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Protein

HLA class I histocompatibility antigen protein P5

Gene

HCP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

Variation Gly-112 is associated with low viral loads in untreated HIV patients. The level of circulating virus in the plasma of HIV patients (viral set point) varies among individuals during the nonsymptomatic phase preceding the progression to AIDS. This polymorphism explains 9.6% of the total variation in set point and is associated with the HLA-B*5701 allele, which has the strongest described protective impact on HIV disease progression. However, it is possible that HPC5 polymorphism, and not HLA-B*5701 allele, plays a direct role in the control in viremia in HIV patients.
HCP5 is localized within the MHC class I region, but is not structurally related to MHC class I genes. HCP5 is related in sequence to human endogenous retroviruses HERV-L and HERV-16. It has sequence homology with retroviral Pol genes in HERV retroviral element; thus, it is itself a good candidate to interact with HIV-1, possibly through an antisense mechanism against retroviral transcript.

GO - Biological processi

  • defense response Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen protein P5
Alternative name(s):
HLA complex protein P5
Protein P5-1
Gene namesi
Name:HCP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:21659 HCP5
MIMi604676 gene
neXtProtiNX_Q6MZN7

Pathology & Biotechi

Organism-specific databases

DisGeNETi10866
PharmGKBiPA134951826

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003290591 – 132HLA class I histocompatibility antigen protein P5Add BLAST132

Proteomic databases

PRIDEiQ6MZN7
ProteomicsDBi66575

Expressioni

Tissue specificityi

Expressed in lymphoid tissues; Detected in spleen as well as in B-cell lines, NK cell lines and activated lymphocytes.1 Publication

Gene expression databases

CleanExiHS_HCP5

Sequencei

Sequence statusi: Complete.

Q6MZN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLRMSEHRN EALGNYLEMR LKSSFLRGLG SWKSNPLRLG GWTILLTLTM
60 70 80 90 100
GQGEPGGPQG DPWVPHELLL PSLCDSSHAS SWGSGSITCA WRGGDSSSHP
110 120 130
LVSGHILSNS PVAAVMCSSM GTHLSPFKGT LL
Length:132
Mass (Da):14,098
Last modified:July 5, 2004 - v1
Checksum:i33BFBD82E613F773
GO

Sequence cautioni

The sequence AAA59986 differs from that shown. Reason: Frameshift at positions 58 and 125.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti59 – 60QG → K in AAA59986 (PubMed:8462994).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04263832W → R. Corresponds to variant dbSNP:rs17206855Ensembl.1
Natural variantiVAR_04263982W → C. Corresponds to variant dbSNP:rs2255221Ensembl.1
Natural variantiVAR_04264093G → E. Corresponds to variant dbSNP:rs2255223Ensembl.1
Natural variantiVAR_042641112V → G Associated with low viral load in HIV patients. 2 PublicationsCorresponds to variant dbSNP:rs2395029Ensembl.1
Natural variantiVAR_042642123H → R. Corresponds to variant dbSNP:rs3130907Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06175 mRNA Translation: AAA59986.1 Frameshift.
AK290875 mRNA Translation: BAF83564.1
BX640979 mRNA Translation: CAE45991.1
CH471081 Genomic DNA Translation: EAX03398.1
BC106759 mRNA Translation: AAI06760.1
UniGeneiHs.691948

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHCP5_HUMAN
AccessioniPrimary (citable) accession number: Q6MZN7
Secondary accession number(s): Q04490
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 5, 2004
Last modified: June 20, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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