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Protein

ATP-dependent zinc metalloprotease FtsH 1

Gene

ftsH1

Organism
Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi425Zinc; catalyticUniRule annotation1
Active sitei426UniRule annotation1
Metal bindingi429Zinc; catalyticUniRule annotation1
Metal bindingi501Zinc; catalyticUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi203 – 210ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciBBAC264462:BD_RS08770-MONOMER

Protein family/group databases

MEROPSiM41.001

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent zinc metalloprotease FtsH 1UniRule annotation (EC:3.4.24.-UniRule annotation)
Gene namesi
Name:ftsH1UniRule annotation
Ordered Locus Names:Bd1928
OrganismiBdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100)
Taxonomic identifieri264462 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaOligoflexiaBdellovibrionalesBdellovibrionaceaeBdellovibrio
Proteomesi
  • UP000008080 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6CytoplasmicUniRule annotation6
Transmembranei7 – 27HelicalUniRule annotationAdd BLAST21
Topological domaini28 – 110PeriplasmicUniRule annotationAdd BLAST83
Transmembranei111 – 131HelicalUniRule annotationAdd BLAST21
Topological domaini132 – 645CytoplasmicUniRule annotationAdd BLAST514

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004003301 – 645ATP-dependent zinc metalloprotease FtsH 1Add BLAST645

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Protein-protein interaction databases

STRINGi264462.Bd1928

Structurei

3D structure databases

ProteinModelPortaliQ6MLS7
SMRiQ6MLS7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

In the central section; belongs to the AAA ATPase family.UniRule annotation
In the C-terminal section; belongs to the peptidase M41 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C3H Bacteria
COG0465 LUCA
HOGENOMiHOG000217276
KOiK03798
OMAiMNKRWRN
OrthoDBiPOG091H02HH

Family and domain databases

HAMAPiMF_01458 FtsH, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR005936 FtsH
IPR027417 P-loop_NTPase
IPR000642 Peptidase_M41
IPR037219 Peptidase_M41-like
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF01434 Peptidase_M41, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF140990 SSF140990, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01241 FtsH_fam, 1 hit
PROSITEiView protein in PROSITE
PS00674 AAA, 1 hit

Sequencei

Sequence statusi: Complete.

Q6MLS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSTQKTLAL WFFLIIMAVF LFQAYESKQQ KAIADFNFSK FTEAVKAGEV
60 70 80 90 100
ATVTFRQDTS EVVGEMKPEF EKKYNGTHFS IVGNTQDEGY KFLQQHGITP
110 120 130 140 150
NYERADNGGF FQSLLVNWLP LILIVAMFLF IMRQIQAGGG KAMSFGKSRA
160 170 180 190 200
RLLTEHKNRV TFKEVAGVDE AKEDLQEIVS FLKDPKKYTK LGGRIPKGVL
210 220 230 240 250
LVGSPGTGKT LLARAVAGEA GVPFFTISGS DFVEMFVGVG ASRVRDLFEQ
260 270 280 290 300
GKKNAPCLIF IDEIDAVGRH RGAGMGGGHD EREQTLNQLL VEMDGFESSE
310 320 330 340 350
GVIMIAATNR PDVLDPALLR PGRFDRRVIV NKPDLKGREQ ILAVHMRKTP
360 370 380 390 400
LGPDVDASKI ARGTPGFSGA DLENLVNEAA LVAARSDKKY LEMEDFEKAK
410 420 430 440 450
DKVTMGAERR SMVISDEDKK VTAYHEAGHT LVGKKLVGLD PIHKVTIIPR
460 470 480 490 500
GMALGVTQTL PEKESVSLSK SKAENMIAFL FGGRAAEELI FKDITTGAGN
510 520 530 540 550
DIERATEIAR RMVCEWGMSK LGPLAYETRD NPVFMGMGYG NKSKEYSDAK
560 570 580 590 600
AQEIDTEVEK IIKHGYDISI QILRDHQDAL ERLTQALLEY ETIDGHEVDM
610 620 630 640
LVNGAAVAEI EKYRNAKKDS NAAIMNAAEK KGSGDPVGNT GPVTI
Length:645
Mass (Da):70,985
Last modified:July 5, 2004 - v1
Checksum:i0C796FF7E166C6E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX842651 Genomic DNA Translation: CAE79779.1
RefSeqiWP_011164381.1, NC_005363.1

Genome annotation databases

EnsemblBacteriaiCAE79779; CAE79779; Bd1928
KEGGibba:Bd1928

Similar proteinsi

Entry informationi

Entry nameiFTSH1_BDEBA
AccessioniPrimary (citable) accession number: Q6MLS7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: July 5, 2004
Last modified: June 20, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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