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Entry version 108 (05 Jun 2019)
Sequence version 1 (05 Jul 2004)
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Protein
Submitted name:

Uncharacterized protein DKFZp686F219

Gene

DKFZp686K139

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized protein DKFZp686F219Imported
Submitted name:
Uncharacterized protein DKFZp686K139Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DKFZp686K139Imported
Synonyms:DKFZp686F219Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28194

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi449 ↔ 475PROSITE-ProRule annotation
Disulfide bondi463 ↔ 490PROSITE-ProRule annotation
Disulfide bondi509 ↔ 535PROSITE-ProRule annotation
Disulfide bondi523 ↔ 550PROSITE-ProRule annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q6MZF4

PRoteomics IDEntifications database

More...
PRIDEi
Q6MZF4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini139 – 179Fibronectin type-IInterPro annotationAdd BLAST41
Domaini184 – 227Fibronectin type-IInterPro annotationAdd BLAST44
Domaini228 – 271Fibronectin type-IInterPro annotationAdd BLAST44
Domaini273 – 317Fibronectin type-IInterPro annotationAdd BLAST45
Domaini318 – 362Fibronectin type-IInterPro annotationAdd BLAST45
Domaini395 – 434Fibronectin type-IInterPro annotationAdd BLAST40
Domaini444 – 492Fibronectin type-IIInterPro annotationAdd BLAST49
Domaini504 – 552Fibronectin type-IIInterPro annotationAdd BLAST49
Domaini557 – 600Fibronectin type-IInterPro annotationAdd BLAST44
Domaini605 – 647Fibronectin type-IInterPro annotationAdd BLAST43
Domaini648 – 691Fibronectin type-IInterPro annotationAdd BLAST44
Domaini699 – 791Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini811 – 901Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini902 – 993Fibronectin type-IIIInterPro annotationAdd BLAST92
Domaini998 – 1089Fibronectin type-IIIInterPro annotationAdd BLAST92

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 23DisorderedSequence analysisAdd BLAST23
Regioni116 – 137DisorderedSequence analysisAdd BLAST22

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IF4N Eukaryota
ENOG410Y2NH LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234344

KEGG Orthology (KO)

