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Entry version 149 (08 May 2019)
Sequence version 3 (13 Nov 2007)
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Protein

Zinc finger and SCAN domain-containing protein 25

Gene

ZSCAN25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri348 – 370C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri403 – 425C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 480C2H2-type 5PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri486 – 508C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri514 – 536C2H2-type 7; degeneratePROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 25
Alternative name(s):
Zinc finger protein 498
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZSCAN25
Synonyms:ZNF498
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21961 ZSCAN25

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6NSZ9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
221785

Open Targets

More...
OpenTargetsi
ENSG00000197037

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134962723

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZSCAN25

Domain mapping of disease mutations (DMDM)

More...
DMDMi
160359044

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003093321 – 544Zinc finger and SCAN domain-containing protein 25Add BLAST544

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki3Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki22Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki128Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki278Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki285Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q6NSZ9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6NSZ9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6NSZ9

PeptideAtlas

More...
PeptideAtlasi
Q6NSZ9

PRoteomics IDEntifications database

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PRIDEi
Q6NSZ9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
66645
66646 [Q6NSZ9-2]
66647 [Q6NSZ9-3]
66648 [Q6NSZ9-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6NSZ9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6NSZ9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000197037 Expressed in 176 organ(s), highest expression level in female gonad

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6NSZ9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6NSZ9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA055127
HPA057173

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
128753, 25 interactors

Protein interaction database and analysis system

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IntActi
Q6NSZ9, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000377708

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q6NSZ9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini42 – 124SCAN boxPROSITE-ProRule annotationAdd BLAST83

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri348 – 370C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri403 – 425C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 480C2H2-type 5PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri486 – 508C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri514 – 536C2H2-type 7; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
ENOG41112SP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162113

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6NSZ9

KEGG Orthology (KO)

More...
KOi
K09229

Identification of Orthologs from Complete Genome Data

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OMAi
LGRTCEQ

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6NSZ9

TreeFam database of animal gene trees

More...
TreeFami
TF350842

Family and domain databases

Conserved Domains Database

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CDDi
cd07765 KRAB_A-box, 1 hit
cd07936 SCAN, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.4020.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 7 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6NSZ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLKEHPEMAE APQQQLGIPV VKLEKELPWG RGREDPSPET FRLRFRQFRY
60 70 80 90 100
QEAAGPQEAL RELQELCRRW LRPELHTKEQ ILELLVLEQF LTILPREFYA
110 120 130 140 150
WIREHGPESG KALAAMVEDL TERALEAKAV PCHRQGEQEE TALCRGAWEP
160 170 180 190 200
GIQLGPVEVK PEWGMPPGEG VQGPDPGTEE QLSQDPGDET RAFQEQALPV
210 220 230 240 250
LQAGPGLPAV NPRDQEMAAG FFTAGSQGLG PFKDMALAFP EEEWRHVTPA
260 270 280 290 300
QIDCFGEYVE PQDCRVSPGG GSKEKEAKPP QEDLKGALVA LTSERFGEAS
310 320 330 340 350
LQGPGLGRVC EQEPGGPAGS APGLPPPQHG AIPLPDEVKT HSSFWKPFQC
360 370 380 390 400
PECGKGFSRS SNLVRHQRTH EEKSYGCVEC GKGFTLREYL MKHQRTHLGK
410 420 430 440 450
RPYVCSECWK TFSQRHHLEV HQRSHTGEKP YKCGDCWKSF SRRQHLQVHR
460 470 480 490 500
RTHTGEKPYT CECGKSFSRN ANLAVHRRAH TGEKPYGCQV CGKRFSKGER
510 520 530 540
LVRHQRIHTG EKPYHCPACG RSFNQRSILN RHQKTQHRQE PLVQ
Length:544
Mass (Da):61,474
Last modified:November 13, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE63AA7ACDA7E7E8B
GO
Isoform 2 (identifier: Q6NSZ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     197-268: Missing.

Show »
Length:472
Mass (Da):53,733
Checksum:i3B5396BD57BD8B29
GO
Isoform 3 (identifier: Q6NSZ9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-216: Missing.

Show »
Length:328
Mass (Da):37,004
Checksum:i54ADCCF0A8BFF578
GO
Isoform 4 (identifier: Q6NSZ9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     130-544: VPCHRQGEQE...TQHRQEPLVQ → VGSMPQAGRAGGNSTLQRRLGARHPAGASGGQA

Show »
Length:162
Mass (Da):18,342
Checksum:i2DBAF62F0025F67A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DFN0A0A0C4DFN0_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN25
465Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9K079C9K079_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN25
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI14574 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI14942 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence BAD18712 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence EAL23869 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036931325P → A. Corresponds to variant dbSNP:rs10239632Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0291451 – 216Missing in isoform 3. 1 PublicationAdd BLAST216
Alternative sequenceiVSP_029146130 – 544VPCHR…EPLVQ → VGSMPQAGRAGGNSTLQRRL GARHPAGASGGQA in isoform 4. 2 PublicationsAdd BLAST415
Alternative sequenceiVSP_029147197 – 268Missing in isoform 2. 1 PublicationAdd BLAST72

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK160369 mRNA Translation: BAD18712.1 Different initiation.
BX640720 mRNA Translation: CAE45839.1
CH236956 Genomic DNA Translation: EAL23869.1 Sequence problems.
CH471091 Genomic DNA Translation: EAW76643.1
CH471091 Genomic DNA Translation: EAW76646.1
CH471091 Genomic DNA Translation: EAW76647.1
BC069644 mRNA Translation: AAH69644.2
BC074902 mRNA Translation: AAH74902.3
BC074903 mRNA Translation: AAH74903.3
BC089402 mRNA Translation: AAH89402.1
BC114573 mRNA Translation: AAI14574.1 Different initiation.
BC114941 mRNA Translation: AAI14942.1 Sequence problems.

