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Protein

Tyrosine-protein phosphatase

Gene

ptpn4

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei823SubstrateUniRule annotation1
Active sitei855Phosphocysteine intermediateUniRule annotation1
Binding sitei899SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphataseUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphataseUniRule annotation (EC:3.1.3.48UniRule annotation)
Gene namesi
Name:ptpn4Imported
Synonyms:MGC83117Imported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-995934 ptpn4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, CytoskeletonUniRule annotation

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ6NRP9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 312FERMInterPro annotationAdd BLAST284
Domaini520 – 592PDZInterPro annotationAdd BLAST73
Domaini658 – 914Tyrosine-protein phosphataseInterPro annotationAdd BLAST257
Domaini831 – 905TYR_PHOSPHATASE_2InterPro annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni855 – 861Substrate bindingUniRule annotation7

Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.UniRule annotation

Phylogenomic databases

HOVERGENiHBG008322
KOiK18037

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR014847 FERM-adjacent
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR012151 Tyr_Pase_non-rcpt_typ-3/4
IPR000387 TYR_PHOSPHATASE_dom
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF08736 FA, 1 hit
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PF00595 PDZ, 1 hit
PF00102 Y_phosphatase, 1 hit
PIRSFiPIRSF000927 Tyr-Ptase_nr3, 1 hit
PRINTSiPR00935 BAND41
PR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01195 FA, 1 hit
SM01196 FERM_C, 1 hit
SM00228 PDZ, 1 hit
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF50156 SSF50156, 1 hit
SSF52799 SSF52799, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00660 FERM_1, 1 hit
PS00661 FERM_2, 1 hit
PS50057 FERM_3, 1 hit
PS50106 PDZ, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequencei

Sequence statusi: Complete.

Q6NRP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTARFRLPAG RTYNVRASEQ ARDRQSTEVV CSVLLLDNSV QTFHVNKHNH
60 70 80 90 100
GQVLLDLVFK FLDLTEQDYF GLQLADDSCD NPRWLDLNKP IRKQLKRGSP
110 120 130 140 150
HNLNFRVKFF VSDPSKLQEE YTRYQYFLQI KQDVLTGRLP CPYNTAALLA
160 170 180 190 200
SYTAQSELGD YSHSEHLPGY LADYSYIPEQ PLDFEKEIAK LHQQHRGLSP
210 220 230 240 250
AEAEFSYLNT ARTLELYGVE LHYARDQSYN EILIGVMSGG ILIYKNRVRI
260 270 280 290 300
NTFPWLKIVK ISFKCKQFFI QQRKELHEYR ETVLGFNMVN YRACKNLWKA
310 320 330 340 350
CVEHHTFFRL DSPLPLQKNF FAHYFTLGSR FRYCGRTEVQ SVQYGKEKAN
360 370 380 390 400
KDRVFARSPS KPLTRKLVSE MDWEIVSRNS LSNSRLETQS LPSRSPPGTP
410 420 430 440 450
NHRNFTFIQE QSRMRPSSVG HLVDRMIHTS PREVFNNHQS SSSTQANSIV
460 470 480 490 500
LDSPPAQDIT MDTPPPALPP KQSKKNSMNQ IHLSHSQQDL DNHIDEPFEA
510 520 530 540 550
PCSPEKSTPN GLVPHDNLVL IKMRPDENGR FGFNVKGGLD QKMPVIVSRV
560 570 580 590 600
APGTPADLCV PRLNEGDQVV LINGRDISEH THDQVVMFIK ASCEMHSQEL
610 620 630 640 650
VLLVRPNAVY DIVEERLESE PDFQYIPEKT AMDGIHSDDD ALRESMIQLA
660 670 680 690 700
EGLYNGTVLA QFDQLYRKKP GMTMSCAKLP QNISKNRYRD ISPYDATRVI
710 720 730 740 750
LADGEDYINA NYINMEISSS SIINRYIACQ GPLPSTCPDF WQMTWEQGSS
760 770 780 790 800
MVVMLTTQVE RGRVKCHQYW PETTGSSEFG KFQISCHSEE GNPAYVFREM
810 820 830 840 850
TLTNVEKNES RPLTQIQYTA WPDHGVPDDS SDFLDFVSLV RQRRSHHDEP
860 870 880 890 900
AVVHCSAGIG RTGVLITMET AMCLMECSQA VYPLDIVRTM RDQRAMMIQT
910 920
PSQYRFVCEA ILKVYREGLV QPALAPFPK
Length:929
Mass (Da):106,387
Last modified:July 5, 2004 - v1
Checksum:iF8766B52734DEA78
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC070687 mRNA Translation: AAH70687.1
RefSeqiNP_001084871.1, NM_001091402.1
UniGeneiXl.14815

Genome annotation databases

GeneIDi431920
KEGGixla:431920

Similar proteinsi

Entry informationi

Entry nameiQ6NRP9_XENLA
AccessioniPrimary (citable) accession number: Q6NRP9
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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