Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Coiled-coil domain-containing protein 70

Gene

CCDC70

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

It is uncertain whether Met-1 or Met-12 is the initiator.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 70
Gene namesi
Name:CCDC70
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000123171.6
HGNCiHGNC:25303 CCDC70
neXtProtiNX_Q6NSX1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000123171
PharmGKBiPA143485421

Polymorphism and mutation databases

BioMutaiCCDC70

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000023443233 – 233Coiled-coil domain-containing protein 70Add BLAST201

Proteomic databases

PaxDbiQ6NSX1
PeptideAtlasiQ6NSX1
PRIDEiQ6NSX1
ProteomicsDBi66644

PTM databases

iPTMnetiQ6NSX1
PhosphoSitePlusiQ6NSX1

Expressioni

Gene expression databases

BgeeiENSG00000123171 Expressed in 28 organ(s), highest expression level in right testis
CleanExiHS_CCDC70
GenevisibleiQ6NSX1 HS

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi123648, 4 interactors
IntActiQ6NSX1, 12 interactors
STRINGi9606.ENSP00000242819

Structurei

3D structure databases

ProteinModelPortaliQ6NSX1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili140 – 164Sequence analysisAdd BLAST25

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiENOG410IVG6 Eukaryota
ENOG410YWSA LUCA
GeneTreeiENSGT00510000049032
HOGENOMiHOG000230956
HOVERGENiHBG080013
InParanoidiQ6NSX1
OMAiKVSKWMG
OrthoDBiEOG091G0JWB
PhylomeDBiQ6NSX1
TreeFamiTF336984

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6NSX1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATPPFRLIR KMFSFKVSRW MGLACFRSLA ASSPSIRQKK LMHKLQEEKA
60 70 80 90 100
FREEMKIFRE KIEDFREEMW TFRGKIHAFR GQILGFWEEE RPFWEEEKTF
110 120 130 140 150
WKEEKSFWEM EKSFREEEKT FWKKYRTFWK EDKAFWKEDN ALWERDRNLL
160 170 180 190 200
QEDKALWEEE KALWVEERAL LEGEKALWED KTSLWEEENA LWEEERAFWM
210 220 230
ENNGHIAGEQ MLEDGPHNAN RGQRLLAFSR GRA
Length:233
Mass (Da):28,767
Last modified:July 5, 2004 - v1
Checksum:iC692D2230C2BD090
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti232R → G in BAC05391 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050763126R → C. Corresponds to variant dbSNP:rs17076052Ensembl.1
Natural variantiVAR_026238206I → V3 PublicationsCorresponds to variant dbSNP:rs1054515Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136887 mRNA Translation: CAB66821.1
AK098719 mRNA Translation: BAC05391.1
AL162377 Genomic DNA No translation available.
BC069691 mRNA Translation: AAH69691.1
BC069748 mRNA Translation: AAH69748.1
BC069770 mRNA Translation: AAH69770.1
BC069806 mRNA Translation: AAH69806.1
CCDSiCCDS9431.1
RefSeqiNP_001333004.1, NM_001346075.1
NP_112580.2, NM_031290.3
UniGeneiHs.120573

Genome annotation databases

EnsembliENST00000242819; ENSP00000242819; ENSG00000123171
GeneIDi83446
KEGGihsa:83446
UCSCiuc001vfu.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136887 mRNA Translation: CAB66821.1
AK098719 mRNA Translation: BAC05391.1
AL162377 Genomic DNA No translation available.
BC069691 mRNA Translation: AAH69691.1
BC069748 mRNA Translation: AAH69748.1
BC069770 mRNA Translation: AAH69770.1
BC069806 mRNA Translation: AAH69806.1
CCDSiCCDS9431.1
RefSeqiNP_001333004.1, NM_001346075.1
NP_112580.2, NM_031290.3
UniGeneiHs.120573

3D structure databases

ProteinModelPortaliQ6NSX1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123648, 4 interactors
IntActiQ6NSX1, 12 interactors
STRINGi9606.ENSP00000242819

PTM databases

iPTMnetiQ6NSX1
PhosphoSitePlusiQ6NSX1

Polymorphism and mutation databases

BioMutaiCCDC70

Proteomic databases

PaxDbiQ6NSX1
PeptideAtlasiQ6NSX1
PRIDEiQ6NSX1
ProteomicsDBi66644

Protocols and materials databases

DNASUi83446
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000242819; ENSP00000242819; ENSG00000123171
GeneIDi83446
KEGGihsa:83446
UCSCiuc001vfu.5 human

Organism-specific databases

CTDi83446
EuPathDBiHostDB:ENSG00000123171.6
GeneCardsiCCDC70
HGNCiHGNC:25303 CCDC70
neXtProtiNX_Q6NSX1
OpenTargetsiENSG00000123171
PharmGKBiPA143485421
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVG6 Eukaryota
ENOG410YWSA LUCA
GeneTreeiENSGT00510000049032
HOGENOMiHOG000230956
HOVERGENiHBG080013
InParanoidiQ6NSX1
OMAiKVSKWMG
OrthoDBiEOG091G0JWB
PhylomeDBiQ6NSX1
TreeFamiTF336984

Miscellaneous databases

GeneWikiiCCDC70
GenomeRNAii83446
PROiPR:Q6NSX1

Gene expression databases

BgeeiENSG00000123171 Expressed in 28 organ(s), highest expression level in right testis
CleanExiHS_CCDC70
GenevisibleiQ6NSX1 HS

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCCD70_HUMAN
AccessioniPrimary (citable) accession number: Q6NSX1
Secondary accession number(s): Q8N7A8, Q9H097
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again