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Entry version 117 (07 Oct 2020)
Sequence version 1 (05 Jul 2004)
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Protein
Submitted name:

Uncharacterized protein DKFZp686K06110

Gene

DKFZp686K06110

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandHyaluronic acidARBA annotation, LectinARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized protein DKFZp686K06110Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DKFZp686K06110Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162408788

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1779 ↔ 1788PROSITE-ProRule annotation
Disulfide bondi1817 ↔ 1826PROSITE-ProRule annotation
Disulfide bondi1960 ↔ 2003PROSITE-ProRule annotation
Disulfide bondi1989 ↔ 2016PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotation

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q6MZK8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6MZK8, HS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1753 – 1789EGF-likeInterPro annotationAdd BLAST37
Domaini1791 – 1827EGF-likeInterPro annotationAdd BLAST37
Domaini1840 – 1954C-type lectinInterPro annotationAdd BLAST115
Domaini1958 – 2018SushiInterPro annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 26DisorderedSequence analysisAdd BLAST26
Regioni88 – 114DisorderedSequence analysisAdd BLAST27
Regioni126 – 160DisorderedSequence analysisAdd BLAST35
Regioni175 – 203DisorderedSequence analysisAdd BLAST29
Regioni382 – 401DisorderedSequence analysisAdd BLAST20
Regioni423 – 453DisorderedSequence analysisAdd BLAST31
Regioni626 – 658DisorderedSequence analysisAdd BLAST33
Regioni770 – 798DisorderedSequence analysisAdd BLAST29
Regioni832 – 852DisorderedSequence analysisAdd BLAST21
Regioni1035 – 1060DisorderedSequence analysisAdd BLAST26
Regioni1109 – 1137DisorderedSequence analysisAdd BLAST29
Regioni1157 – 1182DisorderedSequence analysisAdd BLAST26
Regioni1262 – 1281DisorderedSequence analysisAdd BLAST20
Regioni1498 – 1520DisorderedSequence analysisAdd BLAST23
Regioni1545 – 1569DisorderedSequence analysisAdd BLAST25
Regioni2035 – 2060DisorderedSequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi10 – 26PolyampholyteSequence analysisAdd BLAST17
Compositional biasi99 – 114PolarSequence analysisAdd BLAST16
Compositional biasi126 – 144PolarSequence analysisAdd BLAST19
Compositional biasi382 – 396PolyampholyteSequence analysisAdd BLAST15
Compositional biasi627 – 658PolarSequence analysisAdd BLAST32
Compositional biasi1109 – 1127PolarSequence analysisAdd BLAST19
Compositional biasi1157 – 1181PolarSequence analysisAdd BLAST25
Compositional biasi2042 – 2060PolyampholyteSequence analysisAdd BLAST19

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationARBA annotation, RepeatARBA annotation, SushiPROSITE-ProRule annotationARBA annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033, CCP, 1 hit
cd03588, CLECT_CSPGs, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR018378, C-type_lectin_CS
IPR033987, CSPG_CTLD
IPR016187, CTDL_fold
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00008, EGF, 2 hits
PF00059, Lectin_C, 1 hit
PF00084, Sushi, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032, CCP, 1 hit
SM00034, CLECT, 1 hit
SM00181, EGF, 2 hits
SM00179, EGF_CA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56436, SSF56436, 1 hit
SSF57535, SSF57535, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 1 hit
PS00615, C_TYPE_LECTIN_1, 1 hit
PS50041, C_TYPE_LECTIN_2, 1 hit
PS00022, EGF_1, 2 hits
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 2 hits
PS01187, EGF_CA, 1 hit
PS50923, SUSHI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6MZK8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDLSVIGHP IDSESKEDEP CSEETDPVHD LMAEILPEFP DIIEIDLYHS
60 70 80 90 100
EENEEEEEEC ANATDVTTTP SVQYINGKHL VTTVPKDPEA AEARRGQFES
110 120 130 140 150
VAPSQNFSDS SESDTHPFVI AKTELSTAVQ PNESTETTES LEVTWKPETY
160 170 180 190 200
PETSEHFSGG EPDVFPTVPF HEEFESGTAR KGAESVTERD TEVGHQAHEH
210 220 230 240 250
TEPVSLFPEE SSGEIAIDQE SQKIAFARAT EVTFGEEVEK STSVTYTPTI
260 270 280 290 300
VPSSASAYVS EEEAVTLIGN PWPDDLLSTK ESWVEATPRQ VVELSGSSSI
310 320 330 340 350
PITEGSGEAE EDEDTMFTMV TDLSQRNTTD TLITLDTSRI ITESFFEVPA
360 370 380 390 400
TTIYPVSEQP SAKVVPTKFV SETDTSEWIS STTVEEKKRK EEEGTTGTAS
410 420 430 440 450
TFEVYSSTQR SDQLILPFEL ESPNVATSSD SGTRKSFMSL TTPTRSEREM
460 470 480 490 500
TDSTPVFTET NTLENLGAQT TEHSSIHQPG VQEGLTTLPH SPASVFMEQG
510 520 530 540 550
SGEAAADPET TTVSSFSLNV EYAIQAEKEV AGTLSPHVET TFSTEPTGLV
560 570 580 590 600
LSTVMDRVVA ENITQTSREI AISERLGEPN YGAEIRGFST GFPLEEDFSG
610 620 630 640 650
DFREYSTVSH PIAKEETVMM EGSGDAAFRD TQTSPSTVPT SVHISHISDS
660 670 680 690 700
EGPSSTMVST SAFPWEEFTS SAEGSGEQLV TVSSSVVPVL PSAVQKFSGT
710 720 730 740 750
ASSIIDEGLG EVGTVNEIDR RSTILPTAEV EGTKAPVEKE EVKVSGTVST
760 770 780 790 800
NFPQTIEPAK LWSRQEVNPV RQEIESETTS EEQIQEEKSF ESPQNSPATE
810 820 830 840 850
QTIFDSQTFT ETELKTTDYS VLTTKKTYSD DKEMKEEDTS LVNMSTPDPD
860 870 880 890 900
ANGLESYTTL PEATEKSHFF LATALVTESI PAEHVVTDSP IKKEESTKHF
910 920 930 940 950
PKGMRPTIQE SDTELLFSGL GSGEEVLPTL PTESVNFTEV EQINNTLYPH
960 970 980 990 1000
TSQVESTSSD KIEDYNRMEN VAKEVGPLVS QTDIFEGSGS VTSTTLIEIL
1010 1020 1030 1040 1050
SDTGAEGPTV APLPFSTDIG HPQNQTVRWA EEIQTSRPQT ITEQDSNKNS
1060 1070 1080 1090 1100
STAEINETTT SSTDFLARAY GFEMAKEFVT SAPKPSDLYY EPSGEGSGEV
1110 1120 1130 1140 1150
DIVDSFHTSA TTQATRQESS TTFVSDGSLE KHPEVPSAKA VTADGFPTVS
1160 1170 1180 1190 1200
VMLPLHSEQN KSSPDPTSTL SNTVSYERST DGSFQDRFRE FEDSTLKPNR
1210 1220 1230 1240 1250
KKPTENIIID LDKEDKDLIL TITESTILEI LPELTSDKNT IIDIDHTKPV
1260 1270 1280 1290 1300
YEDILGMQTD IDTEVPSEPH DSNDESNDDS TQVQEIYEAA VNLSLTEETF
1310 1320 1330 1340 1350
EGSADVLASY TQATHDESMT YEDRSQLDHM GFHFTTGIPA PSTETELDVL
1360 1370 1380 1390 1400
LPTATSLPIP RKSATVIPEI EGIKAEAKAL DDMFESSTLS DGQAIADQSE
1410 1420 1430 1440 1450
IIPTLGQFER TQEEYEDKKH AGPSFQPEFS SGAEEALVDH TPYLSIATTH
1460 1470 1480 1490 1500
LMDQSVTEVP DVMEGSNPPY YTDTTLAVST FAKLSSQTPS SPLTIYSGSE
1510 1520 1530 1540 1550
ASGHTEIPQP SALPGIDVGS SVMSPQDSFK EIHVNIEATF KPSSEEYLHI
1560 1570 1580 1590 1600
TEPPSLSPDT KLEPSEDDGK PELLEEMEAS PTELIAVEGT EILQDFQNKT
1610 1620 1630 1640 1650
YGQVSGEAIK MFPTIKTPEA GTVITTADEI ELEGATQWPH STSASATYGV
1660 1670 1680 1690 1700
EAGVVPWLSP QTSERPTLSS SPEINPETQA ALIRGQDSTI AASEQQVAAR
1710 1720 1730 1740 1750
ILDSNDQATV NPVEFNTEVA TPPFSLLETS NETDFLIGIN EESVEGTAIY
1760 1770 1780 1790 1800
LPGPDRCKMN PCLNGGTCYP TETSYVCTCV PGYSGDQCEL DFDECHSNPC
1810 1820 1830 1840 1850
RNGATCVDGF NTFRCLCLPS YVGALCEQDT ETCDYGWHKF QGQCYKYFAH
1860 1870 1880 1890 1900
RRTWDAAERE CRLQGAHLTS ILSHEEQMFV NRVGHDYQWI GLNDKMFEHD
1910 1920 1930 1940 1950
FRWTDGSTLQ YENWRPNQPD SFFSAGEDCV VIIWHENGQW NDVPCNYHLT
1960 1970 1980 1990 2000
YTCKKGTVAC GQPPVVENAK TFGKMKPRYE INSLIRYHCK DGFIQRHLPT
2010 2020 2030 2040 2050
IRCLGNGRWA IPKITCMNPS AYQRTYSMKY FKNSSSAKDN SINTSKHDHR
2060
WSRRWQESRR
Length:2,060
Mass (Da):226,423
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD33CB7F70465D02E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX641036 mRNA Translation: CAE46022.1

NCBI Reference Sequences

More...
RefSeqi
NP_001157569.1, NM_001164097.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1462

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX641036 mRNA Translation: CAE46022.1
RefSeqiNP_001157569.1, NM_001164097.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiQ6MZK8

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1462

Genome annotation databases

GeneIDi1462

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1462
PharmGKBiPA162408788

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
1462, 3 hits in 867 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1462

Gene expression databases

GenevisibleiQ6MZK8, HS

Family and domain databases

CDDicd00033, CCP, 1 hit
cd03588, CLECT_CSPGs, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR018378, C-type_lectin_CS
IPR033987, CSPG_CTLD
IPR016187, CTDL_fold
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00008, EGF, 2 hits
PF00059, Lectin_C, 1 hit
PF00084, Sushi, 1 hit
SMARTiView protein in SMART
SM00032, CCP, 1 hit
SM00034, CLECT, 1 hit
SM00181, EGF, 2 hits
SM00179, EGF_CA, 2 hits
SUPFAMiSSF56436, SSF56436, 1 hit
SSF57535, SSF57535, 1 hit
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 1 hit
PS00615, C_TYPE_LECTIN_1, 1 hit
PS50041, C_TYPE_LECTIN_2, 1 hit
PS00022, EGF_1, 2 hits
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 2 hits
PS01187, EGF_CA, 1 hit
PS50923, SUSHI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6MZK8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6MZK8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 7, 2020
This is version 117 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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