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UniProtKB - Q6NP91 (Q6NP91_DROME)

Entry version 131 (25 May 2022)
Sequence version 1 (03 Oct 2006)
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Protein
Submitted name:

RE44586p

Gene

Tmem63

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channelARBA annotation
Biological processIon transport, Transport
LigandCalciumARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-6798695, Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
RE44586pImported
Submitted name:
Transmembrane protein 63Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tmem63Imported
Synonyms:CT31310Imported, Dmel\CG11210Imported, TMEM63Imported
ORF Names:CG11210Imported, Dmel_CG11210Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0033259, Tmem63

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		VectorBase:FBgn0033259

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei33 – 50HelicalSequence analysisAdd BLAST18
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Transmembranei201 – 220HelicalSequence analysisAdd BLAST20
Transmembranei399 – 423HelicalSequence analysisAdd BLAST25
Transmembranei443 – 462HelicalSequence analysisAdd BLAST20
Transmembranei483 – 506HelicalSequence analysisAdd BLAST24
Transmembranei526 – 548HelicalSequence analysisAdd BLAST23
Transmembranei592 – 614HelicalSequence analysisAdd BLAST23
Transmembranei644 – 667HelicalSequence analysisAdd BLAST24
Transmembranei673 – 694HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0033259, Expressed in digestive system element and 39 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7227.FBpp0087859

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini108 – 219RSN1_TMInterPro annotationAdd BLAST112
Domaini235 – 387PHM7_cytInterPro annotationAdd BLAST153
Domaini399 – 662RSN1_7TMInterPro annotationAdd BLAST264

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni86 – 114DisorderedSequence analysisAdd BLAST29
Regioni740 – 760DisorderedSequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi86 – 110Polar residuesSequence analysisAdd BLAST25
Compositional biasi744 – 760Polar residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CSC1 (TC 1.A.17) family. [View classification]ARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1134, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_015647_0_0_1

Identification of Orthologs from Complete Genome Data

More...OMAi		QGIGMFP

Database of Orthologous Groups

More...OrthoDBi		395194at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR045122, Csc1-like
IPR032880, Csc1_N
IPR027815, PHM7_cyt
IPR003864, RSN1_7TM

The PANTHER Classification System

More...PANTHERi		PTHR13018, PTHR13018, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF14703, PHM7_cyt, 1 hit
PF02714, RSN1_7TM, 1 hit
PF13967, RSN1_TM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6NP91-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVMSENSNIS YCQAVANRTS FFTTAYNGIP ETLILNTIFW VLLILLFTVL 
        60         70         80         90        100
RHQAGDFGRL ALVNSNGSKK RWTEIFYSRA ASVVDPQPST STQVSPRPST 
       110        120        130        140        150
TSQGVPDSTP LSPIQPEEGL FGWIRVTLKL RKETILLHTG PDAVHYLSFQ 
       160        170        180        190        200
QHLMAVMALV TIVSLVIILP VNFLNGPKEN PYDVNAFGRT TMANLSPDSP 
       210        220        230        240        250
WLWVHTIITI LYIPLVVLIM RRASGRNAFK KAATRTIMIS NISSSDRNKT 
       260        270        280        290        300
VVRNYMQELF PDVTIENVSI AYNISRLYVR NAEFERVHEA RLYCEHHRNR 
       310        320        330        340        350
DTLMVKPEMC SCKKENAYEY YQREERKLSG DVARLRASTM NEPLDIAFIT 
       360        370        380        390        400
VSTVQEAQNI VTHFTPGTYR QWHLVFAPSP DDLFWENLNV NKSHWYLKFF 
       410        420        430        440        450
CVNAVLFLVL FFLSTPAMVV SLLNSRPWVK ETEGKISPLV ADFLPTLMLW 
       460        470        480        490        500
TLSALMPVIV AISDKWMRHY TRSKQNYSIM TKCFGYLLMM IMILPSLGLT 
       510        520        530        540        550
SAQALLEWGF LNQTDRWQCI FLPDRGSFYV NYIITAAFIG TALELLRFPE 
       560        570        580        590        600
LIVYIWSLLK AKSKAETPYI RKAILIEFPF GTHYAWTTLV FTIAIVYSVA 
       610        620        630        640        650
CPLIMPFAMI YICLKHFVDR HNLYFAYGPS NMISRKGGKI HSTAVTMTKF 
       660        670        680        690        700
SVVILVLVMA MICFFRGDNG MARFLLLIIS LAITLTLFTF MSPIKRCAAT 
       710        720        730        740        750
RRPSIVEIAG PAPIYVPDVL KDNGIRTSSV RPSAAAFGGY GSDSVSEYDS 
       760
SQYSVNSVEA
Length:760
Mass (Da):86,149
Last modified:October 3, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i01041D807ACE113D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF59136.1
BT011035 mRNA Translation: AAR30195.1

NCBI Reference Sequences

More...RefSeqi		NP_610351.1, NM_136507.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0088781; FBpp0087859; FBgn0033259

Database of genes from NCBI RefSeq genomes

More...GeneIDi		35779

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG11210

UCSC genome browser

More...UCSCi		CG11210-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF59136.1
BT011035 mRNA Translation: AAR30195.1
RefSeqiNP_610351.1, NM_136507.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi7227.FBpp0087859

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		35779

Genome annotation databases

EnsemblMetazoaiFBtr0088781; FBpp0087859; FBgn0033259
GeneIDi35779
KEGGidme:Dmel_CG11210
UCSCiCG11210-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		35779
FlyBaseiFBgn0033259, Tmem63
VEuPathDBiVectorBase:FBgn0033259

Phylogenomic databases

eggNOGiKOG1134, Eukaryota
HOGENOMiCLU_015647_0_0_1
OMAiQGIGMFP
OrthoDBi395194at2759

Enzyme and pathway databases

ReactomeiR-DME-6798695, Neutrophil degranulation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		35779, 1 hit in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		35779

Protein Ontology

More...PROi		PR:Q6NP91

Gene expression databases

BgeeiFBgn0033259, Expressed in digestive system element and 39 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR045122, Csc1-like
IPR032880, Csc1_N
IPR027815, PHM7_cyt
IPR003864, RSN1_7TM
PANTHERiPTHR13018, PTHR13018, 1 hit
PfamiView protein in Pfam
PF14703, PHM7_cyt, 1 hit
PF02714, RSN1_7TM, 1 hit
PF13967, RSN1_TM, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6NP91_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NP91
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: May 25, 2022
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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