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UniProtKB - Q6MZP7 (LIN54_HUMAN)

Entry version 125 (02 Dec 2020)
Sequence version 3 (30 Nov 2010)
Previous versions | rss
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Protein

Protein lin-54 homolog

Gene

LIN54

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context (PubMed:17671431, PubMed:17531812). In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes (PubMed:17671431, PubMed:17531812). In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation (PubMed:17671431, PubMed:17531812). In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner (PubMed:19725879). Specifically recognizes the consensus motif 5'-TTYRAA-3' in target DNA (PubMed:27465258).4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi525Zinc 1Combined sources1
Metal bindingi525Zinc 2Combined sources1
Metal bindingi527Zinc 1Combined sources1
Metal bindingi532Zinc 1Combined sources1
Metal bindingi532Zinc 3Combined sources1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei536Critical for interaction with target DNA1 Publication1
Metal bindingi537Zinc 1Combined sources1
Metal bindingi539Zinc 2Combined sources1
Metal bindingi546Zinc 2Combined sources1
Metal bindingi546Zinc 3Combined sources1
Metal bindingi549Zinc 2Combined sources1
Metal bindingi551Zinc 3Combined sources1
Metal bindingi554Zinc 3Combined sources1
Metal bindingi599Zinc 4Combined sources1
Metal bindingi599Zinc 5Combined sources1
Metal bindingi601Zinc 4Combined sources1
Metal bindingi606Zinc 4Combined sources1
Metal bindingi606Zinc 6Combined sources1
Sitei610Critical for interaction with target DNA1 Publication1
Metal bindingi611Zinc 4Combined sources1
Metal bindingi613Zinc 5Combined sources1
Metal bindingi620Zinc 5Combined sources1
Metal bindingi620Zinc 6Combined sources1
Metal bindingi624Zinc 5Combined sources1
Metal bindingi626Zinc 6Combined sources1
Metal bindingi629Zinc 6Combined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processCell cycle, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6MZP7

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1362277, Transcription of E2F targets under negative control by DREAM complex
R-HSA-1362300, Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
R-HSA-1538133, G0 and Early G1
R-HSA-156711, Polo-like kinase mediated events
R-HSA-69202, Cyclin E associated events during G1/S transition
R-HSA-69205, G1/S-Specific Transcription
R-HSA-69656, Cyclin A:Cdk2-associated events at S phase entry

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein lin-54 homolog
Alternative name(s):
CXC domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LIN54
Synonyms:CXCDC1, KIAA2037
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000189308.10

Human Gene Nomenclature Database

More...HGNCi		HGNC:25397, LIN54

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613367, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6MZP7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi525C → Y: Abolishes DNA-binding to the CDK1 promoter; when associated with Y-527. 1 Publication1
Mutagenesisi527C → Y: Abolishes DNA-binding to the CDK1 promoter; when associated with Y-525. 1 Publication1
Mutagenesisi536Y → A, F or R: Loss of DNA-binding. 1 Publication1
Mutagenesisi610Y → A, F or R: Loss of DNA-binding. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		132660

Open Targets

More...OpenTargetsi		ENSG00000189308

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162394056

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6MZP7, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LIN54

Domain mapping of disease mutations (DMDM)

More...DMDMi		313104222

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003413891 – 749Protein lin-54 homologAdd BLAST749

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki139Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei244N6-acetyllysineCombined sources1
Modified residuei249N6-acetyllysineCombined sources1
Modified residuei264PhosphoserineCombined sources1
Modified residuei282PhosphoserineCombined sources1
Modified residuei310PhosphoserineCombined sources1
Modified residuei314PhosphoserineCombined sources1
Cross-linki357Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei635PhosphoserineCombined sources1
Cross-linki639Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki659Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki661Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6MZP7

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6MZP7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6MZP7

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6MZP7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6MZP7

PeptideAtlas

More...PeptideAtlasi		Q6MZP7

PRoteomics IDEntifications database

More...PRIDEi		Q6MZP7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		66576 [Q6MZP7-1]
66577 [Q6MZP7-2]
66578 [Q6MZP7-3]
66579 [Q6MZP7-4]
66580 [Q6MZP7-5]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		2849, 1 O-Linked glycan (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q6MZP7, 2 sites, 1 O-linked glycan (2 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6MZP7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6MZP7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000189308, Expressed in ventricular zone and 126 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6MZP7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6MZP7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000189308, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.

