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Protein

Glucose-6-phosphatase 3

Gene

G6pc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function.4 Publications

Catalytic activityi

D-glucose 6-phosphate + H2O = D-glucose + phosphate.

Activity regulationi

Inhibited by vanadate.By similarity

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei79SubstrateSequence analysis1
Active sitei114Proton donorSequence analysis1
Binding sitei161SubstrateSequence analysis1
Active sitei167NucleophileBy similarity1

GO - Molecular functioni

  • glucose-6-phosphatase activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processGluconeogenesis

Enzyme and pathway databases

ReactomeiR-MMU-70263 Gluconeogenesis
UniPathwayi
UPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphatase 3 (EC:3.1.3.9)
Short name:
G-6-Pase 3
Short name:
G6Pase 3
Alternative name(s):
Ubiquitous glucose-6-phosphatase catalytic subunit-related protein
Gene namesi
Name:G6pc3
Synonyms:Ugrp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1915651 G6pc3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24LumenalSequence analysisAdd BLAST24
Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Topological domaini46 – 56CytoplasmicSequence analysisAdd BLAST11
Transmembranei57 – 77HelicalSequence analysisAdd BLAST21
Topological domaini78 – 108LumenalSequence analysisAdd BLAST31
Transmembranei109 – 129HelicalSequence analysisAdd BLAST21
Topological domaini130 – 138CytoplasmicSequence analysis9
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Topological domaini160 – 167LumenalSequence analysis8
Transmembranei168 – 186HelicalSequence analysisAdd BLAST19
Topological domaini187 – 197CytoplasmicSequence analysisAdd BLAST11
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
Topological domaini219 – 254LumenalSequence analysisAdd BLAST36
Transmembranei255 – 273HelicalSequence analysisAdd BLAST19
Topological domaini274 – 283CytoplasmicSequence analysis10
Transmembranei284 – 304HelicalSequence analysisAdd BLAST21
Topological domaini305 – 307LumenalSequence analysis3
Transmembranei308 – 328HelicalSequence analysisAdd BLAST21
Topological domaini329 – 346CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice display reduced glucose-6-phosphate hydrolytic activity in the brain. No phenotypic difference was noted at birth but 4 months old female mice display growth retardation. Mutant mice exhibit a decreased plasma cholesterol concentration and an increased plasma glucagon concentration but no difference in blood glucose concentration (PubMed:17023421). Mice display neutropenia and neutrophil dysfunctions.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003345131 – 346Glucose-6-phosphatase 3Add BLAST346

Proteomic databases

EPDiQ6NSQ9
MaxQBiQ6NSQ9
PaxDbiQ6NSQ9
PeptideAtlasiQ6NSQ9
PRIDEiQ6NSQ9

PTM databases

iPTMnetiQ6NSQ9
PhosphoSitePlusiQ6NSQ9
SwissPalmiQ6NSQ9

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in heart, brain, kidney and testis and to a lower extent in lung, spleen, stomach, small intestine, skeletal muscle and uterus. Expressed in muscle, brain, thymus, lung, kidney, spleen and pancreas (at protein level).3 Publications

Gene expression databases

BgeeiENSMUSG00000034793 Expressed in 259 organ(s), highest expression level in testis
GenevisibleiQ6NSQ9 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064276

Structurei

3D structure databases

ProteinModelPortaliQ6NSQ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-6-phosphatase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IDXG Eukaryota
ENOG4110AJ7 LUCA
GeneTreeiENSGT00510000046465
HOGENOMiHOG000264239
HOVERGENiHBG003560
InParanoidiQ6NSQ9
KOiK01084
OMAiTLWPCLV
OrthoDBiEOG091G0AXF
PhylomeDBiQ6NSQ9
TreeFamiTF324388

Family and domain databases

InterProiView protein in InterPro
IPR016275 Glucose-6-phosphatase
IPR036938 P_Acid_Pase_2/haloperoxi_sf
IPR000326 P_Acid_Pase_2/haloperoxidase
PfamiView protein in Pfam
PF01569 PAP2, 1 hit
PIRSFiPIRSF000905 Glucose-6-phosphatase, 1 hit
SMARTiView protein in SMART
SM00014 acidPPc, 1 hit
SUPFAMiSSF48317 SSF48317, 1 hit

Sequencei

Sequence statusi: Complete.

