UniProtKB - Q6NSJ8 (Q6NSJ8_HUMAN)
Protein
Submitted name:
CSF2RB protein
Gene
CSF2RB
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: CSF2RB proteinImportedSubmitted name: Cytokine receptor common subunit betaImported |
Gene namesi | Name:CSF2RBImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2436, CSF2RB |
VEuPathDBi | HostDB:ENSG00000100368.13 |
Subcellular locationi
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 442 – 468 | HelicalSequence analysisAdd BLAST | 27 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_5014310554 | 23 – 889 | Sequence analysisAdd BLAST | 867 |
Proteomic databases
PRIDEi | Q6NSJ8 |
ProteomicsDBi | 66640 |
Expressioni
Gene expression databases
Bgeei | ENSG00000100368, Expressed in blood and 186 other tissues |
ExpressionAtlasi | Q6NSJ8, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 133 – 240 | Fibronectin type-IIIInterPro annotationAdd BLAST | 108 | |
Domaini | 339 – 436 | Fibronectin type-IIIInterPro annotationAdd BLAST | 98 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 498 – 517 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 532 – 630 | DisorderedSequence analysisAdd BLAST | 99 | |
Regioni | 648 – 812 | DisorderedSequence analysisAdd BLAST | 165 | |
Regioni | 830 – 850 | DisorderedSequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 562 – 576 | Pro-richSequence analysisAdd BLAST | 15 | |
Compositional biasi | 715 – 745 | PolarSequence analysisAdd BLAST | 31 |
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00510000048963 |
Family and domain databases
CDDi | cd00063, FN3, 2 hits |
Gene3Di | 2.60.40.10, 4 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR003531, Hempt_rcpt_S_F1_CS IPR013783, Ig-like_fold IPR011365, IL3_rcpt_beta IPR015373, Interferon/interleukin_rcp_dom |
Pfami | View protein in Pfam PF09294, Interfer-bind, 1 hit |
PIRSFi | PIRSF001956, IL3R_beta_c, 1 hit |
SMARTi | View protein in SMART SM00060, FN3, 2 hits |
SUPFAMi | SSF49265, SSF49265, 4 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 2 hits PS01355, HEMATOPO_REC_S_F1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q6NSJ8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVLAQGLLSM ALLALCWERS LAGAEETIPL QTLRCYNDYT SHITCRWADT
60 70 80 90 100
QDAQRLVNVT LIRRVNEDLL EPVSCDLSDD MPWSACPHPR CVPRRCVIPC
110 120 130 140 150
QSFVVTDVDY FSFQPDRPLG TRLTVTLTQH VQPPEPRDLQ ISTDQDHFLL
160 170 180 190 200
TWSVALGSPQ SHWLSPGDLE FEVVYKRLQD SWEDAAILLS NTSQATLGPE
210 220 230 240 250
HLMPSSTYVA RVRTRLAPGS RLSGRPSKWS PEVCWDSQPG DEAQPQNLEC
260 270 280 290 300
FFDGAAVLSC SWEVRKEVAS SVSFGLFYKP SPDAGEEECS PVLREGLGSL
310 320 330 340 350
HTRHHCQIPV PDPATHGQYI VSVQPRRAEK HIKSSVNIQM APPSLNVTKD
360 370 380 390 400
GDSYSLRWET MKMRYEHIDH TFEIQYRKDT ATWKDSKTET LQNAHSMALP
410 420 430 440 450
ALEPSTRYWA RVRVRTSRTG YNGIWSEWSE ARSWDTESVL PMWVLALIVI
460 470 480 490 500
FLTIAVLLAL RFCGIYGYRL RRKWEEKIPN PSKSHLFQNG SAELWPPGSM
510 520 530 540 550
SAFTSGSPPH QGPWGSRFPE LEGVFPVGFG DSEVSPLTIE DPKHVCDPPS
560 570 580 590 600
GPDTTPAASD LPTEQPPSPQ PGPPAASHTP EKQASSFDFN GPYLGPPHSR
610 620 630 640 650
SLPDILGQPE PPQEGGSQKS PPPGSLEYLC LPAGGQVQLV PLAQAMGPGQ
660 670 680 690 700
AVEVERRPSQ GAAGSPSLES GGGPAPPALG PRVGGQDQKD SPVAIPMSSG
710 720 730 740 750
DTEDPGVASG YVSSADLVFT PNSGASSVSL VPSLGLPSDQ TPSLCPGLAS
760 770 780 790 800
GPPGAPGPVK SGFEGYVELP PIEGRSPRSP RNNPVPPEAK SPVLNPGERP
810 820 830 840 850
ADVSPTSPQP EGLLVLQQVG DYCFLPGLGP GPLSLRSKPS SPGPGPEIKN
860 870 880
LDQAFQVKKP PGQAVPQVPV IQLFKALVVS VMSVGPPVP
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP32927 | IL3RB_HUMAN | Cytokine receptor common subunit be... | CSF2RB IL3RB, IL5RB | 897 | Annotation score: | ||
B0QY07 | B0QY07_HUMAN | Cytokine receptor common subunit be... | CSF2RB | 228 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL008637 Genomic DNA No translation available. AL133392 Genomic DNA No translation available. BC070085 mRNA Translation: AAH70085.1 |
RefSeqi | NP_000386.1, NM_000395.2 |
Genome annotation databases
Ensembli | ENST00000262825; ENSP00000262825; ENSG00000100368 |
GeneIDi | 1439 |
KEGGi | hsa:1439 |
UCSCi | uc062dvk.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL008637 Genomic DNA No translation available. AL133392 Genomic DNA No translation available. BC070085 mRNA Translation: AAH70085.1 |
RefSeqi | NP_000386.1, NM_000395.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PRIDEi | Q6NSJ8 |
ProteomicsDBi | 66640 |
Protocols and materials databases
Antibodypediai | 4136, 710 antibodies |
DNASUi | 1439 |
Genome annotation databases
Ensembli | ENST00000262825; ENSP00000262825; ENSG00000100368 |
GeneIDi | 1439 |
KEGGi | hsa:1439 |
UCSCi | uc062dvk.1, human |
Organism-specific databases
CTDi | 1439 |
HGNCi | HGNC:2436, CSF2RB |
OpenTargetsi | ENSG00000100368 |
PharmGKBi | PA26939 |
VEuPathDBi | HostDB:ENSG00000100368.13 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00510000048963 |
Miscellaneous databases
BioGRID-ORCSi | 1439, 8 hits in 876 CRISPR screens |
ChiTaRSi | CSF2RB, human |
GenomeRNAii | 1439 |
Gene expression databases
Bgeei | ENSG00000100368, Expressed in blood and 186 other tissues |
ExpressionAtlasi | Q6NSJ8, baseline and differential |
Family and domain databases
CDDi | cd00063, FN3, 2 hits |
Gene3Di | 2.60.40.10, 4 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR003531, Hempt_rcpt_S_F1_CS IPR013783, Ig-like_fold IPR011365, IL3_rcpt_beta IPR015373, Interferon/interleukin_rcp_dom |
Pfami | View protein in Pfam PF09294, Interfer-bind, 1 hit |
PIRSFi | PIRSF001956, IL3R_beta_c, 1 hit |
SMARTi | View protein in SMART SM00060, FN3, 2 hits |
SUPFAMi | SSF49265, SSF49265, 4 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 2 hits PS01355, HEMATOPO_REC_S_F1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6NSJ8_HUMAN | |
Accessioni | Q6NSJ8Primary (citable) accession number: Q6NSJ8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 5, 2004 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 10, 2021 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |