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Entry version 72 (08 May 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Inhibitor of Bruton tyrosine kinase

Gene

ibtk

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development.By similarity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inhibitor of Bruton tyrosine kinase
Short name:
IBtk
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ibtk
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

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Xenbasei
XB-GENE-5756000 ibtk

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002802781 – 1339Inhibitor of Bruton tyrosine kinaseAdd BLAST1339

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6NRS1

PRoteomics IDEntifications database

More...
PRIDEi
Q6NRS1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati51 – 81ANK 1Add BLAST31
Repeati86 – 115ANK 2Add BLAST30
Repeati119 – 154ANK 3Add BLAST36
Repeati142 – 195RCC1 1Add BLAST54
Repeati196 – 247RCC1 2Add BLAST52
Repeati249 – 302RCC1 3Add BLAST54
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini555 – 636BTB 1PROSITE-ProRule annotationAdd BLAST82
Domaini758 – 826BTB 2PROSITE-ProRule annotationAdd BLAST69

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
94875at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit
2.130.10.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR000210 BTB/POZ_dom
IPR009091 RCC1/BLIP-II
IPR000408 Reg_chr_condens
IPR011333 SKP1/BTB/POZ_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 1 hit
PF00651 BTB, 2 hits
PF00415 RCC1, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00633 RCCNDNSATION

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 2 hits
SM00225 BTB, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit
SSF50985 SSF50985, 1 hit
SSF54695 SSF54695, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
PS50097 BTB, 2 hits
PS50012 RCC1_3, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6NRS1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERVWPECTT RCRSLQHALD VISVVTRASE QHIKVFLSSY CCNAVTLKDD
60 70 80 90 100
FGRNATHIAA SCGKKNVLDW LITGKGVDLA VKDKESGWTA LHRSIFYGHI
110 120 130 140 150
DCALSLLKHG SNLYIQDKDG YTPLDLVMKD RPPHIVFKTS DPTELYTWGD
160 170 180 190 200
NVNFTLGHGT QQSKHHPELV EMFPRSGVYI KQMVLCKFHS VFLSQKGQVY
210 220 230 240 250
TCGHGQGGRL GHGDELTCLV PRLVEGLRGH PCTQVAGAKD HTVVLTEDGY
260 270 280 290 300
VYTFGLNTFH QLGIQPPPPN SNVPRQIQAK TMKGKTVLGV AAGRFHTVLW
310 320 330 340 350
TKDAVYTVGL NGGQLGYLQD PNGEKFVSCP RQVSALHHKD INITLVSASD
360 370 380 390 400
GATVCVSERG DIYLLSEYQC KKLASKQLNL KKVLVSGGIL EHKAAPEHLK
410 420 430 440 450
ENGGQPASVF ALDQAGRVFC WKSPGSSLKQ CWWVYGRQLF MSDVALNKNE
460 470 480 490 500
IMFVTQDGEG FTGKWMLEKK KKENTISNIM CHSDSQNVYE KISMQKLPFV
510 520 530 540 550
HRAVSVATDP SGCNFAVLQS DPKTSLFEVP SVSSSVFAED FEKLLNEANE
560 570 580 590 600
TDSIHDVTFQ VGTKIFPAHK YILALRCDFF SKLFSSGEIN SLDFPEVHQK
610 620 630 640 650
GEDAAGCDLF VIEKIPPELF SHVLQFIYSD TCDMLLQGHK PKLWHKEENE
660 670 680 690 700
NTIICNFQKM GFREDIEGKS AYEVYKNSRI CAENEKQKGK TKQSKKTRSI
710 720 730 740 750
GDETSPVKML QNTAKKFGLS NLSSRLDGVR YENGRINVFH KKSENKLRFN
760 770 780 790 800
QKKCSSHYDV MMKSEDGKEF HCHKCVLCAR LEYFNSMLSS SWIEASCCSQ
810 820 830 840 850
LEMPIHSDVL QVILDYIYTD EVLTVKESAN VEFVCNVLVI ADQLLIVRLK
860 870 880 890 900
EICEVTIAER ITLKNAAELL EFAALYNADQ LKLSCLQFVG LNMGALLEAR
910 920 930 940 950
SLDVLSDDVL KDLSEAYRKM IPSMNKRIIT PYLDGPDISI LQSEDIESLI
960 970 980 990 1000
SVQDDIYSYQ ITQEATLKKS KAKPKKKQRK RLDSSGGYNL SDIIQSPTST
1010 1020 1030 1040 1050
GFVKPEKTNS VESLQDLLTS DSEGSFVGAS SPRDLQSPDL FPVFTHETKE
1060 1070 1080 1090 1100
TICVERNRSS PPVANGAAST KMPIPTTSSP KAIPMSRITP STSPNWVAMP
1110 1120 1130 1140 1150
CSPASPVTMD LRAIMELEEN IQKCGAMPKL NAGGTKPGTH VMKLSQKQRK
1160 1170 1180 1190 1200
MMAMSSKESN NENKPAKVTV APTTIKSPAK TWAAAFHLGE NKSFRDLLLE
1210 1220 1230 1240 1250
EKQSVTSFPS LSSDVKKSKH TEELDPSELA RRPSGTLNQE AKLKCDVPNQ
1260 1270 1280 1290 1300
DNSNPWHLTL SKNNASSAPV TFTAIVEEEE KQEAALIRSR EKPLALIQIE
1310 1320 1330
ERAIQDLLLH YQAIDNPEEY ITIERAAQIP MATPMWNKH
Length:1,339
Mass (Da):149,341
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i483977396F30E5B4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC070653 mRNA Translation: AAH70653.1

NCBI Reference Sequences

More...
RefSeqi
NP_001084927.1, NM_001091458.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
431983

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xla:431983

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC070653 mRNA Translation: AAH70653.1
RefSeqiNP_001084927.1, NM_001091458.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

MaxQBiQ6NRS1
PRIDEiQ6NRS1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi431983
KEGGixla:431983

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
431983
XenbaseiXB-GENE-5756000 ibtk

Phylogenomic databases

OrthoDBi94875at2759

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
2.130.10.30, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR000210 BTB/POZ_dom
IPR009091 RCC1/BLIP-II
IPR000408 Reg_chr_condens
IPR011333 SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00651 BTB, 2 hits
PF00415 RCC1, 3 hits
PRINTSiPR00633 RCCNDNSATION
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SM00225 BTB, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
SSF50985 SSF50985, 1 hit
SSF54695 SSF54695, 2 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
PS50097 BTB, 2 hits
PS50012 RCC1_3, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIBTK_XENLA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NRS1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 5, 2004
Last modified: May 8, 2019
This is version 72 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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