2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei574Interaction with DNA1 Publication1

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		126328, 38 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q6MZP7

Protein interaction database and analysis system

More...IntActi		Q6MZP7, 48 interactors

Molecular INTeraction database

More...MINTi		Q6MZP7

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000341947

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6MZP7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1749
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6MZP7

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini521 – 634CRCPROSITE-ProRule annotationAdd BLAST114

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni523 – 536DNA-binding1 PublicationAdd BLAST14
Regioni583 – 596Linker1 PublicationAdd BLAST14
Regioni599 – 612DNA-binding1 PublicationAdd BLAST14

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The CRC domain mediates DNA-binding (PubMed:19725879, PubMed:27465258). It contains two CXC subdomains (joined by a flexible linker) which are both required for efficient association with target DNA (PubMed:27465258). Each CXC subdomain coordinates three Zn2+ ions (PubMed:27465258).2 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the lin-54 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1171, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155881

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_024128_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6MZP7

Identification of Orthologs from Complete Genome Data

More...OMAi		PHTGSKP

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6MZP7

TreeFam database of animal gene trees

More...TreeFami		TF313189

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR005172, CRC
IPR028307, Lin-54_fam
IPR033467, Tesmin/TSO1-like_CXC

The PANTHER Classification System

More...PANTHERi		PTHR12446, PTHR12446, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03638, TCR, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01114, CXC, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51634, CRC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6MZP7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEVVPAEVNS LLPEEIMDTG ITLVDDDSIE AVIVSSPIPM ETELEEIVNI 
        60         70         80         90        100
NSTGDSTATP ISTEPITVYS NHTNQVAVNT TITKADSNTT VKPAFPSGLQ 
       110        120        130        140        150
KLGAQTPVTI SANQIILNKV SQTSDLKLGN QTLKPDGQKL ILTTLGKSGS 
       160        170        180        190        200
PIVLALPHSQ LPQAQKVTTQ AQSGDAKLPP QQIKVVTIGG RPEVKPVIGV 
       210        220        230        240        250
SALTPGSQLI NTTTQPSVLQ TQQLKTVQIA KKPRTPTSGP VITKLIFAKP 
       260        270        280        290        300
INSKAVTGQT TQVSPPVIAG RVLSQSTPGT PSKTITISES GVIGSTLNST 
       310        320        330        340        350
TQTPNKIAIS PLKSPNKAVK STVQTITVGG VSTSQFKTII PLATAPNVQQ 
       360        370        380        390        400
IQVPGSKFHY VRLVTATSAS SSTQPVSQNP STNTQPLQQA KPVVVNTTPV 
       410        420        430        440        450
RMSVPIVSAQ AVKQVVPKPI NPTSQIVTTS QPQQRLIMPA TPLPQIQPNL 
       460        470        480        490        500
TNLPPGTVLA PAPGTGNVGY AVLPAQYVTQ LQQSSYVSIA SNSTFTGTSG 
       510        520        530        540        550
IQTQARLPFN GIIPSESASR PRKPCNCTKS LCLKLYCDCF ANGEFCNNCN 
       560        570        580        590        600
CTNCYNNLEH ENERQKAIKA CLDRNPEAFK PKIGKGKEGE SDRRHSKGCN 
       610        620        630        640        650
CKRSGCLKNY CECYEAKIMC SSICKCIGCK NFEESPERKT LMHLADAAEV 
       660        670        680        690        700
RVQQQTAAKT KLSSQISDLL TRPTPALNSG GGKLPFTFVT KEVAEATCNC 
       710        720        730        740 
LLAQAEQADK KGKSKAAAER MILEEFGRCL MSVINSAGKA KSDPCAMNC
Length:749
Mass (Da):79,494
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA3E4513CB0118B78
GO
Isoform 2 (identifier: Q6MZP7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     229-317: Missing.

Show »
Length:660
Mass (Da):70,378
Checksum:iF34917B51B87B370
GO
Isoform 3 (identifier: Q6MZP7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     8-228: Missing.

Show »
Length:528
Mass (Da):56,284
Checksum:i7EEAFDD538973450
GO
Isoform 4 (identifier: Q6MZP7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-401: Missing.

Show »
Length:348
Mass (Da):37,613
Checksum:iB65DCCA3258768FB
GO
Isoform 5 (identifier: Q6MZP7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     229-243: IAKKPRTPTSGPVIT → VGFFHSLLPELHQRP
     244-749: Missing.

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Length:243
Mass (Da):25,743
Checksum:i6ECC642FE3E55419
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6REW4D6REW4_HUMAN
Protein lin-54 homolog
LIN54
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC98377 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti9N → S in CAE45981 (PubMed:17974005).Curated1
Sequence conflicti743D → A in CAE45981 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0342721 – 401Missing in isoform 4. 1 PublicationAdd BLAST401
Alternative sequenceiVSP_0342738 – 228Missing in isoform 3. 2 PublicationsAdd BLAST221
Alternative sequenceiVSP_034274229 – 317Missing in isoform 2. 1 PublicationAdd BLAST89
Alternative sequenceiVSP_034275229 – 243IAKKP…GPVIT → VGFFHSLLPELHQRP in isoform 5. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_034276244 – 749Missing in isoform 5. 1 PublicationAdd BLAST506

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB111889 mRNA Translation: BAC98377.1 Different initiation.
AK292769 mRNA Translation: BAF85458.1
BX640657 mRNA Translation: CAE45799.1
BX640966 mRNA Translation: CAE45981.1
AC021105 Genomic DNA No translation available.
BC109277 mRNA Translation: AAI09278.1
BC109278 mRNA Translation: AAI09279.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3599.1 [Q6MZP7-1]
CCDS47089.1 [Q6MZP7-3]
CCDS75157.1 [Q6MZP7-2]

NCBI Reference Sequences

More...RefSeqi		NP_001108479.1, NM_001115007.2 [Q6MZP7-3]
NP_001108480.1, NM_001115008.2 [Q6MZP7-3]
NP_001275925.1, NM_001288996.1 [Q6MZP7-2]
NP_001275926.1, NM_001288997.1 [Q6MZP7-3]
NP_919258.2, NM_194282.3 [Q6MZP7-1]
XP_005262807.1, XM_005262750.4 [Q6MZP7-1]
XP_006714144.1, XM_006714081.3 [Q6MZP7-1]
XP_016863217.1, XM_017007728.1 [Q6MZP7-2]
XP_016863218.1, XM_017007729.1 [Q6MZP7-4]
XP_016863219.1, XM_017007730.1 [Q6MZP7-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000340417; ENSP00000341947; ENSG00000189308 [Q6MZP7-1]
ENST00000442461; ENSP00000398265; ENSG00000189308 [Q6MZP7-3]
ENST00000446851; ENSP00000407139; ENSG00000189308 [Q6MZP7-3]
ENST00000505397; ENSP00000425844; ENSG00000189308 [Q6MZP7-1]
ENST00000506560; ENSP00000423475; ENSG00000189308 [Q6MZP7-2]
ENST00000508171; ENSP00000427413; ENSG00000189308 [Q6MZP7-5]
ENST00000510557; ENSP00000421045; ENSG00000189308 [Q6MZP7-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		132660

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:132660

UCSC genome browser

More...UCSCi		uc003hnx.5, human [Q6MZP7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB111889 mRNA Translation: BAC98377.1 Different initiation.
AK292769 mRNA Translation: BAF85458.1
BX640657 mRNA Translation: CAE45799.1
BX640966 mRNA Translation: CAE45981.1
AC021105 Genomic DNA No translation available.
BC109277 mRNA Translation: AAI09278.1
BC109278 mRNA Translation: AAI09279.1
CCDSiCCDS3599.1 [Q6MZP7-1]
CCDS47089.1 [Q6MZP7-3]
CCDS75157.1 [Q6MZP7-2]
RefSeqiNP_001108479.1, NM_001115007.2 [Q6MZP7-3]
NP_001108480.1, NM_001115008.2 [Q6MZP7-3]
NP_001275925.1, NM_001288996.1 [Q6MZP7-2]
NP_001275926.1, NM_001288997.1 [Q6MZP7-3]
NP_919258.2, NM_194282.3 [Q6MZP7-1]
XP_005262807.1, XM_005262750.4 [Q6MZP7-1]
XP_006714144.1, XM_006714081.3 [Q6MZP7-1]
XP_016863217.1, XM_017007728.1 [Q6MZP7-2]
XP_016863218.1, XM_017007729.1 [Q6MZP7-4]
XP_016863219.1, XM_017007730.1 [Q6MZP7-4]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5FD3X-ray2.42A/B515-646[»]
SMRiQ6MZP7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi126328, 38 interactors
CORUMiQ6MZP7
IntActiQ6MZP7, 48 interactors
MINTiQ6MZP7
STRINGi9606.ENSP00000341947

