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UniProtKB - Q6NS60 (FBX41_MOUSE)

Entry version 120 (16 Oct 2019)
Sequence version 3 (23 Jan 2007)
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Protein

F-box only protein 41

Gene

Fbxo41

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
F-box only protein 41
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Fbxo41
Synonyms:D6Ertd538e, Kiaa1940
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1261912 Fbxo41

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001199411 – 873F-box only protein 41Add BLAST873

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei358Omega-N-methylarginineCombined sources1
Modified residuei476PhosphoserineCombined sources1
Modified residuei477PhosphothreonineCombined sources1
Modified residuei760PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6NS60

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6NS60

PRoteomics IDEntifications database

More...PRIDEi		Q6NS60

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6NS60

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6NS60

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q6NS60

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000047013 Expressed in 106 organ(s), highest expression level in telencephalon

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6NS60 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6NS60 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Directly interacts with SKP1 and CUL1.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		236950, 3 interactors

Protein interaction database and analysis system

More...IntActi		Q6NS60, 3 interactors

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000124754

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini548 – 592F-boxAdd BLAST45

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili207 – 349Sequence analysisAdd BLAST143

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi51 – 61Poly-AlaAdd BLAST11
Compositional biasi107 – 112Poly-His6
Compositional biasi357 – 362Poly-Gly6

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IPN2 Eukaryota
ENOG410YK32 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063713

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000112547

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6NS60

KEGG Orthology (KO)

More...KOi		K10316

Identification of Orthologs from Complete Genome Data

More...OMAi		IQNWHRR

Database of Orthologous Groups

More...OrthoDBi		236860at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6NS60

TreeFam database of animal gene trees

More...TreeFami		TF329439

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12937 F-box-like, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF81383 SSF81383, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6NS60-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASLDLPYRC PRCGEHKRFR SLSSLRAHLE YSHTYETLYI LSKTNSICDG 
        60         70         80         90        100
AAAAAAAAAA ASGFPLAPEP AALLAVPGAR REVFESTSFQ GKEQATGPSP 
       110        120        130        140        150
AGPHLLHHHH HHAPLAHFPA DLVPASLPCE ELAEPGLVPA ARYALREIEI 
       160        170        180        190        200
PLGELFARKS VASSACSTPP PGPGPGPCSG PSSASPASPS PADVAYEEGL 
       210        220        230        240        250
ARLKIRALEK LEVDRRLERL SEEVEQKIAG QVGRLQAELE RKAAELETAR 
       260        270        280        290        300
QESARLGREK EELEERASEL SRQVDVSVEL LASLKQDLVH KEQELSRKQQ 
       310        320        330        340        350
EVVQIDQFLK ETAAREASAK LRLQQFIEEL LERADRAERQ LQVISSSCGS 
       360        370        380        390        400
TPSASLGRGG GGSASGPGVR GPGRMREHHA GSAVPSTYAV SRHGSSPSTG 
       410        420        430        440        450
ASSRVPAASQ SSGCYDSDSL ELPRPEEGPS EDSGPGGLGS RAQATNGGSE 
       460        470        480        490        500
RSQAPRSSGL RRQAIQNWQR RPRRHSTEGE EGDVSDVGSR TTESEAEGPS 
       510        520        530        540        550
DVPRPGPAVA GPLNSCRLSA RPEGGSGRGR RVERGSPSRS NEVISPEILK 
       560        570        580        590        600
MRAALFCIFT YLDTRTLLHA AEVCRDWRFV ARHPAVWTRV LLENARVCSK 
       610        620        630        640        650
FLAMLAQWCT QAHSLTLQNL KPRQRGKKES KEEYARSTRG CLEAGLESLL 
       660        670        680        690        700
KAAGGNLLIL RISHCPNILT DRSLWLASCY CRALQAVTYR SATDPVGHEV 
       710        720        730        740        750
IWALGAGCRD IVSLQVAPLH PCQQPTRFSN RCLQMIGRCW PHLRALGVGG 
       760        770        780        790        800
AGCGVQGLAS LARNCMRLQV LELDHVSEIT QEVAAEVCRE GLKGLEMLVL 
       810        820        830        840        850
TATPVTPKAL LHFNSICRNL KSIVVQIGIA DYFKEPSSPE AQKLFEDMVT 
       860        870 
KLQALRRRPG FSKILHIKVE GGC
Length:873
Mass (Da):94,331
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2B1BA501527F9700
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BC061475 mRNA Translation: AAH61475.1
BC070445 mRNA Translation: AAH70445.1
AK129466 mRNA Translation: BAC98276.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS20296.1

NCBI Reference Sequences

More...RefSeqi		NP_001001160.1, NM_001001160.3
NP_001276603.1, NM_001289674.1
NP_001276604.1, NM_001289675.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000159062; ENSMUSP00000125671; ENSMUSG00000047013
ENSMUST00000161078; ENSMUSP00000124524; ENSMUSG00000047013
ENSMUST00000161546; ENSMUSP00000124754; ENSMUSG00000047013

Database of genes from NCBI RefSeq genomes

More...GeneIDi		330369

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:330369

UCSC genome browser

More...UCSCi		uc009cpw.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC061475 mRNA Translation: AAH61475.1
BC070445 mRNA Translation: AAH70445.1
AK129466 mRNA Translation: BAC98276.1
CCDSiCCDS20296.1
RefSeqiNP_001001160.1, NM_001001160.3
NP_001276603.1, NM_001289674.1
NP_001276604.1, NM_001289675.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGridi236950, 3 interactors
IntActiQ6NS60, 3 interactors
STRINGi10090.ENSMUSP00000124754

PTM databases

iPTMnetiQ6NS60
PhosphoSitePlusiQ6NS60
SwissPalmiQ6NS60

Proteomic databases

MaxQBiQ6NS60
PaxDbiQ6NS60
PRIDEiQ6NS60

Genome annotation databases

EnsembliENSMUST00000159062; ENSMUSP00000125671; ENSMUSG00000047013
ENSMUST00000161078; ENSMUSP00000124524; ENSMUSG00000047013
ENSMUST00000161546; ENSMUSP00000124754; ENSMUSG00000047013
GeneIDi330369
KEGGimmu:330369
UCSCiuc009cpw.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		150726
MGIiMGI:1261912 Fbxo41

Rodent Unidentified Gene-Encoded large proteins database

More...Rougei		Search...

Phylogenomic databases

eggNOGiENOG410IPN2 Eukaryota
ENOG410YK32 LUCA
GeneTreeiENSGT00530000063713
HOGENOMiHOG000112547
InParanoidiQ6NS60
KOiK10316
OMAiIQNWHRR
OrthoDBi236860at2759
PhylomeDBiQ6NS60
TreeFamiTF329439

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q6NS60

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000047013 Expressed in 106 organ(s), highest expression level in telencephalon
ExpressionAtlasiQ6NS60 baseline and differential
GenevisibleiQ6NS60 MM

Family and domain databases

InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
SUPFAMiSSF81383 SSF81383, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFBX41_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NS60
Secondary accession number(s): Q6P7W4, Q6ZPG1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: January 23, 2007
Last modified: October 16, 2019
This is version 120 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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