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  1. 1
    Cited for: NUCLEOTIDE SEQUENCE.
    Category: Sequences.
    Tissue: Human colon endothel primary cell culture.
    Source: UniProtKB/TrEMBL (unreviewed).
  2. 2
    "Different domains of the mitogen-activated protein kinases ERK3 and ERK2 direct subcellular localization and upstream specificity in vivo."
    Robinson M.J., Xu Be B.E., Stippec S., Cobb M.H.
    J. Biol. Chem. 277:5094-5100(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Subcellular Location.
    Annotation: C-terminal halves of ERK2 and ERK3DeltaC are primarily responsible for subcellular localization in resting cells; and the N-terminal folding domain of ERK2 is required for its activation in cells interaction with MEK1 and accumulation in the nucleus.
    Source: GeneRIF:6300.

    This publication is mapped to 9 other entries.

  3. 3
    "Cardiac expression and subcellular localization of the p38 mitogen-activated protein kinase member, stress-activated protein kinase-3 (SAPK3)."
    Court N.W., dos Remedios C.G., Cordell J., Bogoyevitch M.A.
    J. Mol. Cell. Cardiol. 34:413-426(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Subcellular Location.
    Annotation: Cardiac expression and subcellular localization.
    Source: GeneRIF:6300.

    This publication is cited by 2 and mapped to 5 other entries.

  4. 4
    "Different regulation of PKC isoenzymes and MAPK by PSK and IL-2 in the proliferative and cytotoxic activities of the NKL human natural killer cell line."
    Garcia-Lora A., Martinez M., Pedrinaci S., Garrido F.
    Cancer Immunol. Immunother. 52:59-64(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: IL-2 and polysaccharide K increased the expression of ERK3.
    Source: GeneRIF:6300.

    This publication is mapped to 36 other entries.

  5. 5
    "Nuclear export of ERK3 by a CRM1-dependent mechanism regulates its inhibitory action on cell cycle progression."
    Julien C., Coulombe P., Meloche S.
    J. Biol. Chem. 278:42615-42624(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Subcellular Location.
    Annotation: CRM1 binds to ERK3and promotes the cytoplasmic relocalization of ERK3. Enforced localization of ERK3 in the nucleus or cytoplasm markedly attenuates the ability of the kinase to induce cell cycle arrest in fibroblasts.
    Source: GeneRIF:6300.

    This publication is mapped to 14 other entries.

  6. 6
    "p38gamma MAPK regulation of glucose transporter expression and glucose uptake in L6 myotubes and mouse skeletal muscle."
    Ho R.C., Alcazar O., Fujii N., Hirshman M.F., Goodyear L.J.
    Am. J. Physiol. 286:R342-R349(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: data suggest that p38gamma increases basal glucose uptake and decreases DNP- and contraction-stimulated glucose uptake partially by affecting levels of glucose transporter expression in skeletal muscle.
    Source: GeneRIF:6300.

    This publication is mapped to 4 other entries.

  7. 7
    "Phosphorylation of the mitochondrial protein Sab by stress-activated protein kinase 3."
    Court N.W., Kuo I., Quigley O., Bogoyevitch M.A.
    Biochem. Biophys. Res. Commun. 319:130-137(2004) [PubMed] [Europe PMC] [Abstract]
    Category: PTM / Processing.
    Annotation: SAPK3 phosphorylates mitochondrial protein Sab.
    Source: GeneRIF:6300.

    This publication is cited by 1 and mapped to 10 other entries.

  8. 8
    "The stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway."
    Tosti E., Waldbaum L., Warshaw G., Gross E.A., Ruggieri R.
    J. Biol. Chem. 279:47652-47660(2004) [PubMed] [Europe PMC] [Abstract]
    Category: PTM / Processing.
    Annotation: Data show that in response to radiation MRK controls two independent pathways: the Chk2-Cdc25A pathway leading to cell cycle arrest and the p38gamma MAPK pathway.
    Source: GeneRIF:6300.

    This publication is cited by 1 and mapped to 8 other entries.

  9. 9
    "Hyperactive variants of p38alpha induce, whereas hyperactive variants of p38gamma suppress, activating protein 1-mediated transcription."
    Askari N., Diskin R., Avitzour M., Capone R., Livnah O., Engelberg D.
    J. Biol. Chem. 282:91-99(2007) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Pathology & Biotech.
    Annotation: hyperactive variants of p38alpha induce whereas hyperactive variants of p38gamma suppress activating protein 1-mediated transcription.
    Source: GeneRIF:6300.

