDBiQ6NT46
TreeFamiTF340669

Family and domain databases

InterProiView protein in InterPro
IPR031320 GAGE
IPR008625 GAGE_fam
PANTHERiPTHR14047 PTHR14047, 1 hit
PfamiView protein in Pfam
PF05831 GAGE, 1 hit
SMARTiView protein in SMART
SM01379 GAGE, 1 hit

Sequencei

Sequence statusi: Complete.

Q6NT46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWRGRSTYR PRPRRYVEPP EMIGPMRPEQ FSDEVEPATP EEGEPATQRQ
60 70 80 90 100
DPAAAQEGQD EGASAGQGPK PEAHSQEQGH PQTGCECEDG PDGQEMDPPN
110
PEEVKTPEEG EKQSQC
Length:116
Mass (Da):12,785
Last modified:July 5, 2004 - v1
Checksum:iDD24495CB68EF19A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC142497 Genomic DNA No translation available.
BC069397 mRNA Translation: AAH69397.1
CCDSiCCDS48114.1
RefSeqiNP_001120684.1, NM_001127212.1
UniGeneiHs.460641
Hs.722100

Genome annotation databases

EnsembliENST00000362097; ENSP00000355421; ENSG00000189064
GeneIDi729447
KEGGihsa:729447
UCSCiuc004doi.6 human

Similar proteinsi

Entry informationi

Entry nameiGAG2A_HUMAN
AccessioniPrimary (citable) accession number: Q6NT46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 5, 2004
Last modified: June 20, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health