UniProtKB - Q6NSI8 (K1841_HUMAN)
Protein
Uncharacterized protein KIAA1841
Gene
KIAA1841
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Uncharacterized protein KIAA1841 |
Gene namesi | Name:KIAA1841 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000162929.13 |
HGNCi | HGNC:29387, KIAA1841 |
neXtProti | NX_Q6NSI8 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 84542 |
OpenTargetsi | ENSG00000162929 |
PharmGKBi | PA144596415 |
Miscellaneous databases
Pharosi | Q6NSI8, Tdark |
Polymorphism and mutation databases
BioMutai | KIAA1841 |
DMDMi | 172046130 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000324598 | 1 – 718 | Uncharacterized protein KIAA1841Add BLAST | 718 |
Proteomic databases
MassIVEi | Q6NSI8 |
PaxDbi | Q6NSI8 |
PeptideAtlasi | Q6NSI8 |
PRIDEi | Q6NSI8 |
ProteomicsDBi | 66632 [Q6NSI8-1] 66633 [Q6NSI8-2] 66634 [Q6NSI8-3] 66635 [Q6NSI8-4] |
PTM databases
iPTMneti | Q6NSI8 |
PhosphoSitePlusi | Q6NSI8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000162929, Expressed in bronchial epithelial cell and 194 other tissues |
ExpressionAtlasi | Q6NSI8, baseline and differential |
Genevisiblei | Q6NSI8, HS |
Organism-specific databases
HPAi | ENSG00000162929, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 124129, 7 interactors |
IntActi | Q6NSI8, 6 interactors |
STRINGi | 9606.ENSP00000385579 |
Miscellaneous databases
RNActi | Q6NSI8, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the KIAA1841 family.Curated
Phylogenomic databases
eggNOGi | ENOG502QRE4, Eukaryota |
GeneTreei | ENSGT00390000008178 |
HOGENOMi | CLU_016494_0_0_1 |
InParanoidi | Q6NSI8 |
OMAi | ERRIPCV |
OrthoDBi | 904755at2759 |
PhylomeDBi | Q6NSI8 |
TreeFami | TF324503 |
Family and domain databases
CDDi | cd00167, SANT, 1 hit |
InterProi | View protein in InterPro IPR021777, DUF3342 IPR001005, SANT/Myb |
Pfami | View protein in Pfam PF11822, DUF3342, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6NSI8-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSRGYSENNN FLNNNNQMVL DMILYPLIGI PQTINWETIA RLVPGLTPKE
60 70 80 90 100
CAKRFDELKS SGSSPVDNQY NSLMAAGESP VETLATYIKS SLLDIHGEFQ
110 120 130 140 150
ETPVGHDAVS KTGRHSIAST RNCSSESENC TTHNGGEMTE ESEGPNMVIH
160 170 180 190 200
VCDEAKNLKE DFTCPRDLLI SEMKYFAEYL SMDAQRWEEV DISVHCDVHI
210 220 230 240 250
FNWLIKYIKR NTKENKDCEM PTLEPGNVIS ILISSEFLKM DSLVEQCIQY
260 270 280 290 300
CHKNMNAIVA TPCNMNCINA NLLTRIADLF SHNEVDDLKD KKDKFKSKLF
310 320 330 340 350
CKKIERLFDP EYLNPDSRSN AATLYRCCLC KKLLTKETER RIPCIPGKIN
360 370 380 390 400
VDRRGNIVYI HIRDKTWDVH EYLNSLFEEL KSWRDVYWRL WGTINWLTCS
410 420 430 440 450
RCYQAFLCIE FSHCQYHSET VVYPTAASSL NTVGTGIYPC CNQKVLRFDP
460 470 480 490 500
TQLTKGCKVR DHMVTLRDQG EGGDLPSCPT ARMLDDLHKY RDVIVVPFSK
510 520 530 540 550
DTVSDVGVGL CDEKGIECDV LLEPNTPWGP KTGELNAFLS LKNWTLQLKQ