Q6NSQ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESTLSAGII MAEALQNRLP GLENMWLWVT FLGDPKNLFQ FCFPAAYYAS
60 70 80 90 100
RRLGISVLWI TFIAEWLNLV FKWFLFGDRP FWWVHESGYS TQTPIQIHQF
110 120 130 140 150
PSSCETGPGS PSGHCMITGA ALWPVMTAIS SQVASRSRSP WVRVIPGLAY
160 170 180 190 200
CTFLLAVGLS RVFLLAHFPH QVLGGLIVGA ALGWLMSPRV PMERELSFYG
210 220 230 240 250
LTALALMLGA SLMYWTLFTL GLDLSWSINL ASKWCERPEW VHMDSRPFAS
260 270 280 290 300
LSRDSGSALG LGIALHTPCY AQIRRAHLGN GQKIACFVLA MGLLVFLEWL
310 320 330 340
GYPPQISLFY IFNFLKYTLW PCLVLALVPW VVHTLSDQEA PPIRSS
Length:346
Mass (Da):38,782
Last modified:July 5, 2004 - v1
Checksum:i50CDA634BCABA014
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti136R → Q in BAE38159 (PubMed:16141072).Curated1
Sequence conflicti207M → L in AAO39164 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY186239 mRNA Translation: AAO39164.1
AK165395 mRNA Translation: BAE38159.1
AL954730 Genomic DNA No translation available.
BC069959 mRNA Translation: AAH69959.1
CCDSiCCDS25491.1
RefSeqiNP_787949.2, NM_175935.3
UniGeneiMm.22385

Genome annotation databases

EnsembliENSMUST00000070334; ENSMUSP00000064276; ENSMUSG00000034793
ENSMUST00000078975; ENSMUSP00000077995; ENSMUSG00000034793
GeneIDi68401
KEGGimmu:68401
UCSCiuc007lqt.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY186239 mRNA Translation: AAO39164.1
AK165395 mRNA Translation: BAE38159.1
AL954730 Genomic DNA No translation available.
BC069959 mRNA Translation: AAH69959.1
CCDSiCCDS25491.1
RefSeqiNP_787949.2, NM_175935.3
UniGeneiMm.22385

3D structure databases

ProteinModelPortaliQ6NSQ9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064276

PTM databases

iPTMnetiQ6NSQ9
PhosphoSitePlusiQ6NSQ9
SwissPalmiQ6NSQ9

Proteomic databases

EPDiQ6NSQ9
MaxQBiQ6NSQ9
PaxDbiQ6NSQ9
PeptideAtlasiQ6NSQ9
PRIDEiQ6NSQ9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070334; ENSMUSP00000064276; ENSMUSG00000034793
ENSMUST00000078975; ENSMUSP00000077995; ENSMUSG00000034793
GeneIDi68401
KEGGimmu:68401
UCSCiuc007lqt.2 mouse

Organism-specific databases

CTDi92579
MGIiMGI:1915651 G6pc3

Phylogenomic databases

eggNOGiENOG410IDXG Eukaryota
ENOG4110AJ7 LUCA
GeneTreeiENSGT00510000046465
HOGENOMiHOG000264239
HOVERGENiHBG003560
InParanoidiQ6NSQ9
KOiK01084
OMAiTLWPCLV
OrthoDBiEOG091G0AXF
PhylomeDBiQ6NSQ9
TreeFamiTF324388

Enzyme and pathway databases

UniPathwayi
UPA00138

ReactomeiR-MMU-70263 Gluconeogenesis

Miscellaneous databases

PROiPR:Q6NSQ9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034793 Expressed in 259 organ(s), highest expression level in testis
GenevisibleiQ6NSQ9 MM

Family and domain databases

InterProiView protein in InterPro
IPR016275 Glucose-6-phosphatase
IPR036938 P_Acid_Pase_2/haloperoxi_sf
IPR000326 P_Acid_Pase_2/haloperoxidase
PfamiView protein in Pfam
PF01569 PAP2, 1 hit
PIRSFiPIRSF000905 Glucose-6-phosphatase, 1 hit
SMARTiView protein in SMART
SM00014 acidPPc, 1 hit
SUPFAMiSSF48317 SSF48317, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG6PC3_MOUSE
AccessioniPrimary (citable) accession number: Q6NSQ9
Secondary accession number(s): Q3TND0, Q811R8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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