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UniProtKB - Q6MZW2 (FSTL4_HUMAN)

Entry version 142 (02 Dec 2020)
Sequence version 3 (18 May 2010)
Previous versions | rss
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Protein

Follistatin-related protein 4

Gene

FSTL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi187 – 198PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6MZW2

Protein family/group databases

MEROPS protease database

More...MEROPSi		I01.977

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Follistatin-related protein 4
Alternative name(s):
Follistatin-like protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FSTL4
Synonyms:KIAA1061
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000053108.16

Human Gene Nomenclature Database

More...HGNCi		HGNC:21389, FSTL4

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6MZW2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		23105

Open Targets

More...OpenTargetsi		ENSG00000053108

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134969998

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6MZW2, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FSTL4

Domain mapping of disease mutations (DMDM)

More...DMDMi		296439344

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000025192523 – 842Follistatin-related protein 4Add BLAST820

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi87 ↔ 119PROSITE-ProRule annotation
Disulfide bondi93 ↔ 112PROSITE-ProRule annotation
Disulfide bondi101 ↔ 133PROSITE-ProRule annotation
Disulfide bondi270 ↔ 321By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi318N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi362 ↔ 413By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6MZW2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6MZW2

PeptideAtlas

More...PeptideAtlasi		Q6MZW2

PRoteomics IDEntifications database

More...PRIDEi		Q6MZW2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		66588 [Q6MZW2-1]
66589 [Q6MZW2-2]
66590 [Q6MZW2-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q6MZW2, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6MZW2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6MZW2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000053108, Expressed in oocyte and 110 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6MZW2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6MZW2, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000053108, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116730, 4 interactors

Protein interaction database and analysis system

More...IntActi		Q6MZW2, 4 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000265342

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6MZW2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6MZW2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini81 – 135Kazal-likePROSITE-ProRule annotationAdd BLAST55
Domaini174 – 209EF-handPROSITE-ProRule annotationAdd BLAST36
Domaini251 – 338Ig-like 1Add BLAST88
Domaini341 – 426Ig-like 2Add BLAST86

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QPNV, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158076

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_007849_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6MZW2

Identification of Orthologs from Complete Genome Data

More...OMAi		SPQRCVW

Database of Orthologous Groups

More...OrthoDBi		1065760at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6MZW2

TreeFam database of animal gene trees

More...TreeFami		TF350473

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.130.10.10, 1 hit
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR002350, Kazal_dom
IPR036058, Kazal_dom_sf
IPR015943, WD40/YVTN_repeat-like_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07648, Kazal_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00409, IG, 2 hits
SM00408, IGc2, 2 hits
SM00280, KAZAL, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF100895, SSF100895, 1 hit
SSF47473, SSF47473, 1 hit
SSF48726, SSF48726, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00018, EF_HAND_1, 1 hit
PS50222, EF_HAND_2, 1 hit
PS50835, IG_LIKE, 3 hits
PS51465, KAZAL_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6MZW2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKPGGFWLHL TLLGASLPAA LGWMDPGTSR GPDVGVGESQ AEEPRSFEVT 
        60         70         80         90        100
RREGLSSHNE LLASCGKKFC SRGSRCVLSR KTGEPECQCL EACRPSYVPV 
       110        120        130        140        150
CGSDGRFYEN HCKLHRAACL LGKRITVIHS KDCFLKGDTC TMAGYARLKN 
       160        170        180        190        200
VLLALQTRLQ PLQEGDSRQD PASQKRLLVE SLFRDLDADG NGHLSSSELA 
       210        220        230        240        250
QHVLKKQDLD EDLLGCSPGD LLRFDDYNSD SSLTLREFYM AFQVVQLSLA 
       260        270        280        290        300
PEDRVSVTTV TVGLSTVLTC AVHGDLRPPI IWKRNGLTLN FLDLEDINDF 
       310        320        330        340        350
GEDDSLYITK VTTIHMGNYT CHASGHEQLF QTHVLQVNVP PVIRVYPESQ 
       360        370        380        390        400
AQEPGVAASL RCHAEGIPMP RITWLKNGVD VSTQMSKQLS LLANGSELHI 
       410        420        430        440        450
SSVRYEDTGA YTCIAKNEVG VDEDISSLFI EDSARKTLAN ILWREEGLSV 
       460        470        480        490        500
GNMFYVFSDD GIIVIHPVDC EIQRHLKPTE KIFMSYEEIC PQREKNATQP 
       510        520        530        540        550
CQWVSAVNVR NRYIYVAQPA LSRVLVVDIQ AQKVLQSIGV DPLPAKLSYD 
       560        570        580        590        600
KSHDQVWVLS WGDVHKSRPS LQVITEASTG QSQHLIRTPF AGVDDFFIPP 
       610        620        630        640        650
TNLIINHIRF GFIFNKSDPA VHKVDLETMM PLKTIGLHHH GCVPQAMAHT 
       660        670        680        690        700
HLGGYFFIQC RQDSPASAAR QLLVDSVTDS VLGPNGDVTG TPHTSPDGRF 
       710        720        730        740        750
IVSAAADSPW LHVQEITVRG EIQTLYDLQI NSGISDLAFQ RSFTESNQYN 
       760        770        780        790        800
IYAALHTEPD LLFLELSTGK VGMLKNLKEP PAGPAQPWGG THRIMRDSGL 
       810        820        830        840 
FGQYLLTPAR ESLFLINGRQ NTLRCEVSGI KGGTTVVWVG EV
Length:842
Mass (Da):93,096
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9EEE073CD3C99517
GO
Isoform 2 (identifier: Q6MZW2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     78-246: Missing.

