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Entry version 138 (02 Dec 2020)
Sequence version 1 (03 Oct 2006)
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Protein
Submitted name:

LP07472p

Gene

SKI3

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • nuclear-transcribed mRNA catabolic process Source: FlyBase

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-429958, mRNA decay by 3' to 5' exoribonuclease

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
LP07472pImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SKI3Imported
Synonyms:Dmel\CG8777Imported, dSki3Imported, ski3Imported
ORF Names:CG8777Imported, Dmel_CG8777Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0033376, CG8777

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q6NNB2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0033376, Expressed in oviduct (Drosophila) and 39 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0087646

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6NNB2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 60TPR_REGIONInterPro annotationAdd BLAST54
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati7 – 40TPRPROSITE-ProRule annotationAdd BLAST34
Domaini406 – 612TPR_REGIONInterPro annotationAdd BLAST207
Repeati406 – 439TPRPROSITE-ProRule annotationAdd BLAST34
Repeati511 – 544TPRPROSITE-ProRule annotationAdd BLAST34
Repeati545 – 578TPRPROSITE-ProRule annotationAdd BLAST34
Repeati579 – 612TPRPROSITE-ProRule annotationAdd BLAST34
Domaini804 – 871TPR_REGIONInterPro annotationAdd BLAST68
Repeati804 – 837TPRPROSITE-ProRule annotationAdd BLAST34
Repeati838 – 871TPRPROSITE-ProRule annotationAdd BLAST34
Domaini926 – 996TPR_REGIONInterPro annotationAdd BLAST71
Repeati926 – 959TPRPROSITE-ProRule annotationAdd BLAST34
Repeati963 – 996TPRPROSITE-ProRule annotationAdd BLAST34

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

RepeatARBA annotation, TPR repeatPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1127, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016407

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003788_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
QNWNLLG

Database of Orthologous Groups

More...
OrthoDBi
347760at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 6 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039226, Ski3/TTC37
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR15704, PTHR15704, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13181, TPR_8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00028, TPR, 11 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452, SSF48452, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50005, TPR, 9 hits
PS50293, TPR_REGION, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6NNB2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAVKESKAL IKDIRETIKL GKHAEAIPKC QRLLKSEPEN AMGYLLLGAA
60 70 80 90 100
YQNIDKAEAA KNLRQCIKCT DGPAPAALLG LANCAPSNEL PEIYDQLADL
110 120 130 140 150
QPEQSLNYWE KLFNLASDSN VAPFCFTVLK KRVQDTENGN FTKIQEYLGR
160 170 180 190 200
IWVSNDFEIA PEDTQLYKTT MEALLQNSEP SARSVVYKRY LKWLYKKQDY
210 220 230 240 250
ETCVRHACNM TESHPKDVYG FEWICKTYCE HHEQSEIVSW QQELRHPIQV
260 270 280 290 300
YAEQLLELNP NSNLALLVKA LDLFAEGQVV ASRQLALQAQ KSQPAYKVTL
310 320 330 340 350
ELLARIHMEL GAYKLALQLW QEIGQENDAY ALCLSHEKGV SKLREAVTIL
360 370 380 390 400
QTLENSEGNI KSLARCYFKL GELHLLKDLP LDDLTKAEFV LSPSEALQEI
410 420 430 440 450
ADCKTFEAYL LCGKLHMALK NYSDALNYVL KATRLRPHFA ECFDYLGKLY
460 470 480 490 500
PLATGDFSRA RKCYEKCISL NPLAEEAVDA LSFIYQEQGE EELNETLLLN
510 520 530 540 550
TLSHLGSNES IRLQYKLGLH FSHVKKWDSA IQCFRIAIKN DSRCISYWES
560 570 580 590 600
LGDAYAGRGS YNSAIRVFQK ILELSPENNY ALLQIASVKT TIRMYTESIE
610 620 630 640 650
DYDTLLQRNP TYLPGLRGAA EAHIGIANSL KSQNLYGRSK AHFQLALEHL
660 670 680 690 700
QSAFLQREAQ GMVWLWRLSA NIFVQTAQLP HSLANLDVAG NLAKREEPIA
710 720 730 740 750
YLSRKDLLQL AQRFYLCALK LKQNTYLWYE LSLASYYSAI LIPEDANGHL
760 770 780 790 800
ETATKACKMA IKECSNRWQN WNLLGVINMN SENENLPLAQ HCFIQAVVLE
810 820 830 840 850
KKCYTAWTNL GVLYIKLNEV RLANEAFTRA QQSSPVYANA WIGQAMVAEL
860 870 880 890 900
IGDREEAFDL FRHCQQFDYH PEAALGFAHW VCEMLSTPGS FDKPRIKHAI
910 920 930 940 950
EHMYADVLAL DAINWYVQNE ETDATPASLS FQGFLYARKN LYRQAIEAFT
960 970 980 990 1000
RACKLCEPGA DRDKLYTNLG YLYLKIDQPE QAAHALNTVA HATFKPIIGL
1010 1020 1030 1040 1050
AQAYYLAGQL QESYSIYNSV LGNVVDHGDD KAATILVAMA SMIYDFQGEA
1060 1070 1080 1090 1100
DTKTLLYQCV LLKEVPIQAL FSALALGILH RDNALIHTIL TELNAYAFKK
1110 1120 1130 1140 1150
EYCADISYLT AHYILINEGA RRALCYLQTR IRMFPNSRSL RSVVLKFLLD
1160 1170 1180 1190 1200
YFSDDQSYRL ATSNMGRITL TLGHTKQQNS ILASEEALTT IYASQAVSAV
1210 1220 1230
DKTCSMKLLQ RAILLSPTDQ RARQLLSAII ANS
Length:1,233
Mass (Da):139,619
Last modified:October 3, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i14EB42C1B6835BF6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58990.2
BT011380 mRNA Translation: AAR96172.1

