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Entry version 119 (07 Oct 2020)
Sequence version 1 (05 Jul 2004)
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Protein
Submitted name:

Uncharacterized protein DKFZp686A1195

Gene

DKFZp686A1195

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized protein DKFZp686A1195Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DKFZp686A1195Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

MembraneARBA annotation

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36532

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q6MZU1

PRoteomics IDEntifications database

More...
PRIDEi
Q6MZU1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6MZU1, HS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 114PDZInterPro annotationAdd BLAST88
Domaini190 – 268PDZInterPro annotationAdd BLAST79
Domaini425 – 506PDZInterPro annotationAdd BLAST82
Domaini520 – 588SH3InterPro annotationAdd BLAST69
Domaini694 – 795Guanylate kinase-likeInterPro annotationAdd BLAST102
Domaini1558 – 1692ZU5InterPro annotationAdd BLAST135

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni106 – 193DisorderedSequence analysisAdd BLAST88
Regioni299 – 400DisorderedSequence analysisAdd BLAST102
Regioni829 – 924DisorderedSequence analysisAdd BLAST96
Regioni1019 – 1278DisorderedSequence analysisAdd BLAST260
Regioni1297 – 1509DisorderedSequence analysisAdd BLAST213

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi138 – 175PolyampholyteSequence analysisAdd BLAST38
Compositional biasi176 – 190PolarSequence analysisAdd BLAST15
Compositional biasi302 – 330PolyampholyteSequence analysisAdd BLAST29
Compositional biasi362 – 379PolyampholyteSequence analysisAdd BLAST18
Compositional biasi852 – 868AcidicSequence analysisAdd BLAST17
Compositional biasi1034 – 1053PolyampholyteSequence analysisAdd BLAST20
Compositional biasi1115 – 1129PolarSequence analysisAdd BLAST15
Compositional biasi1197 – 1213PolyampholyteSequence analysisAdd BLAST17
Compositional biasi1262 – 1278PolyampholyteSequence analysisAdd BLAST17
Compositional biasi1308 – 1325PolarSequence analysisAdd BLAST18
Compositional biasi1346 – 1360Pro-richSequence analysisAdd BLAST15
Compositional biasi1384 – 1398PolarSequence analysisAdd BLAST15
Compositional biasi1432 – 1456PolarSequence analysisAdd BLAST25
Compositional biasi1482 – 1501PolarSequence analysisAdd BLAST20

Keywords - Domaini

SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

KEGG Orthology (KO)

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KOi
K05701

Database of Orthologous Groups

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OrthoDBi
1175136at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12026, SH3_ZO-1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.42.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008145, GK/Ca_channel_bsu
IPR008144, Guanylate_kin-like_dom
IPR027417, P-loop_NTPase
IPR001478, PDZ
IPR036034, PDZ_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR005417, ZO
IPR005418, ZO-1
IPR035597, ZO-1_SH3
IPR000906, ZU5_dom

The PANTHER Classification System

More...
PANTHERi
PTHR13865:SF25, PTHR13865:SF25, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00625, Guanylate_kin, 1 hit
PF00595, PDZ, 3 hits
PF07653, SH3_2, 1 hit
PF00791, ZU5, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01597, ZONOCCLUDNS
PR01598, ZONOCCLUDNS1

