UniProtKB - Q6N069 (NAA16_HUMAN)
Protein
N-alpha-acetyltransferase 16, NatA auxiliary subunit
Gene
NAA16
Organism
Homo sapiens (Human)
Status
Functioni
Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity.
GO - Molecular functioni
- ribosome binding Source: UniProtKB
GO - Biological processi
- negative regulation of apoptotic process Source: UniProtKB
- N-terminal peptidyl-methionine acetylation Source: GO_Central
- N-terminal protein amino acid acetylation Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- protein stabilization Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q6N069 |
Names & Taxonomyi
Protein namesi | Recommended name: N-alpha-acetyltransferase 16, NatA auxiliary subunitAlternative name(s): NMDA receptor-regulated 1-like protein Short name: NARG1-like protein |
Gene namesi | Name:NAA16 Synonyms:NARG1L, NAT2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000172766.18 |
HGNCi | HGNC:26164, NAA16 |
neXtProti | NX_Q6N069 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- NatA complex Source: UniProtKB
- transcription regulator complex Source: UniProtKB
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 79612 |
OpenTargetsi | ENSG00000172766 |
PharmGKBi | PA165505266 |
Miscellaneous databases
Pharosi | Q6N069, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3430873 |
Polymorphism and mutation databases
BioMutai | NAA16 |
DMDMi | 57012940 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000106297 | 1 – 864 | N-alpha-acetyltransferase 16, NatA auxiliary subunitAdd BLAST | 864 |
Proteomic databases
EPDi | Q6N069 |
jPOSTi | Q6N069 |
MassIVEi | Q6N069 |
MaxQBi | Q6N069 |
PaxDbi | Q6N069 |
PeptideAtlasi | Q6N069 |
PRIDEi | Q6N069 |
ProteomicsDBi | 66613 [Q6N069-1] 66614 [Q6N069-2] 66615 [Q6N069-3] 66616 [Q6N069-4] 66617 [Q6N069-5] |
PTM databases
iPTMneti | Q6N069 |
MetOSitei | Q6N069 |
PhosphoSitePlusi | Q6N069 |
Expressioni
Gene expression databases
Bgeei | ENSG00000172766, Expressed in sural nerve and 235 other tissues |
ExpressionAtlasi | Q6N069, baseline and differential |
Genevisiblei | Q6N069, HS |
Organism-specific databases
HPAi | ENSG00000172766, Low tissue specificity |
Interactioni
Subunit structurei
Component of the N-terminal acetyltransferase A (NatA) complex composed of NAA10 and NAA16.
Protein-protein interaction databases
BioGRIDi | 122746, 20 interactors |
IntActi | Q6N069, 10 interactors |
STRINGi | 9606.ENSP00000368716 |
Miscellaneous databases
RNActi | Q6N069, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 46 – 79 | TPR 1Add BLAST | 34 | |
Repeati | 80 – 113 | TPR 2Add BLAST | 34 | |
Repeati | 148 – 184 | TPR 3Add BLAST | 37 | |
Repeati | 224 – 257 | TPR 4Add BLAST | 34 | |
Repeati | 374 – 407 | TPR 5Add BLAST | 34 | |
Repeati | 409 – 441 | TPR 6Add BLAST | 33 | |
Repeati | 485 – 518 | TPR 7Add BLAST | 34 |
Keywords - Domaini
Repeat, TPR repeatPhylogenomic databases
eggNOGi | KOG1156, Eukaryota |
GeneTreei | ENSGT00950000183174 |
HOGENOMi | CLU_006686_0_0_1 |
InParanoidi | Q6N069 |
OMAi | VNHTAIN |
PhylomeDBi | Q6N069 |
TreeFami | TF106301 |
Family and domain databases
InterProi | View protein in InterPro IPR021183, NatA_aux_su IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR013105, TPR_2 IPR019734, TPR_repeat |
Pfami | View protein in Pfam PF12569, NARP1, 1 hit PF07719, TPR_2, 1 hit |
PIRSFi | PIRSF000422, N-terminal-AcTrfase-A_aux_su, 1 hit |
SMARTi | View protein in SMART SM00028, TPR, 6 hits |