NCBI Reference Sequences

More...
RefSeqi
NP_610452.2, NM_136608.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0088565; FBpp0087646; FBgn0033376

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
35921

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG8777

UCSC genome browser

More...
UCSCi
CG8777-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58990.2
BT011380 mRNA Translation: AAR96172.1
RefSeqiNP_610452.2, NM_136608.4

3D structure databases

SMRiQ6NNB2
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0087646

Proteomic databases

PRIDEiQ6NNB2

Genome annotation databases

EnsemblMetazoaiFBtr0088565; FBpp0087646; FBgn0033376
GeneIDi35921
KEGGidme:Dmel_CG8777
UCSCiCG8777-RA, d. melanogaster

Organism-specific databases

FlyBaseiFBgn0033376, CG8777

Phylogenomic databases

eggNOGiKOG1127, Eukaryota
GeneTreeiENSGT00390000016407
HOGENOMiCLU_003788_0_0_1
OMAiQNWNLLG
OrthoDBi347760at2759

Enzyme and pathway databases

ReactomeiR-DME-429958, mRNA decay by 3' to 5' exoribonuclease

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
35921, 1 hit in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
35921

Gene expression databases

BgeeiFBgn0033376, Expressed in oviduct (Drosophila) and 39 other tissues

Family and domain databases

Gene3Di1.25.40.10, 6 hits
InterProiView protein in InterPro
IPR039226, Ski3/TTC37
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat
PANTHERiPTHR15704, PTHR15704, 1 hit
PfamiView protein in Pfam
PF13181, TPR_8, 1 hit
SMARTiView protein in SMART
SM00028, TPR, 11 hits
SUPFAMiSSF48452, SSF48452, 4 hits
PROSITEiView protein in PROSITE
PS50005, TPR, 9 hits
PS50293, TPR_REGION, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6NNB2_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NNB2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: December 2, 2020
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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