PTM databases

GlyConnecti2849, 1 O-Linked glycan (1 site)
GlyGeniQ6MZP7, 2 sites, 1 O-linked glycan (2 sites)
iPTMnetiQ6MZP7
PhosphoSitePlusiQ6MZP7

Polymorphism and mutation databases

BioMutaiLIN54
DMDMi313104222

Proteomic databases

EPDiQ6MZP7
jPOSTiQ6MZP7
MassIVEiQ6MZP7
MaxQBiQ6MZP7
PaxDbiQ6MZP7
PeptideAtlasiQ6MZP7
PRIDEiQ6MZP7
ProteomicsDBi66576 [Q6MZP7-1]
66577 [Q6MZP7-2]
66578 [Q6MZP7-3]
66579 [Q6MZP7-4]
66580 [Q6MZP7-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		55895, 55 antibodies

The DNASU plasmid repository

More...DNASUi		132660

Genome annotation databases

EnsembliENST00000340417; ENSP00000341947; ENSG00000189308 [Q6MZP7-1]
ENST00000442461; ENSP00000398265; ENSG00000189308 [Q6MZP7-3]
ENST00000446851; ENSP00000407139; ENSG00000189308 [Q6MZP7-3]
ENST00000505397; ENSP00000425844; ENSG00000189308 [Q6MZP7-1]
ENST00000506560; ENSP00000423475; ENSG00000189308 [Q6MZP7-2]
ENST00000508171; ENSP00000427413; ENSG00000189308 [Q6MZP7-5]
ENST00000510557; ENSP00000421045; ENSG00000189308 [Q6MZP7-3]
GeneIDi132660
KEGGihsa:132660
UCSCiuc003hnx.5, human [Q6MZP7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		132660
DisGeNETi132660
EuPathDBiHostDB:ENSG00000189308.10

GeneCards: human genes, protein and diseases

More...GeneCardsi		LIN54
HGNCiHGNC:25397, LIN54
HPAiENSG00000189308, Low tissue specificity
MIMi613367, gene
neXtProtiNX_Q6MZP7
OpenTargetsiENSG00000189308
PharmGKBiPA162394056

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1171, Eukaryota
GeneTreeiENSGT00940000155881
HOGENOMiCLU_024128_1_0_1
InParanoidiQ6MZP7
OMAiPHTGSKP
PhylomeDBiQ6MZP7
TreeFamiTF313189

Enzyme and pathway databases

PathwayCommonsiQ6MZP7
ReactomeiR-HSA-1362277, Transcription of E2F targets under negative control by DREAM complex
R-HSA-1362300, Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
R-HSA-1538133, G0 and Early G1
R-HSA-156711, Polo-like kinase mediated events
R-HSA-69202, Cyclin E associated events during G1/S transition
R-HSA-69205, G1/S-Specific Transcription
R-HSA-69656, Cyclin A:Cdk2-associated events at S phase entry

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		132660, 211 hits in 851 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		LIN54, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		132660
PharosiQ6MZP7, Tdark

Protein Ontology

More...PROi		PR:Q6MZP7
RNActiQ6MZP7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000189308, Expressed in ventricular zone and 126 other tissues
ExpressionAtlasiQ6MZP7, baseline and differential
GenevisibleiQ6MZP7, HS

Family and domain databases

InterProiView protein in InterPro
IPR005172, CRC
IPR028307, Lin-54_fam
IPR033467, Tesmin/TSO1-like_CXC
PANTHERiPTHR12446, PTHR12446, 1 hit
PfamiView protein in Pfam
PF03638, TCR, 2 hits
SMARTiView protein in SMART
SM01114, CXC, 2 hits
PROSITEiView protein in PROSITE
PS51634, CRC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLIN54_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6MZP7
Secondary accession number(s): Q32M68
, Q32M69, Q6N071, Q76B60
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: November 30, 2010
Last modified: December 2, 2020
This is version 125 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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