    This publication is mapped to 22 other entries.

  10. 10
    "p38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response."
    Qi X., Pohl N.M., Loesch M., Hou S., Li R., Qin J.Z., Cuenda A., Chen G.
    J. Biol. Chem. 282:31398-31408(2007) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Mapk14 antagonizes Mapk12 activity through c-jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response.
    Source: GeneRIF:6300.

    This publication is cited by 1 and mapped to 13 other entries.

  11. 11
    "Implication of p38 mitogen-activated protein kinase isoforms (alpha, beta, gamma and delta) in CD4+ T-cell infection with human immunodeficiency virus type I."
    Gutierrez-Sanmartin D., Varela-Ledo E., Aguilera A., Romero-Yuste S., Romero-Jung P., Gomez-Tato A., Regueiro B.J.
    J. Gen. Virol. 89:1661-1671(2008) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Sequences.
    Annotation: These results suggest that in SupT1-based cell lines p38alpha p38gamma and p38delta but not p38beta are implicated in both HIV-1 induced replication and apoptosis in infected and uninfected bystander cells.
    Source: GeneRIF:6300.

    This publication is mapped to 18 other entries.

  12. 12
    "p38alpha and p38gamma mediate oncogenic ras-induced senescence through differential mechanisms."
    Kwong J., Hong L., Liao R., Deng Q., Han J., Sun P.
    J. Biol. Chem. 284:11237-11246(2009) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: p38alpha and p38gamma are essential components of the signaling pathway that regulates the tumor-suppressing senescence response.
    Source: GeneRIF:6300.

    This publication is mapped to 12 other entries.

  13. 13
    Category: Function, Pathology & Biotech.
    Annotation: Observational study of gene-disease association. (HuGE Navigator).
    Source: GeneRIF:6300.

    This publication is mapped to 18735 other entries.

  14. 14
    "PTPH1 dephosphorylates and cooperates with p38gamma MAPK to increase ras oncogenesis through PDZ-mediated interaction."
    Hou S.W., Zhi H.Y., Pohl N., Loesch M., Qi X.M., Li R.S., Basir Z., Chen G.
    Cancer Res. 70:2901-2910(2010) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: PTPH1 plays a role in Ras-dependent malignant growth of colon cancer by a mechanism depending on its p38gamma-binding activity.
    Source: GeneRIF:6300.

    This publication is mapped to 16 other entries.

  15. 15
    "p38gamma regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock."
    Sabio G., Cerezo-Guisado M.I., Del Reino P., Inesta-Vaquera F.A., Rousseau S., Arthur J.S., Campbell D.G., Centeno F., Cuenda A.
    J. Cell Sci. 123:2596-2604(2010) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: In response to hyperosmotic stress p38 also regulates formation of complexes between hDlg and PSF.
    Source: GeneRIF:6300.

    This publication is cited by 1 and mapped to 13 other entries.

  16. 16
    "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."
    Bailey S.D., Xie C., Do R., Montpetit A., Diaz R., Mohan V., Keavney B., Yusuf S., Gerstein H.C., Engert J.C., Anand S.
    Diabetes Care 33:2250-2253(2010) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech, Sequences.
    Annotation: Observational study of gene-disease association gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator).
    Source: GeneRIF:6300.

    This publication is mapped to 18620 other entries.

  17. 17
    "Isoforms of p38MAPK gamma and delta contribute to differentiation of human AML cells induced by 1,25-dihydroxyvitamin D(3)."
    Zhang J., Harrison J.S., Studzinski G.P.
    Exp. Cell Res. 317:117-130(2011) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Isoforms of p38MAPK gamma and delta contribute to differentiation of human AML cells induced by 1 25-dihydroxyvitamin D.
    Source: GeneRIF:6300.

    This publication is mapped to 12 other entries.

  18. 18
    "Loss of p38gamma MAPK induces pleiotropic mitotic defects and massive cell death."
    Kukkonen-Macchi A., Sicora O., Kaczynska K., Oetken-Lindholm C., Pouwels J., Laine L., Kallio M.J.
    J. Cell Sci. 124:216-227(2011) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: The majority of p38gamma-depleted cells die at mitotic arrest or soon after abnormal exit from M-phase.
    Source: GeneRIF:6300.

    This publication is mapped to 4 other entries.

  19. 19
    "p38gamma mitogen-activated protein kinase contributes to oncogenic properties maintenance and resistance to poly (ADP-ribose)-polymerase-1 inhibition in breast cancer."
    Meng F., Zhang H., Liu G., Kreike B., Chen W., Sethi S., Miller F.R., Wu G.
    Neoplasia 13:472-482(2011) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: demonstrates that p38gamma MAPK is a promising target for the design of targeted therapies for basal-like breast cancer with metastatic characteristics and for overcoming potential resistance against the PARP inhibitor.
    Source: GeneRIF:6300.

    This publication is mapped to 11 other entries.

  20. 20
    "p38gamma promotes breast cancer cell motility and metastasis through regulation of RhoC GTPase, cytoskeletal architecture, and a novel leading edge behavior."
    Rosenthal D.T., Iyer H., Escudero S., Bao L., Wu Z., Ventura A.C., Kleer C.G., Arruda E.M., Garikipati K., Merajver S.D.
    Cancer Res. 71:6338-6349(2011) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: p38gamma mitogen-activated protein kinase regulates breast cancer cell motility and metastasis in part by controlling expression of the metastasis-associated small GTPase RhoC.
    Source: GeneRIF:6300.

    This publication is mapped to 7 other entries.

  21. 21
    "Phosphorylation and stabilization of topoisomerase IIalpha protein by p38gamma mitogen-activated protein kinase sensitize breast cancer cells to its poisons."
    Qi X., Hou S., Lepp A., Li R., Basir Z., Lou Z., Chen G.
    J. Biol. Chem. 286:35883-35890(2011) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: a new paradigm in which p38gamma actively regulates the drug-Topo IIalpha signal transduction and this may be exploited to increase the therapeutic activity of Topo II drugs.
    Source: GeneRIF:6300.

    This publication is mapped to 6 other entries.

  22. 22
    "p38gamma mitogen-activated protein kinase (MAPK) confers breast cancer hormone sensitivity by switching estrogen receptor (ER) signaling from classical to nonclassical pathway via stimulating ER phosphorylation and c-Jun transcription."
    Qi X., Zhi H., Lepp A., Wang P., Huang J., Basir Z., Chitambar C.R., Myers C.R., Chen G.
    J. Biol. Chem. 287:14681-14691(2012) [PubMed] [Europe PMC] [Abstract]
    Category: PTM / Processing.
    Annotation: phosphorylation at Ser-118 is required for ER to bind both p38gamma and c-Jun thereby promoting ER relocation from ERE to AP-1 promoter sites.
    Source: GeneRIF:6300.

    This publication is mapped to 89 other entries.

  23. 23
    "TGF-beta1 induces endothelial cell apoptosis by shifting VEGF activation of p38(MAPK) from the prosurvival p38beta to proapoptotic p38alpha."
    Ferrari G., Terushkin V., Wolff M.J., Zhang X., Valacca C., Poggio P., Pintucci G., Mignatti P.
    Mol. Cancer Res. 10:605-614(2012) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Thus in endothelial cells p38alpha mediates apoptotic signaling whereas p38beta and p38gamma transduce survival signaling.
    Source: GeneRIF:6300.

    This publication is mapped to 12 other entries.

  24. 24
    "p38gamma Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response."
    Hou S., Suresh P.S., Qi X., Lepp A., Mirza S.P., Chen G.
    J. Biol. Chem. 287:27895-27905(2012) [PubMed] [Europe PMC] [Abstract]
    Category: PTM / Processing.
    Annotation: p38gamma Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response.
    Source: GeneRIF:6300.

    This publication is mapped to 22 other entries.

  25. 25
    "Delayed cell cycle progression in selenoprotein W-depleted cells is regulated by a mitogen-activated protein kinase kinase 4-p38/c-Jun NH2-terminal kinase-p53 pathway."
    Hawkes W.C., Alkan Z.
    J. Biol. Chem. 287:27371-27379(2012) [PubMed] [Europe PMC] [Abstract]
    Category: PTM / Processing.
    Annotation: SEPW1 silencing increases MKK4 which activates p38gamma p38delta and JNK2 to phosphorylate p53 on Ser-33 and cause a transient G(1) arrest.
    Source: GeneRIF:6300.

    This publication is mapped to 208 other entries.

1 to 25 of 38  Show
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