Show »
Length:673
Mass (Da):74,158
Checksum:i2DDD63D9A07A2983
GO
Isoform 3 (identifier: Q6MZW2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     601-605: TNLII → INLEQ
     606-842: Missing.

Show »
Length:605
Mass (Da):67,196
Checksum:i96EBE5E3C84F9F71
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RHU5D6RHU5_HUMAN
Follistatin-related protein 4
FSTL4
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti60E → K in CAE45915 (PubMed:17974005).Curated1
Sequence conflicti240M → I in AAH24300 (PubMed:15489334).Curated1
Sequence conflicti764L → P in CAE45915 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_027727158R → H. Corresponds to variant dbSNP:rs17683306Ensembl.1
Natural variantiVAR_027728757T → M1 PublicationCorresponds to variant dbSNP:rs3749817Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02080078 – 246Missing in isoform 2. 1 PublicationAdd BLAST169
Alternative sequenceiVSP_020801601 – 605TNLII → INLEQ in isoform 3. 1 Publication5
Alternative sequenceiVSP_020802606 – 842Missing in isoform 3. 1 PublicationAdd BLAST237

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BX640845 mRNA Translation: CAE45915.1
AC005195 Genomic DNA No translation available.
AC010307 Genomic DNA No translation available.
AC010608 Genomic DNA No translation available.
AC012614 Genomic DNA No translation available.
BC024300 mRNA Translation: AAH24300.1
AB028984 mRNA Translation: BAA83013.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34238.1 [Q6MZW2-1]

NCBI Reference Sequences

More...RefSeqi		NP_055897.1, NM_015082.1 [Q6MZW2-1]
XP_011541585.1, XM_011543283.1 [Q6MZW2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000265342; ENSP00000265342; ENSG00000053108 [Q6MZW2-1]
ENST00000621681; ENSP00000484273; ENSG00000053108 [Q6MZW2-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23105

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23105

UCSC genome browser

More...UCSCi		uc003kyn.2, human [Q6MZW2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640845 mRNA Translation: CAE45915.1
AC005195 Genomic DNA No translation available.
AC010307 Genomic DNA No translation available.
AC010608 Genomic DNA No translation available.
AC012614 Genomic DNA No translation available.
BC024300 mRNA Translation: AAH24300.1
AB028984 mRNA Translation: BAA83013.1
CCDSiCCDS34238.1 [Q6MZW2-1]
RefSeqiNP_055897.1, NM_015082.1 [Q6MZW2-1]
XP_011541585.1, XM_011543283.1 [Q6MZW2-1]

3D structure databases

SMRiQ6MZW2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116730, 4 interactors
IntActiQ6MZW2, 4 interactors
STRINGi9606.ENSP00000265342

Protein family/group databases

MEROPSiI01.977

PTM databases

GlyGeniQ6MZW2, 1 site
iPTMnetiQ6MZW2
PhosphoSitePlusiQ6MZW2

Polymorphism and mutation databases

BioMutaiFSTL4
DMDMi296439344

Proteomic databases

MassIVEiQ6MZW2
PaxDbiQ6MZW2
PeptideAtlasiQ6MZW2
PRIDEiQ6MZW2
ProteomicsDBi66588 [Q6MZW2-1]
66589 [Q6MZW2-2]
66590 [Q6MZW2-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		26231, 39 antibodies

Genome annotation databases

EnsembliENST00000265342; ENSP00000265342; ENSG00000053108 [Q6MZW2-1]
ENST00000621681; ENSP00000484273; ENSG00000053108 [Q6MZW2-2]
GeneIDi23105
KEGGihsa:23105
UCSCiuc003kyn.2, human [Q6MZW2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23105
DisGeNETi23105
EuPathDBiHostDB:ENSG00000053108.16

GeneCards: human genes, protein and diseases

More...GeneCardsi		FSTL4
HGNCiHGNC:21389, FSTL4
HPAiENSG00000053108, Tissue enhanced (brain)
neXtProtiNX_Q6MZW2
OpenTargetsiENSG00000053108
PharmGKBiPA134969998

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QPNV, Eukaryota
GeneTreeiENSGT00940000158076
HOGENOMiCLU_007849_0_0_1
InParanoidiQ6MZW2
OMAiSPQRCVW
OrthoDBi1065760at2759
PhylomeDBiQ6MZW2
TreeFamiTF350473

Enzyme and pathway databases

PathwayCommonsiQ6MZW2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23105, 2 hits in 838 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FSTL4, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23105
PharosiQ6MZW2, Tdark

Protein Ontology

More...PROi		PR:Q6MZW2
RNActiQ6MZW2, protein

Gene expression databases

BgeeiENSG00000053108, Expressed in oocyte and 110 other tissues
ExpressionAtlasiQ6MZW2, baseline and differential
GenevisibleiQ6MZW2, HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR002350, Kazal_dom
IPR036058, Kazal_dom_sf
IPR015943, WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF07648, Kazal_2, 1 hit
SMARTiView protein in SMART
SM00409, IG, 2 hits
SM00408, IGc2, 2 hits
SM00280, KAZAL, 1 hit
SUPFAMiSSF100895, SSF100895, 1 hit
SSF47473, SSF47473, 1 hit
SSF48726, SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS00018, EF_HAND_1, 1 hit
PS50222, EF_HAND_2, 1 hit
PS50835, IG_LIKE, 3 hits
PS51465, KAZAL_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFSTL4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6MZW2
Secondary accession number(s): Q8TBU0, Q9UPU1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: May 18, 2010
Last modified: December 2, 2020
This is version 142 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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