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Entry version 133 (29 Sep 2021)
Sequence version 2 (23 Jan 2007)
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Protein

Molybdate-anion transporter

Gene

MFSD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.

1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=546 nM for molybdate (when expressed in yeast)1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6N075

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.1.40.2, the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Molybdate-anion transporter
Alternative name(s):
Major facilitator superfamily domain-containing protein 5
Molybdate transporter 2 homolog
Short name:
hsMOT2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MFSD5
ORF Names:UNQ832/PRO1759
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28156, MFSD5

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6N075

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000182544

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Transmembranei128 – 148HelicalSequence analysisAdd BLAST21
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
Transmembranei249 – 269HelicalSequence analysisAdd BLAST21
Transmembranei278 – 298HelicalSequence analysisAdd BLAST21
Transmembranei311 – 331HelicalSequence analysisAdd BLAST21
Transmembranei344 – 364HelicalSequence analysisAdd BLAST21
Transmembranei376 – 396HelicalSequence analysisAdd BLAST21
Transmembranei409 – 429HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000182544

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671466

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6N075, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MFSD5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
124015161

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002734011 – 450Molybdate-anion transporterAdd BLAST450

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6N075

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6N075

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6N075

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6N075

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6N075

PeptideAtlas

More...
PeptideAtlasi
Q6N075

PRoteomics IDEntifications database

More...
PRIDEi
Q6N075

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
32391
66618 [Q6N075-1]
66619 [Q6N075-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6N075

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6N075

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q6N075

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed ubiquitously but at relatively higher levels in the olfactory bulb and the skeletal muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000182544, Expressed in lower esophagus mucosa and 219 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6N075, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6N075, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000182544, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q6N075
With#Exp.IntAct
ADGRE2 [Q9UHX3]3EBI-3920969,EBI-11277970
AQP6 [Q13520]3EBI-3920969,EBI-13059134
ARL6IP1 [Q15041]3EBI-3920969,EBI-714543
BEST2 [Q8NFU1]3EBI-3920969,EBI-19947314
BLCAP [P62952]3EBI-3920969,EBI-3895726
BTNL9 - isoform 3 [Q6UXG8-3]3EBI-3920969,EBI-17953245
C2CD2L [O14523]3EBI-3920969,EBI-12822627
CBARP - isoform 2 [Q8N350-4]3EBI-3920969,EBI-19051169
CCL4L2 [Q8NHW4]3EBI-3920969,EBI-10271156
CD40 [P25942]3EBI-3920969,EBI-525714
CD79A [P11912]3EBI-3920969,EBI-7797864
CLDN7 [O95471]3EBI-3920969,EBI-740744
CLRN1 [P58418]3EBI-3920969,EBI-17274839
CREB3L1 [Q96BA8]6EBI-3920969,EBI-6942903
CYB5B [O43169]3EBI-3920969,EBI-1058710
FFAR2 [O15552]3EBI-3920969,EBI-2833872
FXYD3 - isoform 3 [Q14802-3]3EBI-3920969,EBI-12175685
GJA5 [P36382]3EBI-3920969,EBI-750433
GOSR2 [O14653]3EBI-3920969,EBI-4401517
GPR101 [Q96P66]3EBI-3920969,EBI-17935713
GPR152 [Q8TDT2]3EBI-3920969,EBI-13345167
GPR25 [O00155]3EBI-3920969,EBI-10178951
GPR42 [O15529]3EBI-3920969,EBI-18076404
GPX8 [Q8TED1]3EBI-3920969,EBI-11721746
HSD17B13 [Q7Z5P4]3EBI-3920969,EBI-18053395
IGFBP5 [P24593]3EBI-3920969,EBI-720480
IL27RA [Q6UWB1]3EBI-3920969,EBI-19045531
KASH5 [Q8N6L0]3EBI-3920969,EBI-749265
LAT - isoform 2 [O43561-2]3EBI-3920969,EBI-8070286
LHFPL5 [Q8TAF8]3EBI-3920969,EBI-2820517
MMGT1 [Q8N4V1]3EBI-3920969,EBI-6163737
MUC1 - isoform Y-LSP [P15941-11]3EBI-3920969,EBI-17263240
PGRMC2 [O15173]3EBI-3920969,EBI-1050125
PKMYT1 - isoform 2 [Q99640-2]3EBI-3920969,EBI-12257782
PLN [P26678]3EBI-3920969,EBI-692836
RNF144A [P50876]3EBI-3920969,EBI-2340657
RNF19B [Q6ZMZ0]3EBI-3920969,EBI-2466594
RTP2 [Q5QGT7]3EBI-3920969,EBI-10244780
SCN3B [Q9NY72]3EBI-3920969,EBI-17247926
SEC22B [O75396]3EBI-3920969,EBI-1058865
SHISAL1 [Q3SXP7]3EBI-3920969,EBI-18037857
SLC10A6 [Q3KNW5]3EBI-3920969,EBI-18159983
SLC18A2 [Q05940]3EBI-3920969,EBI-18036244
SLC39A9 [Q9NUM3]3EBI-3920969,EBI-2823239
SSMEM1 [Q8WWF3]3EBI-3920969,EBI-17280858
STATH [P02808]3EBI-3920969,EBI-738687
TBXA2R [Q0VAB0]3EBI-3920969,EBI-18271435
TIMMDC1 [Q9NPL8]3EBI-3920969,EBI-6268651
TMEM128 - isoform 2 [Q5BJH2-2]3EBI-3920969,EBI-10694905
TMEM130 [Q8N3G9]3EBI-3920969,EBI-19763514
TMEM14B [Q9NUH8]3EBI-3920969,EBI-8638294
TMEM179B [Q7Z7N9]3EBI-3920969,EBI-11724423
TMEM203 [Q969S6]3EBI-3920969,EBI-12274070
TMEM237 - isoform 2 [Q96Q45-2]3EBI-3920969,EBI-10982110
YIPF6 [Q96EC8]3EBI-3920969,EBI-751210

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
124404, 76 interactors

Protein interaction database and analysis system

More...
IntActi
Q6N075, 72 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000442688

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6N075, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4332, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000012629

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_034007_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6N075

Database of Orthologous Groups

More...
OrthoDBi
845354at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6N075

TreeFam database of animal gene trees

More...
TreeFami
TF328562

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1250.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036259, MFS_trans_sf
IPR030163, MFSD5
IPR008509, MOT2/MFSD5

The PANTHER Classification System

More...
PANTHERi
PTHR23516, PTHR23516, 1 hit
PTHR23516:SF14, PTHR23516:SF14, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05631, MFS_5, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473, SSF103473, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6N075-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLVTAYLAFV GLLASCLGLE LSRCRAKPPG RACSNPSFLR FQLDFYQVYF
60 70 80 90 100
LALAADWLQA PYLYKLYQHY YFLEGQIAIL YVCGLASTVL FGLVASSLVD
110 120 130 140 150
WLGRKNSCVL FSLTYSLCCL TKLSQDYFVL LVGRALGGLS TALLFSAFEA
160 170 180 190 200
WYIHEHVERH DFPAEWIPAT FARAAFWNHV LAVVAGVAAE AVASWIGLGP
210 220 230 240 250
VAPFVAAIPL LALAGALALR NWGENYDRQR AFSRTCAGGL RCLLSDRRVL
260 270 280 290 300
LLGTIQALFE SVIFIFVFLW TPVLDPHGAP LGIIFSSFMA ASLLGSSLYR
310 320 330 340 350
IATSKRYHLQ PMHLLSLAVL IVVFSLFMLT FSTSPGQESP VESFIAFLLI
360 370 380 390 400
ELACGLYFPS MSFLRRKVIP ETEQAGVLNW FRVPLHSLAC LGLLVLHDSD
410 420 430 440 450
RKTGTRNMFS ICSAVMVMAL LAVVGLFTVV RHDAELRVPS PTEEPYAPEL
Length:450
Mass (Da):49,765
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA15D005755941BA7
GO
Isoform 2 (identifier: Q6N075-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MEVTAVGEEA...RARVVRGPTM

Show »
Length:557
Mass (Da):61,504
Checksum:i85CD96E4BF023226
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VV69F8VV69_HUMAN
Major facilitator superfamily domai...
MFSD5
412Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC05108 differs from that shown. Probable cloning artifact.Curated
The sequence CAE45795 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti130L → M in AAH67795 (PubMed:16541075).Curated1
Sequence conflicti157V → A in BAC11137 (PubMed:16303743).Curated1
Sequence conflicti425G → E in CAE45795 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0466471M → MEVTAVGEEANQGDLLGFGQ RCCSLGSSNPWLYRTAGIFP EHCTEEKKIGTYFRVAPQAS KSQRSRCHGMAASEARPGEA TAASYGRPFPTHPRRQEFRA RVVRGPTM in isoform 2. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY358604 mRNA Translation: AAQ88967.1
BX640649 mRNA Translation: CAE45795.1 Different initiation.
AK097576 mRNA Translation: BAC05108.1 Sequence problems.
AK074684 mRNA Translation: BAC11137.1
AC021072 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW96679.1
BC007703 mRNA Translation: AAH07703.1
BC067795 mRNA Translation: AAH67795.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS53796.1 [Q6N075-2]
CCDS8851.1 [Q6N075-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001164261.1, NM_001170790.1 [Q6N075-2]
NP_116278.3, NM_032889.4 [Q6N075-1]
XP_005269254.1, XM_005269197.1 [Q6N075-2]
XP_005269255.1, XM_005269198.4 [Q6N075-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000329548; ENSP00000332624; ENSG00000182544 [Q6N075-1]
ENST00000534842; ENSP00000442688; ENSG00000182544 [Q6N075-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
84975

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84975

UCSC genome browser

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UCSCi
uc001sch.3, human [Q6N075-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358604 mRNA Translation: AAQ88967.1
BX640649 mRNA Translation: CAE45795.1 Different initiation.
AK097576 mRNA Translation: BAC05108.1 Sequence problems.
AK074684 mRNA Translation: BAC11137.1
AC021072 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW96679.1
BC007703 mRNA Translation: AAH07703.1
BC067795 mRNA Translation: AAH67795.1
CCDSiCCDS53796.1 [Q6N075-2]
CCDS8851.1 [Q6N075-1]
RefSeqiNP_001164261.1, NM_001170790.1 [Q6N075-2]
NP_116278.3, NM_032889.4 [Q6N075-1]
XP_005269254.1, XM_005269197.1 [Q6N075-2]
XP_005269255.1, XM_005269198.4 [Q6N075-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
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Protein-protein interaction databases

BioGRIDi124404, 76 interactors
IntActiQ6N075, 72 interactors
STRINGi9606.ENSP00000442688

Protein family/group databases

TCDBi2.A.1.40.2, the major facilitator superfamily (mfs)

PTM databases

iPTMnetiQ6N075
PhosphoSitePlusiQ6N075
SwissPalmiQ6N075

Genetic variation databases

BioMutaiMFSD5
DMDMi124015161

Proteomic databases

EPDiQ6N075
jPOSTiQ6N075
MassIVEiQ6N075
MaxQBiQ6N075
PaxDbiQ6N075
PeptideAtlasiQ6N075
PRIDEiQ6N075
ProteomicsDBi32391
66618 [Q6N075-1]
66619 [Q6N075-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
48343, 91 antibodies

The DNASU plasmid repository

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DNASUi
84975

Genome annotation databases

EnsembliENST00000329548; ENSP00000332624; ENSG00000182544 [Q6N075-1]
ENST00000534842; ENSP00000442688; ENSG00000182544 [Q6N075-2]
GeneIDi84975
KEGGihsa:84975
UCSCiuc001sch.3, human [Q6N075-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84975

GeneCards: human genes, protein and diseases

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GeneCardsi
MFSD5
HGNCiHGNC:28156, MFSD5
HPAiENSG00000182544, Low tissue specificity
neXtProtiNX_Q6N075
OpenTargetsiENSG00000182544
PharmGKBiPA142671466
VEuPathDBiHostDB:ENSG00000182544

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4332, Eukaryota
GeneTreeiENSGT00390000012629
HOGENOMiCLU_034007_2_0_1
InParanoidiQ6N075
OrthoDBi845354at2759
PhylomeDBiQ6N075
TreeFamiTF328562

Enzyme and pathway databases

PathwayCommonsiQ6N075

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
84975, 7 hits in 1016 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MFSD5, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84975
PharosiQ6N075, Tdark

Protein Ontology

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PROi
PR:Q6N075
RNActiQ6N075, protein

Gene expression databases

BgeeiENSG00000182544, Expressed in lower esophagus mucosa and 219 other tissues
ExpressionAtlasiQ6N075, baseline and differential
GenevisibleiQ6N075, HS

Family and domain databases

Gene3Di1.20.1250.20, 1 hit
InterProiView protein in InterPro
IPR036259, MFS_trans_sf
IPR030163, MFSD5
IPR008509, MOT2/MFSD5
PANTHERiPTHR23516, PTHR23516, 1 hit
PTHR23516:SF14, PTHR23516:SF14, 1 hit
PfamiView protein in Pfam
PF05631, MFS_5, 1 hit
SUPFAMiSSF103473, SSF103473, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMFSD5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6N075
Secondary accession number(s): G3V1N7
, Q6NW04, Q8N7W8, Q8NCK0, Q96IA5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: September 29, 2021
This is version 133 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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