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Entry version 108 (18 Sep 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Mitogen-activated protein kinase-binding protein 1

Gene

Mapkbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (By similarity). Involved in JNK signaling pathway (PubMed:10471813).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mitogen-activated protein kinase-binding protein 1
Alternative name(s):
JNK-binding protein 1
Short name:
JNKBP-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mapkbp1
Synonyms:Jnkbp1, Kiaa0596
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1347004 Mapkbp1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003341591 – 1503Mitogen-activated protein kinase-binding protein 1Add BLAST1503

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1193PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6NS57

PRoteomics IDEntifications database

More...
PRIDEi
Q6NS57

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6NS57

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6NS57

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed. Highest expression observed in brain.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Can form homodimers (via C-terminus).

Interacts (via C-terminus) with WDR62 (via C-terminus).

Interacts with MAPK9.

Interacts (via N-terminus) with NOD2; the interaction is enhanced in presence of muramyl dipeptide (MDP) (By similarity).

Interacts with MAPK10 (PubMed:10471813).

By similarity1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
204947, 8 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q6NS57

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000068516

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati89 – 130WD 1Add BLAST42
Repeati133 – 174WD 2Add BLAST42
Repeati176 – 214WD 3Add BLAST39
Repeati271 – 310WD 4Add BLAST40
Repeati337 – 376WD 5Add BLAST40
Repeati382 – 431WD 6Add BLAST50
Repeati472 – 511WD 7Add BLAST40
Repeati514 – 556WD 8Add BLAST43
Repeati560 – 601WD 9Add BLAST42
Repeati609 – 648WD 10Add BLAST40
Repeati654 – 693WD 11Add BLAST40
Repeati696 – 735WD 12Add BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi792 – 795Poly-Glu4
Compositional biasi1037 – 1042Poly-Glu6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal WD40 domain is necessary for the interaction with NOD2 and down-regulation of NOD2 function.By similarity

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1408 Eukaryota
ENOG410Y87A LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000010231

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6NS57

KEGG Orthology (KO)

More...
KOi
K21763

Database of Orthologous Groups

More...
OrthoDBi
1017450at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6NS57

