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Entry version 110 (29 Sep 2021)
Sequence version 3 (26 Feb 2008)
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Protein

Coiled-coil domain-containing protein 66

Gene

Ccdc66

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Microtubule-binding protein required for ciliogenesis. May function in ciliogenesis by mediating the transport of proteins like BBS4 to the cilium, but also through the organization of the centriolar satellites (By similarity).

Plays a role in retina morphogenesis and/or homeostasis (PubMed:21680557).

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCilium biogenesis/degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 66Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ccdc66Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2443639, Ccdc66

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000046753

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice lacking Ccdc66 are viable but display degeneration of the retina. Initial formation of the retina is normal up to postnatal stage P10. Malformation of photoreceptors develops around P13. The degeneration progresses slowly until 3 months after birth, when the outer nuclear layer is reduced to 5-6 rows. From 5 to 7 months, only a thin outer nuclear and photoreceptor layer with severely shrunken outer and inner segments is preserved. It is associated with impaired photoreceptor function with early visual impairment detectable 1 month after birth and progressing slightly until 7 months.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003200381 – 935Coiled-coil domain-containing protein 66Add BLAST935

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei114PhosphothreonineBy similarity1
Modified residuei366PhosphoserineCombined sources1
Modified residuei595PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6NS45

PRoteomics IDEntifications database

More...
PRIDEi
Q6NS45

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
265715 [Q6NS45-1]
265716 [Q6NS45-2]
265717 [Q6NS45-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6NS45

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6NS45

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed (PubMed:19777273). Expressed in retina by rod photoreceptors but also detected in outer plexiform and ganglion cell layers (at protein level) (PubMed:21680557, PubMed:19777273).2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in the retina from postnatal stages to adulthood. Highest levels are observed at postnatal stage P1 and P4 and expression decreases afterward. Steady levels are observed from P12 to adulthood. Expression increases in the outer segments from P12 to P19 paralleling the differentiation of outer segments.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000046753, Expressed in blastocyst and 262 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6NS45, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked (Probable).

Interacts with CEP290.

Interacts with PCM1 (By similarity).

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000052546

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6NS45, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6NS45

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni76 – 103DisorderedSequence analysisAdd BLAST28
Regioni470 – 491DisorderedSequence analysisAdd BLAST22
Regioni577 – 602DisorderedSequence analysisAdd BLAST26
Regioni738 – 794DisorderedSequence analysisAdd BLAST57

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili462 – 555Sequence analysisAdd BLAST94

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi76 – 97Polar residuesSequence analysisAdd BLAST22
Compositional biasi738 – 753Polar residuesSequence analysisAdd BLAST16
Compositional biasi754 – 776Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi777 – 794Polar residuesSequence analysisAdd BLAST18

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502R1PQ, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000012411

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_016964_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6NS45

Identification of Orthologs from Complete Genome Data

More...
OMAi
KNSNYER

Database of Orthologous Groups

More...
OrthoDBi
1468611at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6NS45

TreeFam database of animal gene trees

More...
TreeFami
TF350489

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039183, CCD66
IPR040467, CCDC66_dom

The PANTHER Classification System

More...
PANTHERi
PTHR22736, PTHR22736, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15236, CCDC66, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6NS45-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNLGDGLKLE TELLDGKTKL ILSPYEHKSK VSVKMGNKFK IAKCPLRTKQ
60 70 80 90 100
TGHTLKSTQN TYIGNENLSQ KKISTLDTSQ AKPENSRLTF SPSTDKQYSE
110 120 130 140 150
KDSVRVQKEI SPTTSNIRKI INTTGTCPVA KQKPCKKNPT AETMNSGLVC
160 170 180 190 200
LTQDQLRQIL MLSVNQGNGS VCLTETGEEE ASQDSLHLIN IPSQPKDVND
210 220 230 240 250
TGFLQNTEAA SPVTSEHEHV HRRAQEAFQQ CEQKAATENE WKPADIFSTL
260 270 280 290 300
GERERDKSLL EARRAQWKKE LDEQVALKKK EKEASQKWHN PWKPSDIECE
310 320 330 340 350
KSQVHDQSKE ARLLESPCSA IKQEQQRKWI EELNKQVEDD QQRKAEERMI
360 370 380 390 400
YSKGEEHDRW AVHFDSLKSH PGSQSRLSSQ LTHQHLESLC VSPDTQELAD
410 420 430 440 450
VNGVFTPPPG VQAEPSEKEQ RARPVLEMAV SHGPKTNFLR SMTALLDPAQ
460 470 480 490 500
IEERERRRQK QLEHQKAIMA QVEENRRKKR LEEEQRKKEE QELELRLARE
510 520 530 540 550
REEMQRQYEE DILKQRQREE IMTLKTNELF HTMQRAQELA QRLKQEQRIR
560 570 580 590 600
ELAQKGHDTS RLIQNLGAQV DYKAFTTISS SHSDPEETAD TSTASPKKDT
610 620 630 640 650
GVQTDDVNLG IFNDALPPCG SVTEKGIRNI SSPEISAEFS GQTDIRKENQ
660 670 680 690 700
ELSMNKGTNL DKENSWHNGQ CNQYRRTEKQ TKLMKKCPKK PAWNINKPLK
710 720 730 740 750
KYVPASAKYP AHLQKEKEEK KVQRQMELLH LVERNNPENL SQNRGISPLA
760 770 780 790 800
TSHRETESES RLHLIKKVEE PLKTPSVSKE RFQTSPAVKN RTQQTQSNVL
810 820 830 840 850
HLPLKNNDYE KETLTLGDGH TKLSDEMSEP SHFIPYVRTN EIYYLDPDAP
860 870 880 890 900
LSRPSTQDNQ YQKSHDCARE QELFDSDHIR DPLLNPKLVK NRDRQQAILK
910 920 930
GLSELRQGLL QKQKELETNL IPLTANQEDN FSSSF
Length:935
Mass (Da):107,372
Last modified:February 26, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE6535220E4B5BE78
GO
Isoform 2 (identifier: Q6NS45-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-26: E → G
     27-182: Missing.

Show »
Length:779
Mass (Da):90,157
Checksum:i3CFB560410D63F40
GO
Isoform 3 (identifier: Q6NS45-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: MNLGDGLKLETELLDGKTKLILSPYEHKSKVSVK → M

Show »
Length:902
Mass (Da):103,736
Checksum:i0E59A0C641ED9250
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH70471 differs from that shown. Reason: Frameshift.Curated
The sequence AAH72583 differs from that shown. Partial nucleotide duplication in position 392 that disrupts the frame.Curated
The sequence BAC35302 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC39936 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE34603 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti137K → T in BAE26352 (PubMed:16141072).Curated1
Sequence conflicti405F → Y in BAE26352 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0315881 – 34MNLGD…KVSVK → M in isoform 3. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_03158926E → G in isoform 2. 1 Publication1
Alternative sequenceiVSP_03159027 – 182Missing in isoform 2. 1 PublicationAdd BLAST156

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK053185 mRNA Translation: BAC35302.1 Different initiation.
AK087583 mRNA Translation: BAC39936.1 Different initiation.
AK145297 mRNA Translation: BAE26352.1
AK158666 mRNA Translation: BAE34603.1 Different initiation.
BC070471 mRNA Translation: AAH70471.2 Frameshift.
BC072583 mRNA Translation: AAH72583.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS36843.1 [Q6NS45-1]

NCBI Reference Sequences

More...
RefSeqi
NP_796085.3, NM_177111.3 [Q6NS45-1]
XP_006519190.1, XM_006519127.3 [Q6NS45-3]
XP_006519194.1, XM_006519131.3 [Q6NS45-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000050480; ENSMUSP00000052546; ENSMUSG00000046753 [Q6NS45-2]
ENSMUST00000223689; ENSMUSP00000153023; ENSMUSG00000046753 [Q6NS45-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
320234

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:320234

UCSC genome browser

More...
UCSCi
uc007stw.2, mouse [Q6NS45-1]
uc011zhw.2, mouse [Q6NS45-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK053185 mRNA Translation: BAC35302.1 Different initiation.
AK087583 mRNA Translation: BAC39936.1 Different initiation.
AK145297 mRNA Translation: BAE26352.1
AK158666 mRNA Translation: BAE34603.1 Different initiation.
BC070471 mRNA Translation: AAH70471.2 Frameshift.
BC072583 mRNA Translation: AAH72583.1 Sequence problems.
CCDSiCCDS36843.1 [Q6NS45-1]
RefSeqiNP_796085.3, NM_177111.3 [Q6NS45-1]
XP_006519190.1, XM_006519127.3 [Q6NS45-3]
XP_006519194.1, XM_006519131.3 [Q6NS45-2]

3D structure databases

SMRiQ6NS45
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052546

PTM databases

iPTMnetiQ6NS45
PhosphoSitePlusiQ6NS45

Proteomic databases

PaxDbiQ6NS45
PRIDEiQ6NS45
ProteomicsDBi265715 [Q6NS45-1]
265716 [Q6NS45-2]
265717 [Q6NS45-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
31476, 105 antibodies

The DNASU plasmid repository

More...
DNASUi
320234

Genome annotation databases

EnsembliENSMUST00000050480; ENSMUSP00000052546; ENSMUSG00000046753 [Q6NS45-2]
ENSMUST00000223689; ENSMUSP00000153023; ENSMUSG00000046753 [Q6NS45-1]
GeneIDi320234
KEGGimmu:320234
UCSCiuc007stw.2, mouse [Q6NS45-1]
uc011zhw.2, mouse [Q6NS45-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
285331
MGIiMGI:2443639, Ccdc66
VEuPathDBiHostDB:ENSMUSG00000046753

Phylogenomic databases

eggNOGiENOG502R1PQ, Eukaryota
GeneTreeiENSGT00390000012411
HOGENOMiCLU_016964_0_0_1
InParanoidiQ6NS45
OMAiKNSNYER
OrthoDBi1468611at2759
PhylomeDBiQ6NS45
TreeFamiTF350489

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
320234, 1 hit in 61 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Ccdc66, mouse

Protein Ontology

More...
PROi
PR:Q6NS45
RNActiQ6NS45, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000046753, Expressed in blastocyst and 262 other tissues
GenevisibleiQ6NS45, MM

Family and domain databases

InterProiView protein in InterPro
IPR039183, CCD66
IPR040467, CCDC66_dom
PANTHERiPTHR22736, PTHR22736, 1 hit
PfamiView protein in Pfam
PF15236, CCDC66, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCD66_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NS45
Secondary accession number(s): Q3ULU6, Q8C304, Q8C6T6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: September 29, 2021
This is version 110 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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