UniProtKB - Q6MZW2 (FSTL4_HUMAN)
Protein
Follistatin-related protein 4
Gene
FSTL4
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 187 – 198 | PROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- brain-derived neurotrophic factor binding Source: Ensembl
- calcium ion binding Source: InterPro
GO - Biological processi
- cell differentiation Source: GO_Central
- multicellular organism development Source: GO_Central
- negative regulation of brain-derived neurotrophic factor receptor signaling pathway Source: Ensembl
- negative regulation of collateral sprouting Source: Ensembl
- negative regulation of dendritic spine development Source: Ensembl
Keywordsi
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | Q6MZW2 |
Protein family/group databases
MEROPSi | I01.977 |
Names & Taxonomyi
Protein namesi | Recommended name: Follistatin-related protein 4Alternative name(s): Follistatin-like protein 4 |
Gene namesi | Name:FSTL4 Synonyms:KIAA1061 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000053108.16 |
HGNCi | HGNC:21389, FSTL4 |
neXtProti | NX_Q6MZW2 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Other locations
- secretory granule Source: Ensembl
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 23105 |
OpenTargetsi | ENSG00000053108 |
PharmGKBi | PA134969998 |
Miscellaneous databases
Pharosi | Q6MZW2, Tdark |
Polymorphism and mutation databases
BioMutai | FSTL4 |
DMDMi | 296439344 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_0000251925 | 23 – 842 | Follistatin-related protein 4Add BLAST | 820 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 87 ↔ 119 | PROSITE-ProRule annotation | ||
Disulfide bondi | 93 ↔ 112 | PROSITE-ProRule annotation | ||
Disulfide bondi | 101 ↔ 133 | PROSITE-ProRule annotation | ||
Disulfide bondi | 270 ↔ 321 | By similarity | ||
Glycosylationi | 318 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 362 ↔ 413 | By similarity |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | Q6MZW2 |
PaxDbi | Q6MZW2 |
PeptideAtlasi | Q6MZW2 |
PRIDEi | Q6MZW2 |
ProteomicsDBi | 66588 [Q6MZW2-1] 66589 [Q6MZW2-2] 66590 [Q6MZW2-3] |
PTM databases
GlyGeni | Q6MZW2, 1 site |
iPTMneti | Q6MZW2 |
PhosphoSitePlusi | Q6MZW2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000053108, Expressed in oocyte and 110 other tissues |
ExpressionAtlasi | Q6MZW2, baseline and differential |
Genevisiblei | Q6MZW2, HS |
Organism-specific databases
HPAi | ENSG00000053108, Tissue enhanced (brain) |
Interactioni
GO - Molecular functioni
- brain-derived neurotrophic factor binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 116730, 4 interactors |
IntActi | Q6MZW2, 4 interactors |
STRINGi | 9606.ENSP00000265342 |
Miscellaneous databases
RNActi | Q6MZW2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 81 – 135 | Kazal-likePROSITE-ProRule annotationAdd BLAST | 55 | |
Domaini | 174 – 209 | EF-handPROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 251 – 338 | Ig-like 1Add BLAST | 88 | |
Domaini | 341 – 426 | Ig-like 2Add BLAST | 86 |
Keywords - Domaini
Immunoglobulin domain, Repeat, SignalPhylogenomic databases
eggNOGi | ENOG502QPNV, Eukaryota |
GeneTreei | ENSGT00940000158076 |
HOGENOMi | CLU_007849_0_0_1 |
InParanoidi | Q6MZW2 |
OMAi | SPQRCVW |
OrthoDBi | 1065760at2759 |
PhylomeDBi | Q6MZW2 |
