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Protein

Regulator of G-protein signaling 7-binding protein

Gene

RGS7BP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the R7-Gbeta5 complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cytoplasmic shuttling. May also act by controlling the proteolytic stability of R7 proteins, probably by protecting them from degradation.By similarity

GO - Biological processi

Keywordsi

Molecular functionSignal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 7-binding protein
Alternative name(s):
R7 family-binding protein
Gene namesi
Name:RGS7BP
Synonyms:R7BP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000186479.4
HGNCiHGNC:23271 RGS7BP
MIMi610890 gene
neXtProtiNX_Q6MZT1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi401190
OpenTargetsiENSG00000186479
PharmGKBiPA162401279

Polymorphism and mutation databases

DMDMi296452985

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002875951 – 257Regulator of G-protein signaling 7-binding proteinAdd BLAST257

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi252S-palmitoyl cysteineBy similarity1
Lipidationi253S-palmitoyl cysteineBy similarity1

Post-translational modificationi

Palmitoylation regulates the cell membrane and nuclear shuttling and the regulation of GPCR signaling. Upon depalmitoylation, it is targeted into the nucleus.By similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ6MZT1
PeptideAtlasiQ6MZT1
PRIDEiQ6MZT1
ProteomicsDBi66586
TopDownProteomicsiQ6MZT1

PTM databases

PhosphoSitePlusiQ6MZT1

Expressioni

Gene expression databases

BgeeiENSG00000186479 Expressed in 129 organ(s), highest expression level in primary visual cortex
CleanExiHS_RGS7BP
GenevisibleiQ6MZT1 HS

Organism-specific databases

HPAiHPA039600

Interactioni

Subunit structurei

Interacts with 'R7' family proteins RGS6, RGS7, RGS9 and RGS11. Component of some R7-Gbeta5 complex composed of some R7 protein (RGS6, RGS7, RGS9 or RGS11), Gbeta5 (GNB5) and RGS7BP.By similarity

Protein-protein interaction databases

BioGridi134967, 3 interactors
STRINGi9606.ENSP00000334851

Structurei

3D structure databases

ProteinModelPortaliQ6MZT1
SMRiQ6MZT1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi242 – 247Nuclear localization signalBy similarity6

Domaini

The nuclear localization signal is both required for nuclear localization and palmitoylation.By similarity

Sequence similaritiesi

Belongs to the RGS7BP/RGS9BP family.Curated

Phylogenomic databases

eggNOGiENOG410IH1X Eukaryota
ENOG410YXJD LUCA
GeneTreeiENSGT00390000006968
HOGENOMiHOG000154060
HOVERGENiHBG104928
InParanoidiQ6MZT1
OMAiRMIVQEF
OrthoDBiEOG091G0GG3
PhylomeDBiQ6MZT1
TreeFamiTF330985

Family and domain databases

InterProiView protein in InterPro
IPR026512 RGS7BP/RGS9BP
PANTHERiPTHR21029 PTHR21029, 1 hit

Sequencei

Sequence statusi: Complete.

Q6MZT1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSAPNGRKK RPSRSTRSSI FQISKPPLQS GDWERRGSGS ESAHKTQRAL
60 70 80 90 100
DDCKMLVQEF NTQVALYREL VISIGDVSVS CPSLRAEMHK TRTKGCEMAR
110 120 130 140 150
QAHQKLAAIS GPEDGEIHPE ICRLYIQLQC CLEMYTTEML KSICLLGSLQ
160 170 180 190 200
FHRKGKEPGG GTKSLDCKIE ESAETPALED SSSSPVDSQQ HSWQVSTDIE
210 220 230 240 250
NTERDMREMK NLLSKLRETM PLPLKNQDDS SLLNLTPYPL VRRRKRRFFG

LCCLISS
Length:257
Mass (Da):28,962
Last modified:May 18, 2010 - v3
Checksum:i889F690C6DCC40F5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032334255I → V3 PublicationsCorresponds to variant dbSNP:rs889248Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK296443 mRNA Translation: BAH12357.1
AC091862 Genomic DNA No translation available.
AC035143 Genomic DNA No translation available.
AC008854 Genomic DNA No translation available.
CH471137 Genomic DNA Translation: EAW51372.1
BC140707 mRNA Translation: AAI40708.1
BX640900 mRNA Translation: CAE45947.1
CCDSiCCDS34170.1
RefSeqiNP_001025046.1, NM_001029875.2
NP_001258819.1, NM_001271890.1
NP_001258820.1, NM_001271891.1
UniGeneiHs.657133

Genome annotation databases

EnsembliENST00000334025; ENSP00000334851; ENSG00000186479
GeneIDi401190
KEGGihsa:401190
UCSCiuc003jtj.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK296443 mRNA Translation: BAH12357.1
AC091862 Genomic DNA No translation available.
AC035143 Genomic DNA No translation available.
AC008854 Genomic DNA No translation available.
CH471137 Genomic DNA Translation: EAW51372.1
BC140707 mRNA Translation: AAI40708.1
BX640900 mRNA Translation: CAE45947.1
CCDSiCCDS34170.1
RefSeqiNP_001025046.1, NM_001029875.2
NP_001258819.1, NM_001271890.1
NP_001258820.1, NM_001271891.1
UniGeneiHs.657133

3D structure databases

ProteinModelPortaliQ6MZT1
SMRiQ6MZT1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi134967, 3 interactors
STRINGi9606.ENSP00000334851

PTM databases

PhosphoSitePlusiQ6MZT1

Polymorphism and mutation databases

DMDMi296452985

Proteomic databases

PaxDbiQ6MZT1
PeptideAtlasiQ6MZT1
PRIDEiQ6MZT1
ProteomicsDBi66586
TopDownProteomicsiQ6MZT1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334025; ENSP00000334851; ENSG00000186479
GeneIDi401190
KEGGihsa:401190
UCSCiuc003jtj.5 human

Organism-specific databases

CTDi401190
DisGeNETi401190
EuPathDBiHostDB:ENSG00000186479.4
GeneCardsiRGS7BP
H-InvDBiHIX0024981
HGNCiHGNC:23271 RGS7BP
HPAiHPA039600
MIMi610890 gene
neXtProtiNX_Q6MZT1
OpenTargetsiENSG00000186479
PharmGKBiPA162401279
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH1X Eukaryota
ENOG410YXJD LUCA
GeneTreeiENSGT00390000006968
HOGENOMiHOG000154060
HOVERGENiHBG104928
InParanoidiQ6MZT1
OMAiRMIVQEF
OrthoDBiEOG091G0GG3
PhylomeDBiQ6MZT1
TreeFamiTF330985

Miscellaneous databases

ChiTaRSiRGS7BP human
GenomeRNAii401190
PROiPR:Q6MZT1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186479 Expressed in 129 organ(s), highest expression level in primary visual cortex
CleanExiHS_RGS7BP
GenevisibleiQ6MZT1 HS

Family and domain databases

InterProiView protein in InterPro
IPR026512 RGS7BP/RGS9BP
PANTHERiPTHR21029 PTHR21029, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiR7BP_HUMAN
AccessioniPrimary (citable) accession number: Q6MZT1
Secondary accession number(s): B7Z3X1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 95 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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