More...
KOi
K05717

Database of Orthologous Groups

More...
OrthoDBi
6580at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00061 FN1, 9 hits
cd00062 FN2, 2 hits
cd00063 FN3, 4 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.10.10.10, 2 hits
2.60.40.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000083 Fibronectin_type1
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR000562 FN_type2_dom
IPR036943 FN_type2_sf
IPR013783 Ig-like_fold
IPR013806 Kringle-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00039 fn1, 9 hits
PF00040 fn2, 2 hits
PF00041 fn3, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00058 FN1, 9 hits
SM00059 FN2, 2 hits
SM00060 FN3, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 3 hits
SSF57440 SSF57440, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01253 FN1_1, 5 hits
PS51091 FN1_2, 9 hits
PS00023 FN2_1, 1 hit
PS51092 FN2_2, 2 hits
PS50853 FN3, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q6MZF4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
GPRRLCCTGG GEGTPGASGK RGPAATTSLV LCIPSVPPPV PFPTLWPPPS
60 70 80 90 100
WRRQPPGGIR RDFSRRLRRE ANLVATCLPV RASLPHRLNM LRGPGPGLLL
110 120 130 140 150
LAVLCLGTAV PSTGASKSKR QAQQMVQPQS PVAVSQSKPG CYDNGKHYQI
160 170 180 190 200
NQQWERTYLG NALVCTCYGG SRGFNCESKP EAEETCFDKY TGNTYRVGDT
210 220 230 240 250
YERPKDSMIW DCTCIGAGRG RISCTIANRC HEGGQSYKIG DTWRRPHETG
260 270 280 290 300
GYMLECVCLG NGKGEWTCKP IAEKCFDHAA GTSYVVGETW EKPYQGWMMV
310 320 330 340 350
DCTCLGEGSG RITCTSRNRC NDQDTRTSYR IGDTWSKKDN RGNLLQCICT
360 370 380 390 400
GNGRGEWKCE RHTSVQTTSS GSGPFTDVRA AVYQPQPHPQ PPPYGHCVTD
410 420 430 440 450
SGVVYSVGMQ WLKTQGNKQM LCTCLGNGVS CQETAVTQTY GGNSNGEPCV
460 470 480 490 500
LPFTYNGRTF YSCTTEGRQD GHLWCSTTSN YEQDQKYSFC TDHTVLVQTR
510 520 530 540 550
GGNSNGALCH FPFLYNNHNY TDCTSEGRRD NMKWCGTTQN YDADQKFGFC
560 570 580 590 600
PMAAHEEICT TNEGVMYRIG DQWDKQHDMG HMMRCTCVGN GRGEWTCIAY
610 620 630 640 650
SQLRDQCIVD DITYNVNDTF HKRHEEGHML NCTCFGQGRG RWKCDPVDQC
660 670 680 690 700
QDSETGTFYQ IGDSWEKYVH GVRYQCYCYG RGIGEWHCQP LQTYPSSSGP
710 720 730 740 750
VEVFITETPS QPNSHPIQWN APQPSHISKY ILRWRPKNSV GRWKEATIPG
760 770 780 790 800
HLNSYTIKGL KPGVVYEGQL ISIQQYGHQE VTRFDFTTTS TSTPVTSNTV
810 820 830 840 850
TGETTPFSPL VATSESVTEI TASSFVVSWV SASDTVSGFR VEYELSEEGD
860 870 880 890 900
EPQYLDLPST ATSVNIPDLL PGRKYIVNVY QISEDGEQSL ILSTSQTTAP
910 920 930 940 950
DAPPDPTVDQ VDDTSIVVRW SRPQAPITGY RIVYSPSVEG SSTELNLPET
960 970 980 990 1000
ANSVTLSDLQ PGVQYNITIY AVEENQEGTP VVIQQETTGT PRSDTVPSPR
1010 1020 1030 1040 1050
DLQFVEVTDV KVTIMWTPPE SAVTGYRVDV IPVNLPGEHG QRLPISRNTF
1060 1070 1080 1090 1100
AEVTGLSPGV TYYFKVFAVS HGRESKPLTA QQTTKLDAPT NLQLSMKLIL

LSW
Length:1,103
Mass (Da):122,114
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i82FEC4CAF634AD56
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX640802 mRNA Translation: CAE45885.1
BX649182 mRNA Translation: CAE46200.1

NCBI Reference Sequences

More...
RefSeqi
NP_002017.1, NM_002026.3
NP_997643.1, NM_212478.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2335

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2335

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640802 mRNA Translation: CAE45885.1
BX649182 mRNA Translation: CAE46200.1
RefSeqiNP_002017.1, NM_002026.3
NP_997643.1, NM_212478.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiQ6MZF4
PRIDEiQ6MZF4

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
2335
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2335
KEGGihsa:2335

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2335
PharmGKBiPA28194

Phylogenomic databases

eggNOGiENOG410IF4N Eukaryota
ENOG410Y2NH LUCA
HOGENOMiHOG000234344
KOiK05717
OrthoDBi6580at2759

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2335

Family and domain databases

CDDicd00061 FN1, 9 hits
cd00062 FN2, 2 hits
cd00063 FN3, 4 hits
Gene3Di2.10.10.10, 2 hits
2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR000083 Fibronectin_type1
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR000562 FN_type2_dom
IPR036943 FN_type2_sf
IPR013783 Ig-like_fold
IPR013806 Kringle-like
PfamiView protein in Pfam
PF00039 fn1, 9 hits
PF00040 fn2, 2 hits
PF00041 fn3, 4 hits
SMARTiView protein in SMART
SM00058 FN1, 9 hits
SM00059 FN2, 2 hits
SM00060 FN3, 4 hits
SUPFAMiSSF49265 SSF49265, 3 hits
SSF57440 SSF57440, 2 hits
PROSITEiView protein in PROSITE
PS01253 FN1_1, 5 hits
PS51091 FN1_2, 9 hits
PS00023 FN2_1, 1 hit
PS51092 FN2_2, 2 hits
PS50853 FN3, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6MZF4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6MZF4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: June 5, 2019
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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