TreeFami | TF350473 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 IPR002350, Kazal_dom IPR036058, Kazal_dom_sf IPR015943, WD40/YVTN_repeat-like_dom_sf |
Pfami | View protein in Pfam PF07648, Kazal_2, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 2 hits SM00408, IGc2, 2 hits SM00280, KAZAL, 1 hit |
SUPFAMi | SSF100895, SSF100895, 1 hit SSF47473, SSF47473, 1 hit SSF48726, SSF48726, 2 hits |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 1 hit PS50835, IG_LIKE, 3 hits PS51465, KAZAL_2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6MZW2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKPGGFWLHL TLLGASLPAA LGWMDPGTSR GPDVGVGESQ AEEPRSFEVT
60 70 80 90 100
RREGLSSHNE LLASCGKKFC SRGSRCVLSR KTGEPECQCL EACRPSYVPV
110 120 130 140 150
CGSDGRFYEN HCKLHRAACL LGKRITVIHS KDCFLKGDTC TMAGYARLKN
160 170 180 190 200
VLLALQTRLQ PLQEGDSRQD PASQKRLLVE SLFRDLDADG NGHLSSSELA
210 220 230 240 250
QHVLKKQDLD EDLLGCSPGD LLRFDDYNSD SSLTLREFYM AFQVVQLSLA
260 270 280 290 300
PEDRVSVTTV TVGLSTVLTC AVHGDLRPPI IWKRNGLTLN FLDLEDINDF
310 320 330 340 350
GEDDSLYITK VTTIHMGNYT CHASGHEQLF QTHVLQVNVP PVIRVYPESQ
360 370 380 390 400
AQEPGVAASL RCHAEGIPMP RITWLKNGVD VSTQMSKQLS LLANGSELHI
410 420 430 440 450
SSVRYEDTGA YTCIAKNEVG VDEDISSLFI EDSARKTLAN ILWREEGLSV
460 470 480 490 500
GNMFYVFSDD GIIVIHPVDC EIQRHLKPTE KIFMSYEEIC PQREKNATQP
510 520 530 540 550
CQWVSAVNVR NRYIYVAQPA LSRVLVVDIQ AQKVLQSIGV DPLPAKLSYD
560 570 580 590 600
KSHDQVWVLS WGDVHKSRPS LQVITEASTG QSQHLIRTPF AGVDDFFIPP
610 620 630 640 650
TNLIINHIRF GFIFNKSDPA VHKVDLETMM PLKTIGLHHH GCVPQAMAHT
660 670 680 690 700
HLGGYFFIQC RQDSPASAAR QLLVDSVTDS VLGPNGDVTG TPHTSPDGRF
710 720 730 740 750
IVSAAADSPW LHVQEITVRG EIQTLYDLQI NSGISDLAFQ RSFTESNQYN
760 770 780 790 800
IYAALHTEPD LLFLELSTGK VGMLKNLKEP PAGPAQPWGG THRIMRDSGL
810 820 830 840
FGQYLLTPAR ESLFLINGRQ NTLRCEVSGI KGGTTVVWVG EV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD6RHU5 | D6RHU5_HUMAN | Follistatin-related protein 4 | FSTL4 | 157 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 60 | E → K in CAE45915 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 240 | M → I in AAH24300 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 764 | L → P in CAE45915 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_027727 | 158 | R → H. Corresponds to variant dbSNP:rs17683306Ensembl. | 1 | |
Natural variantiVAR_027728 | 757 | T → M1 PublicationCorresponds to variant dbSNP:rs3749817Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_020800 | 78 – 246 | Missing in isoform 2. 1 PublicationAdd BLAST | 169 | |
Alternative sequenceiVSP_020801 | 601 – 605 | TNLII → INLEQ in isoform 3. 1 Publication | 5 | |
Alternative sequenceiVSP_020802 | 606 – 842 | Missing in isoform 3. 1 PublicationAdd BLAST | 237 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX640845 mRNA Translation: CAE45915.1 AC005195 Genomic DNA No translation available. AC010307 Genomic DNA No translation available. AC010608 Genomic DNA No translation available. AC012614 Genomic DNA No translation available. BC024300 mRNA Translation: AAH24300.1 AB028984 mRNA Translation: BAA83013.1 |
CCDSi | CCDS34238.1 [Q6MZW2-1] |
RefSeqi | NP_055897.1, NM_015082.1 [Q6MZW2-1] XP_011541585.1, XM_011543283.1 [Q6MZW2-1] |
Genome annotation databases
Ensembli | ENST00000265342; ENSP00000265342; ENSG00000053108 [Q6MZW2-1] ENST00000621681; ENSP00000484273; ENSG00000053108 [Q6MZW2-2] |