560 570 580 590 600
QSLFSEEEEY TTGSEVTEDE VGDEEEVSKK QRKKEKPKKF TRQPKKQVSS
610 620 630 640 650
PCAQRKEKAL EKSASRDVSP FVMSMQKNKW DATRSLRFNQ DAQREDDQRR
660 670 680 690 700
MTEITGHLIK MRLGDLDRVK SKEAKEFAGG IYSRLEAQIK ASVPVSARQS
710
SSEKNTRSKS RFGQGRPA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF8VWD7 | F8VWD7_HUMAN | Uncharacterized protein KIAA1841 | KIAA1841 | 116 | Annotation score: |
Sequence cautioni
The sequence BAB47470 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 207 | Y → F in BAB47470 (PubMed:11347906).Curated | 1 | |
Sequence conflicti | 215 | N → S in AAH70104 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 398 | T → A in AAH70104 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 640 | Q → K in AAH39298 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Isoform 2 (identifier: Q6NSI8-2) | |||||
Natural variantiVAR_082836 | 685 | G → SCuratedCorresponds to variant dbSNP:rs13424173Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_032299 | 1 – 146 | Missing in isoform 3. 1 PublicationAdd BLAST | 146 | |
Alternative sequenceiVSP_032300 | 364 – 379 | DKTWD…SLFEE → CREDKIHTCIFVYIYI in isoform 4. 1 PublicationAdd BLAST | 16 | |
Alternative sequenceiVSP_032301 | 380 – 718 | Missing in isoform 4. 1 PublicationAdd BLAST | 339 | |
Alternative sequenceiVSP_032302 | 677 – 718 | FAGGI…QGRPA → TDKLRPRDGTVSKSNRKSGL SSVLLMTVLLC in isoform 2. 1 PublicationAdd BLAST | 42 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK131267 mRNA Translation: BAD18445.1 BC039298 mRNA Translation: AAH39298.1 BC070104 mRNA Translation: AAH70104.1 AB058744 mRNA Translation: BAB47470.1 Different initiation. |
CCDSi | CCDS1867.1 [Q6NSI8-2] CCDS46296.1 [Q6NSI8-1] CCDS82456.1 [Q6NSI8-3] |
RefSeqi | NP_001123465.1, NM_001129993.2 [Q6NSI8-1] NP_001317361.1, NM_001330432.1 [Q6NSI8-3] NP_001317362.1, NM_001330433.1 [Q6NSI8-2] NP_001317364.1, NM_001330435.1 [Q6NSI8-2] NP_001317365.1, NM_001330436.1 [Q6NSI8-1] NP_115895.2, NM_032506.3 [Q6NSI8-2] XP_011531429.1, XM_011533127.2 |
Genome annotation databases
Ensembli | ENST00000295031; ENSP00000295031; ENSG00000162929 [Q6NSI8-2] ENST00000356719; ENSP00000349154; ENSG00000162929 [Q6NSI8-2] ENST00000402291; ENSP00000385579; ENSG00000162929 [Q6NSI8-1] ENST00000453873; ENSP00000416795; ENSG00000162929 [Q6NSI8-1] ENST00000612149; ENSP00000482126; ENSG00000162929 [Q6NSI8-3] |
GeneIDi | 84542 |
KEGGi | hsa:84542 |
UCSCi | uc002saw.5, human [Q6NSI8-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK131267 mRNA Translation: BAD18445.1 BC039298 mRNA Translation: AAH39298.1 BC070104 mRNA Translation: AAH70104.1 AB058744 mRNA Translation: BAB47470.1 Different initiation. |
CCDSi | CCDS1867.1 [Q6NSI8-2] CCDS46296.1 [Q6NSI8-1] CCDS82456.1 [Q6NSI8-3] |
RefSeqi | NP_001123465.1, NM_001129993.2 [Q6NSI8-1] NP_001317361.1, NM_001330432.1 [Q6NSI8-3] NP_001317362.1, NM_001330433.1 [Q6NSI8-2] NP_001317364.1, NM_001330435.1 [Q6NSI8-2] NP_001317365.1, NM_001330436.1 [Q6NSI8-1] NP_115895.2, NM_032506.3 [Q6NSI8-2] XP_011531429.1, XM_011533127.2 |
3D structure databases
SMRi | Q6NSI8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124129, 7 interactors |
IntActi | Q6NSI8, 6 interactors |
STRINGi | 9606.ENSP00000385579 |
PTM databases
iPTMneti | Q6NSI8 |
PhosphoSitePlusi | Q6NSI8 |
Polymorphism and mutation databases
BioMutai | KIAA1841 |
DMDMi | 172046130 |
Proteomic databases
MassIVEi | Q6NSI8 |
PaxDbi | Q6NSI8 |
PeptideAtlasi | Q6NSI8 |
PRIDEi | Q6NSI8 |
ProteomicsDBi | 66632 [Q6NSI8-1] 66633 [Q6NSI8-2] 66634 [Q6NSI8-3] 66635 [Q6NSI8-4] |
Protocols and materials databases
Antibodypediai | 30587, 52 antibodies |
Genome annotation databases
Ensembli | ENST00000295031; ENSP00000295031; ENSG00000162929 [Q6NSI8-2] ENST00000356719; ENSP00000349154; ENSG00000162929 [Q6NSI8-2] ENST00000402291; ENSP00000385579; ENSG00000162929 [Q6NSI8-1] ENST00000453873; ENSP00000416795; ENSG00000162929 [Q6NSI8-1] ENST00000612149; ENSP00000482126; ENSG00000162929 [Q6NSI8-3] |
GeneIDi | 84542 |
KEGGi | hsa:84542 |
UCSCi | uc002saw.5, human [Q6NSI8-1] |
Organism-specific databases
CTDi | 84542 |
DisGeNETi | 84542 |
EuPathDBi | HostDB:ENSG00000162929.13 |
GeneCardsi | KIAA1841 |
HGNCi | HGNC:29387, KIAA1841 |
HPAi | ENSG00000162929, Low tissue specificity |
neXtProti | NX_Q6NSI8 |
OpenTargetsi | ENSG00000162929 |
PharmGKBi | PA144596415 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QRE4, Eukaryota |
GeneTreei | ENSGT00390000008178 |
HOGENOMi | CLU_016494_0_0_1 |
InParanoidi | Q6NSI8 |
OMAi | ERRIPCV |
OrthoDBi | 904755at2759 |
PhylomeDBi | Q6NSI8 |
TreeFami | TF324503 |
Enzyme and pathway databases
PathwayCommonsi | Q6NSI8 |
Miscellaneous databases
BioGRID-ORCSi | 84542, 17 hits in 848 CRISPR screens |
ChiTaRSi | KIAA1841, human |
GenomeRNAii | 84542 |
Pharosi | Q6NSI8, Tdark |
PROi | PR:Q6NSI8 |
RNActi | Q6NSI8, protein |
Gene expression databases
Bgeei | ENSG00000162929, Expressed in bronchial epithelial cell and 194 other tissues |
ExpressionAtlasi | Q6NSI8, baseline and differential |
Genevisiblei | Q6NSI8, HS |
Family and domain databases
CDDi | cd00167, SANT, 1 hit |
InterProi | View protein in InterPro IPR021777, DUF3342 IPR001005, SANT/Myb |
Pfami | View protein in Pfam PF11822, DUF3342, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | K1841_HUMAN | |
Accessioni | Q6NSI8Primary (citable) accession number: Q6NSI8 Secondary accession number(s): Q49AF0, Q6ZND0, Q96JI6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 18, 2008 |
Last sequence update: | March 18, 2008 | |
Last modified: | December 2, 2020 | |
This is version 141 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM