UniProtKB - Q6NQ87 (CRK22_ARATH)
Protein
Cysteine-rich receptor-like protein kinase 22
Gene
CRK22
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 381 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 478 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 359 – 367 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein serine/threonine kinase activity Source: GO_Central
- protein serine kinase activity Source: RHEA
- protein threonine kinase activity Source: RHEA
GO - Biological processi
- defense response to bacterium Source: GO_Central
- protein phosphorylation Source: GO_Central
Keywordsi
Molecular function | Kinase, Receptor, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Cysteine-rich receptor-like protein kinase 22 (EC:2.7.11.-)Short name: Cysteine-rich RLK22 |
Gene namesi | Name:CRK22 Ordered Locus Names:At4g23300 ORF Names:F21P8.190 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT4G23300 |
TAIRi | locus:2121711, AT4G23300 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass membrane protein Curated
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 25 – 294 | ExtracellularSequence analysisAdd BLAST | 270 | |
Transmembranei | 295 – 315 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 316 – 660 | CytoplasmicSequence analysisAdd BLAST | 345 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
ChainiPRO_0000295069 | 25 – 660 | Cysteine-rich receptor-like protein kinase 22Add BLAST | 636 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 37 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 53 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 105 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 125 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 191 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 230 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 256 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 280 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 284 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 426 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 482 | PhosphoserineBy similarity | 1 | |
Modified residuei | 518 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 526 | PhosphotyrosineBy similarity | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | Q6NQ87 |
PRIDEi | Q6NQ87 |
ProteomicsDBi | 220415 |
Expressioni
Gene expression databases
ExpressionAtlasi | Q6NQ87, baseline and differential |
Genevisiblei | Q6NQ87, AT |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 128 | Gnk2-homologous 1PROSITE-ProRule annotationAdd BLAST | 104 | |
Domaini | 137 – 250 | Gnk2-homologous 2PROSITE-ProRule annotationAdd BLAST | 114 | |
Domaini | 353 – 632 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 280 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CRK subfamily.PROSITE-ProRule annotation
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QWDY, Eukaryota |
HOGENOMi | CLU_000288_35_2_1 |
InParanoidi | Q6NQ87 |
OMAi | TTNSLQY |
OrthoDBi | 684563at2759 |
PhylomeDBi | Q6NQ87 |
Family and domain databases
Gene3Di | 3.30.430.20, 2 hits |
InterProi | View protein in InterPro IPR002902, GNK2 IPR038408, GNK2_sf IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit PF01657, Stress-antifung, 2 hits |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51473, GNK2, 2 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q6NQ87-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKQRSFLSIL CFILLAFGVA SVSAQTCIEN RKYFTPNGTY DSNRRLILSS
60 70 80 90 100
LPNNTASQDG FYYGSIGEEQ DRVYALGMCI PRSTPSDCFN CIKGAAGWLI
110 120 130 140 150
QDCVNQTDAY YWALDPTLCL VRYSNISFSG SAAFWEIEPQ YLVLNTATIA
160 170 180 190 200
SDLTDFKNIW EDLTSRTITA ASAARSTPSS SDNHYRVDFA NLTKFQNIYA
210 220 230 240 250
LMQCTPDISS DECNNCLQRG VLEYQSCCGN NTGGYVMRPI CFFRWQLFTF
260 270 280 290 300
SKAFHNITLA TPPKPPMNVP RPPSVGHGAN TTDNDSRGVS AGIVVVITVP
310 320 330 340 350
AVVIVLILVV LGFFICWRRK SLQRTEFESD SDVSTTNSLQ YEFKTIEAAT
360 370 380 390 400
NKFSKSNKLG EGRFGEVYKG KFSNGTEVAV KRLSKVSGQD TKKFRNEAVL
410 420 430 440 450
VSKIQHRNLA RLLGFCLQGD GKFLIYEFVL NKSLDYFLFD PEKQGELDWT
460 470 480 490 500
RRYKIIGGIA QGILHLHQDP QLTIIYRDFK ASNILLDADM NPKISDFGMA
510 520 530 540 550
TVFGMEESRG NTNWIAETFV YMSPEYAVHG KFSMKSDVYS FGILILEIIS
560 570 580 590 600
GKKNSSLYQN DETTTAGNLV TYAWRLWRNG SQLKLLDSSI GRNYQSNEVT
610 620 630 640 650
RCIHIALLCV QENPEDRPKL STIVSMLTSN TISVPAPGIP GFFPQSRREL
660
DPLSEGLESG
Sequence cautioni
The sequence CAA18477 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB79285 differs from that shown. Reason: Erroneous gene model prediction.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL022347 Genomic DNA Translation: CAA18477.1 Sequence problems. AL161559 Genomic DNA Translation: CAB79285.1 Sequence problems. CP002687 Genomic DNA Translation: AEE84736.1 BT010572 mRNA Translation: AAQ65195.1 AK176570 mRNA Translation: BAD44333.1 |
PIRi | T04847 |
RefSeqi | NP_194061.2, NM_118459.5 |
Genome annotation databases
EnsemblPlantsi | AT4G23300.1; AT4G23300.1; AT4G23300 |
GeneIDi | 828429 |
Gramenei | AT4G23300.1; AT4G23300.1; AT4G23300 |
KEGGi | ath:AT4G23300 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL022347 Genomic DNA Translation: CAA18477.1 Sequence problems. AL161559 Genomic DNA Translation: CAB79285.1 Sequence problems. CP002687 Genomic DNA Translation: AEE84736.1 BT010572 mRNA Translation: AAQ65195.1 AK176570 mRNA Translation: BAD44333.1 |
PIRi | T04847 |
RefSeqi | NP_194061.2, NM_118459.5 |
3D structure databases
SMRi | Q6NQ87 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 3702.AT4G23300.1 |
Proteomic databases
PaxDbi | Q6NQ87 |
PRIDEi | Q6NQ87 |
ProteomicsDBi | 220415 |
Genome annotation databases
EnsemblPlantsi | AT4G23300.1; AT4G23300.1; AT4G23300 |
GeneIDi | 828429 |
Gramenei | AT4G23300.1; AT4G23300.1; AT4G23300 |
KEGGi | ath:AT4G23300 |
Organism-specific databases
Araporti | AT4G23300 |
TAIRi | locus:2121711, AT4G23300 |
Phylogenomic databases
eggNOGi | ENOG502QWDY, Eukaryota |
HOGENOMi | CLU_000288_35_2_1 |
InParanoidi | Q6NQ87 |
OMAi | TTNSLQY |
OrthoDBi | 684563at2759 |
PhylomeDBi | Q6NQ87 |
Miscellaneous databases
PROi | PR:Q6NQ87 |
Gene expression databases
ExpressionAtlasi | Q6NQ87, baseline and differential |
Genevisiblei | Q6NQ87, AT |
Family and domain databases
Gene3Di | 3.30.430.20, 2 hits |
InterProi | View protein in InterPro IPR002902, GNK2 IPR038408, GNK2_sf IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit PF01657, Stress-antifung, 2 hits |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51473, GNK2, 2 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CRK22_ARATH | |
Accessioni | Q6NQ87Primary (citable) accession number: Q6NQ87 Secondary accession number(s): O65481 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 10, 2007 |
Last sequence update: | July 5, 2004 | |
Last modified: | April 7, 2021 | |
This is version 129 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families