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UniProtKB - Q6N084 (Q6N084_HUMAN)

Entry version 90 (07 Apr 2021)
Sequence version 1 (05 Jul 2004)
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Protein

Fibronectin

Gene

DKFZp686L11144

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHeparin-bindingARBA annotation
Biological processAcute phaseARBA annotation, Cell adhesionARBA annotation, Cell shapeARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FibronectinARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DKFZp686L11144Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28194

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

Disulfide bondARBA annotation, OxidationARBA annotation

Proteomic databases

PeptideAtlas

More...PeptideAtlasi		Q6N084

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6N084, HS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 35Fibronectin type-IIIInterPro annotationAdd BLAST35
Domaini38 – 130Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini131 – 218Fibronectin type-IIIInterPro annotationAdd BLAST88
Domaini219 – 312Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini313 – 403Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini404 – 496Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini497 – 583Fibronectin type-IIIInterPro annotationAdd BLAST87
Domaini584 – 674Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini753 – 845Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini852 – 896Fibronectin type-IInterPro annotationAdd BLAST45
Domaini897 – 939Fibronectin type-IInterPro annotationAdd BLAST43
Domaini941 – 981Fibronectin type-IInterPro annotationAdd BLAST41

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni338 – 362DisorderedSequence analysisAdd BLAST25

Phylogenomic databases

Database of Orthologous Groups

More...OrthoDBi		6580at2759

Family and domain databases

Conserved Domains Database

More...CDDi		cd00061, FN1, 3 hits
cd00063, FN3, 8 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 9 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000083, Fibronectin_type1
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00039, fn1, 3 hits
PF00041, fn3, 8 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00058, FN1, 3 hits
SM00060, FN3, 8 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49265, SSF49265, 6 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01253, FN1_1, 1 hit
PS51091, FN1_2, 3 hits
PS50853, FN3, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q6N084-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
CTFDNLSPGL EYNVSVYTVK DDKESVPISD TIIPAVPPPT DLRFTNIGPD 
        60         70         80         90        100
TMRVTWAPPP SIDLTNFLVR YSPVKNEEDV AELSISPSDN AVVLTNLLPG 
       110        120        130        140        150
TEYVVSVSSV YEQHESTPLR GRQKTGLDSP TGIDFSDITA NSFTVHWIAP 
       160        170        180        190        200
RATITGYRIR HHPEHFSGRP REDRVPHSRN SITLTNLTPG TEYVVSIVAL 
       210        220        230        240        250
NGREESPLLI GQQSTVSDVP RDLEVVAATP TSLLISWDAP AVTVRYYRIT 
       260        270        280        290        300
YGETGGNSPV QEFTVPGSKS TATISGLKPG VDYTITVYAV TGRGDSPASS 
       310        320        330        340        350
KPISINYRTE IDKPSQMQVT DVQDNSISVK WLPSSSPVTG YRVTTTPKNG 
       360        370        380        390        400
PGPTKTKTAG PDQTEMTIEG LQPTVEYVVS VYAQNPSGES QPLVQTAVTT 
       410        420        430        440        450
IPAPTDLKFT QVTPTSLSAQ WTPPNVQLTG YRVRVTPKEK TGPMKEINLA 
       460        470        480        490        500
PDSSSVVVSG LMVATKYEVS VYALKDTLTS RPAQGVVTTL ENVSPPRRAR 
       510        520        530        540        550
VTDATETTIT ISWRTKTETI TGFQVDAVPA NGQTPIQRTI KPDVRSYTIT 
       560        570        580        590        600
GLQPGTDYKI YLYTLNDNAR SSPVVIDAST AIDAPSNLRF LATTPNSLLV 
       610        620        630        640        650
SWQPPRARIT GYIIKYEKPG SPPREVVPRP RPGVTEATIT GLEPGTEYTI 
       660        670        680        690        700
YVIALKNNQK SEPLIGRKKT DELPQLVTLP HPNLHGPEIL DVPSTVQKTP 
       710        720        730        740        750
FVTHPGYDTG NGIQLPGTSG QQPSVGQQMI FEEHGFRRTT PPTTATPIRH 
       760        770        780        790        800
RPRPYPPNVG QEALSQTTIS WAPFQDTSEY IISCHPVGTD EEPLQFRVPG 
       810        820        830        840        850
TSTSATLTGL TRGATYNIIV EALKDQQRHK VREEVVTVGN SVNEGLNQPT 
       860        870        880        890        900
DDSCFDPYTV SHYAVGDEWG RMSESGFKLL CQCLGFGSGH FRCDSSRWCH 
       910        920        930        940        950
DNGVNYKIGE KWDRQGENGQ MMSCTCLGNG KGEFKCDPHE ATCYDDGKTY 
       960        970        980        990       1000
HVGEQWQKEY LGAICSCTCF GGQRGWRCDN CRRPGGEPSP EGTTGQSYNQ 
      1010       1020       1030 
YSQRYHQRTN TNVNCPIECF MPLDVQADRE DSRE
Length:1,034
Mass (Da):113,372
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3765128365FD0659
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BX640638 mRNA Translation: CAE45786.1

NCBI Reference Sequences

More...RefSeqi		NP_002017.1, NM_002026.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2335

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640638 mRNA Translation: CAE45786.1
RefSeqiNP_002017.1, NM_002026.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Proteomic databases

PeptideAtlasiQ6N084

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		2335

Genome annotation databases

GeneIDi2335

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2335
PharmGKBiPA28194

Phylogenomic databases

OrthoDBi6580at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2335, 5 hits in 997 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2335

Gene expression databases

GenevisibleiQ6N084, HS

Family and domain databases

CDDicd00061, FN1, 3 hits
cd00063, FN3, 8 hits
Gene3Di2.60.40.10, 9 hits
InterProiView protein in InterPro
IPR000083, Fibronectin_type1
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold
PfamiView protein in Pfam
PF00039, fn1, 3 hits
PF00041, fn3, 8 hits
SMARTiView protein in SMART
SM00058, FN1, 3 hits
SM00060, FN3, 8 hits
SUPFAMiSSF49265, SSF49265, 6 hits
PROSITEiView protein in PROSITE
PS01253, FN1_1, 1 hit
PS51091, FN1_2, 3 hits
PS50853, FN3, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6N084_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6N084
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: April 7, 2021
This is version 90 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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