LIN54

Functionⁱ

Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context (PubMed:17671431, PubMed:17531812). In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes (PubMed:17671431, PubMed:17531812). In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation (PubMed:17671431, PubMed:17531812). In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner (PubMed:19725879). Specifically recognizes the consensus motif 5'-TTYRAA-3' in target DNA (PubMed:27465258).4 Publications

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	525	Zinc 1Combined sources	1
Metal bindingⁱ	525	Zinc 2Combined sources	1
Metal bindingⁱ	527	Zinc 1Combined sources	1
Metal bindingⁱ	532	Zinc 1Combined sources	1
Metal bindingⁱ	532	Zinc 3Combined sources	1
Siteⁱ	536	Critical for interaction with target DNA1 Publication	1
Metal bindingⁱ	537	Zinc 1Combined sources	1
Metal bindingⁱ	539	Zinc 2Combined sources	1
Metal bindingⁱ	546	Zinc 2Combined sources	1
Metal bindingⁱ	546	Zinc 3Combined sources	1
Metal bindingⁱ	549	Zinc 2Combined sources	1
Metal bindingⁱ	551	Zinc 3Combined sources	1
Metal bindingⁱ	554	Zinc 3Combined sources	1
Metal bindingⁱ	599	Zinc 4Combined sources	1
Metal bindingⁱ	599	Zinc 5Combined sources	1
Metal bindingⁱ	601	Zinc 4Combined sources	1
Metal bindingⁱ	606	Zinc 4Combined sources	1
Metal bindingⁱ	606	Zinc 6Combined sources	1
Siteⁱ	610	Critical for interaction with target DNA1 Publication	1
Metal bindingⁱ	611	Zinc 4Combined sources	1
Metal bindingⁱ	613	Zinc 5Combined sources	1
Metal bindingⁱ	620	Zinc 5Combined sources	1
Metal bindingⁱ	620	Zinc 6Combined sources	1
Metal bindingⁱ	624	Zinc 5Combined sources	1
Metal bindingⁱ	626	Zinc 6Combined sources	1
Metal bindingⁱ	629	Zinc 6Combined sources	1

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell cycle Source: UniProtKB-KW
regulation of cell cycle Source: Reactome
regulation of transcription, DNA-templated Source: UniProtKB-KW
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Repressor
Biological process	Cell cycle, Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1538133 G0 and Early G1 R-HSA-156711 Polo-like kinase mediated events R-HSA-539107 Activation of E2F1 target genes at G1/S R-HSA-69202 Cyclin E associated events during G1/S transition R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry

Reactomeⁱ

R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex
R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
R-HSA-1538133 G0 and Early G1
R-HSA-156711 Polo-like kinase mediated events
R-HSA-539107 Activation of E2F1 target genes at G1/S
R-HSA-69202 Cyclin E associated events during G1/S transition
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein lin-54 homolog Alternative name(s): CXC domain-containing protein 1
Gene namesⁱ	Name:LIN54 Synonyms:CXCDC1, KIAA2037
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000189308.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25397 LIN54
MIMⁱ	613367 gene
neXtProtⁱ	NX_Q6MZP7

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	525	C → Y: Abolishes DNA-binding to the CDK1 promoter; when associated with Y-527. 1 Publication	1
Mutagenesisⁱ	527	C → Y: Abolishes DNA-binding to the CDK1 promoter; when associated with Y-525. 1 Publication	1
Mutagenesisⁱ	536	Y → A, F or R: Loss of DNA-binding. 1 Publication	1
Mutagenesisⁱ	610	Y → A, F or R: Loss of DNA-binding. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	132660
Open Targets More...OpenTargetsⁱ	ENSG00000189308
PharmGKBⁱ	PA162394056

Polymorphism and mutation databases

DMDMⁱ	313104222

DMDMⁱ

313104222

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000341389	1 – 749	Protein lin-54 homologAdd BLAST		749

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	139	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	244	N6-acetyllysineCombined sources	1
Modified residueⁱ	249	N6-acetyllysineCombined sources	1
Modified residueⁱ	264	PhosphoserineCombined sources	1
Modified residueⁱ	282	PhosphoserineCombined sources	1
Modified residueⁱ	310	PhosphoserineCombined sources	1
Modified residueⁱ	314	PhosphoserineCombined sources	1
Cross-linkⁱ	357	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	635	PhosphoserineCombined sources	1
Cross-linkⁱ	639	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	659	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	661	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q6MZP7
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6MZP7
PaxDbⁱ	Q6MZP7
PeptideAtlas More...PeptideAtlasⁱ	Q6MZP7
PRIDEⁱ	Q6MZP7
ProteomicsDBⁱ	66576 66577 [Q6MZP7-2] 66578 [Q6MZP7-3] 66579 [Q6MZP7-4] 66580 [Q6MZP7-5]

PTM databases

iPTMnetⁱ	Q6MZP7
PhosphoSitePlusⁱ	Q6MZP7

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000189308 Expressed in 105 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_LIN54
ExpressionAtlasⁱ	Q6MZP7 baseline and differential
Genevisibleⁱ	Q6MZP7 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA056606

HPAⁱ

HPA056606

Interactionⁱ

Subunit structureⁱ

Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	574	Interaction with DNA1 Publication		1

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
MYBL2	P10244	4	EBI-1389411,EBI-1389468
RBL2	Q08999	10	EBI-1389411,EBI-971439

Protein-protein interaction databases

BioGridⁱ	126328, 27 interactors
CORUMⁱ	Q6MZP7
IntActⁱ	Q6MZP7, 42 interactors
Molecular INTeraction database More...MINTⁱ	Q6MZP7
STRINGⁱ	9606.ENSP00000341947

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	528 – 530	Combined sources	3
Helixⁱ	538 – 541	Combined sources	4
Helixⁱ	558 – 560	Combined sources	3
Helixⁱ	561 – 574	Combined sources	14
Turnⁱ	576 – 579	Combined sources	4
Beta strandⁱ	602 – 604	Combined sources	3
Helixⁱ	612 – 615	Combined sources	4
Helixⁱ	636 – 642	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	Q6MZP7
SMRⁱ	Q6MZP7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	521 – 634	CRCPROSITE-ProRule annotationAdd BLAST		114

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	523 – 536	DNA-binding1 PublicationAdd BLAST	14
Regionⁱ	583 – 596	Linker1 PublicationAdd BLAST	14
Regionⁱ	599 – 612	DNA-binding1 PublicationAdd BLAST	14

Domainⁱ

The CRC domain mediates DNA-binding (PubMed:19725879, PubMed:27465258). It contains two CXC subdomains (joined by a flexible linker) which are both required for efficient association with target DNA (PubMed:27465258). Each CXC subdomain coordinates three Zn²⁺ ions (PubMed:27465258).2 Publications

Sequence similaritiesⁱ

Belongs to the lin-54 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1171 Eukaryota ENOG4110UR5 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013974
HOGENOMⁱ	HOG000082518
HOVERGENⁱ	HBG108088
InParanoidⁱ	Q6MZP7
KEGG Orthology (KO) More...KOⁱ	K21776
OMAⁱ	TPGIQTQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09E2
PhylomeDBⁱ	Q6MZP7
TreeFamⁱ	TF313189

Family and domain databases

InterProⁱ	View protein in InterPro IPR005172 CRC IPR028307 Lin-54_fam IPR033467 Tesmin/TSO1-like_CXC
PANTHERⁱ	PTHR12446 PTHR12446, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03638 TCR, 2 hits
SMARTⁱ	View protein in SMART SM01114 CXC, 2 hits
PROSITEⁱ	View protein in PROSITE PS51634 CRC, 1 hit

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.ⁱShow all

Isoform 1 (identifier: Q6MZP7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MEVVPAEVNS LLPEEIMDTG ITLVDDDSIE AVIVSSPIPM ETELEEIVNI 
        60         70         80         90        100
NSTGDSTATP ISTEPITVYS NHTNQVAVNT TITKADSNTT VKPAFPSGLQ 
       110        120        130        140        150
KLGAQTPVTI SANQIILNKV SQTSDLKLGN QTLKPDGQKL ILTTLGKSGS 
       160        170        180        190        200
PIVLALPHSQ LPQAQKVTTQ AQSGDAKLPP QQIKVVTIGG RPEVKPVIGV 
       210        220        230        240        250
SALTPGSQLI NTTTQPSVLQ TQQLKTVQIA KKPRTPTSGP VITKLIFAKP 
       260        270        280        290        300
INSKAVTGQT TQVSPPVIAG RVLSQSTPGT PSKTITISES GVIGSTLNST 
       310        320        330        340        350
TQTPNKIAIS PLKSPNKAVK STVQTITVGG VSTSQFKTII PLATAPNVQQ 
       360        370        380        390        400
IQVPGSKFHY VRLVTATSAS SSTQPVSQNP STNTQPLQQA KPVVVNTTPV 
       410        420        430        440        450
RMSVPIVSAQ AVKQVVPKPI NPTSQIVTTS QPQQRLIMPA TPLPQIQPNL 
       460        470        480        490        500
TNLPPGTVLA PAPGTGNVGY AVLPAQYVTQ LQQSSYVSIA SNSTFTGTSG 
       510        520        530        540        550
IQTQARLPFN GIIPSESASR PRKPCNCTKS LCLKLYCDCF ANGEFCNNCN 
       560        570        580        590        600
CTNCYNNLEH ENERQKAIKA CLDRNPEAFK PKIGKGKEGE SDRRHSKGCN 
       610        620        630        640        650
CKRSGCLKNY CECYEAKIMC SSICKCIGCK NFEESPERKT LMHLADAAEV 
       660        670        680        690        700
RVQQQTAAKT KLSSQISDLL TRPTPALNSG GGKLPFTFVT KEVAEATCNC 
       710        720        730        740 
LLAQAEQADK KGKSKAAAER MILEEFGRCL MSVINSAGKA KSDPCAMNC

Length:749

Mass (Da):79,494

Last modified:November 30, 2010 - v3

Checksum:ⁱA3E4513CB0118B78

GO

Isoform 2 (identifier: Q6MZP7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
229-317: Missing.

« Hide

        10         20         30         40         50
MEVVPAEVNS LLPEEIMDTG ITLVDDDSIE AVIVSSPIPM ETELEEIVNI 
        60         70         80         90        100
NSTGDSTATP ISTEPITVYS NHTNQVAVNT TITKADSNTT VKPAFPSGLQ 
       110        120        130        140        150
KLGAQTPVTI SANQIILNKV SQTSDLKLGN QTLKPDGQKL ILTTLGKSGS 
       160        170        180        190        200
PIVLALPHSQ LPQAQKVTTQ AQSGDAKLPP QQIKVVTIGG RPEVKPVIGV 
       210        220        230        240        250
SALTPGSQLI NTTTQPSVLQ TQQLKTVQAV KSTVQTITVG GVSTSQFKTI 
       260        270        280        290        300
IPLATAPNVQ QIQVPGSKFH YVRLVTATSA SSSTQPVSQN PSTNTQPLQQ 
       310        320        330        340        350
AKPVVVNTTP VRMSVPIVSA QAVKQVVPKP INPTSQIVTT SQPQQRLIMP 
       360        370        380        390        400
ATPLPQIQPN LTNLPPGTVL APAPGTGNVG YAVLPAQYVT QLQQSSYVSI 
       410        420        430        440        450
ASNSTFTGTS GIQTQARLPF NGIIPSESAS RPRKPCNCTK SLCLKLYCDC 
       460        470        480        490        500
FANGEFCNNC NCTNCYNNLE HENERQKAIK ACLDRNPEAF KPKIGKGKEG 
       510        520        530        540        550
ESDRRHSKGC NCKRSGCLKN YCECYEAKIM CSSICKCIGC KNFEESPERK 
       560        570        580        590        600
TLMHLADAAE VRVQQQTAAK TKLSSQISDL LTRPTPALNS GGGKLPFTFV 
       610        620        630        640        650
TKEVAEATCN CLLAQAEQAD KKGKSKAAAE RMILEEFGRC LMSVINSAGK 
       660
AKSDPCAMNC

Note: No experimental confirmation available.

Show »

Length:660

Mass (Da):70,378

Checksum:ⁱF34917B51B87B370

GO

Isoform 3 (identifier: Q6MZP7-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
8-228: Missing.

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        10         20         30         40         50
MEVVPAEIAK KPRTPTSGPV ITKLIFAKPI NSKAVTGQTT QVSPPVIAGR 
        60         70         80         90        100
VLSQSTPGTP SKTITISESG VIGSTLNSTT QTPNKIAISP LKSPNKAVKS 
       110        120        130        140        150
TVQTITVGGV STSQFKTIIP LATAPNVQQI QVPGSKFHYV RLVTATSASS 
       160        170        180        190        200
STQPVSQNPS TNTQPLQQAK PVVVNTTPVR MSVPIVSAQA VKQVVPKPIN 
       210        220        230        240        250
PTSQIVTTSQ PQQRLIMPAT PLPQIQPNLT NLPPGTVLAP APGTGNVGYA 
       260        270        280        290        300
VLPAQYVTQL QQSSYVSIAS NSTFTGTSGI QTQARLPFNG IIPSESASRP 
       310        320        330        340        350
RKPCNCTKSL CLKLYCDCFA NGEFCNNCNC TNCYNNLEHE NERQKAIKAC 
       360        370        380        390        400
LDRNPEAFKP KIGKGKEGES DRRHSKGCNC KRSGCLKNYC ECYEAKIMCS 
       410        420        430        440        450
SICKCIGCKN FEESPERKTL MHLADAAEVR VQQQTAAKTK LSSQISDLLT 
       460        470        480        490        500
RPTPALNSGG GKLPFTFVTK EVAEATCNCL LAQAEQADKK GKSKAAAERM 
       510        520 
ILEEFGRCLM SVINSAGKAK SDPCAMNC

Show »

Length:528

Mass (Da):56,284

Checksum:ⁱ7EEAFDD538973450

GO

Isoform 4 (identifier: Q6MZP7-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-401: Missing.

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        10         20         30         40         50
MSVPIVSAQA VKQVVPKPIN PTSQIVTTSQ PQQRLIMPAT PLPQIQPNLT 
        60         70         80         90        100
NLPPGTVLAP APGTGNVGYA VLPAQYVTQL QQSSYVSIAS NSTFTGTSGI 
       110        120        130        140        150
QTQARLPFNG IIPSESASRP RKPCNCTKSL CLKLYCDCFA NGEFCNNCNC 
       160        170        180        190        200
TNCYNNLEHE NERQKAIKAC LDRNPEAFKP KIGKGKEGES DRRHSKGCNC 
       210        220        230        240        250
KRSGCLKNYC ECYEAKIMCS SICKCIGCKN FEESPERKTL MHLADAAEVR 
       260        270        280        290        300
VQQQTAAKTK LSSQISDLLT RPTPALNSGG GKLPFTFVTK EVAEATCNCL 
       310        320        330        340 
LAQAEQADKK GKSKAAAERM ILEEFGRCLM SVINSAGKAK SDPCAMNC

Note: No experimental confirmation available.

Show »

Length:348

Mass (Da):37,613

Checksum:ⁱB65DCCA3258768FB

GO

Isoform 5 (identifier: Q6MZP7-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
229-243: IAKKPRTPTSGPVIT → VGFFHSLLPELHQRP
244-749: Missing.

« Hide

        10         20         30         40         50
MEVVPAEVNS LLPEEIMDTG ITLVDDDSIE AVIVSSPIPM ETELEEIVNI 
        60         70         80         90        100
NSTGDSTATP ISTEPITVYS NHTNQVAVNT TITKADSNTT VKPAFPSGLQ 
       110        120        130        140        150
KLGAQTPVTI SANQIILNKV SQTSDLKLGN QTLKPDGQKL ILTTLGKSGS 
       160        170        180        190        200
PIVLALPHSQ LPQAQKVTTQ AQSGDAKLPP QQIKVVTIGG RPEVKPVIGV 
       210        220        230        240 
SALTPGSQLI NTTTQPSVLQ TQQLKTVQVG FFHSLLPELH QRP

Note: No experimental confirmation available.

Show »

Length:243

Mass (Da):25,743

Checksum:ⁱ6ECC642FE3E55419

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation
	D6REW4	D6REW4_HUMAN		Protein lin-54 homolog Protein lin-54 homolog	LIN54	62	Annotation score:

Sequence cautionⁱ

The sequence BAC98377 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	9	N → S in CAE45981 (PubMed:17974005).Curated		1
Sequence conflictⁱ	743	D → A in CAE45981 (PubMed:17974005).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_034272	1 – 401	Missing in isoform 4. 1 PublicationAdd BLAST	401
Alternative sequenceⁱVSP_034273	8 – 228	Missing in isoform 3. 2 PublicationsAdd BLAST	221
Alternative sequenceⁱVSP_034274	229 – 317	Missing in isoform 2. 1 PublicationAdd BLAST	89
Alternative sequenceⁱVSP_034275	229 – 243	IAKKP…GPVIT → VGFFHSLLPELHQRP in isoform 5. 1 PublicationAdd BLAST	15
Alternative sequenceⁱVSP_034276	244 – 749	Missing in isoform 5. 1 PublicationAdd BLAST	506

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB111889 mRNA Translation: BAC98377.1 Different initiation. AK292769 mRNA Translation: BAF85458.1 BX640657 mRNA Translation: CAE45799.1 BX640966 mRNA Translation: CAE45981.1 AC021105 Genomic DNA No translation available. BC109277 mRNA Translation: AAI09278.1 BC109278 mRNA Translation: AAI09279.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3599.1 [Q6MZP7-1] CCDS47089.1 [Q6MZP7-3] CCDS75157.1 [Q6MZP7-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001108479.1, NM_001115007.2 [Q6MZP7-3] NP_001108480.1, NM_001115008.2 [Q6MZP7-3] NP_001275925.1, NM_001288996.1 [Q6MZP7-2] NP_001275926.1, NM_001288997.1 [Q6MZP7-3] NP_919258.2, NM_194282.3 [Q6MZP7-1] XP_005262807.1, XM_005262750.4 [Q6MZP7-1] XP_006714144.1, XM_006714081.3 [Q6MZP7-1] XP_016863217.1, XM_017007728.1 [Q6MZP7-2] XP_016863218.1, XM_017007729.1 [Q6MZP7-4] XP_016863219.1, XM_017007730.1 [Q6MZP7-4]
UniGeneⁱ	Hs.96952

Genome annotation databases

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6MZP7	Protein lin-54 homolog isoform a (Fragment)		MACMU		560	UniRef100_Q6MZP7
Uncharacterized protein		HUMAN		749
LIN54 isoform 2		PANTR		749
Lin-54 DREAM MuvB core complex component		RHIRO		749
CXC domain-containing protein 1		MACFA		749
+9
Q6MZP7-2	LIN54 isoform 7		PANTR		660	UniRef100_A0A2I3T8P0
Lin-54 DREAM MuvB core complex component		MACMU		660
Lin-54 DREAM MuvB core complex component		COLAP		660
Lin-54 DREAM MuvB core complex component		CERAT		660
Lin-54 DREAM MuvB core complex component		RHIRO		660
+7
Q6MZP7-3	Protein lin-54 homolog		PONAB		528	UniRef100_Q5RBN8
Uncharacterized protein DKFZp686L18142 (Fragment)		HUMAN		621
LIN54 isoform 4		PANTR		528
Lin-54 DREAM MuvB core complex component		CERAT		528
Lin-54 DREAM MuvB core complex component		MACFA		528
+2
Q6MZP7-4	Lin-54 DREAM MuvB core complex component		NOMLE		749	UniRef100_A0A2I3HIB9
Protein lin-54 homolog isoform a (Fragment)		MACMU		521
UPI00062AABB6		NOMLE		805
Q6MZP7-5	Lin-54 DREAM MuvB core complex component		MACMU		243	UniRef100_F6U395
LIN54 isoform 8		PANTR		243

Protein	Similar proteins		Species	Score	Length	Source
Q6MZP7	Protein lin-54 homolog		RAT		749	UniRef90_Q6MZP7
Protein lin-54 homolog		MOUSE		749
Protein lin-54 homolog isoform a (Fragment)		MACMU		560
Uncharacterized protein		HUMAN		749
LIN54 isoform 2		PANTR		749
+134
Q6MZP7-2	Protein lin-54 homolog		MOUSE		660	UniRef90_E9Q8B7
Lin-54 DREAM MuvB core complex component		PAPAN		660
Lin-54 DREAM MuvB core complex component		CAVPO		660
Lin-54 DREAM MuvB core complex component		Cebus capucinus imitator		660
protein lin-54 homolog isoform X2		ERIEU		660
+40
Q6MZP7-3	Protein lin-54 homolog		PONAB		528	UniRef90_Q5RBN8
Uncharacterized protein DKFZp686L18142 (Fragment)		HUMAN		621
LIN54 isoform 4		PANTR		528
Lin-54 DREAM MuvB core complex component		CERAT		528
Lin-54 DREAM MuvB core complex component		MACFA		528
+127
Q6MZP7-5	Isoform 3 of Protein lin-54 homolog		MOUSE		237	UniRef90_Q571G4-3
Lin-54 DREAM MuvB core complex component		MACMU		243
LIN54 isoform 8		PANTR		243
LIN54 isoform 8		PONAB		243
Protein lin-54 homolog		MOUSE		243
+1

Protein	Similar proteins		Species	Score	Length	Source
Q6MZP7	Protein lin-54 homolog		MOUSE		749	UniRef50_Q6MZP7
Protein lin-54 homolog		RAT		749
Protein lin-54 homolog isoform a (Fragment)		MACMU		560
Uncharacterized protein		HUMAN		749
LIN54 isoform 2		PANTR		749
+230
Q6MZP7-2	Protein lin-54 homolog		MOUSE		660	UniRef50_E9Q8B7
LIN54 isoform 7		PONAB		660
Lin-54 DREAM MuvB core complex component		CAVPO		660
Lin-54 DREAM MuvB core complex component		Cebus capucinus imitator		660
LIN54 isoform 7		PANTR		660
+54
Q6MZP7-3	Protein lin-54 homolog		PONAB		528	UniRef50_Q5RBN8
Uncharacterized protein DKFZp686L18142 (Fragment)		HUMAN		621
LIN54 isoform 4		PANTR		528
Lin-54 DREAM MuvB core complex component		CERAT		528
Lin-54 DREAM MuvB core complex component		MACFA		528
+137
Q6MZP7-5	Isoform 3 of Protein lin-54 homolog		MOUSE		237	UniRef50_Q571G4-3
Lin-54 DREAM MuvB core complex component		MACMU		243
LIN54 isoform 8		PANTR		243
LIN54 isoform 8		PONAB		243
Uncharacterized protein		ORNAN		268
+2

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB111889 mRNA Translation: BAC98377.1 Different initiation. AK292769 mRNA Translation: BAF85458.1 BX640657 mRNA Translation: CAE45799.1 BX640966 mRNA Translation: CAE45981.1 AC021105 Genomic DNA No translation available. BC109277 mRNA Translation: AAI09278.1 BC109278 mRNA Translation: AAI09279.1
CCDSⁱ	CCDS3599.1 [Q6MZP7-1] CCDS47089.1 [Q6MZP7-3] CCDS75157.1 [Q6MZP7-2]
RefSeqⁱ	NP_001108479.1, NM_001115007.2 [Q6MZP7-3] NP_001108480.1, NM_001115008.2 [Q6MZP7-3] NP_001275925.1, NM_001288996.1 [Q6MZP7-2] NP_001275926.1, NM_001288997.1 [Q6MZP7-3] NP_919258.2, NM_194282.3 [Q6MZP7-1] XP_005262807.1, XM_005262750.4 [Q6MZP7-1] XP_006714144.1, XM_006714081.3 [Q6MZP7-1] XP_016863217.1, XM_017007728.1 [Q6MZP7-2] XP_016863218.1, XM_017007729.1 [Q6MZP7-4] XP_016863219.1, XM_017007730.1 [Q6MZP7-4]
UniGeneⁱ	Hs.96952

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5FD3	X-ray	2.42	A/B	515-646	[»]
ProteinModelPortalⁱ	Q6MZP7
SMRⁱ	Q6MZP7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	126328, 27 interactors
CORUMⁱ	Q6MZP7
IntActⁱ	Q6MZP7, 42 interactors
MINTⁱ	Q6MZP7
STRINGⁱ	9606.ENSP00000341947

PTM databases

iPTMnetⁱ	Q6MZP7
PhosphoSitePlusⁱ	Q6MZP7

Polymorphism and mutation databases

DMDMⁱ	313104222

DMDMⁱ

313104222

Proteomic databases

EPDⁱ	Q6MZP7
MaxQBⁱ	Q6MZP7
PaxDbⁱ	Q6MZP7
PeptideAtlasⁱ	Q6MZP7
PRIDEⁱ	Q6MZP7
ProteomicsDBⁱ	66576 66577 [Q6MZP7-2] 66578 [Q6MZP7-3] 66579 [Q6MZP7-4] 66580 [Q6MZP7-5]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	132660
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000340417; ENSP00000341947; ENSG00000189308 [Q6MZP7-1] ENST00000442461; ENSP00000398265; ENSG00000189308 [Q6MZP7-3] ENST00000446851; ENSP00000407139; ENSG00000189308 [Q6MZP7-3] ENST00000505397; ENSP00000425844; ENSG00000189308 [Q6MZP7-1] ENST00000506560; ENSP00000423475; ENSG00000189308 [Q6MZP7-2] ENST00000508171; ENSP00000427413; ENSG00000189308 [Q6MZP7-5] ENST00000510557; ENSP00000421045; ENSG00000189308 [Q6MZP7-3]
GeneIDⁱ	132660
KEGGⁱ	hsa:132660
UCSCⁱ	uc003hnx.5 human [Q6MZP7-1]

Organism-specific databases

CTDⁱ	132660
DisGeNETⁱ	132660
EuPathDBⁱ	HostDB:ENSG00000189308.10
GeneCardsⁱ	LIN54
H-InvDBⁱ	HIX0024607
HGNCⁱ	HGNC:25397 LIN54
HPAⁱ	HPA056606
MIMⁱ	613367 gene
neXtProtⁱ	NX_Q6MZP7
OpenTargetsⁱ	ENSG00000189308
PharmGKBⁱ	PA162394056
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1171 Eukaryota ENOG4110UR5 LUCA
GeneTreeⁱ	ENSGT00390000013974
HOGENOMⁱ	HOG000082518
HOVERGENⁱ	HBG108088
InParanoidⁱ	Q6MZP7
KOⁱ	K21776
OMAⁱ	TPGIQTQ
OrthoDBⁱ	EOG091G09E2
PhylomeDBⁱ	Q6MZP7
TreeFamⁱ	TF313189

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1538133 G0 and Early G1 R-HSA-156711 Polo-like kinase mediated events R-HSA-539107 Activation of E2F1 target genes at G1/S R-HSA-69202 Cyclin E associated events during G1/S transition R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry

Reactomeⁱ

R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex
R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
R-HSA-1538133 G0 and Early G1
R-HSA-156711 Polo-like kinase mediated events
R-HSA-539107 Activation of E2F1 target genes at G1/S
R-HSA-69202 Cyclin E associated events during G1/S transition
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry

Miscellaneous databases

ChiTaRSⁱ	LIN54 human
GenomeRNAiⁱ	132660
Protein Ontology More...PROⁱ	PR:Q6MZP7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000189308 Expressed in 105 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_LIN54
ExpressionAtlasⁱ	Q6MZP7 baseline and differential
Genevisibleⁱ	Q6MZP7 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR005172 CRC IPR028307 Lin-54_fam IPR033467 Tesmin/TSO1-like_CXC
PANTHERⁱ	PTHR12446 PTHR12446, 1 hit
Pfamⁱ	View protein in Pfam PF03638 TCR, 2 hits
SMARTⁱ	View protein in SMART SM01114 CXC, 2 hits
PROSITEⁱ	View protein in PROSITE PS51634 CRC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LIN54_HUMAN
Accessionⁱ	Q6MZP7Primary (citable) accession number: Q6MZP7 Secondary accession number(s): Q32M68 , Q32M69, Q6N071, Q76B60
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 22, 2008
	Last sequence update:	November 30, 2010
	Last modified:	September 12, 2018
	This is version 110 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

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UniProtKB - Q6MZP7 (LIN54_HUMAN)

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Protein lin-54 homolog

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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Organism-specific databases

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<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Amino acid modifications

Keywords - PTMi

Proteomic databases

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Gene expression databases

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<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

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Computationally mapped potential isoform sequencesi

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

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PTM databases

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Proteomic databases

Protocols and materials databases

Genome annotation databases

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Miscellaneous databases

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Computationally mapped potential isoform sequencesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