GeneIDi | 23105 |
KEGGi | hsa:23105 |
UCSCi | uc003kyn.2, human [Q6MZW2-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX640845 mRNA Translation: CAE45915.1 AC005195 Genomic DNA No translation available. AC010307 Genomic DNA No translation available. AC010608 Genomic DNA No translation available. AC012614 Genomic DNA No translation available. BC024300 mRNA Translation: AAH24300.1 AB028984 mRNA Translation: BAA83013.1 |
CCDSi | CCDS34238.1 [Q6MZW2-1] |
RefSeqi | NP_055897.1, NM_015082.1 [Q6MZW2-1] XP_011541585.1, XM_011543283.1 [Q6MZW2-1] |
3D structure databases
SMRi | Q6MZW2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116730, 4 interactors |
IntActi | Q6MZW2, 4 interactors |
STRINGi | 9606.ENSP00000265342 |
Protein family/group databases
MEROPSi | I01.977 |
PTM databases
GlyGeni | Q6MZW2, 1 site |
iPTMneti | Q6MZW2 |
PhosphoSitePlusi | Q6MZW2 |
Polymorphism and mutation databases
BioMutai | FSTL4 |
DMDMi | 296439344 |
Proteomic databases
MassIVEi | Q6MZW2 |
PaxDbi | Q6MZW2 |
PeptideAtlasi | Q6MZW2 |
PRIDEi | Q6MZW2 |
ProteomicsDBi | 66588 [Q6MZW2-1] 66589 [Q6MZW2-2] 66590 [Q6MZW2-3] |
Protocols and materials databases
Antibodypediai | 26231, 39 antibodies |
Genome annotation databases
Ensembli | ENST00000265342; ENSP00000265342; ENSG00000053108 [Q6MZW2-1] ENST00000621681; ENSP00000484273; ENSG00000053108 [Q6MZW2-2] |
GeneIDi | 23105 |
KEGGi | hsa:23105 |
UCSCi | uc003kyn.2, human [Q6MZW2-1] |
Organism-specific databases
CTDi | 23105 |
DisGeNETi | 23105 |
EuPathDBi | HostDB:ENSG00000053108.16 |
GeneCardsi | FSTL4 |
HGNCi | HGNC:21389, FSTL4 |
HPAi | ENSG00000053108, Tissue enhanced (brain) |
neXtProti | NX_Q6MZW2 |
OpenTargetsi | ENSG00000053108 |
PharmGKBi | PA134969998 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QPNV, Eukaryota |
GeneTreei | ENSGT00940000158076 |
HOGENOMi | CLU_007849_0_0_1 |
InParanoidi | Q6MZW2 |
OMAi | SPQRCVW |
OrthoDBi | 1065760at2759 |
PhylomeDBi | Q6MZW2 |
TreeFami | TF350473 |
Enzyme and pathway databases
PathwayCommonsi | Q6MZW2 |
Miscellaneous databases
BioGRID-ORCSi | 23105, 2 hits in 838 CRISPR screens |
ChiTaRSi | FSTL4, human |
GenomeRNAii | 23105 |
Pharosi | Q6MZW2, Tdark |
PROi | PR:Q6MZW2 |
RNActi | Q6MZW2, protein |
Gene expression databases
Bgeei | ENSG00000053108, Expressed in oocyte and 110 other tissues |
ExpressionAtlasi | Q6MZW2, baseline and differential |
Genevisiblei | Q6MZW2, HS |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 IPR002350, Kazal_dom IPR036058, Kazal_dom_sf IPR015943, WD40/YVTN_repeat-like_dom_sf |
Pfami | View protein in Pfam PF07648, Kazal_2, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 2 hits SM00408, IGc2, 2 hits SM00280, KAZAL, 1 hit |
SUPFAMi | SSF100895, SSF100895, 1 hit SSF47473, SSF47473, 1 hit SSF48726, SSF48726, 2 hits |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 1 hit PS50835, IG_LIKE, 3 hits PS51465, KAZAL_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FSTL4_HUMAN | |
Accessioni | Q6MZW2Primary (citable) accession number: Q6MZW2 Secondary accession number(s): Q8TBU0, Q9UPU1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2006 |
Last sequence update: | May 18, 2010 | |
Last modified: | December 2, 2020 | |
This is version 142 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations