UniProtKB - Q6NS60 (FBX41_MOUSE)
Protein
F-box only protein 41
Gene
Fbxo41
Organism
Mus musculus (Mouse)
Status
Functioni
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity
Keywordsi
Biological process | Ubl conjugation pathway |
Enzyme and pathway databases
Reactomei | R-MMU-8951664, Neddylation R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Names & Taxonomyi
Protein namesi | Recommended name: F-box only protein 41 |
Gene namesi | Name:Fbxo41 Synonyms:D6Ertd538e, Kiaa1940 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1261912, Fbxo41 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000119941 | 1 – 873 | F-box only protein 41Add BLAST | 873 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 358 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 476 | PhosphoserineCombined sources | 1 | |
Modified residuei | 477 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 760 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
MaxQBi | Q6NS60 |
PaxDbi | Q6NS60 |
PRIDEi | Q6NS60 |
ProteomicsDBi | 271676 |
PTM databases
iPTMneti | Q6NS60 |
PhosphoSitePlusi | Q6NS60 |
SwissPalmi | Q6NS60 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000047013, Expressed in primary visual cortex and 127 other tissues |
ExpressionAtlasi | Q6NS60, baseline and differential |
Genevisiblei | Q6NS60, MM |
Interactioni
Subunit structurei
Directly interacts with SKP1 and CUL1.
By similarityProtein-protein interaction databases
BioGRIDi | 236950, 7 interactors |
IntActi | Q6NS60, 3 interactors |
STRINGi | 10090.ENSMUSP00000124754 |
Miscellaneous databases
RNActi | Q6NS60, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 548 – 592 | F-boxAdd BLAST | 45 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 207 – 349 | Sequence analysisAdd BLAST | 143 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 51 – 61 | Poly-AlaAdd BLAST | 11 | |
Compositional biasi | 107 – 112 | Poly-His | 6 | |
Compositional biasi | 357 – 362 | Poly-Gly | 6 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG4341, Eukaryota |
GeneTreei | ENSGT00530000063713 |
HOGENOMi | CLU_018140_0_0_1 |
InParanoidi | Q6NS60 |
OMAi | QNWHRRP |
OrthoDBi | 236860at2759 |
PhylomeDBi | Q6NS60 |
TreeFami | TF329439 |
Family and domain databases
InterProi | View protein in InterPro IPR036047, F-box-like_dom_sf IPR001810, F-box_dom |
Pfami | View protein in Pfam PF12937, F-box-like, 1 hit |
SUPFAMi | SSF81383, SSF81383, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6NS60-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASLDLPYRC PRCGEHKRFR SLSSLRAHLE YSHTYETLYI LSKTNSICDG
60 70 80 90 100
AAAAAAAAAA ASGFPLAPEP AALLAVPGAR REVFESTSFQ GKEQATGPSP
110 120 130 140 150
AGPHLLHHHH HHAPLAHFPA DLVPASLPCE ELAEPGLVPA ARYALREIEI
160 170 180 190 200
PLGELFARKS VASSACSTPP PGPGPGPCSG PSSASPASPS PADVAYEEGL
210 220 230 240 250
ARLKIRALEK LEVDRRLERL SEEVEQKIAG QVGRLQAELE RKAAELETAR
260 270 280 290 300
QESARLGREK EELEERASEL SRQVDVSVEL LASLKQDLVH KEQELSRKQQ
310 320 330 340 350
EVVQIDQFLK ETAAREASAK LRLQQFIEEL LERADRAERQ LQVISSSCGS
360 370 380 390 400
TPSASLGRGG GGSASGPGVR GPGRMREHHA GSAVPSTYAV SRHGSSPSTG
410 420 430 440 450
ASSRVPAASQ SSGCYDSDSL ELPRPEEGPS EDSGPGGLGS RAQATNGGSE
460 470 480 490 500
RSQAPRSSGL RRQAIQNWQR RPRRHSTEGE EGDVSDVGSR TTESEAEGPS
510 520 530 540 550
DVPRPGPAVA GPLNSCRLSA RPEGGSGRGR RVERGSPSRS NEVISPEILK
