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Protein

Mdm2-binding protein

Gene

mtbp

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in mdm2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of mdm2, thereby enhancing mdm2 stability. This promotes mdm2-mediated ubiquitination of p53/TP53 and its subsequent degradation (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCell cycle, Growth arrest, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Mdm2-binding protein
Gene namesi
Name:mtbp
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-990926 mtbp

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003237471 – 860Mdm2-binding proteinAdd BLAST860

Structurei

3D structure databases

ProteinModelPortaliQ6NRW0
SMRiQ6NRW0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MTBP family.Curated

Phylogenomic databases

HOVERGENiHBG108152

Family and domain databases

InterProiView protein in InterPro
IPR039061 MTBP
IPR029418 MTBP_C
IPR029420 MTBP_central
IPR029421 MTBP_N
PANTHERiPTHR14382 PTHR14382, 1 hit
PfamiView protein in Pfam
PF14920 MTBP_C, 1 hit
PF14919 MTBP_mid, 1 hit
PF14918 MTBP_N, 1 hit

Sequencei

Sequence statusi: Complete.

Q6NRW0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERFVLCIHW ERRAEQQQPV PQGLVYAQDI YTQLKEYSTN CTSTFPACSL
60 70 80 90 100
TGNPGIRKWF FALQSLYGFS QFCSSDWEDL CPAVTTDDSE EPVQTALDEC
110 120 130 140 150
LDALQFPDGE DDNSRDSISQ TNLFEEAAEL LHQLSDKLPA PGRALVDVLL
160 170 180 190 200
FPSEAPKLKD CLSAIGAIKH LKEWHTAKIT IVSKDCKGWQ KIGKFLSANV
210 220 230 240 250
VVSDCPRQLI DPQELWRGTI EIKERKFTSE VEFPEFCLRS VSDDKVPYFE
260 270 280 290 300
NNGDDKNKTV LSEVFHYYGA SLEYVQMVAL SEIPSYFVSD SVFELSITRN
310 320 330 340 350
GLQGKSKLML DQLCSLTEKV GAIFMLPCNV CSLPNPPALQ RSSKKWREYM
360 370 380 390 400
SRKPKDIKVP GVELKGEYCS YYFLIQGKGS GLCKATLLHS ASQISGAASL
410 420 430 440 450
LLLHQRLNNN HPVNMAESTS DILDSLPHFN GEQIALREQI LARAQVLAVK
460 470 480 490 500
EYLKRQEAQP HASVSQSNNL GRLLALTREH VIGDCESRLD SVSYKNMQNI
510 520 530 540 550
TVSTPAFPES EAMISNPADW PERNVLQNLE NFEKIKQRLR ASILSGSAEQ
560 570 580 590 600
LLGRKDGLKE GMTLLDAKEL LKYFTPQGLA VGELQPLQVQ RGDNAFLVTP
610 620 630 640 650
KLTPRKLKGL PFEKAAECHY HGLEYCLDNR KALDRDVAFS ELQSRLIRYE
660 670 680 690 700
TQTTCTRECC PIPFALSPIP SPAVLSEPGS VPDGESIQTE LRGDPLRLKR
710 720 730 740 750
RSKDIEGLYP SKRLAKSGSS DSLVSLASEG SGHQQPTRLR TERTASSVSG
760 770 780 790 800
AQPSSTRVRT APSVPAQSKP SSHLELEQKE SRSQKHNRML KEVVSKTLQK
810 820 830 840 850
HSIGVEHPCY AACNQRLFEI SKFFLKDLKT SRGLLDEMKK AASNNAKQVI
860
QWELDKLKKN
Length:860
Mass (Da):96,308
Last modified:July 5, 2004 - v1
Checksum:i279019BF58BDDBEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC070600 mRNA Translation: AAH70600.1
RefSeqiNP_001084870.1, NM_001091401.1
UniGeneiXl.5551

Genome annotation databases

GeneIDi431919
KEGGixla:431919

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC070600 mRNA Translation: AAH70600.1
RefSeqiNP_001084870.1, NM_001091401.1
UniGeneiXl.5551

3D structure databases

ProteinModelPortaliQ6NRW0
SMRiQ6NRW0
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi431919
KEGGixla:431919

Organism-specific databases

CTDi431919
XenbaseiXB-GENE-990926 mtbp

Phylogenomic databases

HOVERGENiHBG108152

Family and domain databases

InterProiView protein in InterPro
IPR039061 MTBP
IPR029418 MTBP_C
IPR029420 MTBP_central
IPR029421 MTBP_N
PANTHERiPTHR14382 PTHR14382, 1 hit
PfamiView protein in Pfam
PF14920 MTBP_C, 1 hit
PF14919 MTBP_mid, 1 hit
PF14918 MTBP_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMTBP_XENLA
AccessioniPrimary (citable) accession number: Q6NRW0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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