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00072, GuKc, 1 hit
SM00228, PDZ, 3 hits
SM00218, ZU5, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044, SSF50044, 1 hit
SSF50156, SSF50156, 3 hits
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50052, GUANYLATE_KINASE_2, 1 hit
PS50106, PDZ, 3 hits
PS50002, SH3, 1 hit
PS51145, ZU5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6MZU1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERNTFSMDC HSKSTAMEET AIWEQHTVTL HRAPGFGFGI AISGGRDNPH
60 70 80 90 100
FQSGETSIVI SDVLKGGPAE GQLQENDRVA MVNGVSMDNV EHAFAVQQLR
110 120 130 140 150
KSGKNAKITI RRKKKVQIPV SRPDPEPVSD NEEDSYDEEI HDPRSGRSGV
160 170 180 190 200
VNRRSEKIWP RDRSASRERS LSPRSDRRSV ASSQPAKPTK VTLVKSRKNE
210 220 230 240 250
EYGLRLASHI FVKEISQDSL AARDGNIQEG DVVLKINGTV TENMSLTDAK
260 270 280 290 300
TLIERSKGKL KMVVQRDERA TLLNVPDLSD SIHSANASER DDISEIQSLA
310 320 330 340 350
SDHSGRSHDR PPRRSRSRSP DQRSEPSDHS RHSPQQPSNG SLRSRDEERI
360 370 380 390 400
SKPGAVSTPV KHADDHTPKT VEEVTVERNE KQTPSLPEPK PVYAQVGQPD
410 420 430 440 450
VDLPVSPSDG VLPNSTHEDG ILRPSMKLVK FRKGDSVGLR LAGGNDVGIF
460 470 480 490 500
VAGVLEDSPA AKEGLEEGDQ ILRVSNVDFT NIIREEAVLF LLDLPKGEEV
510 520 530 540 550
TILAQKKKDV YRRIVESDVG DSFYIRTHFE YEKESPYGLS FNKGEVFRVV
560 570 580 590 600
DTLYNGKLGS WLAIRIGKNH KEVERGIIPN KNRAEQLASV QYTLPKTAGG
610 620 630 640 650
DRADFWRFRG LRSSKRNLRK SREDLSAQPV QTKFPAYERV VLREAGFLRP
660 670 680 690 700
VTIFGPIADV AREKLAREEP DIYQIAKSEP RDAGTDQRSS GIIRLHTIKQ
710 720 730 740 750
IIDQGKHALL DVTPNAVDRL NYAQWYPIVV FLNPDSKQGV KTMRMRLCLE
760 770 780 790 800
SRKSARKLYE RSHKLRKNNH HLFTTTINLN SMNDGWYGAL KEAIQQQQNQ
810 820 830 840 850
LVWVSEGKAD GATSDDLDLH DDRLSYLSAP GSEYSMYSTD SRHTSDYEDT
860 870 880 890 900
DTEGGAYTDQ ELDETLNDEV GTPPESAITR SSEPVREDSS GMHHENQTYP
910 920 930 940 950
PYSPQAQPQP IHRIDSPGFK PASQQVYRKD PYPEEMMRQN HVLKQPAVSH
960 970 980 990 1000
PGHRPDKEPN LTYEPQLPYV EKQASRDLEQ PTYRYESSSY TDQFSRNYEH
1010 1020 1030 1040 1050
RLRYEDRVPM YEEQWSYYDD KQPYPSRPPF DNQHSQDLDS RQHPEESSER
1060 1070 1080 1090 1100
GYFPRFEEPA PLSYDSRPRY EQAPRASALR HEEQPAPGYD THGRLRPEAQ
1110 1120 1130 1140 1150
PHPSAGPKPA ESKQYFEQYS RSYEQVPPQG FTSRAGHFEP LHGAAAVPPL
1160 1170 1180 1190 1200
IPSSQHKPEA LPSNTKPLPP PPTQTEEEED PAMKPQSVLT RVKMFENKRS
1210 1220 1230 1240 1250
ASLETKKDVN DTGSFKPPEV ASKPSGAPII GPKPTSQNQF SEHDKTLYRV
1260 1270 1280 1290 1300
PEPQKPQLKP PEDIVRSNHY DPEEDEEYYR KQLSYFDRRS FENKPPAHIA
1310 1320 1330 1340 1350
ASHLSEPAKL AHSQNQSNFS SYSSKGKPPE ADGVDRSFGE KRYEPIQATP
1360 1370 1380 1390 1400
PPPPLPSQYA QPSQPVTSAS LHIHSKGAHG EGNSVSLDFQ NSLVSKPDPP
1410 1420 1430 1440 1450
PSQNKPATFR PPNREDTAQA AFYPQKSFPD KAPVNGTEQT QKTVTPAYNR
1460 1470 1480 1490 1500
FTPKPYTSSA RPFERKFESP KFNHNLLPSE TAHKPDLSSK TPTSPKTLVK
1510 1520 1530 1540 1550
SHSLAQPPEF DSGVETFSIH AEKPKYQINN ISTVPKAIPV SPSAVEEDED
1560 1570 1580 1590 1600
EDGHTVVATA RGIFNSNGGV LSSIETGVSI IIPQGAIPEG VEQEIYFKVC
1610 1620 1630 1640 1650
RDNSILPPLD KEKGETLLSP LVMCGPHGLK FLKPVELRLP HCASMTPAGW
1660 1670 1680 1690
SFALKSSDSS SGDPKTWQNK RLPGDPNYLV GANCVSVLID HF
Length:1,692
Mass (Da):189,618
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE117187B0B6BA309
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX640879 mRNA Translation: CAE45936.1

NCBI Reference Sequences

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RefSeqi
NP_001287955.1, NM_001301026.1
NP_003248.3, NM_003257.4
NP_783297.2, NM_175610.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7082

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7082

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640879 mRNA Translation: CAE45936.1
RefSeqiNP_001287955.1, NM_001301026.1
NP_003248.3, NM_003257.4
NP_783297.2, NM_175610.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiQ6MZU1
PRIDEiQ6MZU1

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
7082

Genome annotation databases

GeneIDi7082
KEGGihsa:7082

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7082
PharmGKBiPA36532

Phylogenomic databases

KOiK05701
OrthoDBi1175136at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
7082, 12 hits in 876 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7082

Gene expression databases

GenevisibleiQ6MZU1, HS

Family and domain databases

CDDicd12026, SH3_ZO-1, 1 hit
Gene3Di2.30.42.10, 3 hits
InterProiView protein in InterPro
IPR008145, GK/Ca_channel_bsu
IPR008144, Guanylate_kin-like_dom
IPR027417, P-loop_NTPase
IPR001478, PDZ
IPR036034, PDZ_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR005417, ZO
IPR005418, ZO-1
IPR035597, ZO-1_SH3
IPR000906, ZU5_dom
PANTHERiPTHR13865:SF25, PTHR13865:SF25, 2 hits
PfamiView protein in Pfam
PF00625, Guanylate_kin, 1 hit
PF00595, PDZ, 3 hits
PF07653, SH3_2, 1 hit
PF00791, ZU5, 1 hit
PRINTSiPR01597, ZONOCCLUDNS
PR01598, ZONOCCLUDNS1
SMARTiView protein in SMART
SM00072, GuKc, 1 hit
SM00228, PDZ, 3 hits
SM00218, ZU5, 1 hit
SUPFAMiSSF50044, SSF50044, 1 hit
SSF50156, SSF50156, 3 hits
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50052, GUANYLATE_KINASE_2, 1 hit
PS50106, PDZ, 3 hits
PS50002, SH3, 1 hit
PS51145, ZU5, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6MZU1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6MZU1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 7, 2020
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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