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Protein

Error-prone DNA polymerase

Gene

dnaE2

Organism
Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.UniRule annotation

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-directed DNA polymerase, Nucleotidyltransferase, Transferase
Biological processDNA damage, DNA repair, DNA replication

Enzyme and pathway databases

BioCyciRPAL258594:G1GT2-1850-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Error-prone DNA polymeraseUniRule annotation (EC:2.7.7.7UniRule annotation)
Gene namesi
Name:dnaE2UniRule annotation
Ordered Locus Names:RPA1803
OrganismiRhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Taxonomic identifieri258594 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
Proteomesi
  • UP000001426 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001033981 – 1195Error-prone DNA polymeraseAdd BLAST1195

Interactioni

Protein-protein interaction databases

STRINGi258594.RPA1803

Structurei

3D structure databases

ProteinModelPortaliQ6N8V0
SMRiQ6N8V0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA polymerase type-C family. DnaE2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C0B Bacteria
COG0587 LUCA
HOGENOMiHOG000021783
KOiK14162
OMAiNSWPMGF
OrthoDBiPOG091H02F7
PhylomeDBiQ6N8V0

Family and domain databases

HAMAPiMF_01902 DNApol_error_prone, 1 hit
InterProiView protein in InterPro
IPR011708 DNA_pol3_alpha
IPR023073 DNA_pol_error_prone
IPR029460 DNAPol_HHH
IPR004365 NA-bd_OB_tRNA
IPR004013 PHP_dom
IPR003141 Pol/His_phosphatase_N
IPR004805 PolC_alpha
PANTHERiPTHR32294 PTHR32294, 2 hits
PTHR32294:SF4 PTHR32294:SF4, 2 hits
PfamiView protein in Pfam
PF07733 DNA_pol3_alpha, 1 hit
PF14579 HHH_6, 1 hit
PF02811 PHP, 1 hit
PF01336 tRNA_anti-codon, 1 hit
SMARTiView protein in SMART
SM00481 POLIIIAc, 1 hit
TIGRFAMsiTIGR00594 polc, 1 hit

Sequencei

Sequence statusi: Complete.

Q6N8V0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSARYAEIGV TTNFSFLEGG SHPQDYVHEA SRLGLDAIGI ADRNTLAGVV
60 70 80 90 100
RAFSEFDNEE LIHKPKLLIG TRLCFADGTP DLLAYPTDRA AYGRLCRLLS
110 120 130 140 150
AGKLRAGKGE CHLTFADLEA FIHERSPSIH ELATVIHPPS ASINQPSASI
160 170 180 190 200
HQFPTPSWPG LTRPSTPTSK VVLVSVDARV KPGHDGGKRV ADNSQILLVV
210 220 230 240 250
MPSYRFQTKT IAIALERLTA LNADAVWLGL TPYYRGDDKR RLARLRRIAA
260 270 280 290 300
VARVPCIATN DVLYHHPRRR ALQDVLTCVR EKTSIDKAGR RLEGNAERHL
310 320 330 340 350
KPAAEMARLF RHDPEAIAET LRFADRISFT LDELKYHYPD EPVPPGKTAQ
360 370 380 390 400
AHLQDLTEQG IKQYFPNGIS DRLRATIAKE LAIIERRGYA HYFLTVHDIV
410 420 430 440 450
RYARSQDILC QGRGSAANSA VCYVLGITCV DPTEIDLLFE RFVSEERDEP
460 470 480 490 500
PDIDVDFEHS RREEVMQYIY RRYGRHRAAI VATVIHYRPR SAIRDVGKAL
510 520 530 540 550
GLSEDVTAAL ADTVWGSWGK GLNEMQVRQA GLDPHNPMIG RAVELATELI
560 570 580 590 600
GFPRHLSQHV GGYVLTQDRL DSYVPIGNAA MADRTFIEWD KDDIDAVKMM
610 620 630 640 650
KVDVLALGML TCIRKGFHLI AQHKGVRFQL SDIKSEDDNA VYKMLQRGES
660 670 680 690 700
IGVFQVESRA QMNMLPRLKP RCFYDLVIEV AIVRPGPIQG DMVHPYLRRR
710 720 730 740 750
NGQEPVVYPS PSGEAGDKNE LRQILGKTLG VPLFQEQAMR IAIEAAHFTP
760 770 780 790 800
DEANQLRRAM ATFRNVGTIG KFEAKMIGNL VKRGYDATFA KNCFEQIKGF
810 820 830 840 850
GSYGFPESHA ASFAKLVYVS AWMKCEHPDA FCCALLNSQP MGFYAPAQIV
860 870 880 890 900
GDARSNGVEV RPVDVSFSEG QCTLEERCGR HHAVRLGFRM IDGFRWADPD
910 920 930 940 950
EERVQLEAGE PPSDDWAARI VAARARGAFT SLEQFARITA LPKRALILLA
960 970 980 990 1000
DADAFRSLGL DRRAALWAVR RLPDDVPLPL FEAASAREQE DERAAPLPAM
1010 1020 1030 1040 1050
PMAEHVVADY QTVRLSLKGH PMEFLRALFA AERVVTCREV SRSEQRASGC
1060 1070 1080 1090 1100
WLRCAGVVLV RQRPGSANGV IFMTIEDETG IANIVVWPAV MEKYRKEVMG
1110 1120 1130 1140 1150
ARLVLVEGKV QASAEGVVHL VAERLIDRSA EMGRLAEGLV RPALPDGADL
1160 1170 1180 1190
YEPLTSEKYN YEALNGDRRD TPDAPAQRHR HPRDVRILPP SRDFH
Length:1,195
Mass (Da):133,397
Last modified:July 5, 2004 - v1
Checksum:i1D1F8E9803B1E1D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX572598 Genomic DNA Translation: CAE27244.1
RefSeqiWP_011157309.1, NC_005296.1

Genome annotation databases

EnsemblBacteriaiCAE27244; CAE27244; RPA1803
KEGGirpa:RPA1803

Similar proteinsi

Entry informationi

Entry nameiDNAE2_RHOPA
AccessioniPrimary (citable) accession number: Q6N8V0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 5, 2004
Last modified: February 28, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health