560 570 580 590 600
MRAALFCIFT YLDTRTLLHA AEVCRDWRFV ARHPAVWTRV LLENARVCSK
610 620 630 640 650
FLAMLAQWCT QAHSLTLQNL KPRQRGKKES KEEYARSTRG CLEAGLESLL
660 670 680 690 700
KAAGGNLLIL RISHCPNILT DRSLWLASCY CRALQAVTYR SATDPVGHEV
710 720 730 740 750
IWALGAGCRD IVSLQVAPLH PCQQPTRFSN RCLQMIGRCW PHLRALGVGG
760 770 780 790 800
AGCGVQGLAS LARNCMRLQV LELDHVSEIT QEVAAEVCRE GLKGLEMLVL
810 820 830 840 850
TATPVTPKAL LHFNSICRNL KSIVVQIGIA DYFKEPSSPE AQKLFEDMVT
860 870
KLQALRRRPG FSKILHIKVE GGC
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC061475 mRNA Translation: AAH61475.1 BC070445 mRNA Translation: AAH70445.1 AK129466 mRNA Translation: BAC98276.1 |
CCDSi | CCDS20296.1 |
RefSeqi | NP_001001160.1, NM_001001160.3 NP_001276603.1, NM_001289674.1 NP_001276604.1, NM_001289675.1 |
Genome annotation databases
Ensembli | ENSMUST00000159062; ENSMUSP00000125671; ENSMUSG00000047013 ENSMUST00000161078; ENSMUSP00000124524; ENSMUSG00000047013 ENSMUST00000161546; ENSMUSP00000124754; ENSMUSG00000047013 |
GeneIDi | 330369 |
KEGGi | mmu:330369 |
UCSCi | uc009cpw.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC061475 mRNA Translation: AAH61475.1 BC070445 mRNA Translation: AAH70445.1 AK129466 mRNA Translation: BAC98276.1 |
CCDSi | CCDS20296.1 |
RefSeqi | NP_001001160.1, NM_001001160.3 NP_001276603.1, NM_001289674.1 NP_001276604.1, NM_001289675.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 236950, 7 interactors |
IntActi | Q6NS60, 3 interactors |
STRINGi | 10090.ENSMUSP00000124754 |
PTM databases
iPTMneti | Q6NS60 |
PhosphoSitePlusi | Q6NS60 |
SwissPalmi | Q6NS60 |
Proteomic databases
MaxQBi | Q6NS60 |
PaxDbi | Q6NS60 |
PRIDEi | Q6NS60 |
ProteomicsDBi | 271676 |
Protocols and materials databases
Antibodypediai | 65168, 56 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000159062; ENSMUSP00000125671; ENSMUSG00000047013 ENSMUST00000161078; ENSMUSP00000124524; ENSMUSG00000047013 ENSMUST00000161546; ENSMUSP00000124754; ENSMUSG00000047013 |
GeneIDi | 330369 |
KEGGi | mmu:330369 |
UCSCi | uc009cpw.2, mouse |
Organism-specific databases
CTDi | 150726 |
MGIi | MGI:1261912, Fbxo41 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG4341, Eukaryota |
GeneTreei | ENSGT00530000063713 |
HOGENOMi | CLU_018140_0_0_1 |
InParanoidi | Q6NS60 |
OMAi | QNWHRRP |
OrthoDBi | 236860at2759 |
PhylomeDBi | Q6NS60 |
TreeFami | TF329439 |
Enzyme and pathway databases
Reactomei | R-MMU-8951664, Neddylation R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Miscellaneous databases
BioGRID-ORCSi | 330369, 1 hit in 52 CRISPR screens |
PROi | PR:Q6NS60 |
RNActi | Q6NS60, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000047013, Expressed in primary visual cortex and 127 other tissues |
ExpressionAtlasi | Q6NS60, baseline and differential |
Genevisiblei | Q6NS60, MM |
Family and domain databases
InterProi | View protein in InterPro IPR036047, F-box-like_dom_sf IPR001810, F-box_dom |
Pfami | View protein in Pfam PF12937, F-box-like, 1 hit |
SUPFAMi | SSF81383, SSF81383, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FBX41_MOUSE | |
Accessioni | Q6NS60Primary (citable) accession number: Q6NS60 Secondary accession number(s): Q6P7W4, Q6ZPG1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 31, 2004 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 128 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot