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Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.UniRule annotation

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.UniRule annotation

Cofactori

NAD+UniRule annotationNote: Binds 1 NAD+ per subunit.UniRule annotation

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei58SubstrateUniRule annotation1
Binding sitei133SubstrateUniRule annotation1
Binding sitei195SubstrateUniRule annotation1
Binding sitei225SubstrateUniRule annotation1
Binding sitei229SubstrateUniRule annotation1
Binding sitei230NADUniRule annotation1
Binding sitei282NADUniRule annotation1
Binding sitei317NADUniRule annotation1
Binding sitei383NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi196 – 198NADUniRule annotation3
Nucleotide bindingi259 – 264NADUniRule annotation6
Nucleotide bindingi338 – 340NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

BioCyciRPAL258594:TX73_RS20475-MONOMER
UniPathwayiUPA00314; UER00076

Names & Taxonomyi

Protein namesi
Recommended name:
AdenosylhomocysteinaseUniRule annotation (EC:3.3.1.1UniRule annotation)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolaseUniRule annotation
Short name:
AdoHcyaseUniRule annotation
Gene namesi
Name:ahcYUniRule annotation
Ordered Locus Names:RPA4015
OrganismiRhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Taxonomic identifieri258594 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
Proteomesi
  • UP000001426 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001169841 – 469AdenosylhomocysteinaseAdd BLAST469

Proteomic databases

PRIDEiQ6N2N5

Interactioni

Protein-protein interaction databases

STRINGi258594.RPA4015

Structurei

3D structure databases

ProteinModelPortaliQ6N2N5
SMRiQ6N2N5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C3E Bacteria
COG0499 LUCA
HOGENOMiHOG000227986
KOiK01251
OMAiTGNRDII
OrthoDBiPOG091H00W2
PhylomeDBiQ6N2N5

Family and domain databases

CDDicd00401 SAHH, 1 hit
HAMAPiMF_00563 AdoHcyase, 1 hit
InterProiView protein in InterPro
IPR034373 Adenosylhomocysteinase
IPR000043 Adenosylhomocysteinase-like
IPR015878 Ado_hCys_hydrolase_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020082 S-Ado-L-homoCys_hydrolase_CS
PANTHERiPTHR23420 PTHR23420, 1 hit
PfamiView protein in Pfam
PF05221 AdoHcyase, 1 hit
PF00670 AdoHcyase_NAD, 1 hit
PIRSFiPIRSF001109 Ad_hcy_hydrolase, 1 hit
SMARTiView protein in SMART
SM00996 AdoHcyase, 1 hit
SM00997 AdoHcyase_NAD, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00936 ahcY, 1 hit
PROSITEiView protein in PROSITE
PS00738 ADOHCYASE_1, 1 hit
PS00739 ADOHCYASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6N2N5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAKFTDYIV KDIGLAEFGR KEISLAETEM PGLMATREEY GPKQPLKGAK
60 70 80 90 100
IAGSLHMTIQ TAVLIETLVA LGAEVRWVSC NIYSTQDHAA AAIAAAGIPV
110 120 130 140 150
FAVKGETLKD YWDYTAKLFD WSDGGTPNMI LDDGGDATMF VHQGLRAENG
160 170 180 190 200
DTMFLDQHNS EEEEIFFALI KRILKEKPKG YFATLAKNIK GVSEETTTGV
210 220 230 240 250
HRLYDMEKAG KLLFPAINVN DSVTKSKFDN LYGCRESLVD GIRRGTDVML
260 270 280 290 300
SGKVAMVAGF GDVGKGSAAS LRQAGCRVMV SEVDPICALQ AAMEGYQVVT
310 320 330 340 350
MEDAAPIADI FVTATGNKDI ITIEHMRAMK DRAIVCNIGH FDNEIQVATL
360 370 380 390 400
KNMKWDNIKP QVDEITFPDG KRMILLSEGR LVNLGNAMGH PSFVMSASFT
410 420 430 440 450
NQTLAQIELF QNQGKYEKKV YVLPKTLDEK VARLHLAKIG VKLTELRKDQ
460
ADYIGVKVEG PFKADHYRY
Length:469
Mass (Da):51,699
Last modified:July 5, 2004 - v1
Checksum:i65C3E800744B4A4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX572606 Genomic DNA Translation: CAE29456.1
RefSeqiWP_011159550.1, NC_005296.1

Genome annotation databases

EnsemblBacteriaiCAE29456; CAE29456; RPA4015
KEGGirpa:RPA4015

Similar proteinsi

Entry informationi

Entry nameiSAHH_RHOPA
AccessioniPrimary (citable) accession number: Q6N2N5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: June 20, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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