The Consensus CDS (CCDS) project

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CCDSi
CCDS5671.2 [Q6NSZ9-1]

NCBI Reference Sequences

More...
RefSeqi
NP_660090.2, NM_145115.2 [Q6NSZ9-1]
XP_005250251.1, XM_005250194.2
XP_011514207.1, XM_011515905.2 [Q6NSZ9-1]
XP_011514208.1, XM_011515906.2
XP_011514209.1, XM_011515907.2 [Q6NSZ9-1]
XP_011514210.1, XM_011515908.2
XP_016867313.1, XM_017011824.1 [Q6NSZ9-1]
XP_016867314.1, XM_017011825.1
XP_016867315.1, XM_017011826.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000334715; ENSP00000334800; ENSG00000197037 [Q6NSZ9-1]
ENST00000394150; ENSP00000377706; ENSG00000197037 [Q6NSZ9-4]
ENST00000394152; ENSP00000377708; ENSG00000197037 [Q6NSZ9-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
221785

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:221785

UCSC genome browser

More...
UCSCi
uc003url.1 human [Q6NSZ9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK160369 mRNA Translation: BAD18712.1 Different initiation.
BX640720 mRNA Translation: CAE45839.1
CH236956 Genomic DNA Translation: EAL23869.1 Sequence problems.
CH471091 Genomic DNA Translation: EAW76643.1
CH471091 Genomic DNA Translation: EAW76646.1
CH471091 Genomic DNA Translation: EAW76647.1
BC069644 mRNA Translation: AAH69644.2
BC074902 mRNA Translation: AAH74902.3
BC074903 mRNA Translation: AAH74903.3
BC089402 mRNA Translation: AAH89402.1
BC114573 mRNA Translation: AAI14574.1 Different initiation.
BC114941 mRNA Translation: AAI14942.1 Sequence problems.
CCDSiCCDS5671.2 [Q6NSZ9-1]
RefSeqiNP_660090.2, NM_145115.2 [Q6NSZ9-1]
XP_005250251.1, XM_005250194.2
XP_011514207.1, XM_011515905.2 [Q6NSZ9-1]
XP_011514208.1, XM_011515906.2
XP_011514209.1, XM_011515907.2 [Q6NSZ9-1]
XP_011514210.1, XM_011515908.2
XP_016867313.1, XM_017011824.1 [Q6NSZ9-1]
XP_016867314.1, XM_017011825.1
XP_016867315.1, XM_017011826.1

3D structure databases

SMRiQ6NSZ9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128753, 25 interactors
IntActiQ6NSZ9, 7 interactors
STRINGi9606.ENSP00000377708

PTM databases

iPTMnetiQ6NSZ9
PhosphoSitePlusiQ6NSZ9

Polymorphism and mutation databases

BioMutaiZSCAN25
DMDMi160359044

Proteomic databases

EPDiQ6NSZ9
MaxQBiQ6NSZ9
PaxDbiQ6NSZ9
PeptideAtlasiQ6NSZ9
PRIDEiQ6NSZ9
ProteomicsDBi66645
66646 [Q6NSZ9-2]
66647 [Q6NSZ9-3]
66648 [Q6NSZ9-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334715; ENSP00000334800; ENSG00000197037 [Q6NSZ9-1]
ENST00000394150; ENSP00000377706; ENSG00000197037 [Q6NSZ9-4]
ENST00000394152; ENSP00000377708; ENSG00000197037 [Q6NSZ9-1]
GeneIDi221785
KEGGihsa:221785
UCSCiuc003url.1 human [Q6NSZ9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
221785
DisGeNETi221785

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZSCAN25
HGNCiHGNC:21961 ZSCAN25
HPAiHPA055127
HPA057173
neXtProtiNX_Q6NSZ9
OpenTargetsiENSG00000197037
PharmGKBiPA134962723

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
ENOG41112SP LUCA
GeneTreeiENSGT00940000162113
InParanoidiQ6NSZ9
KOiK09229
OMAiLGRTCEQ
OrthoDBi1318335at2759
PhylomeDBiQ6NSZ9
TreeFamiTF350842

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZSCAN25 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
221785

Protein Ontology

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PROi
PR:Q6NSZ9

Gene expression databases

BgeeiENSG00000197037 Expressed in 176 organ(s), highest expression level in female gonad
ExpressionAtlasiQ6NSZ9 baseline and differential
GenevisibleiQ6NSZ9 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
cd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 7 hits
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 7 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZSC25_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NSZ9
Secondary accession number(s): A4D290
, D6W5T5, Q14C82, Q14C99, Q5EBM9, Q6DJZ0, Q6N032, Q6ZML3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: May 8, 2019
This is version 149 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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