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Entry version 106 (16 Oct 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Probable aminopeptidase NPEPL1

Gene

Npepl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probably catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.By similarity

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi260Zinc 2By similarity1
Metal bindingi265Zinc 1By similarity1
Metal bindingi265Zinc 2By similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei272Sequence analysis1
Metal bindingi283Zinc 2By similarity1
Metal bindingi342Zinc 1By similarity1
Metal bindingi344Zinc 1By similarity1
Metal bindingi344Zinc 2By similarity1
Active sitei346Sequence analysis1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminopeptidase, Hydrolase, Protease
LigandManganese, Metal-binding, Zinc

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M17.006

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable aminopeptidase NPEPL1 (EC:3.4.11.-)
Alternative name(s):
Aminopeptidase-like 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Npepl1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2448523 Npepl1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001658291 – 524Probable aminopeptidase NPEPL1Add BLAST524

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6NSR8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6NSR8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6NSR8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6NSR8

PRoteomics IDEntifications database

More...
PRIDEi
Q6NSR8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6NSR8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6NSR8

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q6NSR8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000039263 Expressed in 259 organ(s), highest expression level in brown adipose tissue

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6NSR8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6NSR8 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000042808

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6NSR8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M17 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2597 Eukaryota
COG0260 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063255

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000243131

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6NSR8

KEGG Orthology (KO)

More...
KOi
K09611

Identification of Orthologs from Complete Genome Data

More...
OMAi
VAYACKD

Database of Orthologous Groups

More...
OrthoDBi
562530at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6NSR8

TreeFam database of animal gene trees

More...
TreeFami
TF314954

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00433 Peptidase_M17, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011356 Leucine_aapep/pepB
IPR041417 NPEPL1_N
IPR000819 Peptidase_M17_C

The PANTHER Classification System

More...
PANTHERi
PTHR11963 PTHR11963, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18295 Pdase_M17_N2, 1 hit
PF00883 Peptidase_M17, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00481 LAMNOPPTDASE

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00631 CYTOSOL_AP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6NSR8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASVGLQFQA SAGDADPQSR PLLLLGQLQH LHRVPWSHVR GKLQPRVTEE
60 70 80 90 100
LWQAALATLN PNPTDSCPLY LNCATVAALP SRVSRHNSPS AAHFITRLVR
110 120 130 140 150
TCLPPGTHRC ILMVCEQTEV FASACALARA FPLFTHRSGA SRRAEKRTVM
160 170 180 190 200
VEFFLVGQDN GPVEVSTLQC LTNATEGVRL AARIVDTPCN EMNTDIFLEE
210 220 230 240 250
IIQVGKELGI TPTIIRDEQL KTKGFGGIYG VGKAALHPPA LAILSHTPDG
260 270 280 290 300
ATQTIAWVGK GIVYDTGGLS IKGKTTMPGM KRDCGGAAAV LGAFRAAIKQ
310 320 330 340 350
GFKDNLHAVF CLAENAVGPN ATRPDDIHLL YSGKTVEINN TDAEGRLVLA
360 370 380 390 400
DGVSYACKDL GADIIVDMAT LTGAQGIATG KYHAAVLTNS AEWEAACVKA
410 420 430 440 450
GRKCGDLVHP LVYCPELHFS EFTSAVADMK NSVADRDNSP SSCAGLFIAS
460 470 480 490 500
HIGFDWPGVW VHLDIAAPVH AGERATGFGV ALLLALFGRA SEDPLLNLVS
510 520
PLDCEVDAQE GDNMGRDSKR RRLV
Length:524
Mass (Da):55,940
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4B45CD164D1F65CC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6T2H5F6T2H5_MOUSE
Probable aminopeptidase NPEPL1
Npepl1
210Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL669896 Genomic DNA No translation available.
BC069933 mRNA Translation: AAH69933.1
BC080707 mRNA Translation: AAH80707.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS17148.1

NCBI Reference Sequences

More...
RefSeqi
NP_998898.1, NM_213733.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000044415; ENSMUSP00000042808; ENSMUSG00000039263

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
228961

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:228961

UCSC genome browser

More...
UCSCi
uc008oeo.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL669896 Genomic DNA No translation available.
BC069933 mRNA Translation: AAH69933.1
BC080707 mRNA Translation: AAH80707.1
CCDSiCCDS17148.1
RefSeqiNP_998898.1, NM_213733.2

3D structure databases

SMRiQ6NSR8
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042808

Protein family/group databases

MEROPSiM17.006

PTM databases

iPTMnetiQ6NSR8
PhosphoSitePlusiQ6NSR8
SwissPalmiQ6NSR8

Proteomic databases

EPDiQ6NSR8
jPOSTiQ6NSR8
MaxQBiQ6NSR8
PaxDbiQ6NSR8
PRIDEiQ6NSR8

Genome annotation databases

EnsembliENSMUST00000044415; ENSMUSP00000042808; ENSMUSG00000039263
GeneIDi228961
KEGGimmu:228961
UCSCiuc008oeo.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79716
MGIiMGI:2448523 Npepl1

Phylogenomic databases

eggNOGiKOG2597 Eukaryota
COG0260 LUCA
GeneTreeiENSGT00530000063255
HOGENOMiHOG000243131
InParanoidiQ6NSR8
KOiK09611
OMAiVAYACKD
OrthoDBi562530at2759
PhylomeDBiQ6NSR8
TreeFamiTF314954

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Npepl1 mouse

Protein Ontology

More...
PROi
PR:Q6NSR8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000039263 Expressed in 259 organ(s), highest expression level in brown adipose tissue
ExpressionAtlasiQ6NSR8 baseline and differential
GenevisibleiQ6NSR8 MM

Family and domain databases

CDDicd00433 Peptidase_M17, 1 hit
InterProiView protein in InterPro
IPR011356 Leucine_aapep/pepB
IPR041417 NPEPL1_N
IPR000819 Peptidase_M17_C
PANTHERiPTHR11963 PTHR11963, 1 hit
PfamiView protein in Pfam
PF18295 Pdase_M17_N2, 1 hit
PF00883 Peptidase_M17, 1 hit
PRINTSiPR00481 LAMNOPPTDASE
PROSITEiView protein in PROSITE
PS00631 CYTOSOL_AP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPEPL1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NSR8
Secondary accession number(s): A2ACM6, Q66JY0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2004
Last modified: October 16, 2019
This is version 106 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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