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Entry version 52 (31 Jul 2019)
Sequence version 1 (05 Jul 2004)
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Protein
Submitted name:

Uncharacterized protein DKFZp686E2242

Gene

DKFZp686E2242

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized protein DKFZp686E2242Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DKFZp686E2242Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q6MZT4

PRoteomics IDEntifications database

More...
PRIDEi
Q6MZT4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni66 – 86DisorderedSequence analysisAdd BLAST21
Regioni784 – 840DisorderedSequence analysisAdd BLAST57
Regioni853 – 874DisorderedSequence analysisAdd BLAST22
Regioni1116 – 1150DisorderedSequence analysisAdd BLAST35
Regioni1270 – 1290DisorderedSequence analysisAdd BLAST21

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili17 – 44Sequence analysisAdd BLAST28
Coiled coili121 – 162Sequence analysisAdd BLAST42
Coiled coili195 – 286Sequence analysisAdd BLAST92
Coiled coili378 – 422Sequence analysisAdd BLAST45
Coiled coili965 – 1002Sequence analysisAdd BLAST38
Coiled coili1064 – 1087Sequence analysisAdd BLAST24
Coiled coili1164 – 1198Sequence analysisAdd BLAST35
Coiled coili1323 – 1343Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi799 – 816PolyampholyteSequence analysisAdd BLAST18
Compositional biasi1135 – 1149PolyampholyteSequence analysisAdd BLAST15

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J2NR Eukaryota
ENOG411281S LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231999

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q6MZT4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
SEMKKMHEGD LAMALVLDEK DRLIEELKLS LKSKEALIQC LKEEKSQMAC
60 70 80 90 100
PDENVSSGEL RGLCAAPREE KERETEAAQM EHQKERNSFQ ERIQALEEDL
110 120 130 140 150
REKEREIATE KKNSLKRDKA IQGLTMALKS KEKKVEELNS EIEKLSAAFA
160 170 180 190 200
KAREALQKAQ TQEFQGSEDY ETALSGKEAL SAALRSQNLT KSTENHRLRR
210 220 230 240 250
SIKKITQELS DLQQERERLE KDLEEAHREK SKGDCTIRDL RNEVEKLRNE
260 270 280 290 300
VNEREKAMEN RYKSLLSESN KKLHNQEQVI KHLTESTNQR DVLLQKFNEK
310 320 330 340 350
DLEVIQQNCY LMAAEDLELR SEGLITEKCS SQQPPGSKTI FSKEKKQSSD
360 370 380 390 400
YEELIQVLKK EQDIYTHLVK SLQESDSINN LQAELNKIFA LRKQLEQDVL
410 420 430 440 450
SYQNLRKTLE EQISEIRRRE EESFSLYSDQ TSYLSICLEE NNRFQVEHFS
460 470 480 490 500
QEELKKKVSD LIQLVKELYT DNQHLKKTIF DLSCMGFQGN GFPDRLASTE
510 520 530 540 550
QTEIMKDLSK GGCKNGYLRH TESKISDCDG AHAPGCLEEG AFINLLAPLF
560 570 580 590 600
NEKATLLLES RPDLLKVVRE LLLGQLFLTE QEVSGEHLDG KTEKTPKQKG
610 620 630 640 650
ELVHFVQTNS FSKPHDELKL SCEAQLVKAG EVPKVGLKDA SVQTVATEGD
660 670 680 690 700
LLRFKHEATR EAWEEKPINT ALSAEHRPEN LHGVPGWQAA LLSLPGITNR
710 720 730 740 750
EAKKSRLPIL IKPSRSLGNM YRLPATQEVV TQLQSQILEL QGELKEFKTC
760 770 780 790 800
NKQLHQKLIL AEAVMEGRPT PDKTLLNAQP PVGAAYQDSP GEQKGIKTTS
810 820 830 840 850
SVWRDKEMDS DQQRSYEIDS EICPPDDLAS LPSCKENPED VLSPTSVATY
860 870 880 890 900
LSSKSQPSAK VSVMGTDQSE SINTSNETEY LKQKIHDLET ELEGYQNFIF
910 920 930 940 950
QLQKHSQCSE AIITVLCGTE GAQDGLSKPK NGSDGEEMTF SSLHQVRYVK
960 970 980 990 1000
HVKILGPLAP EMIDSRVLEN LKQQLEEQEY KLQKEQNLNM QLFSEIHNLQ
1010 1020 1030 1040 1050
NKFRDLSPPR YDSLVQSQAR GLSLQRQQIK DGHGICVISR QHMNTMIKAF
1060 1070 1080 1090 1100
EELLQASDVD YCVAEGFQEQ LNQCAELLEK LEKLFLNGKS VGVEMNTQNE
1110 1120 1130 1140 1150
LMEGIEEDNL TYQHLLPESP EPSASHALSD YETSEKSFFS RDQKQDNETE
1160 1170 1180 1190 1200
KTSVMVNSFS QDLLMEHIQE IRTLRKRLEE SIKTNEKLRK QLERQGSEFV
1210 1220 1230 1240 1250
QGSTSIFASG SELHSSLTSE IHFLRKQNQA LNAMLIKGSR DKQKENDKLR
1260 1270 1280 1290 1300
ESLSRKTVSL EHLQREYASV KEENERLQKE GSEKERHNQQ LIQEVRCSGQ
1310 1320 1330 1340 1350
ELSRVQEELK LRQQLLSQND KLLQSLRVEL KAYEKLDEEH RRLRGTEALL

TLRLLCFGL
Length:1,359
Mass (Da):155,499
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBE61CB9964ED2CB2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX640896 mRNA Translation: CAE45944.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640896 mRNA Translation: CAE45944.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiQ6MZT4
PRIDEiQ6MZT4

Phylogenomic databases

eggNOGiENOG410J2NR Eukaryota
ENOG411281S LUCA
HOGENOMiHOG000231999

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6MZT4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6MZT4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 31, 2019
This is version 52 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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