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Entry version 136 (16 Oct 2019)
Sequence version 3 (18 May 2010)
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Protein

Follistatin-related protein 4

Gene

FSTL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi187 – 198PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Metal-binding

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I01.977

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Follistatin-related protein 4
Alternative name(s):
Follistatin-like protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FSTL4
Synonyms:KIAA1061
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21389 FSTL4

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6MZW2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23105

Open Targets

More...
OpenTargetsi
ENSG00000053108

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134969998

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6MZW2

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FSTL4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439344

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000025192523 – 842Follistatin-related protein 4Add BLAST820

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi87 ↔ 119PROSITE-ProRule annotation
Disulfide bondi93 ↔ 112PROSITE-ProRule annotation
Disulfide bondi101 ↔ 133PROSITE-ProRule annotation
Disulfide bondi270 ↔ 321By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi318N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi362 ↔ 413By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6MZW2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6MZW2

PeptideAtlas

More...
PeptideAtlasi
Q6MZW2

PRoteomics IDEntifications database

More...
PRIDEi
Q6MZW2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
66588 [Q6MZW2-1]
66589 [Q6MZW2-2]
66590 [Q6MZW2-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6MZW2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6MZW2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000053108 Expressed in 90 organ(s), highest expression level in oocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6MZW2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6MZW2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA045920

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116730, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q6MZW2, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000265342

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini81 – 135Kazal-likePROSITE-ProRule annotationAdd BLAST55
Domaini174 – 209EF-handPROSITE-ProRule annotationAdd BLAST36
Domaini251 – 338Ig-like 1Add BLAST88
Domaini341 – 426Ig-like 2Add BLAST86

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEEJ Eukaryota
ENOG410YBHC LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158076

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000236319

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6MZW2

Identification of Orthologs from Complete Genome Data

More...
OMAi
IINHVRF

Database of Orthologous Groups

More...
OrthoDBi
1065760at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6MZW2

TreeFam database of animal gene trees

More...
TreeFami
TF350473

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07648 Kazal_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SM00280 KAZAL, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100895 SSF100895, 1 hit
SSF47473 SSF47473, 1 hit
SSF48726 SSF48726, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS50835 IG_LIKE, 3 hits
PS51465 KAZAL_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6MZW2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKPGGFWLHL TLLGASLPAA LGWMDPGTSR GPDVGVGESQ AEEPRSFEVT
60 70 80 90 100
RREGLSSHNE LLASCGKKFC SRGSRCVLSR KTGEPECQCL EACRPSYVPV
110 120 130 140 150
CGSDGRFYEN HCKLHRAACL LGKRITVIHS KDCFLKGDTC TMAGYARLKN
160 170 180 190 200
VLLALQTRLQ PLQEGDSRQD PASQKRLLVE SLFRDLDADG NGHLSSSELA
210 220 230 240 250
QHVLKKQDLD EDLLGCSPGD LLRFDDYNSD SSLTLREFYM AFQVVQLSLA
260 270 280 290 300
PEDRVSVTTV TVGLSTVLTC AVHGDLRPPI IWKRNGLTLN FLDLEDINDF
310 320 330 340 350
GEDDSLYITK VTTIHMGNYT CHASGHEQLF QTHVLQVNVP PVIRVYPESQ
360 370 380 390 400
AQEPGVAASL RCHAEGIPMP RITWLKNGVD VSTQMSKQLS LLANGSELHI
410 420 430 440 450
SSVRYEDTGA YTCIAKNEVG VDEDISSLFI EDSARKTLAN ILWREEGLSV
460 470 480 490 500
GNMFYVFSDD GIIVIHPVDC EIQRHLKPTE KIFMSYEEIC PQREKNATQP
510 520 530 540 550
CQWVSAVNVR NRYIYVAQPA LSRVLVVDIQ AQKVLQSIGV DPLPAKLSYD
560 570 580 590 600
KSHDQVWVLS WGDVHKSRPS LQVITEASTG QSQHLIRTPF AGVDDFFIPP
610 620 630 640 650
TNLIINHIRF GFIFNKSDPA VHKVDLETMM PLKTIGLHHH GCVPQAMAHT
660 670 680 690 700
HLGGYFFIQC RQDSPASAAR QLLVDSVTDS VLGPNGDVTG TPHTSPDGRF
710 720 730 740 750
IVSAAADSPW LHVQEITVRG EIQTLYDLQI NSGISDLAFQ RSFTESNQYN
760 770 780 790 800
IYAALHTEPD LLFLELSTGK VGMLKNLKEP PAGPAQPWGG THRIMRDSGL
810 820 830 840
FGQYLLTPAR ESLFLINGRQ NTLRCEVSGI KGGTTVVWVG EV
Length:842
Mass (Da):93,096
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9EEE073CD3C99517
GO
Isoform 2 (identifier: Q6MZW2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     78-246: Missing.

Show »
Length:673
Mass (Da):74,158
Checksum:i2DDD63D9A07A2983
GO
Isoform 3 (identifier: Q6MZW2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     601-605: TNLII → INLEQ
     606-842: Missing.

Note: No experimental confirmation available.
Show »
Length:605
Mass (Da):67,196
Checksum:i96EBE5E3C84F9F71
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RHU5D6RHU5_HUMAN
Follistatin-related protein 4
FSTL4
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti60E → K in CAE45915 (PubMed:17974005).Curated1
Sequence conflicti240M → I in AAH24300 (PubMed:15489334).Curated1
Sequence conflicti764L → P in CAE45915 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_027727158R → H. Corresponds to variant dbSNP:rs17683306Ensembl.1
Natural variantiVAR_027728757T → M1 PublicationCorresponds to variant dbSNP:rs3749817Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02080078 – 246Missing in isoform 2. 1 PublicationAdd BLAST169
Alternative sequenceiVSP_020801601 – 605TNLII → INLEQ in isoform 3. 1 Publication5
Alternative sequenceiVSP_020802606 – 842Missing in isoform 3. 1 PublicationAdd BLAST237

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX640845 mRNA Translation: CAE45915.1
AC005195 Genomic DNA No translation available.
AC010307 Genomic DNA No translation available.
AC010608 Genomic DNA No translation available.
AC012614 Genomic DNA No translation available.
BC024300 mRNA Translation: AAH24300.1
AB028984 mRNA Translation: BAA83013.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34238.1 [Q6MZW2-1]

NCBI Reference Sequences

More...
RefSeqi
NP_055897.1, NM_015082.1 [Q6MZW2-1]
XP_011541585.1, XM_011543283.1 [Q6MZW2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000265342; ENSP00000265342; ENSG00000053108 [Q6MZW2-1]
ENST00000621681; ENSP00000484273; ENSG00000053108 [Q6MZW2-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23105

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23105

UCSC genome browser

More...
UCSCi
uc003kyn.2 human [Q6MZW2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640845 mRNA Translation: CAE45915.1
AC005195 Genomic DNA No translation available.
AC010307 Genomic DNA No translation available.
AC010608 Genomic DNA No translation available.
AC012614 Genomic DNA No translation available.
BC024300 mRNA Translation: AAH24300.1
AB028984 mRNA Translation: BAA83013.1
CCDSiCCDS34238.1 [Q6MZW2-1]
RefSeqiNP_055897.1, NM_015082.1 [Q6MZW2-1]
XP_011541585.1, XM_011543283.1 [Q6MZW2-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi116730, 4 interactors
IntActiQ6MZW2, 4 interactors
STRINGi9606.ENSP00000265342

Protein family/group databases

MEROPSiI01.977

PTM databases

iPTMnetiQ6MZW2
PhosphoSitePlusiQ6MZW2

Polymorphism and mutation databases

BioMutaiFSTL4
DMDMi296439344

Proteomic databases

MassIVEiQ6MZW2
PaxDbiQ6MZW2
PeptideAtlasiQ6MZW2
PRIDEiQ6MZW2
ProteomicsDBi66588 [Q6MZW2-1]
66589 [Q6MZW2-2]
66590 [Q6MZW2-3]

Genome annotation databases

EnsembliENST00000265342; ENSP00000265342; ENSG00000053108 [Q6MZW2-1]
ENST00000621681; ENSP00000484273; ENSG00000053108 [Q6MZW2-2]
GeneIDi23105
KEGGihsa:23105
UCSCiuc003kyn.2 human [Q6MZW2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23105
DisGeNETi23105

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FSTL4
HGNCiHGNC:21389 FSTL4
HPAiHPA045920
neXtProtiNX_Q6MZW2
OpenTargetsiENSG00000053108
PharmGKBiPA134969998

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEEJ Eukaryota
ENOG410YBHC LUCA
GeneTreeiENSGT00940000158076
HOGENOMiHOG000236319
InParanoidiQ6MZW2
OMAiIINHVRF
OrthoDBi1065760at2759
PhylomeDBiQ6MZW2
TreeFamiTF350473

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FSTL4 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23105
PharosiQ6MZW2

Protein Ontology

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PROi
PR:Q6MZW2

Gene expression databases

BgeeiENSG00000053108 Expressed in 90 organ(s), highest expression level in oocyte
ExpressionAtlasiQ6MZW2 baseline and differential
GenevisibleiQ6MZW2 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF07648 Kazal_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SM00280 KAZAL, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF47473 SSF47473, 1 hit
SSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS50835 IG_LIKE, 3 hits
PS51465 KAZAL_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFSTL4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6MZW2
Secondary accession number(s): Q8TBU0, Q9UPU1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: May 18, 2010
Last modified: October 16, 2019
This is version 136 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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