SUPFAMi | SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50005, TPR, 5 hits PS50293, TPR_REGION, 3 hits |
s (5)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q6N069-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPNVLLPPKE SNLFKRILKC YEQKQYKNGL KFCKMILSNP KFAEHGETLA
60 70 80 90 100
MKGLTLNCLG KKEEAYEFVR KGLRNDVKSH VCWHVYGLLQ RSDKKYDEAI
110 120 130 140 150
KCYRNALKLD KDNLQILRDL SLLQIQMRDL EGYRETRYQL LQLRPTQRAS
160 170 180 190 200
WIGYAIAYHL LKDYDMALKL LEEFRQTQQV PPNKIDYEYS ELILYQNQVM
210 220 230 240 250
READLLQESL EHIEMYEKQI CDKLLVEEIK GEILLKLGRL KEASEVFKNL
260 270 280 290 300
IDRNAENWCY YEGLEKALQI STLEERLQIY EEISKQHPKA ITPRRLPLTL
310 320 330 340 350
VPGERFRELM DKFLRVNFSK GCPPLFTTLK SLYYNTEKVS IIQELVTNYE
360 370 380 390 400
ASLKTCDFFS PYENGEKEPP TTLLWVQYFL AQHFDKLGQY SLALDYINAA
410 420 430 440 450
IASTPTLIEL FYMKAKIYKH IGNLKEAAKW MDEAQSLDTA DRFINSKCAK
460 470 480 490 500
YMLRANMIKE AEEMCSKFTR EGTSAMENLN EMQCMWFQTE CISAYQRLGR
510 520 530 540 550
YGDALKKCHE VERHFFEITD DQFDFHTYCM RKMTLRAYVD LLRLEDILRR
560 570 580 590 600
HAFYFKAARS AIEIYLKLYD NPLTNESKQQ EINSENLSAK ELKKMLSKQR
610 620 630 640 650
RAQKKAKLEE ERKHAERERQ QKNQKKKRDE EEEEASGLKE ELIPEKLERV
660 670 680 690 700
ENPLEEAVKF LIPLKNLVAD NIDTHLLAFE IYFRKGKFLL MLQSVKRAFA
710 720 730 740 750
INSNNPWLHE CLIRFSKSVS NHSNLPDIVS KVLSQEMQKI FVKKDLESFN
760 770 780 790 800
EDFLKRNATS LQHLLSGAKM MYFLDKSRQE KAIAIATRLD ETIKDKDVKT
810 820 830 840 850
LIKVSEALLD GSFGNCSSQY EEYRMACHNL LPFTSAFLPA VNEVDNPNVA
860
LNHTANYDVL ANEI
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052618 | 344 | E → G. Corresponds to variant dbSNP:rs17062054Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_012562 | 304 – 311 | ERFRELMD → FYNPGTCY in isoform 5. 1 Publication | 8 | |
Alternative sequenceiVSP_012563 | 312 – 864 | Missing in isoform 5. 1 PublicationAdd BLAST | 553 | |
Alternative sequenceiVSP_012564 | 420 – 429 | HIGNLKEAAK → VKSESCFLSS in isoform 4. 1 Publication | 10 | |
Alternative sequenceiVSP_012565 | 430 – 864 | Missing in isoform 4. 1 PublicationAdd BLAST | 435 | |
Alternative sequenceiVSP_012566 | 514 – 516 | HFF → VSC in isoform 3. 1 Publication | 3 | |
Alternative sequenceiVSP_012568 | 515 – 530 | FFEIT…HTYCM → SPSTWTTGGKEPQMHP in isoform 2. 1 PublicationAdd BLAST | 16 | |
Alternative sequenceiVSP_012567 | 517 – 864 | Missing in isoform 3. 1 PublicationAdd BLAST | 348 | |
Alternative sequenceiVSP_012569 | 531 – 864 | Missing in isoform 2. 1 PublicationAdd BLAST | 334 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL354696 Genomic DNA No translation available. AL590665 Genomic DNA No translation available. AL731858 Genomic DNA No translation available. AK097224 mRNA No translation available. BX640665 mRNA Translation: CAE45801.1 CH471075 Genomic DNA Translation: EAX08654.1 BC032318 mRNA Translation: AAH32318.1 BC064592 mRNA Translation: AAH64592.1 |
CCDSi | CCDS45044.1 [Q6N069-4] CCDS9379.1 [Q6N069-1] |
RefSeqi | NP_001104268.1, NM_001110798.1 [Q6N069-4] NP_060997.2, NM_018527.3 [Q6N069-5] NP_078837.3, NM_024561.4 [Q6N069-1] XP_011533530.1, XM_011535228.1 [Q6N069-2] |
Genome annotation databases
Ensembli | ENST00000379406; ENSP00000368716; ENSG00000172766 [Q6N069-1] ENST00000403412; ENSP00000386103; ENSG00000172766 [Q6N069-4] ENST00000464857; ENSP00000432364; ENSG00000172766 [Q6N069-3] |
GeneIDi | 79612 |
KEGGi | hsa:79612 |
UCSCi | uc001uye.5, human [Q6N069-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL354696 Genomic DNA No translation available. AL590665 Genomic DNA No translation available. AL731858 Genomic DNA No translation available. AK097224 mRNA No translation available. BX640665 mRNA Translation: CAE45801.1 CH471075 Genomic DNA Translation: EAX08654.1 BC032318 mRNA Translation: AAH32318.1 BC064592 mRNA Translation: AAH64592.1 |
CCDSi | CCDS45044.1 [Q6N069-4] CCDS9379.1 [Q6N069-1] |
RefSeqi | NP_001104268.1, NM_001110798.1 [Q6N069-4] NP_060997.2, NM_018527.3 [Q6N069-5] NP_078837.3, NM_024561.4 [Q6N069-1] XP_011533530.1, XM_011535228.1 [Q6N069-2] |
3D structure databases
SMRi | Q6N069 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122746, 20 interactors |
IntActi | Q6N069, 10 interactors |
STRINGi | 9606.ENSP00000368716 |
Chemistry databases
ChEMBLi | CHEMBL3430873 |
PTM databases
iPTMneti | Q6N069 |
MetOSitei | Q6N069 |
PhosphoSitePlusi | Q6N069 |
Polymorphism and mutation databases
BioMutai | NAA16 |
DMDMi | 57012940 |
Proteomic databases
EPDi | Q6N069 |
jPOSTi | Q6N069 |
MassIVEi | Q6N069 |
MaxQBi | Q6N069 |
PaxDbi | Q6N069 |
PeptideAtlasi | Q6N069 |
PRIDEi | Q6N069 |
ProteomicsDBi | 66613 [Q6N069-1] 66614 [Q6N069-2] 66615 [Q6N069-3] 66616 [Q6N069-4] 66617 [Q6N069-5] |
Protocols and materials databases
Antibodypediai | 23410, 59 antibodies |
DNASUi | 79612 |
Genome annotation databases
Ensembli | ENST00000379406; ENSP00000368716; ENSG00000172766 [Q6N069-1] ENST00000403412; ENSP00000386103; ENSG00000172766 [Q6N069-4] ENST00000464857; ENSP00000432364; ENSG00000172766 [Q6N069-3] |
GeneIDi | 79612 |
KEGGi | hsa:79612 |
UCSCi | uc001uye.5, human [Q6N069-1] |
Organism-specific databases
CTDi | 79612 |
DisGeNETi | 79612 |
EuPathDBi | HostDB:ENSG00000172766.18 |
GeneCardsi | NAA16 |
HGNCi | HGNC:26164, NAA16 |
HPAi | ENSG00000172766, Low tissue specificity |
neXtProti | NX_Q6N069 |
OpenTargetsi | ENSG00000172766 |
PharmGKBi | PA165505266 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1156, Eukaryota |
GeneTreei | ENSGT00950000183174 |
HOGENOMi | CLU_006686_0_0_1 |
InParanoidi | Q6N069 |
OMAi | VNHTAIN |
PhylomeDBi | Q6N069 |
TreeFami | TF106301 |
Enzyme and pathway databases
PathwayCommonsi | Q6N069 |
Miscellaneous databases
BioGRID-ORCSi | 79612, 14 hits in 846 CRISPR screens |
ChiTaRSi | NAA16, human |
GenomeRNAii | 79612 |
Pharosi | Q6N069, Tbio |
PROi | PR:Q6N069 |
RNActi | Q6N069, protein |
Gene expression databases
Bgeei | ENSG00000172766, Expressed in sural nerve and 235 other tissues |
ExpressionAtlasi | Q6N069, baseline and differential |
Genevisiblei | Q6N069, HS |
Family and domain databases
InterProi | View protein in InterPro IPR021183, NatA_aux_su IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR013105, TPR_2 IPR019734, TPR_repeat |
Pfami | View protein in Pfam PF12569, NARP1, 1 hit PF07719, TPR_2, 1 hit |
PIRSFi | PIRSF000422, N-terminal-AcTrfase-A_aux_su, 1 hit |
SMARTi | View protein in SMART SM00028, TPR, 6 hits |
SUPFAMi | SSF48452, SSF48452, 1 hit |
PROSITEi | View protein in PROSITE PS50005, TPR, 5 hits PS50293, TPR_REGION, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NAA16_HUMAN | |
Accessioni | Q6N069Primary (citable) accession number: Q6N069 Secondary accession number(s): B0QZ59 Q8N870 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 4, 2005 |
Last sequence update: | January 4, 2005 | |
Last modified: | December 2, 2020 | |
This is version 155 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations