UniProtKB - Q6MZP7 (LIN54_HUMAN)
Protein lin-54 homolog
LIN54
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 525 | Zinc 1Combined sources | 1 | |
Metal bindingi | 525 | Zinc 2Combined sources | 1 | |
Metal bindingi | 527 | Zinc 1Combined sources | 1 | |
Metal bindingi | 532 | Zinc 1Combined sources | 1 | |
Metal bindingi | 532 | Zinc 3Combined sources | 1 | |
Sitei | 536 | Critical for interaction with target DNA1 Publication | 1 | |
Metal bindingi | 537 | Zinc 1Combined sources | 1 | |
Metal bindingi | 539 | Zinc 2Combined sources | 1 | |
Metal bindingi | 546 | Zinc 2Combined sources | 1 | |
Metal bindingi | 546 | Zinc 3Combined sources | 1 | |
Metal bindingi | 549 | Zinc 2Combined sources | 1 | |
Metal bindingi | 551 | Zinc 3Combined sources | 1 | |
Metal bindingi | 554 | Zinc 3Combined sources | 1 | |
Metal bindingi | 599 | Zinc 4Combined sources | 1 | |
Metal bindingi | 599 | Zinc 5Combined sources | 1 | |
Metal bindingi | 601 | Zinc 4Combined sources | 1 | |
Metal bindingi | 606 | Zinc 4Combined sources | 1 | |
Metal bindingi | 606 | Zinc 6Combined sources | 1 | |
Sitei | 610 | Critical for interaction with target DNA1 Publication | 1 | |
Metal bindingi | 611 | Zinc 4Combined sources | 1 | |
Metal bindingi | 613 | Zinc 5Combined sources | 1 | |
Metal bindingi | 620 | Zinc 5Combined sources | 1 | |
Metal bindingi | 620 | Zinc 6Combined sources | 1 | |
Metal bindingi | 624 | Zinc 5Combined sources | 1 | |
Metal bindingi | 626 | Zinc 6Combined sources | 1 | |
Metal bindingi | 629 | Zinc 6Combined sources | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- minor groove of adenine-thymine-rich DNA binding Source: ARUK-UCL
- regulatory region nucleic acid binding Source: ARUK-UCL
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- nucleosome positioning Source: ARUK-UCL
- regulation of cell cycle Source: Reactome
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding, Repressor |
Biological process | Cell cycle, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q6MZP7 |
Reactomei | R-HSA-1362277, Transcription of E2F targets under negative control by DREAM complex R-HSA-1362300, Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1538133, G0 and Early G1 R-HSA-156711, Polo-like kinase mediated events R-HSA-69202, Cyclin E associated events during G1/S transition R-HSA-69205, G1/S-Specific Transcription R-HSA-69656, Cyclin A:Cdk2-associated events at S phase entry |
Names & Taxonomyi
Protein namesi | Recommended name: Protein lin-54 homologAlternative name(s): CXC domain-containing protein 1 |
Gene namesi | Name:LIN54 Synonyms:CXCDC1, KIAA2037 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25397, LIN54 |
MIMi | 613367, gene |
neXtProti | NX_Q6MZP7 |
VEuPathDBi | HostDB:ENSG00000189308.10 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 525 | C → Y: Abolishes DNA-binding to the CDK1 promoter; when associated with Y-527. 1 Publication | 1 | |
Mutagenesisi | 527 | C → Y: Abolishes DNA-binding to the CDK1 promoter; when associated with Y-525. 1 Publication | 1 | |
Mutagenesisi | 536 | Y → A, F or R: Loss of DNA-binding. 1 Publication | 1 | |
Mutagenesisi | 610 | Y → A, F or R: Loss of DNA-binding. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 132660 |
OpenTargetsi | ENSG00000189308 |
PharmGKBi | PA162394056 |
Miscellaneous databases
Pharosi | Q6MZP7, Tdark |
Genetic variation databases
BioMutai | LIN54 |
DMDMi | 313104222 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000341389 | 1 – 749 | Protein lin-54 homologAdd BLAST | 749 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 139 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 244 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 249 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 264 | PhosphoserineCombined sources | 1 | |
Modified residuei | 282 | PhosphoserineCombined sources | 1 | |
Modified residuei | 310 | PhosphoserineCombined sources | 1 | |
Modified residuei | 314 | PhosphoserineCombined sources | 1 | |
Cross-linki | 357 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 635 | PhosphoserineCombined sources | 1 | |
Cross-linki | 639 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 659 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 661 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q6MZP7 |
jPOSTi | Q6MZP7 |
MassIVEi | Q6MZP7 |
MaxQBi | Q6MZP7 |
PaxDbi | Q6MZP7 |
PeptideAtlasi | Q6MZP7 |
PRIDEi | Q6MZP7 |
ProteomicsDBi | 66576 [Q6MZP7-1] 66577 [Q6MZP7-2] 66578 [Q6MZP7-3] 66579 [Q6MZP7-4] 66580 [Q6MZP7-5] |
PTM databases
GlyConnecti | 2849, 1 O-Linked glycan (1 site) |
GlyGeni | Q6MZP7, 2 sites, 1 O-linked glycan (2 sites) |
iPTMneti | Q6MZP7 |
PhosphoSitePlusi | Q6MZP7 |
Expressioni
Gene expression databases
Bgeei | ENSG00000189308, Expressed in ventricular zone and 126 other tissues |
ExpressionAtlasi | Q6MZP7, baseline and differential |
Genevisiblei | Q6MZP7, HS |
Organism-specific databases
HPAi | ENSG00000189308, Low tissue specificity |
Interactioni
Subunit structurei
Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.
2 PublicationsSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 574 | Interaction with DNA1 Publication | 1 |
Binary interactionsi
Hide detailsQ6MZP7
Protein-protein interaction databases
BioGRIDi | 126328, 39 interactors |
CORUMi | Q6MZP7 |
IntActi | Q6MZP7, 48 interactors |
MINTi | Q6MZP7 |
STRINGi | 9606.ENSP00000341947 |
Miscellaneous databases
RNActi | Q6MZP7, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q6MZP7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 521 – 634 | CRCPROSITE-ProRule annotationAdd BLAST | 114 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 523 – 536 | DNA-binding1 PublicationAdd BLAST | 14 | |
Regioni | 583 – 596 | Linker1 PublicationAdd BLAST | 14 | |
Regioni | 599 – 612 | DNA-binding1 PublicationAdd BLAST | 14 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1171, Eukaryota |
GeneTreei | ENSGT00940000155881 |
HOGENOMi | CLU_024128_1_0_1 |
InParanoidi | Q6MZP7 |
OMAi | PHTGSKP |
PhylomeDBi | Q6MZP7 |
TreeFami | TF313189 |
Family and domain databases
InterProi | View protein in InterPro IPR005172, CRC IPR028307, Lin-54_fam IPR033467, Tesmin/TSO1-like_CXC |
PANTHERi | PTHR12446, PTHR12446, 1 hit |
Pfami | View protein in Pfam PF03638, TCR, 2 hits |
SMARTi | View protein in SMART SM01114, CXC, 2 hits |
PROSITEi | View protein in PROSITE PS51634, CRC, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEVVPAEVNS LLPEEIMDTG ITLVDDDSIE AVIVSSPIPM ETELEEIVNI
60 70 80 90 100
NSTGDSTATP ISTEPITVYS NHTNQVAVNT TITKADSNTT VKPAFPSGLQ
110 120 130 140 150
KLGAQTPVTI SANQIILNKV SQTSDLKLGN QTLKPDGQKL ILTTLGKSGS
160 170 180 190 200
PIVLALPHSQ LPQAQKVTTQ AQSGDAKLPP QQIKVVTIGG RPEVKPVIGV
210 220 230 240 250
SALTPGSQLI NTTTQPSVLQ TQQLKTVQIA KKPRTPTSGP VITKLIFAKP
260 270 280 290 300
INSKAVTGQT TQVSPPVIAG RVLSQSTPGT PSKTITISES GVIGSTLNST
310 320 330 340 350
TQTPNKIAIS PLKSPNKAVK STVQTITVGG VSTSQFKTII PLATAPNVQQ
360 370 380 390 400
IQVPGSKFHY VRLVTATSAS SSTQPVSQNP STNTQPLQQA KPVVVNTTPV
410 420 430 440 450
RMSVPIVSAQ AVKQVVPKPI NPTSQIVTTS QPQQRLIMPA TPLPQIQPNL
460 470 480 490 500
TNLPPGTVLA PAPGTGNVGY AVLPAQYVTQ LQQSSYVSIA SNSTFTGTSG
510 520 530 540 550
IQTQARLPFN GIIPSESASR PRKPCNCTKS LCLKLYCDCF ANGEFCNNCN
560 570 580 590 600
CTNCYNNLEH ENERQKAIKA CLDRNPEAFK PKIGKGKEGE SDRRHSKGCN
610 620 630 640 650
CKRSGCLKNY CECYEAKIMC SSICKCIGCK NFEESPERKT LMHLADAAEV
660 670 680 690 700
RVQQQTAAKT KLSSQISDLL TRPTPALNSG GGKLPFTFVT KEVAEATCNC
710 720 730 740
LLAQAEQADK KGKSKAAAER MILEEFGRCL MSVINSAGKA KSDPCAMNC
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD6REW4 | D6REW4_HUMAN | Protein lin-54 homolog | LIN54 | 62 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 9 | N → S in CAE45981 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 743 | D → A in CAE45981 (PubMed:17974005).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_034272 | 1 – 401 | Missing in isoform 4. 1 PublicationAdd BLAST | 401 | |
Alternative sequenceiVSP_034273 | 8 – 228 | Missing in isoform 3. 2 PublicationsAdd BLAST | 221 | |
Alternative sequenceiVSP_034274 | 229 – 317 | Missing in isoform 2. 1 PublicationAdd BLAST | 89 | |
Alternative sequenceiVSP_034275 | 229 – 243 | IAKKP…GPVIT → VGFFHSLLPELHQRP in isoform 5. 1 PublicationAdd BLAST | 15 | |
Alternative sequenceiVSP_034276 | 244 – 749 | Missing in isoform 5. 1 PublicationAdd BLAST | 506 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB111889 mRNA Translation: BAC98377.1 Different initiation. AK292769 mRNA Translation: BAF85458.1 BX640657 mRNA Translation: CAE45799.1 BX640966 mRNA Translation: CAE45981.1 AC021105 Genomic DNA No translation available. BC109277 mRNA Translation: AAI09278.1 BC109278 mRNA Translation: AAI09279.1 |
CCDSi | CCDS3599.1 [Q6MZP7-1] CCDS47089.1 [Q6MZP7-3] CCDS75157.1 [Q6MZP7-2] |
RefSeqi | NP_001108479.1, NM_001115007.2 [Q6MZP7-3] NP_001108480.1, NM_001115008.2 [Q6MZP7-3] NP_001275925.1, NM_001288996.1 [Q6MZP7-2] NP_001275926.1, NM_001288997.1 [Q6MZP7-3] NP_919258.2, NM_194282.3 [Q6MZP7-1] XP_005262807.1, XM_005262750.4 [Q6MZP7-1] XP_006714144.1, XM_006714081.3 [Q6MZP7-1] XP_016863217.1, XM_017007728.1 [Q6MZP7-2] XP_016863218.1, XM_017007729.1 [Q6MZP7-4] XP_016863219.1, XM_017007730.1 [Q6MZP7-4] |
Genome annotation databases
Ensembli | ENST00000340417; ENSP00000341947; ENSG00000189308 [Q6MZP7-1] ENST00000442461; ENSP00000398265; ENSG00000189308 [Q6MZP7-3] ENST00000446851; ENSP00000407139; ENSG00000189308 [Q6MZP7-3] ENST00000505397; ENSP00000425844; ENSG00000189308 [Q6MZP7-1] ENST00000506560; ENSP00000423475; ENSG00000189308 [Q6MZP7-2] ENST00000508171; ENSP00000427413; ENSG00000189308 [Q6MZP7-5] ENST00000510557; ENSP00000421045; ENSG00000189308 [Q6MZP7-3] |
GeneIDi | 132660 |
KEGGi | hsa:132660 |
UCSCi | uc003hnx.5, human [Q6MZP7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB111889 mRNA Translation: BAC98377.1 Different initiation. AK292769 mRNA Translation: BAF85458.1 BX640657 mRNA Translation: CAE45799.1 BX640966 mRNA Translation: CAE45981.1 AC021105 Genomic DNA No translation available. BC109277 mRNA Translation: AAI09278.1 BC109278 mRNA Translation: AAI09279.1 |
CCDSi | CCDS3599.1 [Q6MZP7-1] CCDS47089.1 [Q6MZP7-3] CCDS75157.1 [Q6MZP7-2] |
RefSeqi | NP_001108479.1, NM_001115007.2 [Q6MZP7-3] NP_001108480.1, NM_001115008.2 [Q6MZP7-3] NP_001275925.1, NM_001288996.1 [Q6MZP7-2] NP_001275926.1, NM_001288997.1 [Q6MZP7-3] NP_919258.2, NM_194282.3 [Q6MZP7-1] XP_005262807.1, XM_005262750.4 [Q6MZP7-1] XP_006714144.1, XM_006714081.3 [Q6MZP7-1] XP_016863217.1, XM_017007728.1 [Q6MZP7-2] XP_016863218.1, XM_017007729.1 [Q6MZP7-4] XP_016863219.1, XM_017007730.1 [Q6MZP7-4] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5FD3 | X-ray | 2.42 | A/B | 515-646 | [»] | |
SMRi | Q6MZP7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 126328, 39 interactors |
CORUMi | Q6MZP7 |
IntActi | Q6MZP7, 48 interactors |
MINTi | Q6MZP7 |
STRINGi | 9606.ENSP00000341947 |
PTM databases
GlyConnecti | 2849, 1 O-Linked glycan (1 site) |
GlyGeni | Q6MZP7, 2 sites, 1 O-linked glycan (2 sites) |
iPTMneti | Q6MZP7 |
PhosphoSitePlusi | Q6MZP7 |
Genetic variation databases
BioMutai | LIN54 |
DMDMi | 313104222 |
Proteomic databases
EPDi | Q6MZP7 |
jPOSTi | Q6MZP7 |
MassIVEi | Q6MZP7 |
MaxQBi | Q6MZP7 |
PaxDbi | Q6MZP7 |
PeptideAtlasi | Q6MZP7 |
PRIDEi | Q6MZP7 |
ProteomicsDBi | 66576 [Q6MZP7-1] 66577 [Q6MZP7-2] 66578 [Q6MZP7-3] 66579 [Q6MZP7-4] 66580 [Q6MZP7-5] |
Protocols and materials databases
Antibodypediai | 55895, 55 antibodies |
DNASUi | 132660 |
Genome annotation databases
Organism-specific databases
CTDi | 132660 |
DisGeNETi | 132660 |
GeneCardsi | LIN54 |
HGNCi | HGNC:25397, LIN54 |
HPAi | ENSG00000189308, Low tissue specificity |
MIMi | 613367, gene |
neXtProti | NX_Q6MZP7 |
OpenTargetsi | ENSG00000189308 |
PharmGKBi | PA162394056 |
VEuPathDBi | HostDB:ENSG00000189308.10 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1171, Eukaryota |
GeneTreei | ENSGT00940000155881 |
HOGENOMi | CLU_024128_1_0_1 |
InParanoidi | Q6MZP7 |
OMAi | PHTGSKP |
PhylomeDBi | Q6MZP7 |
TreeFami | TF313189 |
Enzyme and pathway databases
PathwayCommonsi | Q6MZP7 |
Reactomei | R-HSA-1362277, Transcription of E2F targets under negative control by DREAM complex R-HSA-1362300, Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-1538133, G0 and Early G1 R-HSA-156711, Polo-like kinase mediated events R-HSA-69202, Cyclin E associated events during G1/S transition R-HSA-69205, G1/S-Specific Transcription R-HSA-69656, Cyclin A:Cdk2-associated events at S phase entry |
Miscellaneous databases
BioGRID-ORCSi | 132660, 211 hits in 882 CRISPR screens |
ChiTaRSi | LIN54, human |
GenomeRNAii | 132660 |
Pharosi | Q6MZP7, Tdark |
PROi | PR:Q6MZP7 |
RNActi | Q6MZP7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000189308, Expressed in ventricular zone and 126 other tissues |
ExpressionAtlasi | Q6MZP7, baseline and differential |
Genevisiblei | Q6MZP7, HS |
Family and domain databases
InterProi | View protein in InterPro IPR005172, CRC IPR028307, Lin-54_fam IPR033467, Tesmin/TSO1-like_CXC |
PANTHERi | PTHR12446, PTHR12446, 1 hit |
Pfami | View protein in Pfam PF03638, TCR, 2 hits |
SMARTi | View protein in SMART SM01114, CXC, 2 hits |
PROSITEi | View protein in PROSITE PS51634, CRC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LIN54_HUMAN | |
Accessioni | Q6MZP7Primary (citable) accession number: Q6MZP7 Secondary accession number(s): Q32M68 Q76B60 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 22, 2008 |
Last sequence update: | November 30, 2010 | |
Last modified: | February 10, 2021 | |
This is version 126 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families