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Protein

Probable malate:quinone oxidoreductase

Gene

mqo

Organism
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + a quinone = oxaloacetate + reduced quinone.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable malate:quinone oxidoreductase (mqo)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandFAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01008

Names & Taxonomyi

Protein namesi
Recommended name:
Probable malate:quinone oxidoreductaseUniRule annotation (EC:1.1.5.4UniRule annotation)
Alternative name(s):
MQOUniRule annotation
Malate dehydrogenase [quinone]UniRule annotation
Gene namesi
Name:mqoUniRule annotation
Ordered Locus Names:DIP1492
OrganismiCorynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Taxonomic identifieri257309 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000002198 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003254931 – 499Probable malate:quinone oxidoreductaseAdd BLAST499

Structurei

3D structure databases

ProteinModelPortaliQ6NGL9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MQO family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000109379
KOiK00116
OMAiEPIAATK

Family and domain databases

Gene3Di3.50.50.60, 2 hits
HAMAPiMF_00212 MQO, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR006231 MQO
PfamiView protein in Pfam
PF06039 Mqo, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
TIGRFAMsiTIGR01320 mal_quin_oxido, 1 hit

Sequencei

Sequence statusi: Complete.

Q6NGL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSTTAQHV TDEVDVALIG AGIMSATLGA MLRTLEPGWT QVMFERLDAP
60 70 80 90 100
AQESSSPWNN AGTGHSALCE LNYTPEVKGR VQIDKALGVN EKFQISRQFW
110 120 130 140 150
SYQVNEGVLP SPREWINPVP HVSFGRGEDQ VAYLKKRYEA LAAHPLFPNM
160 170 180 190 200
QYTDDRAKFA EMLPLMADGR SEFEKVAISW TDAGTDINYG SQTRQFLKAA
210 220 230 240 250
EKNGTEIRYG HEVKDIKRDG AKWRVTVKNV HTGDTQVIRA NFVFVGAGGM
260 270 280 290 300
ALPLLQKTGI VEIRGWGGFP VSGQWLRCTN PDIIEQHAAK VYGKASIGAP
310 320 330 340 350
PMSVPHLDTR VIDGEKGLLF GPYAGWTPKF LKKGSYLDLF KSIRPTNLMS
360 370 380 390 400
YLGVGAQEFG LTKYLITEVM KDQAARMESL REYMPNAKDE DWELVTAGQR
410 420 430 440 450
VQAIQPVVGP RFSTLAFGTS LINSADGSVA GILGASPGAS IAPAAMLELL
460 470 480 490
ERCFGQKMVE WGPTIKDMIP SYGIRLATDQ KLFNEIWDHT QATLQLDKK
Length:499
Mass (Da):55,033
Last modified:July 5, 2004 - v1
Checksum:iA3637D30BFAC4560
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248358 Genomic DNA Translation: CAE50019.1
RefSeqiWP_010935102.1, NC_002935.2

Genome annotation databases

EnsemblBacteriaiCAE50019; CAE50019; DIP1492
KEGGicdi:DIP1492

Similar proteinsi

Entry informationi

Entry nameiMQO_CORDI
AccessioniPrimary (citable) accession number: Q6NGL9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 5, 2004
Last modified: February 28, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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