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Protein

Elongation factor Tu

Gene

tuf

Organism
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi19 – 26GTPUniRule annotation8
Nucleotide bindingi83 – 87GTPUniRule annotation5
Nucleotide bindingi138 – 141GTPUniRule annotation4

GO - Molecular functioni

Keywordsi

Molecular functionElongation factor
Biological processProtein biosynthesis
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor TuUniRule annotation
Short name:
EF-TuUniRule annotation
Gene namesi
Name:tufUniRule annotation
Ordered Locus Names:DIP0470
OrganismiCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Taxonomic identifieri257309 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000002198 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000156411 – 396Elongation factor TuAdd BLAST396

Proteomic databases

PRIDEiQ6NJD5

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ6NJD5
SMRiQ6NJD5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 205tr-type GAdd BLAST196

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni19 – 26G1By similarity8
Regioni62 – 66G2By similarity5
Regioni83 – 86G3By similarity4
Regioni138 – 141G4By similarity4
Regioni175 – 177G5By similarity3

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000229290
KOiK02358
OMAiYGHIDCP

Family and domain databases

CDDicd03697 EFTU_II, 1 hit
HAMAPiMF_00118_B EF_Tu_B, 1 hit
InterProiView protein in InterPro
IPR004161 EFTu-like_2
IPR033720 EFTU_2
IPR031157 G_TR_CS
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR000795 TF_GTP-bd_dom
IPR009000 Transl_B-barrel_sf
IPR009001 Transl_elong_EF1A/Init_IF2_C
IPR004541 Transl_elong_EFTu/EF1A_bac/org
IPR004160 Transl_elong_EFTu/EF1A_C
PfamiView protein in Pfam
PF00009 GTP_EFTU, 1 hit
PF03144 GTP_EFTU_D2, 1 hit
PF03143 GTP_EFTU_D3, 1 hit
PRINTSiPR00315 ELONGATNFCT
SUPFAMiSSF50447 SSF50447, 1 hit
SSF50465 SSF50465, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00485 EF-Tu, 1 hit
TIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS00301 G_TR_1, 1 hit
PS51722 G_TR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6NJD5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKAKFERTK PHVNIGTIGH VDHGKTTTTA AITKVLADAY PELNEAFAFD
60 70 80 90 100
AIDKAPEEKE RGITINISHV EYQTEKRHYA HVDAPGHADY IKNMITGAAQ
110 120 130 140 150
MDGAILVVAA TDGPMPQTRE HVLLARQVGV PYILVALNKC DMVDDEEIIE
160 170 180 190 200
LVEMEIRELL AEQDYDEEAP IIHISALKAL EGDEKWTQSI IDLMQACDDS
210 220 230 240 250
IPDPERETDK PFLMPIEDIF TITGRGTVVT GRVERGSLKV NEDVEIIGIR
260 270 280 290 300
EKATTTTVTG IEMFRKLLDY TEAGDNCGLL LRGVKREDVE RGQVVVKPGA
310 320 330 340 350
YTPHTEFEGS VYVLSKDEGG RHTPFFDNYR PQFYFRTTDV TGVVKLPEGT
360 370 380 390
EMVMPGDNVD MSVTLIQPVA MDEGLRFAIR EGSRTVGAGR VTKIIK
Length:396
Mass (Da):43,944
Last modified:July 5, 2004 - v1
Checksum:iAFDEAE4CF3C9FC27
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248355 Genomic DNA Translation: CAE48974.1
RefSeqiWP_004566712.1, NC_002935.2

Genome annotation databases

EnsemblBacteriaiCAE48974; CAE48974; DIP0470
GeneIDi29422031
KEGGicdi:DIP0470

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248355 Genomic DNA Translation: CAE48974.1
RefSeqiWP_004566712.1, NC_002935.2

3D structure databases

ProteinModelPortaliQ6NJD5
SMRiQ6NJD5
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ6NJD5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE48974; CAE48974; DIP0470
GeneIDi29422031
KEGGicdi:DIP0470

Phylogenomic databases

HOGENOMiHOG000229290
KOiK02358
OMAiYGHIDCP

Family and domain databases

CDDicd03697 EFTU_II, 1 hit
HAMAPiMF_00118_B EF_Tu_B, 1 hit
InterProiView protein in InterPro
IPR004161 EFTu-like_2
IPR033720 EFTU_2
IPR031157 G_TR_CS
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR000795 TF_GTP-bd_dom
IPR009000 Transl_B-barrel_sf
IPR009001 Transl_elong_EF1A/Init_IF2_C
IPR004541 Transl_elong_EFTu/EF1A_bac/org
IPR004160 Transl_elong_EFTu/EF1A_C
PfamiView protein in Pfam
PF00009 GTP_EFTU, 1 hit
PF03144 GTP_EFTU_D2, 1 hit
PF03143 GTP_EFTU_D3, 1 hit
PRINTSiPR00315 ELONGATNFCT
SUPFAMiSSF50447 SSF50447, 1 hit
SSF50465 SSF50465, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00485 EF-Tu, 1 hit
TIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS00301 G_TR_1, 1 hit
PS51722 G_TR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEFTU_CORDI
AccessioniPrimary (citable) accession number: Q6NJD5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: October 10, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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