TreeFam database of animal gene trees

More...
TreeFami
TF323254

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00400 WD40, 6 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 12 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6NS57-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMAGEGSTIT SRIKNLLRSP SIKLRRSKAG NRREDLSSKV TLEKVLGVTV
60 70 80 90 100
SGGRGLACDP RSGLVAYSAG CVVVLFNPRK HKQHHILNSS RKTITALAFS
110 120 130 140 150
PDGKYLVTGE SGHMPAVRVW DVAERSQVAE LQEHKYGVAC VAFSPSAKYI
160 170 180 190 200
VSVGYQHDMI VNVWAWKKNI VVASNKVSSR VTAVSFSEDC SYFVTAGNRH
210 220 230 240 250
IKFWYLDDSK TSKVNATVPL LGRSGLLGEL RNNLFTDVAC GRGEKADSTF
260 270 280 290 300
CITSSGLLCE FSDRRLLDKW VELRTTVAHC ISVTQEYIFC GCADGTVRLF
310 320 330 340 350
NPSNLHFLST LPRPHALGTD IASITEASRL FSGGVNARYP DTIALTFDPT
360 370 380 390 400
NQWLSCVYND HSIYVWDVRD PKKVGKVYSA LYHSSCVWSV EVYPEIKDSH
410 420 430 440 450
QACLPPSSFI TCSSDNTIRL WNTESSGVHG STLHRNILSN DLIKIIYVDG
460 470 480 490 500
NTQALLDTEL PGGDKADGSL MDPRVGIRSV CISPNGQHLA SGDRMGTLRI
510 520 530 540 550
HELQSLSEML KVEAHDSEIL CLEYSKPDTG LKLLASASRD RLIHVLDAGR
560 570 580 590 600
EYSLQQTLDE HSSSITAVKF AASDGQVRMI SCGADKSIYF RTAQKSGEGV
610 620 630 640 650
QFTRTHHVVR KTTLYDMDVE PSWKYTAIGC QDRNIRIFNI SSGKQKKLFK
660 670 680 690 700
GSQGEDGTLI KVQTDPSGIY IATSCSDKNL SIFDFSSGEC VATMFGHSEI
710 720 730 740 750
VTGMKFSNDC KHLISVSGDS CIFVWRLSSE MTISMRQRLA ELRQRQRGIK
760 770 780 790 800
QQGPTSPQRA SGAKQHHAPV VPPSGPALSS DSDKEGEDEG TEEEELPALP
810 820 830 840 850
ILSKSTKKEL ASGSSPALLR SLSHWEMSRA QETMEYLDPA PVANTGPKRR
860 870 880 890 900
GRWAQPGVEL SVRSMLDLRQ IETLAPSPRG PSQDSLAVSP AGPGKHGPQG
910 920 930 940 950
PELSCVSQNE RAPRLQTSQP CSCPHIIQLL SQEEGVFAQD LEPAPIEDGI
960 970 980 990 1000
VYPEPSDSPT MDTSAFQVQA PTGGSLGRMY PGSRGSEKHS PDSACSVDYS
1010 1020 1030 1040 1050
SSRLSSPEHP NEDSESTEPL SVDGISSDLE EPAEGDEDEE EEGGTGLCGL
1060 1070 1080 1090 1100
QEGGPHTPDQ EQFLKQHFET LANGTAPGGP ARVLERTESQ SISSRFLLQV
1110 1120 1130 1140 1150
QTSPLREPSL SSSGLALTSR PDQVSQVSGE QLKGSGATPP GAPPEMEPSS
1160 1170 1180 1190 1200
GNSGPKQVAP VLLTRRHNNL DNSWASKKMA ATRPLAGLQK AQSVHSLVPQ
1210 1220 1230 1240 1250
DEVPSSRPLL FQEAETQGSL GSLPQAGGCS SQPHSYQNHT TSSMAKLARS
1260 1270 1280 1290 1300
ISVGENPGLA TEPQAPVPIR ISPFNKLALP SRAHLVLDIP KPLPDRPTLT
1310 1320 1330 1340 1350
TFSPVSKGLA HNETEQSGPL VSLGKAHTTV EKHSCLGEGT THKSRTECQA
1360 1370 1380 1390 1400
YPGPNHPCAQ QLPVNNLLQG PESLQPLSPE KTRNPVESSR PGVALSQDSE
1410 1420 1430 1440 1450
LALSLQQCEQ LVAELQGNVR QAVELYRAVT SYKTPSAEQS HITRLLRDTF
1460 1470 1480 1490 1500
SSVRQELEVL AGAVLSSPGG SPGAVGAEQT QALLEQYSEL LLRAVERRME

RRL
Length:1,503
Mass (Da):162,892
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF727BB02C687084B
GO
Isoform 2 (identifier: Q6NS57-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     274-274: R → RNTDSFT

Note: No experimental confirmation available.
Show »
Length:1,509
Mass (Da):163,558
Checksum:i3A766FC5C3F76E66
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MQA2A0A0A0MQA2_MOUSE
Mitogen-activated protein kinase-bi...
Mapkbp1
1,503Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8VK23A0A2R8VK23_MOUSE
Mitogen-activated protein kinase-bi...
Mapkbp1
1,509Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti59D → E in BAA85449 (PubMed:10471813).Curated1
Sequence conflicti68S → P in BAA85449 (PubMed:10471813).Curated1
Sequence conflicti68S → P in CAM21732 (PubMed:19468303).Curated1
Sequence conflicti68S → P in CAM22679 (PubMed:19468303).Curated1
Sequence conflicti406P → L in BAA85449 (PubMed:10471813).Curated1
Sequence conflicti545V → E in BAA85449 (PubMed:10471813).Curated1
Sequence conflicti740 – 742AEL → RER in BAA85449 (PubMed:10471813).Curated3
Sequence conflicti900G → A in BAA85449 (PubMed:10471813).Curated1
Sequence conflicti900G → A in BAC65605 (PubMed:12693553).Curated1
Sequence conflicti925H → D in BAA85449 (PubMed:10471813).Curated1
Sequence conflicti1056H → R in BAA85449 (PubMed:10471813).Curated1
Sequence conflicti1056H → R in BAC65605 (PubMed:12693553).Curated1
Sequence conflicti1067H → L in BAA85449 (PubMed:10471813).Curated1
Sequence conflicti1090Q → R in BAA85449 (PubMed:10471813).Curated1
Sequence conflicti1090Q → R in BAC65605 (PubMed:12693553).Curated1
Sequence conflicti1103S → L in BAA85449 (PubMed:10471813).Curated1
Sequence conflicti1107 – 1119EPSLS…LALTS → YGPPHMALLT in BAC65605 (PubMed:12693553).CuratedAdd BLAST13
Sequence conflicti1167H → R in BAA85449 (PubMed:10471813).Curated1
Sequence conflicti1167H → R in BAC65605 (PubMed:12693553).Curated1
Sequence conflicti1212Q → R in BAA85449 (PubMed:10471813).Curated1
Sequence conflicti1212Q → R in BAC65605 (PubMed:12693553).Curated1
Sequence conflicti1267V → A in BAA85449 (PubMed:10471813).Curated1
Sequence conflicti1267V → A in BAC65605 (PubMed:12693553).Curated1
Sequence conflicti1310A → T in BAA85449 (PubMed:10471813).Curated1
Sequence conflicti1321 – 1324VSLG → REPR in BAA85449 (PubMed:10471813).Curated4
Sequence conflicti1359A → R in BAA85449 (PubMed:10471813).Curated1
Sequence conflicti1370 – 1371GP → A in BAA85449 (PubMed:10471813).Curated2
Sequence conflicti1432Y → C in BAA85449 (PubMed:10471813).Curated1
Sequence conflicti1432Y → C in BAC65605 (PubMed:12693553).Curated1
Sequence conflicti1452S → P in BAA85449 (PubMed:10471813).Curated1
Sequence conflicti1476G → A in BAA85449 (PubMed:10471813).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_033636274R → RNTDSFT in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB029482 mRNA Translation: BAA85449.1
AL954662, AL833774 Genomic DNA Translation: CAM21732.1
AL833774, AL954662 Genomic DNA Translation: CAM22679.1
BC070449 mRNA Translation: AAH70449.1
AK122323 Transcribed RNA Translation: BAC65605.3

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS16612.1 [Q6NS57-1]

NCBI Reference Sequences

More...
RefSeqi
NP_036071.3, NM_011941.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
26390

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:26390

UCSC genome browser

More...
UCSCi
uc008lux.2 mouse [Q6NS57-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029482 mRNA Translation: BAA85449.1
AL954662, AL833774 Genomic DNA Translation: CAM21732.1
AL833774, AL954662 Genomic DNA Translation: CAM22679.1
BC070449 mRNA Translation: AAH70449.1
AK122323 Transcribed RNA Translation: BAC65605.3
CCDSiCCDS16612.1 [Q6NS57-1]
RefSeqiNP_036071.3, NM_011941.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi204947, 8 interactors
ELMiQ6NS57
STRINGi10090.ENSMUSP00000068516

PTM databases

iPTMnetiQ6NS57
PhosphoSitePlusiQ6NS57

Proteomic databases

PaxDbiQ6NS57
PRIDEiQ6NS57

Genome annotation databases

GeneIDi26390
KEGGimmu:26390
UCSCiuc008lux.2 mouse [Q6NS57-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23005
MGIiMGI:1347004 Mapkbp1

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiKOG1408 Eukaryota
ENOG410Y87A LUCA
HOGENOMiHOG000010231
InParanoidiQ6NS57
KOiK21763
OrthoDBi1017450at2759
PhylomeDBiQ6NS57
TreeFamiTF323254

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Mapkbp1 mouse

Protein Ontology

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PROi
PR:Q6NS57

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 6 hits
SMARTiView protein in SMART
SM00320 WD40, 12 hits
SUPFAMiSSF50978 SSF50978, 2 hits
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMABP1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NS57
Secondary accession number(s): A2AWL8, Q80TW5, Q9R0L0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 5, 2004
Last modified: September 18, 2019
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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